{"id":1997,"date":"2009-07-01T02:43:07","date_gmt":"2009-07-01T06:43:07","guid":{"rendered":"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=1997"},"modified":"2013-01-25T10:49:13","modified_gmt":"2013-01-25T14:49:13","slug":"secret-ingredient-in-the-herbicide-roundup-kills-human-cells","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2009\/07\/secret-ingredient-in-the-herbicide-roundup-kills-human-cells\/","title":{"rendered":"Secret Ingredient in the Herbicide Roundup Kills Human Cells"},"content":{"rendered":"

(Beyond Pesticides<\/em>, July 1, 2009) Researchers have found that one of the so-called “inert” ingredients in the popular herbicide product Roundup can kill human cells, particularly embryonic, placental and umbilical cord cells. Over 4,000 inert ingredients are approved for use in the U.S. and can be mixed with pesticide “active” ingredients; however these chemicals are not disclosed to consumers or users on pesticide product labels due to EPA’s intepretation (many would say incorrect interpretation) of federal pesticide law. Many inerts are classified as highly toxic, while others have not been adequately studied.<\/span><\/p>\n

About 100 million pounds of Roundup are applied to U.S. farms and lawns every year and until now, most health studies have focused on the safety of glyphosate<\/a> the active ingredient in Roundup, rather than the mixture of \u201cinert\u201d ingredients found in the herbicidal product. In this new study, \u201cGlyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, and Placental Cells<\/a>,\u201d researchers found that Roundup\u2019s inert ingredients amplified the toxic effect on human cells\u201d\u201deven at concentrations much more diluted than those used on farms and lawns, and which correspond to low levels of residues in food or feed. One specific inert ingredient, polyethoxylated tallowamine, or POEA, was more deadly to human embryonic, placental and umbilical cord cells than the herbicide itself \u2014 a finding the researchers call \u201castonishing.\u201d POEA is a surfactant, or detergent, derived from animal fat. It is added to Roundup and other herbicides to help them penetrate plants’ surfaces, making the weed killer more effective.<\/p>\n

The researchers compared the formulations (glyphosate with POEA) with glyphosate and POEA alone. All formulations cause total cell death within 24 hours, through an inhibition of the mitochondrial succinate dehydrogenase activity, and necrosis, by release of cytosolic adenylate kinase measuring membrane damage. While glyphosate also damaged cells, the researchers found that POEA changes human cell permeability and amplifies toxicity induced already by glyphosate, through apoptosis and necrosis. POEA alone was more deadly to cells than glyphosate. The study concluded that the work clearly confirms that the adjuvants in Roundup formulations are not biologically or chemically inert. Moreover, the proprietary mixtures available on the market, according to the research, could cause cell damage and even death around residual levels to be expected, especially in food and feed derived from Roundup-treated crops, such as soybeans, alfalfa and corn, or lawns and gardens. The research team also suspects that Roundup might cause pregnancy problems by interfering with hormone production, possibly leading to abnormal fetal development, low birth weights or miscarriages.<\/p>\n

Monsanto, Roundup\u2019s manufacturer, contends that the methods used in the study do not reflect realistic conditions and that their product, which has been sold since the 1970s, is safe when used as directed. EPA and the U.S. Department of Agriculture both recognize POEA as an inert ingredient. POEA is allowed in products certified organic by the USDA. EPA has concluded that it is not dangerous to public health or the environment. The researchers however, believe that their results highlight the need for health agencies to reconsider the safety of Roundup.<\/p>\n

\u201cThe authorizations for using these Roundup herbicides must now clearly be revised since their toxic effects depend on, and are multiplied by, other compounds used in the mixtures,\u201d said Gilles-Eric Seralini, Ph.D., a University of Caen molecular biologist and lead researcher, wrote.<\/p>\n

World controversy over the safety of the weed killer continues. In May, an environmental group petitioned Argentina\u2019s Supreme Court, seeking a temporary ban on glyphosate use after an Argentine scientist and local activists reported a high incidence of birth defects and cancers in people living near crop-spraying areas. Scientists there also linked genetic malformations in amphibians to glyphosate. In addition, last year in Sweden, a scientific team found that exposure is a risk factor for people developing non-Hodgkin lymphoma.<\/p>\n

Inert ingredients are often less scrutinized than active pest-killing ingredients. Since specific herbicide formulations are protected as trade secrets, manufacturers are not required to publicly disclose them. Caroline Cox, research director of the Center for Environmental Health, an Oakland-based environmental organization, says that the term \u201cinert ingredient\u201d is often misleading. EPA classifies all pesticide ingredients that do not harm pests as \u201cinert,\u201d Ms. Cox said. Inert compounds, therefore, are not necessarily biologically or toxicologically harmless.<\/p>\n

Other inert ingredients have been found to potentially affect human health. Many amplify the effects of active ingredients by helping them penetrate clothing, protective equipment and cell membranes, or by increasing their toxicity. A study recently found that an herbicide formulation containing atrazine caused DNA damage, which can lead to cancer, while atrazine alone did not.<\/p>\n

For years, scientists and activists have been calling for inert disclosures<\/a>. In 2006, the Northwest Coalition for Alternatives to Pesticides, along with Beyond Pesticides and other allies, filed a legal petition<\/a> challenging the EPA\u2019s policy of secrecy on these inert ingredients. The court found that manufacturers are not able to protect inerts as proprietary from competitors, but only keep the ingredients secret from consumers and users. An agency decision on the issue is due this fall. A December 2006 commentary<\/a> in the National Institute of Environmental Health Sciences\u2019 journal Environmental Health Perspectives <\/em>calls for improvements in pesticide regulation and \u201cinert\u201d ingredient disclosure, citing an extensive body of literature illustrating the concern over related human and environmental health effects. In May 2009<\/a>, the California State Senate\u2019s Health Committee passed legislation that requires the disclosure of inert ingredients in pesticides before they are approved for use by state regulators, and that provides public health agencies and emergency responders timely access to complete ingredient lists of aerial pesticides. For more about pesticide ingredients, visit \u201cWhat\u2019s in a Pesticide<\/a>\u201d by Beyond Pesticides.<\/p>\n

Source: Environmental Health News<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, July 1, 2009) Researchers have found that one of the so-called “inert” ingredients in the popular herbicide product Roundup can kill human cells, particularly embryonic, placental and umbilical cord cells. Over 4,000 inert ingredients are approved for use in the U.S. and can be mixed with pesticide “active” ingredients; however these chemicals are not disclosed to consumers or users on pesticide product labels due to EPA’s intepretation (many would say incorrect interpretation) of federal pesticide law. Many inerts are classified as highly toxic, while others have not been adequately studied. About 100 million pounds of Roundup are applied to U.S. farms and lawns every year and until now, most health studies have focused on the safety of glyphosate the active ingredient in Roundup, rather than the mixture of \u201cinert\u201d ingredients found in the herbicidal product. In this new study, \u201cGlyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, and Placental Cells,\u201d researchers found that Roundup\u2019s inert ingredients amplified the toxic effect on human cells\u201d\u201deven at concentrations much more diluted than those used on farms and lawns, and which correspond to low levels of residues in food or feed. One specific inert ingredient, polyethoxylated tallowamine, or POEA, was […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,41,53,10,236],"tags":[],"class_list":["post-1997","post","type-post","status-publish","format-standard","hentry","category-diseasehealth-effects","category-glyphosate","category-inerts","category-pesticide-regulation","category-polyethoxylated-tallowamine"],"yoast_head":"\nSecret Ingredient in the Herbicide Roundup Kills Human Cells - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2009\/07\/secret-ingredient-in-the-herbicide-roundup-kills-human-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Secret Ingredient in the Herbicide Roundup Kills Human Cells - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, July 1, 2009) Researchers have found that one of the so-called “inert” ingredients in the popular herbicide product Roundup can kill human cells, particularly embryonic, placental and umbilical cord cells. Over 4,000 inert ingredients are approved for use in the U.S. and can be mixed with pesticide “active” ingredients; however these chemicals are not disclosed to consumers or users on pesticide product labels due to EPA’s intepretation (many would say incorrect interpretation) of federal pesticide law. Many inerts are classified as highly toxic, while others have not been adequately studied. About 100 million pounds of Roundup are applied to U.S. farms and lawns every year and until now, most health studies have focused on the safety of glyphosate the active ingredient in Roundup, rather than the mixture of \u201cinert\u201d ingredients found in the herbicidal product. 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The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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