{"id":18466,"date":"2016-07-18T00:00:20","date_gmt":"2016-07-18T04:00:20","guid":{"rendered":"http:\/\/beyondpesticides.org\/dailynewsblog\/?p=18466"},"modified":"2016-08-15T15:01:58","modified_gmt":"2016-08-15T19:01:58","slug":"glyphosate-causes-changes-dna-resulting-chronic-disease","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/","title":{"rendered":"Glyphosate Causes Changes to DNA Function Resulting in Chronic Disease, According to Study"},"content":{"rendered":"

(Beyond Pesticides July 18, 2016)<\/em> A \u00a0review of the scientific literature<\/a> links \u00a0glyphosate<\/a>, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, to a wide range of diseases through a mechanism that modifies DNA functioning, adding a new even more troubling dimension to the herbicide’s cancer classification <\/a>by the International Agency for Research on Cancer. According to the most recent review, Glyphosate pathways to modern disease V: Amino acid analogue of glycine in diverse proteins<\/em><\/a>, conducted by independent scientists Anthony Samsel, Ph.D. and Stephanie Seneff, Ph.D., a scientist at Massachusetts Institute of Technology (MIT), glyphosate acts as a glycine analogue that \u00a0incorporates into peptides during protein synthesis. In this process, it alters a number of proteins that depend on conserved glycine for proper function. According to the authors, glyphosate substitution for glycine correlates with \u00a0several diseases, including diabetes, obesity, asthma, Alzheimer\u2019s disease, amyotrophic lateral sclerosis (ALS), and Parkinson\u2019s disease, among others.\"DNA\"<\/p>\n

Glycine, the smallest amino acid commonly found in proteins, has unique properties that support flexibility and the ability to anchor to the plasma membrane or the cytoskeleton. \u00a0This new direct biological evidence, taken together with correlational data, make a compelling case that glyphosate action as a glycine analogue accounts for much of glyphosate\u2019s toxicity, according to the study. The authors find that glyphosate, as an amino acid analogue of \u00a0 glycine, may \u00a0 be \u00a0incorporated into polypeptide chains during protein synthesis. In doing so, it has an impact on the structure and function of the proteins. Proteins fold up, and glycine is a small molecule that is often found at the folding places. Since glyphosate is much larger, it prevents the protein molecule from folding properly, leading to the disruption of function of many \u00a0 proteins with essential roles in metabolism and regulatory processes.<\/p>\n

The article cites a \u00a0number of ways that this affects humans and other organisms. According to the study, the consequences of this action can lead to impaired fatty acid release leading to obesity, impaired insulin receptor response leading to diabetes, impaired one-carbon metabolism leading to neural tube defects and autism, impaired cell cycle control during DNA synthesis, and disregulated phosphorylation cascades leading to cancer, lung disorders, and autoimmune diseases.<\/p>\n

Stephen Frantz, Ph.D., a pathobiologist research scientist explains it like this: \u201cWhen a cell is trying to form proteins, it may grab glyphosate instead of glycine to form a damaged, mis-folded protein. After that it\u2019s medical chaos. Where glyphosate replaces glycine, the cell can no longer conduct business as usual causing unpredicted consequences with many diseases and disorders as a result.\u201d<\/p>\n

The release of this study comes on the heels of several other discussions and actions on glyphosate that have taken place over the past few weeks. Last month at a Congressional briefing<\/a> sponsored by U.S Representative Ted Lieu, a delegation of independent scientists including this study\u2019s authors, presented their findings, urging lawmakers to call on the EPA to ban RoundUp, Monsanto\u2019s flagship herbicide. Beyond Pesticides participated on the panel, providing testimony on the impact of glyphosate on soil systems, as well as the unreasonable risk it poses to humans, animals, and the environment. Following the congressional briefing, scientists spoke at a closed meeting with the Environmental Protection Agency (EPA), explaining the biochemical and physiological reasons why exposure to glyphosate, the active ingredient in RoundUp, is linked to autism, Alzheimer\u2019s, cancer, birth defects, obesity, and gluten intolerance, among other health issues. EPA\u2019s Office of Pesticide Programs\u2019 Deputy Director and his staff met with the panelists and provided an overview of EPA\u2019s registration process for glyphosate. EPA staff had some interest in the information presented, which was forwarded to relevant staffers. However, EPA indicated that much of the information provided may not impact their current risk assessment for glyphosate, which is expected sometime in 2017.<\/p>\n

Glyphosate<\/a>, created by Monsanto, is touted as a \u201clow toxicity\u201d chemical and \u201csafer\u201d than other chemicals by industry. But glyphosate has been shown to have \u00a0detrimental impacts<\/a> \u00a0on humans and the environment. Given its widespread use on residential and agricultural sites, its toxicity is of increasing concern. In early 2015, glyphosate was classified by the World Health Organization\u2019s (WHO) International Agency for Research on Cancer (IARC) of as a \u201cprobable human carcinogen.<\/a>\u201d \u00a0Just a few months later, a study published in \u00a0Environmental Health News<\/em> \u00a0found that \u00a0chronic, low-dose exposure to glyphosate<\/a> \u00a0led to adverse effects on liver and kidney health. Roundup formulations can also induce a dose-dependent formation of DNA adducts (altered forms of DNA linked to chemical exposure, playing a key role in chemical carcinogenesis) in the kidneys and liver of mice. Human cell endocrine disruption on the androgen receptor, inhibition of transcriptional activities on estrogen receptors on HepG2, DNA damage and cytotoxic effects occurring at concentrations well below \u201cacceptable\u201d residues have all been observed.<\/p>\n

Roundup also harms crops\u2019 ability to capture carbon from the air, an important factor in fighting climate change. \u201cGlyphosate negatively affects the soil microbiome,\u201d said Frantz. \u201cIt is destroying the ability of soil to be a nutritive medium for producing crops. Organic or biological regenerative agriculture is the solution for the sustainable agricultural sector and will conserve soil, air and water quality, and sequester carbon that helps to mitigate the climate crisis. We call for a ban on glyphosate.\u201d<\/p>\n

Beyond Pesticides urges individuals concerned about glyphosate exposure to support organic systems that do not rely on hazardous carcinogenic pesticides. In agriculture, concerned consumers can \u00a0buy food with the certified organic label<\/a>, which not only disallows synthetic pesticides like glyphosate, but also the use of sewage sludge and genetically engineered ingredients. Beyond Pesticides also urges the adoption of \u00a0organic lawn and landscape programs<\/a>.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Research Gate<\/a>, Huffington Post<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides July 18, 2016) A \u00a0review of the scientific literature links \u00a0glyphosate, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, to a wide range of diseases through a mechanism that modifies DNA functioning, adding a new even more troubling dimension to the herbicide’s cancer classification by the International Agency for Research on Cancer. According to the most recent review, Glyphosate pathways to modern disease V: Amino acid analogue of glycine in diverse proteins, conducted by independent scientists Anthony Samsel, Ph.D. and Stephanie Seneff, Ph.D., a scientist at Massachusetts Institute of Technology (MIT), glyphosate acts as a glycine analogue that \u00a0incorporates into peptides during protein synthesis. In this process, it alters a number of proteins that depend on conserved glycine for proper function. According to the authors, glyphosate substitution for glycine correlates with \u00a0several diseases, including diabetes, obesity, asthma, Alzheimer\u2019s disease, amyotrophic lateral sclerosis (ALS), and Parkinson\u2019s disease, among others. Glycine, the smallest amino acid commonly found in proteins, has unique properties that support flexibility and the ability to anchor to the plasma membrane or the cytoskeleton. \u00a0This new direct biological evidence, taken together with correlational data, make a compelling case that […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[249,2,124,21,3,41],"tags":[],"class_list":["post-18466","post","type-post","status-publish","format-standard","hentry","category-agriculture","category-alternativesorganics","category-announcements","category-chemicals","category-diseasehealth-effects","category-glyphosate"],"yoast_head":"\nGlyphosate Causes Changes to DNA Function Resulting in Chronic Disease, According to Study - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glyphosate Causes Changes to DNA Function Resulting in Chronic Disease, According to Study - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides July 18, 2016) A \u00a0review of the scientific literature links \u00a0glyphosate, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, to a wide range of diseases through a mechanism that modifies DNA functioning, adding a new even more troubling dimension to the herbicide’s cancer classification by the International Agency for Research on Cancer. According to the most recent review, Glyphosate pathways to modern disease V: Amino acid analogue of glycine in diverse proteins, conducted by independent scientists Anthony Samsel, Ph.D. and Stephanie Seneff, Ph.D., a scientist at Massachusetts Institute of Technology (MIT), glyphosate acts as a glycine analogue that \u00a0incorporates into peptides during protein synthesis. In this process, it alters a number of proteins that depend on conserved glycine for proper function. According to the authors, glyphosate substitution for glycine correlates with \u00a0several diseases, including diabetes, obesity, asthma, Alzheimer\u2019s disease, amyotrophic lateral sclerosis (ALS), and Parkinson\u2019s disease, among others. 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According to the most recent review, Glyphosate pathways to modern disease V: Amino acid analogue of glycine in diverse proteins, conducted by independent scientists Anthony Samsel, Ph.D. and Stephanie Seneff, Ph.D., a scientist at Massachusetts Institute of Technology (MIT), glyphosate acts as a glycine analogue that \u00a0incorporates into peptides during protein synthesis. In this process, it alters a number of proteins that depend on conserved glycine for proper function. According to the authors, glyphosate substitution for glycine correlates with \u00a0several diseases, including diabetes, obesity, asthma, Alzheimer\u2019s disease, amyotrophic lateral sclerosis (ALS), and Parkinson\u2019s disease, among others. Glycine, the smallest amino acid commonly found in proteins, has unique properties that support flexibility and the ability to anchor to the plasma membrane or the cytoskeleton. \u00a0This new direct biological evidence, taken together with correlational data, make a compelling case that […]","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2016-07-18T04:00:20+00:00","article_modified_time":"2016-08-15T19:01:58+00:00","og_image":[{"url":"http:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2016\/07\/DNA-300x206.jpg","type":"","width":"","height":""}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"Glyphosate Causes Changes to DNA Function Resulting in Chronic Disease, According to Study","datePublished":"2016-07-18T04:00:20+00:00","dateModified":"2016-08-15T19:01:58+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/"},"wordCount":983,"commentCount":5,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/#primaryimage"},"thumbnailUrl":"http:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2016\/07\/DNA-300x206.jpg","articleSection":["Agriculture","Alternatives\/Organics","Announcements","Chemicals","Disease\/Health Effects","Glyphosate"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2016\/07\/glyphosate-causes-changes-dna-resulting-chronic-disease\/","name":"Glyphosate Causes Changes to DNA Function Resulting in Chronic Disease, According to Study - 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