(Beyond Pesticides, April 29, 2009) The U.S. Environmental Protection Agency (EPA) announced earlier this month that it is finally ready to move forward with preliminary testing of 67 active and inert pesticide ingredients for possible endocrine disrupting effects. But, according to prominent researcher and author Theo Colborn, PhD, these tests are outdated, insensitive, crude, and narrowly limited, and will fail to detect many serious effects on human development. In an eye-opening opinion-editorial published in Environmental Health News, Dr. Colborn, founder and president of The Endocrine Disruption Exchange, and Co-author of Stolen Future, says that EPA’s testing protocol is “a pitiful skeleton” of what it needs to be. The tests to be used by EPA were first recommended in 1998. Since then the science has made progress and become more sophisticated. Current research is based on different assumptions than the toxicological assumptions that first drove the EPA test designs. However, EPA has not updated its protocol. Each of EPA’s tests and assays was designed under the surveillance of corporate lawyers who had bottom lines to protect and assorted toxicologists who were not trained in endocrinology and developmental biology. For over a decade, EPA ignored the vast wealth of information on endocrine […]

(Beyond Pesticides, March 31, 2009) More than 20 percent of private domestic wells sampled nationwide contain at least one contaminant at levels of potential health concern, according to a study by the U.S. Geological Survey (USGS). About 43 million people – or 15 percent of the Nation’s population – use drinking water from private wells, which are not regulated by the federal Safe Drinking Water Act. USGS scientists sampled about 2,100 private wells in 48 states and found that the contaminants most frequently measured at concentrations of potential health concern were inorganic contaminants, including radon and arsenic. These contaminants are mostly derived from the natural geologic materials that make up the aquifers from which well water is drawn. Nitrate was the most common inorganic contaminant derived from man-made sources””such as from fertilizer applications and septic-tanks””that was found at concentrations greater than the federal drinking-water standard for public-water supplies (10 parts per million). Nitrate was greater than the standard in about four percent of sampled wells. Other contaminants found in the private wells were man-made organics, including herbicides, insecticides, solvents, disinfection by-products, and gasoline chemicals. The study shows that the occurrence of selected contaminants varies across the country, often following distinct […]

(Beyond Pesticides, March 19, 2009) Researchers investigating the long-term immune effects of dioxin have found that exposure to dioxin during development or while nursing diminishes the capacity to fight infection later in life. The study, published in Toxicological Sciences, reported that mouse pups born to pregnant mice that were exposed to a small amount of dioxins had fewer white blood cells that normally kill the flu virus and more of a different kind that increases lung inflammation. The study entitled, “The aryl hydrocarbon receptor affects distinct tissue compartments during ontogeny of the immune system,” aimed to identify the critical windows of exposure where fetuses are most sensitive to dioxin’s harmful effects. Pregnant mice were given a dose of 1,000 ppt dioxin either during pregnancy, lactation, or throughout pregnancy and lactation. After dosing, mothers and pups were kept dioxin-free. Researchers then infected mothers and pups with a non-lethal dose of the influenza virus. Researchers found that the number of specialized white blood cells – referred to as CD8+ T-cells that specifically recognize and kill the flu virus, were significantly reduced in the pups but not their mothers. The most severe reduction in these white blood cells was seen when dioxin was […]

(Beyond Pesticides, March 12, 2009) An updated database on pesticide residues on chemically-produced food released by the Environmental Working Group (EWG) supports one of the important benefits of eating organically produced and processed food –a safer diet. At the same time, consumers choosing organic food support production practices that: (i) ensure cleaner air and water; (ii) improve soil health and sustainability; (iii) reduce escalating global warming; (iv) protect bees and other pollinators; and, (v) create safer workplaces for those who grow and harvest food. When organic foods are not easily accessible due to cost or availability, Beyond Pesticides recommends that consumers buy organically produced commodities for those foods they eat most often (e.g. children’s juice) and for those foods that contain the greatest amount of pesticides. EWG’s recently released 5th edition Shopper’s Guide to Pesticides is a tool to help individuals avoid produce containing the highest amount of pesticides. However, research indicates that regulators know much less than they should and do not collect residue data on most of pesticides’ toxic breakdown products (metabolites), inert ingredients, and contaminants. Additionally, pesticides that are untested by EPA for certain health effects of concern (e.g. endocrine disruption, behavioral impacts) may be dismissed as […]

(Beyond Pesticides, February 23, 2009) Permethrin and lindane metabolites are found in children who use lice shampoos containing the insecticides, according to researchers affiliated with the Centers for Disease Control and Prevention. The study, “Pesticide exposure resulting from treatment of lice infestations in school-aged children in Georgia,” published in the February issue of the journal Environment International, is the first to measure children’s exposure to chemical lice treatments. The researchers collected baseline urine samples from 78 enrolled children between the ages of six to ten years of age. About one-third of those children were diagnosed with head lice and subsequently treated with at least one over-the-counter permethrin lice treatment, a prescription lindane treatment, or both. Within seven days of the insecticide application, urine samples were again collected. The permethrin exposed children had significantly higher urinary pryrethoid metabolite levels in their post-exposure urine samples. Lindane metabolites were also elevated in urine samples after treatment. Interestingly, the study states, “Exposed participants appeared to have higher pre-exposure metabolite levels — likely from multiple treatments before enrollment — than unexposed participants.” Pentachlorophenol, a metabolite of lindane, was significantly higher in the urine of those children who used a lice treatment regardless of whether it […]

(Beyond Pesticides, February 19, 2009) The Endocrine Exchange (TEDX) has released a new database on the prenatal origins of endocrine disruption, called Critical Windows of Development. It compares human development in the womb with laboratory research showing where and when low-dose exposures to chemicals have effects. The timeline currently charts three chemicals: dioxin, bisphenol A (BPA), and phthalates. TEDX plans to expand the database to include PCBs, PBDEs, DDT, and other endocrine-disrupting pesticides. Examples of conclusions from the prenatal exposure research include: BPA affects development of the male and female reproductive systems, increases susceptibility to breast cancer and alters behavior in adult animals; Phthalates decrease sperm production and increase body weight; and, dioxin affects male reproduction and the immune system. Before a baby is born it is exposed to a myriad of endocrine disrupting chemicals (EDCs). EDCs interfere with the delicate system of vital hormones, glands and organs that control how a baby develops and functions throughout life. EDCs such as BPA, dioxin and phthalates can penetrate the womb and cause adverse effects at extremely low exposure levels. These chemicals are found in water bottles, food cans, dental resins, cleaning products, cosmetics, fragrances, packaging and construction material, cars, planes, recreational […]

Transforming Government’s Approach to Regulating Pesticides to Protect Public Health and the Environment is a document drafted by Beyond Pesticides and Pesticide Action Network North America that captures grassroots pesticide priorities for the Obama Administration. While we have already submitted these priorities to the Obama transition team, we ask for your support and suggestions because we will continue to use this document as we begin to work with the new administration. To sign on to the document, follow the link above and include your name, organization/company affiliation (if any), city and state in the comment field. The document identifies what the Obama administration can/should take on under existing authority/statutory responsibility, with a specific focus on the first 100 days. Most of the comments in our document focus on pending regulatory actions and pending petitions before the government, either because of ongoing chemical reviews, pending rulemaking, or petitions. While we incorporate big picture thinking, we are focused on specific actions that the relevant agencies could take now. We plan to meet and communicate with the Obama administration to put these suggested actions in place. Issues covered in the document include, but are not limited to: Promoting organic agriculture; Protecting sensitive species; […]

(Beyond Pesticides, December 18, 2008) The New Zealand’s Environmental Risk Management Authority (ERMA) has announced it will ban the controversial organochlorine pesticide endosulfan, effective January 16, 2009. Endosulfan, already banned in numerous countries including all the European Union countries, is an insecticide used on a wide range of fruits and vegetables and also on athletic fields in New Zealand. Illegal residues have been found in beef destined for South Korea, resulting in enormous costs for New Zealand exporters. Use of endosulfan for agriculture continues in the U.S., despite causing severe health and environmental problems. A coalition of groups, including the Pesticide Action Network Aotearoa New Zealand (PAN ANZ), Soil and Health Association and Safe Food Campaign, have long campaigned for the banning of endosulfan. Earlier this year, the three organizations carried out a number of residue tests on produce to draw attention to the extent of endosulfan residues, especially in tomatoes. “We are delighted that ERMA has overturned its earlier ”˜proposed’ decision to keep using this pesticide,” stated Meriel Watts, Ph.D., co-coordinator of PAN ANZ. “It would have been deeply embarrassing for New Zealand to continue its use when the pesticide has entered the process for a global ban under […]

(Beyond Pesticides, December 12, 2008) A new study has found pesticides in surface waters around the United States. The U.S. Geological Survey (USGS) analyzed water from nine selected rivers, which are used as a source for public water systems and found that low levels of certain xynthetic chemicals remain in public water supplies after being treated in selected community water facilities. “Most of the man-made chemicals assessed in the USGS study are unregulated in drinking water and not required to be monitored or removed,” says Tom Jacobus, General Manager of the Washington Aqueduct. “These findings are not surprising and they will be important in helping regulators and assisting water utility managers arrive at decisions about future water treatment processes.” Scientists tested water samples for about 260 commonly used chemicals, including pesticides, solvents, gasoline hydrocarbons, personal care and household-use products, disinfection by-products, and manufacturing additives. This study did not look at pharmaceuticals or hormones. Low levels of about 130 of the synthetic chemicals are detected in streams and rivers before treatment at the public water facilities (source water). Nearly two-thirds of these chemicals are also detected after treatment. Most of the chemicals found are at levels equivalent to one thimble of […]

(Beyond Pesticides, December 11, 2008) In a recent study, researchers find that triclosan, the antibacterial agent found in many consumer products including soaps, toothpaste, cosmetics, counter tops and toys, alters thyroid function in male rats. These effects are observed at concentrations that may be used in consumer products and highlight the growing threat consumers face from this hazardous and ubiquitous chemical. The study, entitled, “The effects of triclosan on puberty and thyroid hormones in male wistar rats,” was reviewed by the National Health and Environmental Effects Research Laboratory, the U.S. Environmental Protection Agency (EPA) and approved for publication in Toxicological Sciences. Researchers measured blood concentrations of testosterone and several other types of hormones and weighed a variety of organs that are essential for rat development and puberty, including the pituitary gland, the testes, the prostate gland and the liver of male rat pups fed an oral dose of triclosan for 31 days. The purpose of the experiment was to determine what effects triclosan would have on concentrations of thyroid hormones and the onset of puberty. Results show a dramatic decrease in the thyroid hormone -thyroxine in rats exposed to increasing concentrations of triclosan, as well as significant increases in liver […]

(Beyond Pesticides, November 17, 2008) A toxic soup of the most commonly used pesticides frequently detected in nature can adversely affect the environment and decimate amphibian populations even if the concentration of the individual chemicals are within limits considered safe, according to University of Pittsburgh research published in the online edition of Oecologia. The results of this study build on a nine-year effort to understand potential links between the global decline in amphibians, routine pesticide use, and the possible threat to humans in the future. Amphibians are considered an environmental indicator species because of their unique sensitivity to pollutants. Their demise from pesticide exposure could foreshadow the fate of less sensitive animals, according to study author Dr. Rick Relyea, Ph.D., an associate professor of biological sciences in the University of Pittsburgh’s School of Arts and Sciences. Leopard frogs, in particular, are vulnerable to contamination; once plentiful across North America, their population has declined in recent years as pollution and deforestation has increased. Dr. Relyea exposed gray tree frog and leopard frog tadpoles to small amounts of the ten pesticides that are widely used throughout the world. Dr. Relyea selected five insecticides: carbaryl, chlorpyrifos, diazinon, endosulfan, and malathion; and five herbicides: […]

(Beyond Pesticides, November 11, 2008) Researchers at the Duke University School of Medicine have linked organophosphate pesticides to the epidemics of obesity and type 2 diabetes. The researchers specifically link neonatal low-dose parathion exposure in rats to disruption of glucose and fat homeostasis. The study, “Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Reprogramming of Metabolism and Alters the Response to a High-Fat Diet in Adulthood,” was published in the November 2008 issue of Environmental Health Perspectives. It follows research by the National Institutes of Health (NIH) that links pesticide exposure to type 2 diabetes using epidemiological data from the Agricultural Health Study. Although most studies of organophosphates focus on their neurotoxicity, there is increasing evidence that these agents may also have a lasting impact on metabolic function. According to authors, obesity and consequent type II diabetes are rising at epidemic rates in the U.S. and many other countries around the world. Two of three U.S. adults are now classified as overweight. There are epidemiologic links between pesticide exposure and diabetes, and the same subpopulations that have the highest rates of obesity””inner-city, low-socioeconomic-status, agricultural populations””are also those that have greater exposure to organophosphates and other pesticides. The researchers chose parathion […]

(Beyond Pesticides, October 6, 2008) University of Pittsburgh researchers have found that the commonly used insecticide malathion can decimate tadpole populations by altering their food chain. The study, published in the October 1 edition of Ecological Applications, finds that gradual amounts of malathion that were too small to directly kill developing leopard frog tadpoles instead sparked a biological chain of events that deprived them of their primary food source. As a result, nearly half the tadpoles in the experiment did not reach maturity and would have died in nature. The results build on a nine-year effort to investigate whether there is a link between pesticides and the global decline in amphibians, which are considered an environmental indicator species because of their sensitivity to pollutants. According to the researchers, their deaths may foreshadow the poisoning of other less environmentally-sensitivespecies, including humans. According to the U.S. Environmental Protection Agency (EPA), malathion is the most commonly used insecticide in U.S. agriculture and the third most commonly used insecticide in the U.S. home and garden sector. It has been detected in the wetlands where frogs and other amphibians live. The researchers created simulated ponds from 300-gallon outdoor tanks containing wood frog and leopard frog […]

(Beyond Pesticides, September 22, 2008) A study published in the September issue of Environmental Health Perspectives finds that low-dose, short-term exposure to esfenvalerate, a synthetic pyrethroid pesticide, delays the onset of puberty in rats at doses two times lower than U.S. EPA’s stated no observable effect level (NOEL) of 2.0 mg/kg/day. Synthetic pyrethroids are used for everything from lawn care and household insecticides, to mosquito control and agriculture. There are currently 348 pesticide products registered by the U.S. EPA. The researchers conclude: “Although the exact mechanism of action is unknown at this time, we observed the effects at dosage levels below the NOEL established through chronic dietary exposure studies in rats. The U.S. EPA (1998) http://www.epa.gov/fedrgstr/EPA-PEST/1998/April/Day-29/p11372.htm stated that ”˜There is no evidence of additional sensitivity to young rats or rabbits following pre- or postnatal exposure to esfenvalerate.’ The present study shows that immature female rats exposed to 1.0 mg/kg/day are sensitive to this pesticide, as evidenced by their delay in the onset of puberty. Delayed pubertal onset in humans has been associated with low bone mass density (Ho and Kung 2005), and estrogen is necessary for bone mineral acquisition in both girls and boys (Yilmaz et al. 2005). Importantly, a […]

(Beyond Pesticides, July 17, 2008) In a new study published in Environmental Health Perspectives, researchers have found an increased occurrence of intersex toads in areas with greater agricultural land cover. This points to a link between certain pesticides and endocrine disruption, a change in the hormonal balance that can have sexual and reproductive effects. Such results implicate pesticides in the decline of amphibian populations, and suggests that these chemicals are also adversely affecting humans. The study, which was conducted in south Florida, looked at cane toads, Bufo marinus, at five sites with differing land use patterns ranging from suburban to nearly completely agricultural (primarily sugarcane and vegetables). Researchers examined physical characteristics such as coloration, sexual organs, and forelimb length, as well as hormone concentrations, and found a higher rate of feminization for toads in agricultural areas. In these areas, glyphosate (the active ingredient in Round Up herbicide) and atrazine (an herbicide) use is common. Tyrone Hayes, PhD, was one of the first to document the endocrine disrupting effects of atrazine on frogs in a laboratory setting. Countering any doubts of why this work is important, Dr. Hayes said, “People often say, ”˜It is just frogs, so who cares?’ Well it […]

*July 14, 2008 Update: Officials have reported that the cause for poisoning of these Maryland residents was jimsonweed, not pesticides. Jimsonweed was found in the garden of the home where the stew had been prepared. Symptoms are similar to organophosphate pesticide poisonings. (Source: NBC4) (Beyond Pesticides, July 10, 2008) Showing just how toxic common pesticides can be, six people in Gaithersburg, Maryland who ate potentially contaminated stew have been hospitalized with probable pesticide poisoning. Reports say that mint leaves from a backyard garden that were in a potato stew are suspected to have contained organophosphate pesticide residues. Unfortunately, the media is reporting this as a case of failing to wash produce properly, which does not address the root of the pesticide poisoning problem””that pesticides are hazardous and their uses cause harm. In fact, when EPA registers pesticides for use in food production, whether in the garden or commercial agriculture, it does not disclose or warn the public about pesticide residues or require the washing of treated food commodities, and it does not point to the availability of nontoxic alternatives. The Washington Post reports, “In a textbook illustration of the importance of thoroughly washing plants and vegetables before eating them, authorities […]

(Beyond Pesticides, June 30, 2008) The European Union’s (EU) agricultural ministers have agreed to revise pesticide restrictions across the 27-member state. The draft proposals ban pesticides that are known to cause cancer, endocrine disruption, or reproductive harm in humans, affecting up to 15 percent of currently used products. However, in “exceptional cases, when available products do not offer sufficiently effective plant protection, other hazardous substances may be used, but only under strictly regulated conditions.” The agreement’s next step is parliamentary approval, where lawmakers could make the final rule even stricter.The proposal would push farmers and chemical companies to replace the most toxic products with alternatives, remove provisional licenses for pesticides not yet registered with the EU, restrict the use of crop-dusters, and ban pesticides near sensitive areas.“One of the main aims of the proposal is to maintain a high level of protection for humans, animals and the environment. This is essential for our citizens,” said EU Health Commissioner Androulla Vassiliou, who advocated for this ban in May. “We will not authorize what is known to be harmful for public health.” Hungary, the Irish Republic, Romania, and the UK abstained from voting, citing risk of crop yields and lack of research […]

(Beyond Pesticides, June 13, 2008) A recent study by Newcastle University, published in the Journal of Science of Food and Agriculture, finds that organic farmers who let their cows graze as nature intended are producing better quality milk. The Nafferton Ecological Farming Group study finds that grazing cows on organic farms in the UK produce milk which contains significantly higher beneficial fatty acids, antioxidants and vitamins than their conventional ”˜high input’ counterparts. During the summer months, one of the beneficial fats in particular — conjugated linoleic acid, or CLA9 — is found to be 60% higher.”We have known for some time that what cows are fed has a big influence on milk quality,” explained Gillian Butler, livestock project manager for the Nafferton Ecological Farming Group at Newcastle University, who led the study. “What is different about this research is it clearly shows that on organic farms, letting cows graze naturally, using forage-based diet, is the most important reason for the differences in the composition between organic and conventional milk.“We’ve shown that significant seasonal differences exist, with nutritionally desirable fatty acids and antioxidants being highest during the summer, when the cows are eating fresh grass and clover.” “As a result, our […]

(Beyond Pesticides, June 4, 2008) On May 29, 2008, the U.S. Environmental Protection Agency (EPA) released its final risk mitigation decision for ten rodenticides, which outlines new measures it says will help protect children and the public from accidental poisonings as well as to decrease exposures to pets and wildlife from rodent-control products. However, because the decision omits key uses, allows continued applicator use of dangerous formulations, and recognizes a lack of product efficacy without a fully integrated program (yet does not require it on the label), environmentalists feel the final risk mitigation decision falls short of adequately protecting the health of people, wildlife and the environment.EPA is requiring that ten rodenticides used in bait products marketed to consumers be enclosed in bait stations, making the pesticide inaccessible to children and pets, and is also prohibiting the sale of loose bait, such as pellets, for use in homes. These ten rodenticides are: ”¢ Brodifacoum ”¢ Bromadiolone ”¢ Bromethalin ”¢ Chlorophacinone ”¢ Cholecalciferol ”¢ Difenacoum ”¢ Difethialone ”¢ Diphacinone ”¢ Warfarin ”¢ Zinc phosphide Exposure to children is also a major concern for these chemicals. According to the 2006 Annual Report of the American Association Poison Control Centers’ National Poison Data […]

(Beyond Pesticides, May 30, 2008) A recent study has linked the common herbicide atrazine with endocrine disruption in both fish and human cells. Entitled “The Herbicide Atrazine Activates Endocrine Gene Networks via Non-Steroidal NR5A Nuclear Receptors in Fish and Mammalian Cells,” the University of Califonia, San Francisco (UCSF) research examines the reaction of zebrafish to environmentally relevant levels of atrazine, and mirrors the study in human placental cells. The zebrafish, which are particularly sensitive to endocrine disruptors,  are “feminized”  in greater proportion than the unexposed control group. Fish exposed to atrazine for 48 hours at levels found in agricultural runoff produced twice as many female fish as male. “These fish are very sensitive to endocrine disrupting chemicals, so one might think of them as ‘sentinels’ to potential developmental dangers in humans,” said senior author Holly Ingraham, PhD. “These atrazine-sensitive genes are central to normal reproduction and are found in steroid producing tissues. You have to wonder about the long-term effects of exposing the rapidly developing fetus to atrazine or other endocrine disruptors.” In human cell studies, the researchers found that atrazine activates genes involved in hormone signally and steroid synthesis. “Endocrine-related cell types with a capacity for steroid generation appear […]

(Beyond Pesticides, April 3, 2008) Wines on sale in the European Union (EU), including wines made by world famous vineyards, contain residues of a number of pesticides, according to a new report by Pesticide Action Network Europe. The organization tested 40 bottles of wine purchased inside the EU from Australia, Austria, Chile, France, Italy, Germany, Portugal and South Africa, six of which were organic wines. Every bottle of conventional wine included in the analysis was found to contain pesticides, with one bottle containing 10 different pesticides. On average each wine sample contained over four pesticides. The analysis revealed 24 different pesticide contaminants, including five classified as being carcinogenic, mutagenic, toxic to the reproductive system or endocrine disrupting. The most widespread pesticide contaminant was pyrimethanil, a possible carcinogen, which was detected in 25 bottles of conventional wine — almost 75% of all conventional samples analyzed. While the majority of wines tested were selected from low cost affordable brands, three of the bottles are world famous Bordeaux wines and more expensive, according to PAN Europe. The discovery of pesticides in samples of wine follows the publication of a report by the French Ministry of Agriculture which identified 15 pesticides as being systematically […]

(Beyond Pesticides, March 20, 2008) A 2000-2005 U.S. Geological Survey (USGS) study, Pesticide Occurrence and Distribution in the Lower Clackamas River Basin, Oregon, 2000-2005, finds a variety of pesticides in river and tributary samples, along with trace-level detections of pesticides in treated drinking-water samples collected from a drinking-water treatment plant that uses the Clackamas River as a raw-water source. While the federal government is quick to point out that detections in drinking water are below existing Environmental Protection Agency (EPA) drinking-water standards and most river samples are below the agency’s aquatic life benchmarks, studies show hazardous endocrine-disrupting and immunosuppressive effects at extremely low levels — far below EPA standards. A total of 63 pesticide compounds were detected in 119 water samples collected during storm and non-storm conditions using low-level detection methods. More pesticides were detected in the tributaries than in the Clackamas River mainstem. One or more of 15 pesticides were detected in nine of 15 samples of drinking water. Environmental and public health advocates are concerned that these results add to a pattern of contamination across the country. USGS data released in 2008, shows widespread pesticide contamination in the Chesapeake Bay watershed, and a 2004 USGS report of nationwide […]

(Beyond Pesticides, March 4, 2008) Concern about environmental health and justice has exploded in our communities and around the world as a political and moral issue. One of the central threats, toxic pesticides, is directly linked to adverse health effects, particularly in children, and poisoning of the environment. We have learned enough in the last several decades since the publication of Silent Spring to make dramatic shifts away from toxic chemical dependency — as science increasingly links exposure to disease; insect, plant and bacteria resistance to chemicals multiplies; the energy and carbon footprint associated with pesticide use is documented; and the viability of sound and safe practices is realized. While the shift away from pesticide dependency has begun to take hold in communities around the world, conventional chemical intensive practices in agriculture and residential and institutional management continue to pose unjustifiable and unwarranted hazards. Regulatory standards and underlying laws accept unnecessary risks for workers that handle and work around pesticides and children who eat treated food, breathe contaminated air, or touch toxic surfaces. Studies link pesticides to cancer and immune, reproductive and nervous system damage. Subtle low level exposure effects that cause learning disabilities or impede brain function defy classical […]