in an organophosphate insecticide used for the control of roaches, ants,
fleas, ticks, moths, mosquitoes, and termites either indoors or in vector
eradication programs to protect public health, and in veterinary
applications to combat parasites including ticks, lice and mites in
livestock. Its total annual usage is estimated to be 90,000 pounds active
ingredient (U.S. EPA, 2000). Propetamphos is in U.S. Environmental
Protection Agency (EPA) toxicity class II, moderately toxic and labels
must carry the signal word "Warning."
propetamphos is considered moderately toxic, with a LD50 75-119 mg/kg in
rats. It is slightly toxic dermally, with LD50 values of 2,300 to greater
than 3,100 mg/kg in rats, and greater than 10,000 mg/kg in rabbits. It is
slightly toxic via inhalation. Acute
exposure can cause nausea, numbness, tingling, incoordination, headache,
tremor, dizziness, confusion, abdominal cramps, sweating, blurred vision,
respiratory paralysis, neurological and neuromuscular effects, and death
due to cholinesterase inhibition (ETN, 1996).
have indicated that propetamphos does not cause reproductive toxicity, is
not teratogenic, is weakly or nonmutagenic, and is noncarcinogenic. The
primary target organ affected by propetamphos is the nervous system (ETN,
are no data available concerning the breakdown of propetamphos in soil,
groundwater, or vegetation. It is rapidly degraded in water only under
extreme pH conditions or in the presence of sunlight (ETN, 1996).
is moderately toxic to birds, and highly toxic to fish and aquatic
invertebrates (ETN, 1996).
Toxicology Network (ETN). 1996. Pesticide Information Profiles:
U.S. EPA. 2000. Reregistration Eligibility Document: Propetamphos. Office of Pesticide Programs. Washington D.C.