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Hydroprene Hydroprene
is an insect growth regulator, meaning it controls insect populations by
inhibiting reproduction and breaking the life cycle. It is found in the
commercial roach control product Gentrol Point Source™, registered in
1986 by Sandoz Agro, Inc. ToxicityHydroprene
is an eye irritant; sensitive individuals may develop an allergic reaction
after repeated use. It is also a mild skin irritant and sensitizer. There
is no anticipated acute toxicity hazard "due to the nature of the
product form" (MSDS 1995). In
a subchronic feeding study of rats, the NOEL (No Observable Effect Limit)
was 50 mg/kg/day, with changes in body weight with organ weights observed
at higher dose levels. In 2-generation reproductive and developmental
toxicity tests on rats, parental reproductive performance remained
unaffected up to a dose level of 7500 ppm. Histologically, all females in
the 7500 parts per million (ppm) dose group had regression of the corpora
lutea and cytoplasmic vaxuolation in the ovaries, but without affected
reproductive performance. The NOEL for pup development is 1500 ppm. There
were no observable immunotoxic, teratogenic, fetotoxic, or mutagenic
effects found. The
environmental fate of hydroprene is not available, nor is the toxicity to
wildlife. Resource: Material Safety Data Sheet (MSDS): Gentrol Point Source. 1995. Sandoz Agro, Inc. Des Plaines, IL.
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