{"id":12678,"date":"2014-01-29T00:01:20","date_gmt":"2014-01-29T04:01:20","guid":{"rendered":"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=12678"},"modified":"2014-02-03T12:32:53","modified_gmt":"2014-02-03T16:32:53","slug":"ddt-linked-to-higher-risk-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2014\/01\/ddt-linked-to-higher-risk-of-alzheimers-disease\/","title":{"rendered":"Higher Risk of Alzheimer’s Disease Linked to Pesticide Exposure"},"content":{"rendered":"

(Beyond Pesticides, January 29, 2014<\/i>) People with high levels of exposure to the banned insecticide DDT are four times more likely to have Alzheimer\u2019s disease than people with low levels, according to a new study of patients in Georgia and Texas. The research is among the first to report a connection between Alzheimer\u2019s disease, which is the world\u2019s most common neurodegenerative disease, and chemicals in the environment.\"Portrait<\/a><\/p>\n

The traces of the insecticide found in the study\u2019s Alzheimer\u2019s patients are comparable to the amounts found in most Americans today. Although it was banned more than 40 years ago in the U.S., DDT still persists in the environment worldwide and is still used today in developing countries for malaria abatement programs.<\/p>\n

\u201cOur findings suggest that genetically susceptible individuals with higher levels of DDT exposure may be more at risk,\u201d said Jason Richardson, PhD, a Rutgers University researcher who led the study.<\/p>\n

The case-control study consisting of existing samples from patients with Alzheimer\u2019s disease and control participants from the Emory University Alzheimer\u2019s Disease Research Center and the University of Texas Southwestern Medical School\u2019s Alzheimer\u2019s Disease Center measured serum levels of DDE in 79 control and 86 Alzheimer\u2019s disease cases. Levels of DDE, a breakdown product of DDT, were 3.8 times higher in people who had the disease than in those who did not, according to the study, \u201cElevated Serum Pesticide Levels and Risk for Alzheimer Disease<\/a>,\u201d which was published in JAMA Neurology. Participants with the highest DDE levels were 4.18 times more likely to have Alzheimer\u2019s than those with the lowest levels.<\/p>\n

The researchers also found that people with both risk factors \u00a0\u2014high exposure and genetic susceptibility\u2014 \u00a0\u201cmight have a more severe form of the disease,\u201d Dr. Richardson said. Patients scored lower on a mental test if they had the highest DDE levels and a particular genetic variation associated with Alzheimer\u2019s than if they had high DDE but did not have the genetic factor.<\/p>\n

Seventy percent of the non-Alzheimer\u2019s patients had detectable DDE in their blood, compared with 80 percent of the Alzheimer\u2019s patients. Nationwide, 75 to 80 percent of all Americans tested have measurable levels in their blood. Because some of the Alzheimer\u2019s patients had no DDE and some without the disease had high levels, the study \u201csuggests that exposure to DDE may contribute to Alzheimer\u2019s disease only in a subset of cases, perhaps those with genetic polymorphisms that render them more susceptible to DDT\/DDE exposure,\u201d the authors wrote.<\/p>\n

More than 5 million<\/a> people in the U.S. alone are living with Alzheimer\u2019s, and cases are expected to triple over the next few decades. In recent decades, Alzheimer\u2019s research has focused heavily on finding genetic causes of the disease. But fewer than half of cases can be blamed on genes alone, and researchers are now looking at how lifestyle and environmental factors may interact with genetic factors. According to Dr. Richardson, it is likely that any environmental exposures that may have contributed to the disease happened long before the patients had symptoms. Alzheimer\u2019s is a slow-moving disease that develops over the course of decades. Because DDT takes many years to break down and leave the body, \u201cresults suggest that cumulative lifetime exposures may be important.\u201d<\/p>\n

The findings build upon previous research<\/a> \u00a0in which elevated levels of DDE were detected in the blood of 20 Alzheimer\u2019s patients. While only a few studies have looked at potential environmental risk factors for Alzheimer\u2019s, researchers have found links between pesticides and Parkinson\u2019s<\/a>, another degenerative brain disease. It is unclear whether there are periods early in life during which exposures to certain chemicals in the environment would be more likely to increase a person\u2019s risk of eventually developing Alzheimer\u2019s.<\/p>\n

DDT already has been linked in other studies to reduced fertility, diabetes<\/a>, and other health effects. But little has been known about its potential effects on the brain. A recent study reports that DDT affects multiple generations, ultimately contributing to obesity<\/a> three generations down the line. However, the adverse impacts to humans \u201d\u201dincluding cancer<\/a>, reproductive disease, neurological disease, developmental problems<\/a>, diabetes and now Alzheimer\u2019s disease\u201d\u201d paint a cautionary tale that long-banned pesticides continue to impact human health and the environment.<\/p>\n

The Pesticide Induced Diseases Database (PIDD)<\/a> keeps track of the most recent studies related to pesticide exposure. For more information on the multiple harms pesticides can cause, see Beyond Pesticides’ PIDD pages on Alzheimer\u2019s<\/a>, Parkinson\u2019s<\/a>, cancer<\/a>, and other diseases.<\/p>\n

Source: Environmental Health News <\/a><\/em><\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, January 29, 2014) People with high levels of exposure to the banned insecticide DDT are four times more likely to have Alzheimer\u2019s disease than people with low levels, according to a new study of patients in Georgia and Texas. The research is among the first to report a connection between Alzheimer\u2019s disease, which is the world\u2019s most common neurodegenerative disease, and chemicals in the environment. The traces of the insecticide found in the study\u2019s Alzheimer\u2019s patients are comparable to the amounts found in most Americans today. Although it was banned more than 40 years ago in the U.S., DDT still persists in the environment worldwide and is still used today in developing countries for malaria abatement programs. \u201cOur findings suggest that genetically susceptible individuals with higher levels of DDT exposure may be more at risk,\u201d said Jason Richardson, PhD, a Rutgers University researcher who led the study. The case-control study consisting of existing samples from patients with Alzheimer\u2019s disease and control participants from the Emory University Alzheimer\u2019s Disease Research Center and the University of Texas Southwestern Medical School\u2019s Alzheimer\u2019s Disease Center measured serum levels of DDE in 79 control and 86 Alzheimer\u2019s disease cases. Levels of DDE, a […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[268,21,26,3],"tags":[],"class_list":["post-12678","post","type-post","status-publish","format-standard","hentry","category-alzheimerss","category-chemicals","category-ddt","category-diseasehealth-effects"],"yoast_head":"\nHigher Risk of Alzheimer's Disease Linked to Pesticide Exposure - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2014\/01\/ddt-linked-to-higher-risk-of-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Higher Risk of Alzheimer's Disease Linked to Pesticide Exposure - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, January 29, 2014) People with high levels of exposure to the banned insecticide DDT are four times more likely to have Alzheimer\u2019s disease than people with low levels, according to a new study of patients in Georgia and Texas. The research is among the first to report a connection between Alzheimer\u2019s disease, which is the world\u2019s most common neurodegenerative disease, and chemicals in the environment. The traces of the insecticide found in the study\u2019s Alzheimer\u2019s patients are comparable to the amounts found in most Americans today. Although it was banned more than 40 years ago in the U.S., DDT still persists in the environment worldwide and is still used today in developing countries for malaria abatement programs. \u201cOur findings suggest that genetically susceptible individuals with higher levels of DDT exposure may be more at risk,\u201d said Jason Richardson, PhD, a Rutgers University researcher who led the study. The case-control study consisting of existing samples from patients with Alzheimer\u2019s disease and control participants from the Emory University Alzheimer\u2019s Disease Research Center and the University of Texas Southwestern Medical School\u2019s Alzheimer\u2019s Disease Center measured serum levels of DDE in 79 control and 86 Alzheimer\u2019s disease cases. 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The research is among the first to report a connection between Alzheimer\u2019s disease, which is the world\u2019s most common neurodegenerative disease, and chemicals in the environment. The traces of the insecticide found in the study\u2019s Alzheimer\u2019s patients are comparable to the amounts found in most Americans today. Although it was banned more than 40 years ago in the U.S., DDT still persists in the environment worldwide and is still used today in developing countries for malaria abatement programs. \u201cOur findings suggest that genetically susceptible individuals with higher levels of DDT exposure may be more at risk,\u201d said Jason Richardson, PhD, a Rutgers University researcher who led the study. The case-control study consisting of existing samples from patients with Alzheimer\u2019s disease and control participants from the Emory University Alzheimer\u2019s Disease Research Center and the University of Texas Southwestern Medical School\u2019s Alzheimer\u2019s Disease Center measured serum levels of DDE in 79 control and 86 Alzheimer\u2019s disease cases. 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