(Beyond Pesticides, April 28, 2011) In recognition of the 3rd annual Save the Frogs Day, a “Save the Frogs/Ban Atrazine Rally” will be held tomorrow, Friday, April 29th in Washington, DC. The rally will take place at the steps of the U.S. Environmental Protection Agency (1200 Pennsylvania Ave, NW), and is intended to raise awareness of the rapid disappearance of frog species worldwide, and bring attention to the harmful effects of the endocrine disrupting herbicide atrazine. Amphibian populations worldwide have been declining at unprecedented rates, and nearly one-third of the world’s amphibian species are threatened with extinction. Up to 200 species have completely disappeared in recent years. Amphibians are faced with an onslaught of environmental problems, including climate change, infectious diseases, habitat loss, invasive species, and over-harvesting for the pet and food trades. Numerous studies have definitively linked pesticide use with significant effects on amphibians. Pesticides can cause abnormalities, diseases, injury and death in these frogs and other amphibians. Because amphibians breathe through their permeable skin, they are especially vulnerable to chemical contamination. Frog eggs float exposed on the water surface, where pesticides tend to concentrate, and hatched larvae live solely in aquatic environments for five to seven months before […]

(Beyond Pesticides, April 22, 2011) Three independent investigations published in the journal Environmental Health Perspectives (EHP) have reached similar conclusions, associating prenatal exposure to organophosphate (OP) pesticides with IQ deficits in school-age children. The fact that three research groups reached such similar conclusions independently adds considerable support to the validity of the findings. The three studies were conducted at the School of Public Health at the University of California, Berkeley, the Mailman School of Public Health at Columbia University, and Mount Sinai School of Medicine. All three involved cohorts of women enrolled during pregnancy. The Berkeley and Mount Sinai investigators measured OP pesticide breakdown products in the pregnant women’s urine, while the Columbia investigators measured the OP pesticide chlorpyrifos in umbilical cord blood. Intelligence tests were administered to children of these mothers between ages 6 and 9 years at Mount Sinai and at age 7 years at Berkeley and Columbia. Although the study findings are not directly comparable, all three investigations found evidence linking prenatal OP pesticide exposures with adverse effects on cognitive function that continued into early childhood.”¨”¨“It is well known that findings from individual epidemiologic studies may be influenced by chance and other sources of error. This is […]

(Beyond Pesticides, April 14, 2011) Researchers at the University of South Florida have discovered that the most widely used fungicide in the U.S., chlorothalonil, is lethal to frogs even at low doses. Chemical pollution, according to the researchers, is considered the second greatest threat to aquatic and amphibious species in the U.S. Because many vital systems of amphibians are similar to those in humans, researchers believe that amphibians may be an underused model for studying the impacts of chemicals in the environment on human health and set out to quantify amphibian responses to chlorothalonil. The study, lead by Teagan McMahon, PhD, was published in Environmental Health Perspectives and opens the door for researchers to quantify the effects of the chemical on other species as well as other toxic pesticides on amphibian populations and human health. Researchers looked at Rana sphenocephala (Southern leopard frog) and Osteopilus septentrionalis (Cuban treefrog) in outdoor aquatic mesocosms (experimental water enclosures) with and without the expected environmental concentration as well as twice the amount of chlorothalonil. They also conducted two dose-response experiments on O. septentrionalis, Hyla squirella (squirrel treefrog), H. cinerea (green treefrogs), and R. sphenocephala, evaluating the effects of the fungicide on the stress hormone […]

(Beyond Pesticides, March 16, 2011) Congresswoman Louise Slaughter (D-NY) introduced legislation last week that seeks to help protect Americans from widespread antibiotic overuse in food animal production. Antibiotic use in agriculture, as well as in antimicrobial soaps containing materials such as triclosan, offer little to no benefit for public health, but instead contributes to increases in the growth of resistant bacteria. This makes antibiotic and antibacterial resistance a national health concern, due to the fact that it can make infections difficult or impossible to treat. Rep. Slaughter’s bill, H.R. 965 — the Preservation of Antibiotics for Medical Treatment Act, would preserve the effectiveness of antibiotics used to treat human disease by requiring the Food and Drug Administration (FDA) to revoke approval of antibiotics for non-therapeutic purposes unless the agency determines that the drugs do not produce unsafe levels of antibiotic resistance. The bill would allow farmers to continue to treat sick animals with antibiotics. “Antibiotic resistance is a major public health crisis, and yet antibiotics are used regularly and with little oversight in agriculture,” said Rep. Slaughter. The main culprits are confined animal feeding operation (CAFO) operators that routinely add human antibiotics to livestock feed for non-therapeutic purposes, such as […]

(Beyond Pesticides, March 10, 2011) The American Public Health Association (APHA) recently adopted 17 new policies at its 138th Annual Meeting in Denver, addressing a broad range of public health concerns, including a new policy calling for greater government action to protect the public from endocrine-disrupting chemicals (EDCs). The policy statement follows official positions released earlier in 2010 by both the American Medical Association (AMA) and the Endocrine Society in that more needs to be done to protect the public from endocrine-disrupting chemicals, or those that interfere with hormone action. Specifically, APHA urges: ”¢ Support for the Endocrine Society and the American Medical Association in proclaiming that more needs to be done to protect the public from potential health risks of exposure to EDCs. ”¢ That given the magnitude and urgency of the public health threat and the recognition that collectively EDCs likely will have common or overlapping effects on the endocrine system, steps should therefore be taken by federal agencies with regulatory oversight for various individual EDCs to coordinate and find synergies among themselves to coordinate and find synergy among federal agencies with regulatory oversight over various individual EDCs. ”¢ Health professionals and scientists with expertise in various aspects […]

(Beyond Pesticides, March 1, 2011) As insect resistance to pesticides steadily increases, and the underlying conditions of poverty, poor water management, and indecent living conditions contribute to the spread of malaria, the search for silver bullet solutions escalates. Researchers are exploring genetic engineering as the next frontier for a product-based approach to fighting malaria, which annually kills nearly one million people worldwide. While releasing genetically engineered organisms into the environment raises serious concerns that must be fully studied, some in the public health community believe this could help slow the spread of malaria as part of an integrated campaign. At the same time, the long-term underlying causes that support the spread of malaria must be addressed. The new research indicates that a genetically engineered fungus carrying genes for a human anti-malarial antibody or a scorpion anti-malarial toxin could be an effective tool for combating malaria, at a time when the effectiveness of current pesticides against malaria mosquitoes is declining. The researchers also say that this general approach could be used for controlling other devastating insect and tick bug-borne diseases, such as or dengue fever and Lyme disease. “Though applied here to combat malaria, our transgenic fungal approach is a very […]

(Beyond Pesticides, January 27, 2011) The U.S. Environmental Protection Agency (EPA) expanded protections for humans used as subjects in pesticide studies on January 19, 2011, making it harder for the chemical industry to experiment on people. EPA has proposed dramatic changes in how studies that intentionally expose people to pesticides can be conducted and in what studies it will accept. These proposed changes should force the chemical industry to avoid these types of studies altogether. EPA’s proposal is posted on the agency’s website and will soon be published in the Federal Register under Docket ID number EPA-HQ-OPP-2010-0785. Following this, the proposal will be open to a 60-day public comment period per a June 17, 2010 settlement agreement reached between EPA and a coalition of public health groups, farm worker advocates and environmental organizations. In 2006, the coalition, led by Natural Resources Defense Council (NRDC), filed a lawsuit against EPA, claiming that the agency’s 2006 rule violated a law Congress passed in 2005 requiring strict ethical and scientific protections for pesticide testing on humans. Attorneys with NRDC, Earthjustice, and Farmworker Justice served as legal counsel for the coalition. Specifically, the 2006 rule followed a temporary ban on human testing put in […]

(Beyond Pesticides, December 20, 2010) A new study examines the residue levels of the organophosphate insecticide chlorpyrifos in Colombian potatoes, finding that residual levels of the pesticide are still present even after being cooked. According to researchers, the pesticide has a tendency to build up in the raw potatoes, but once they were cooked, the levels dropped by 14%, leaving a fraction of the allowable levels of chlorpyrifos in the potato, under European Union (EU) daily intake limits. While it may be true that there are relatively low residual levels of the pesticide found in the potato once it has been cooked, many adocates are concerned about the remaining residues. The study, entitled “Pesticide Uptake in Potatoes: Model and Field Experiments,” was published in the journal Environmental Science and Technology. The fact that there remains some residual chlorpyrifos in the cooked potatoes is a concern because studies show that even at low doses, in utero exposure can cause changes in brain function and altered thyroid levels that last into adulthood. Young children are particularly susceptible to the effects of exposure. Because children’s diets often include significant quantities of potatoes, this is particularly alarming in light of a recent study that […]

(Beyond Pesticides, December 15, 2010) Every year, more than 10,000 kids are poisoned by rodenticides (pesticides made to kill rodents) and virtually all of the calls to U.S. poison control centers concern children under six. New rules and restrictions set by the U.S. Environmental Protection Agency (EPA) will go into effect next June in an attempt to prevent incidents involving children, but do not go far enough to protect children or wildlife. EPA has known for a generation that children have easy access to these super-toxic rat poisons. Every year, more than 10,000 kids are getting a hold of them, with Black and Hispanic children living below the poverty line being disproportionately affected. Records show that the EPA is aware that children have been getting into these poisons in significant numbers, according to data since 1983. Between 2004 and 2008, U.S. poison control centers continued to receive 10,000 to 14,000 calls about the rat killers annually. EPA has estimated that these incidents reported to poison control centers probably account for only about one-fourth of all exposures. On average, about 3,700 of these cases are treated by medical professionals each year, according to reports of the American Association of Poison Control […]

(Beyond Pesticides, December 6, 2010) A new study finds that exposure to dioxin in the womb can affect female reproduction for generations, reducing fertility and increasing the chance for premature delivery. Scientists from the Women’s Reproductive Health Research Center at Vanderbilt University School of Medicine examined the effects of a specific variety of dioxin on female mice and found that subsequent generations of the mice exposed to dioxin are at risk. The study, entitled “Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations,” was published in the journal Reproductive Toxicology. Dioxin refers to a family of chemicals linked to cancer, endocrine disruption, weakened immune systems and reproductive problems. They are persistent organic pollutants that bioaccumulate in humans and other animals, especially in fatty tissue, meaning that concentrations of dioxin in the body generally increase with age. So, even in very low doses, dioxins can cause health problems. Scientists in this study specifically looked at the variety of dioxin that is considered the most toxic, known as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a well-known contaminant of the herbicide 2,4-D, which was originally a part of the deadly chemical weapon Agent Orange. As such, TCDD is still found […]

(Beyond Pesticides, November 17, 2010) Researchers with the U.S. Geological Survey (USGS) have found a dozen agricultural fungicides in the waters and sediments downstream of farms and orchards in western states. Presented November 8, 2010 at the annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC) in Portland, Oregon, the findings represent the first such data on fungicides in the western U.S. Farmers routinely use fungus-killing compounds to spray or dust food crops, such as strawberries, corn, and soybeans. Some crops receive up to a dozen doses per growing season. Nationwide, fungicide use has risen considerably since the 1990s, reaching 350 million pounds in 2001. However, the environmental prevalence and effects on wildlife and ecosystems, particularly of newer fungicides, are poorly understood, says Kathryn Kuivila, PhD, of the USGS California Water Science Center. Environmental monitoring programs monitor concentrations of few or no fungicides, she notes. The study entitled, “Occurrence of Azoxystrobin, Propiconazole, and Selected Other Fungicides in US Streams, 2005—2006,” documents the occurrence of fungicides in select U.S. streams soon after the first documentation of soybean rust in the U.S. and prior to the corresponding increase in fungicide use to treat this problem. Water samples were collected from […]

(Beyond Pesticides, October 21, 2010) Last week, the U.S. Environmental Protection Agency (EPA) announced that it has forwarded to the Secretary of Agriculture a draft proposed rule to amend EPA’s protocol for the testing of pesticides on humans. This draft proposed rule is a result of a settlement agreement reached on June 2010 in a lawsuit over its 2006 final rule. The 2006 final rule lifted a ban on human testing put in place by Congress. It allows experiments in which people are intentionally dosed with pesticides to assess the chemicals’ toxicity and allows EPA to use such experiment to set allowable exposure standards. In such experiments, people have been paid to eat or drink pesticides, to enter pesticide vapor “chambers,” and to have pesticides sprayed into their eyes or rubbed onto their skin. The pesticide industry has used such experiments to argue for weaker regulation of harmful chemicals. The coalition that challenged the regulation argued in the U.S. Court of Appeals for the Second Circuit that the rule ignores scientific criteria proposed by the National Academy of Sciences, did not prohibit testing on pregnant women and children, and even violated the most basic elements of the Nuremberg Code, including […]

(Beyond Pesticides, October 14, 2010) Over 13,000 organizations and individuals -consumers, parents, health advocates, farmworkers and others- from across the U.S. sent a letter to the Environmental Protection Agency (EPA) yesterday calling for a ban on the insecticide chlorpyrifos and a phase out of other organophosphate (OP) pesticides. Chlorpyrifos was phased out for residential use under a 2000 agreement between EPA and Dow Agrosciences, but continues to expose farmworkers and consumers through its use in agriculture. Also on October 13, the Endocrine Disruption Exchange (TEDX), led by renowned scientist Theo Colborn, PhD, announced the addition of chlorpyrifos to its online database, Critical Windows of Development, spotlighting research that links prenatal, low dose chlorpyrifos exposure to altered health outcomes in the brain and other organs. “Human studies have now linked prenatal exposure to chlorpyrifos with mental and developmental delays emphasizing even more the urgency to remove the product from the market,” said Dr. Colborn, President of TEDX and a signatory on the letter. “Chlorpyrifos illustrates the urgent need to be cautious, prevent further exposure and protect our children from the time they are conceived onward.” Beyond Pesticides calls EPA’s 2000 chlorpyrifos settlement with Dow a classic failure of the risk assessment […]

(Beyond Pesticides, September 28, 2010) A study published in the September 2010 issue of the journal Environmental Health Perspectives links low dose exposure to some persistent organic pollutants (POPs) to type 2 diabetes. The authors report that some POPs, including highly chlorinated PCBs, PBB153 and the organochlorine insecticides trans-nonachlor, oxychlordane and mirex, were associated with type 2 diabetes over an 18-year period, especially in obsese people. However, POPs did not show a traditional dose—response relationship with diabetes. Instead, POPs showed strong associations at relatively low exposures. The authors conclude that exposure to relatively low concentrations of certain POPs may play a role in the increased incidence of diabetes in the United States. The study, “Low Dose of Some Persistent Organic Pollutants Predicts Type 2 Diabetes: A Nested Case—Control Study,” examines participants who were diabetes free in 1987—1988. By 2005—2006, the 90 controls remained free of diabetes, whereas the 90 cases developed diabetes. Using serum collected in 1987—1988, the authors measured 8 organochlorine pesticides, 22 polychlorinated biphenyl congeners (PCBs), and 1 polybrominated biphenyl (PBB). They compare POP concentrations from Coronary Artery Risk Development in Young Adults (CARDIA) cohort and the National Health and Nutrition Examination Survey (NHANES) in 2003—2004. Persistent organic […]

(Beyond Pesticides, September 22, 2010) The National Conversation on Public Health and Chemical Exposures, a collaborative initiative aimed at developing an action agenda for strengthening the nation’s approach to protecting the public’s health from harmful chemical exposures, has drafted six work group reports on cross-cutting public health and chemical exposure topics. Public comment is invited and has been extended to Monday, September 27, 2010. Supported by the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ASTDR), the National Conversation is a collaborative project that was launched in June 2009 to engage CDC, ATSDR, other organizations working on chemical exposure issues, and the public to develop an action agenda with clear, achievable recommendations that can help government agencies and other organizations strengthen their efforts to protect the public from harmful chemical exposures. Beyond Pesticides is an active participant in the National Conversation. Six work groups have convened to research and make recommendations on public health and chemical exposure issues. Public comment is needed for each work groups’ final reports as they work to develop the action agenda. To view work group reports and instructions for submitting comments, visit each work group’s page: Monitoring […]

(Beyond Pesticides, September 20, 2010) California-based discount retailer 99 Cents Only Stores Inc. has been fined over $400,000 for selling three household products containing unregistered or mislabeled pesticides. It is the largest contested penalty ever handed down by EPA. According to EPA, the retailer continued to sell the products even after being notified that they were violating regulations. EPA found 99 Cents Only Stores were selling products in violation of the Federal Insecticide Fungicide and Rodenticide Act (FIFRA) during a routine inspection in 2004. Subsequent inspections up until 2008 found additional problems resulting in a total of 166 separate violations. Originally. EPA handed down a $1 million fine. 99 Cents Only Stores Inc decided to contest the penalty. These types of fines are rarely contested. In the end, EPA Administrative Law Judge Susan Biro ruled the company would pay a fine of $409,490, declaring the retailer’s management had a “culture of indifference.” Of the 166 violations committed by 99 Cents Only stores Inc., 164 were related to a household cleaner and sanitizer imported from Mexico called Bref Limpieza y Disinfeccion Total con Densicloro which translates into “Bref Complete Cleaning and Disinfection with Densicloro.” The product had pesticidal claims on the […]

(Beyond Pesticides, August 31, 2010) As the Environmental Protection Agency (EPA) continues its review of the popular herbicide atrazine, a new study shows that male rats prenatally exposed to low doses of the gender-bending chemical are more likely to develop prostate inflammation and to go through puberty later than non-exposed animals. The research adds to a growing body of literature on atrazine, an herbicide used in agriculture, especially in corn and sugar cane production, and on golf courses and residential lawns. Atrazine and its byproducts are known to be relatively persistent in the environment, potentially finding their way into water supplies. It has been linked to a myriad of health problems in humans including disruption of hormone activity, birth defects, and cancer. The research, “Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats,” which is available online and will be featured on the cover of Reproductive Toxicology (Vol. 30, # 4), found that the incidence of prostate inflammation went from 48 percent in the control group to 81 percent in the male offspring who were exposed to a mixture of atrazine and its breakdown products prenatally. The severity […]

(Beyond Pesticides, August 20, 2010) Behind closed doors this past Monday, the U.S. Environmental Protection Agency (EPA) and Bayer CropScience reached an agreement on a set of measures to gradually reduce and ultimately ban fully the use of the insecticde aldicarb in the U.S. This decision arrives on the heels of a revised risk assessment in which EPA found that babies and children under the age of five can ingest levels of the insecticide through food and drinking water at levels that exceed limits that the agency finds safe, and 25 years after 2,000 people fell ill after eating watermelons that were tainted with the pesticide. Though Beyond Pesticides applauds any decision to remove toxic chemicals from the environment, the problem with this cancellation, as with virtually all voluntary cancellations, is that the chemical can be legally used for years —eight years in this case — leaving open the opportunity for continued human and environmental exposure and harm. The decision was reached after EPA completed a revised risk assessment indicating that the pesticide does not meet the agency’s food safety standards. EPA scrutinized recent food consumption data from USDA to complete the risk assessment, which considered the percent of the […]

(Beyond Pesticides, August 5, 2010) A 400-year old large old grape vine considered to be the nation’s oldest in Manteo, North Carolina and known lovingly as “Mother Vine,” is slowly recovering from a powerful dose of herbicide sprayed by a utility company. The Virginia-based Dominion Power Company contracted Lewis Tree Service to spray power poles along the roads in the Manteo in May. The herbicide they used, Garlon3A, was accidentally sprayed on a tiny shoot from the vine that had grown a few feet up a pole on 84-year old Jack Wilson’s property. Unaware of the recent herbicide spraying by the utility power company, he noticed various brown, dead sections that began to appear in the plant in May. Not only did the vine suffer, but about 10 feet of a nearby hedge died, along with three limbs of a large pecan tree that had to be trimmed. The active ingredient in Garlon 3A, a Dow Chemical product, is triclopyr. It is a systemic herbicide which means that the poison spreads from the ends of the vine back toward the root. As a broadleaf weed killer, triclopyr is frequently used along rights-of-way and on industrial sites. In laboratory tests, triclopyr […]

(Beyond Pesticides, August 3, 2010) A new study shows that due to a flaw in standard risk assessments, which consider toxic effects at fixed exposure times, the risks posed by the neonicotinoid pesticides imidacloprid and thiacloprid are likely to be underestimated. The authors believe that minute quantities of imidicloprid may be playing a much larger role in killing bees over extended periods of time than previously thought. The study, “The significance of the Druckrey—Küpfmüller equation for risk assessment””The toxicity of neonicotinoid insecticides to arthropods is reinforced by exposure time,” was published online July 23, 2010 in the journal Toxicology. The authors believe that standard risk assessment calculations underestimate toxicity because they do not accurately account for the interplay of time and level of exposure. According the study: The essence of the Druckrey—Küpfmüller equation states that the total dose required to produce the same effect decreases with decreasing exposure levels, even though the exposure times required to produce the same effect increase with decreasing exposure levels. Druckrey and Küpfmüller inferred that if both receptor binding and the effect are irreversible, exposure time would reinforce the effect. The Druckrey—Küpfmüller equation explains why toxicity may occur after prolonged exposure to very low toxicant […]

(Beyond Pesticides, July 27, 2010) Groups filed a lawsuit in federal court to force the Environmental Protection Agency (EPA) to decide whether or not it will cancel all remaining uses and tolerances for the pesticide chlorpyrifos, which has been banned for residential use, but continues to expose farmworkers and consumers through its use in agriculture. In September 2007, the Natural Resources Defense Council (NRDC) and Pesticide Action Network North America (PANNA) filed a petition with EPA asking the agency to ban chlorpyrifos. In the nearly three years since, the agency has not responded. NRDC and PANNA v. EPA, filed by the nonprofit environmental law firm Earthjustice on July 22, 2010, would force EPA to make a decision on the pesticide’s ban. “This dangerous pesticide has no place in our fields, near our children, or on our food,” said Earthjustice attorney Kevin Regan. “We’re asking a court to rule so that EPA will finish the job and ban this poison.” According to Beyond Pesticides, EPA’s 2000 negotiated settlement with Dow AgroSciences, which allows the highest volume chlorpyrifos uses to continue, represents a classic failure of the risk assessment process (including the so-called cumulative risk assessment which accounts for all chemicals with […]

(Beyond Pesticides, June 21, 2010) Pesticide experiments using people as test subjects will have stricter federal rules to follow under a new agreement reached on June 17, 2010 between the U.S. Environmental Protection Agency (EPA) and public health groups, farm worker advocates and environmental organizations. “People should never have been used as lab rats for testing pesticides,” said Natural Resources Defense Council (NRDC) senior attorney Michael Wall. “Under today’s settlement, EPA will propose far stronger safeguards to prevent unethical and unscientific pesticide research on humans.” In 2006, a coalition of health and environmental advocates and farmworker protection groups led by NRDC filed a lawsuit against EPA, claiming EPA’s recent rule violated a law Congress passed in 2005 requiring strict ethical and scientific protections for pesticide testing on humans. EPA’s 2006 rule lifted a ban on human testing put in place by Congress. It also allows experiments in which people are intentionally dosed with pesticides to assess the chemicals’ toxicity and allows EPA to use such experiment to set allowable exposure standards. In such experiments, people have been paid to eat or drink pesticides, to enter pesticide vapor “chambers,” and to have pesticides sprayed into their eyes or rubbed onto their […]

(Beyond Pesticides, June 16, 2010) Men with certain genetic variations who were exposed to some toxic pesticides that are now largely banned run an increased risk of developing Parkinson’s disease, French scientists said Monday. In a study published in Archives of Neurology, entitled “Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease,” French researchers found that among men exposed to pesticides such as DDT, carriers of the gene variants are three and a half times more likely to develop Parkinson’s than those with the more common version of the gene. The scientists think the brains of people with the gene variant fail to flush out toxic chemicals as efficiently as those with common versions of the gene, suggesting that environmental as well as genetic factors are important in the risk of Parkinson’s. Alexis Elbaz, MD, PhD and Fabien Dutheil, PhD, of France’s National Institute for Health and Medical Research (INSERM) studied 101 men with Parkinson’s and 234 without the disease to look at links between organochlorine exposure and Parkinson’s disease. The study includes only men, and all of them had high levels of exposure to pesticides through their work as farmers. The scientists found the link was […]