{"id":25787,"date":"2019-10-18T00:00:28","date_gmt":"2019-10-18T04:00:28","guid":{"rendered":"http:\/\/beyondpesticides.org\/dailynewsblog\/?p=25787"},"modified":"2019-10-17T21:49:10","modified_gmt":"2019-10-18T01:49:10","slug":"epa-directive-to-end-animal-testing-of-pesticides-welcomed-and-challenged-as-not-addressing-inadequate-reviews-of-adverse-effects","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2019\/10\/epa-directive-to-end-animal-testing-of-pesticides-welcomed-and-challenged-as-not-addressing-inadequate-reviews-of-adverse-effects\/","title":{"rendered":"EPA Directive to End Animal Testing of Pesticides Welcomed and Challenged as Not Addressing Inadequate Reviews of Adverse Effects"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-25810\" src=\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2019\/10\/images.png\" alt=\"\" width=\"319\" height=\"255\" \/>(Beyond Pesticides, October 18, 2019)\u00a0The U.S. Environmental Protection Agency <a href=\"https:\/\/www.forbes.com\/sites\/jennysplitter\/2019\/10\/14\/the-epa-is-changing-how-it-tests-agricultural-pesticides\/#785bd7d82c14\">(EPA) issued a directive<\/a> in September, under Administrator Andrew Wheeler, that changes its pesticide approval process and aims to reduce (mammalian) animal testing significantly by 2035. The agency also announced awards totaling $4.25 million to four universities for development of alternative methods to evaluate chemicals, including pesticides. The move will likely be seen both as an advancement of animal rights, and as a setback for the kinds of testing that <em>can<\/em> have important implications for human health. Resolution of this issue could be found in a shift away from chemical agriculture and to <a href=\"https:\/\/www.beyondpesticides.org\/programs\/organic-agriculture\/why-organic\/health-benefits\">organic and regenerative practices<\/a>, which eschew toxic chemicals and synthetic fertilizers, and obviate need for them.<\/p>\n<p>The <a href=\"https:\/\/chemicalwatch.com\/81881\/us-epa-to-eliminate-all-mammal-study-funding-by-2035#overlay-strip\">directive affects not only the agency\u2019s own research,<\/a> but also, as the memo says, EPA will \u201ccome as close as possible to excluding from its approval process any reliance on mammal studies conducted after January 1, 2035, including those performed by third parties.\u201d The schools receiving EPA funds to work on alternative testing are Johns Hopkins University, Vanderbilt University and Vanderbilt\u2019s Medical Center, Oregon State University, and the University of California-Riverside.<\/p>\n<p><a href=\"https:\/\/www.cnn.com\/2019\/09\/10\/politics\/epa-animal-testing\/index.html\">President of the International Science Consortium for People for the Ethical Treatment of Animals (PETA), Amy Clippinger, PhD commented<\/a>, \u201cPETA is celebrating the EPA\u2019s decision to protect animals certainly, but also humans and the environment, by switching from cruel and scientifically flawed animal tests in favor of modern, non-animal testing methods.\u201d Those who oppose animal testing comprise some unusual bedfellows: animal rights advocates, such as PETA and the Human Society of the U.S.; the Physicians Committee for Responsible Medicine; small-government activists; and the chemical industry.<\/p>\n<p>Those bedfellows are no doubt pleased with the announcement because, enacted, it would largely eliminate what they regard as inhumane treatment of subject animals. They further argue that animal testing is actually a poor predictor of human health impacts for a <a href=\"https:\/\/animal-testing.procon.org\/\">variety of reasons, including<\/a>:<br \/>\n\u2022 reactions to chemicals vary enormously from species to species<\/p>\n<ul>\n<li>lab animals are typically psychologically stressed, which can jeopardize the validity of results<\/li>\n<li>there are other useful ways to test impacts of chemicals exposure, such as through <em>in vitro<\/em> (conducted in a controlled laboratory setting) and <em>in silico<\/em> (conducted by computer modeling) experiments<\/li>\n<li>many animal experiments are fundamentally flawed<\/li>\n<\/ul>\n<p><a href=\"https:\/\/animal-testing.procon.org\/\">Supporters of animal testing for chemicals used in pesticide products maintain that:<\/a><\/p>\n<ul>\n<li>animals provide models of biology and pathology similar enough to those of humans to yield results salient to human health<\/li>\n<li>there is no adequate alternative to testing on living, whole-body systems<\/li>\n<li>animal research is highly regulated so as to protect animals from mistreatment<\/li>\n<li>animals often are better research subjects (than humans, even were it ethical to use people) because of their shorter life cycles<\/li>\n<li>animals must be used in cases in which ethical considerations prevent the use of human subjects<\/li>\n<li>alternative methodologies are not meet to the toxicological challenges of the complex dynamics inherent in <a href=\"https:\/\/www.forbes.com\/sites\/jennysplitter\/2019\/10\/14\/the-epa-is-changing-how-it-tests-agricultural-pesticides\/#785bd7d82c14\">cancer or reproductive toxicology<\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.forbes.com\/sites\/jennysplitter\/2019\/10\/14\/the-epa-is-changing-how-it-tests-agricultural-pesticides\/#785bd7d82c14\">Lena Smirnova, PhD of Johns Hopkins<\/a> Center for Alternatives to Animal Testing notes that animal \u2014 and especially rodent \u2014 physiology differs in many ways from that of humans, and that, e.g., in one research study comparing human and animal drug toxicities,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4522464\/\">rodent models correctly predicted<\/a>\u00a0human toxicity in only 43% of the cases. She adds, \u201cIf you look at something very complex, like reproductive toxicity or developmental toxicity or carcinogenicity, rats predict mice by around 60%. So why would we expect that it would be better in humans?\u201d Her laboratory at Johns Hopkins is working on microphysiological systems dubbed \u201c<a href=\"https:\/\/www.scientificamerican.com\/article\/lab-grown-mini-brains-can-now-mimic-the-neural-activity-of-a-preterm-infant\/\">mini brains<\/a>\u201d to observe neurotoxic effects, currently for <a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-gateway?pesticideid=17\">chlorpyrifos<\/a> and <a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-gateway?pesticideid=69\">rotenone.<\/a><\/p>\n<p>The legitimacy of using of animal subjects in experiments is an ongoing debate in the scientific community. But the EPA announcement may be understood in some quarters as an agency end-run around <a href=\"https:\/\/www.epa.gov\/aboutepa\/our-mission-and-what-we-do\">EPA\u2019s responsibility<\/a> \u201cto protect human health and the environment.\u201d Administrator Andrew Wheeler, who is a former coal industry lobbyist, has led the Trump administration\u2019s aggressive campaign to roll back critical environmental regulations.<\/p>\n<p>In this effort, <a href=\"https:\/\/www.ehn.org\/epa-lab-animals-chemical-testing-2640450647.html\">Mr. Wheeler has charged senior EPA leadership<\/a> with developing a plan that \u201cwill identify tangible steps to ensure that the agency&#8217;s regulatory, compliance and enforcement activities, including chemical and pesticide approvals and agency research, remain fully protective of human health and the environment while pursing these reduction goals.\u201d This is a laudable goal whose achievement is, unfortunately, belied by the <a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2019\/07\/epas-office-of-inspector-general-must-investigate-epas-failure-to-fully-assess-pesticide-hazards\/\">already-inadequate review<\/a> of pesticides that occurs under EPA auspices.<\/p>\n<p>An <a href=\"https:\/\/www.ehn.org\/u\/thomaszoeller\">article co-written for <em>Environmental Health News<\/em><\/a> by Laura Vandenberg, PhD, Associate Professor of Environmental Health Sciences at the University of Massachusetts Amherst (UMass Amherst) School of Public Health and Health Sciences, and Thomas Zoeller, PhD, Professor of Biology at UMass Amherst, says squarely: \u201cChemical testing by the EPA and other regulatory agencies must be improved\u201d because it is currently inadequate.<\/p>\n<p><a href=\"https:\/\/www.ehn.org\/epa-lab-animals-chemical-testing-2640450647.html?rebelltitem=2#rebelltitem2\">Drs. Vandenberg and Zoeller maintain<\/a> that current testing for chemical safety (which would include pesticides review) does not adequately protect human health. They cite: the record levels of chronic diseases, both in the U.S. and elsewhere; the strong links between exposure to environmental chemicals, and developmental disorders and endocrine disruption; and research evidence showing that chemicals that are approved by EPA are contributing to chronic disease development. Although open to new technologies to reduce use of animal testing, <a href=\"https:\/\/www.ehn.org\/epa-lab-animals-chemical-testing-2640450647.html?rebelltitem=2#rebelltitem2\">the scientists say that<\/a> \u201cunless the Agency [EPA] changes the way it evaluates the effects of chemicals on health, a shift away from animal testing will reduce an already inadequate protection for human health.\u201d<\/p>\n<p><a href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/epa-attack-science-targets-critical-animal-tests\">The Natural Resources Defense Council (NRDC) has written,<\/a> \u201cThis is yet another Trump Administration attack on scientific information, this time targeting the laboratory animal tests that show whether and how chemicals may harm people, wildlife, and ecosystems. Instead, the Trump EPA is pushing the use of non-animal alternative methods that are mostly still in development, and cannot capture the complexity of many chemical exposure risks like infertility and cancer.\u201d<\/p>\n<p><a href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/epa-attack-science-targets-critical-animal-tests\">NRDC welcomes<\/a> the development of non-animal test methods that could help identify potential toxicity and adverse effects on humans, wildlife, and the environment. <a href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/epa-attack-science-targets-critical-animal-tests\">Organization scientists say that<\/a> \u201cuse of these tests \u2014 like any scientific or other toxicity information \u2014 can be harmful if used to explain away adverse effects (that is, incorrectly identifying a toxic chemical as harmless). In cases where this happens, harmful chemicals can get into our air, water, cosmetics and personal care products, household items, food and food packaging, etc., threatening the health of humans, pets and wildlife. Thus, if used to permit chemicals onto the market, the regulatory system must use the test information in a health-protective and precautionary manner. That is not the case with the Trump EPA, and it isn\u2019t clear when EPA, the FDA or other regulatory agencies will adopt a simple health-protective approach, rather than favoring the chemical industry that it is supposed to regulate.\u201d<\/p>\n<p><a href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/epa-attack-science-targets-critical-animal-tests\">Part of critics\u2019 concern is that the move away from animal testing will fast-track approval<\/a> of pesticide and other chemical products into the marketplace with inadequate or flawed toxicity testing. Despite some advances in non-animal acute toxicity testing, the arena of chronic and systemic health impacts is more challenging territory for such protocols. Such impacts tend to be more complex disorders \u2014 such as reproductive, oncological, and endocrine diseases \u2014 whose chemical-exposure catalysts or causes some scientists say are more accurately evaluated via whole-animal testing. In addition, the evaluation of exposure effects and developmental windows in children cannot be evaluated, e.g., in a petri dish. <a href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/epa-attack-science-targets-critical-animal-tests\">NRDC and other critics say<\/a> that imposing an artificial deadline, when <em>in vitro<\/em> and <em>in silico<\/em> approaches are still nascent, is ill advised, and that funding and animal testing are important to the mission of informing and protecting the public.<\/p>\n<p><a href=\"https:\/\/wtop.com\/animals-pets\/2019\/09\/epa-to-reduce-use-of-animal-testing-in-predicting-hazards\/\">NRDC senior scientist Jennifer Sass, PhD, critiqued EPA\u2019s announcement,<\/a> saying that \u201cEPA is phasing out the tools that lay the groundwork for protecting the public from dangers like formaldehyde and chlorpyrifos, a pesticide used on crops, animals and buildings. The EPA\u2019s plan is a \u2018gift\u2019 to the chemical industry that will result in a \u2018rigged system that gives the green light to harmful chemicals. Our concern is not with the alternative tests themselves. Our concern is with how EPA is interpreting the data from them. If the tests themselves are not indicating a toxic effect, then EPA is presuming there is no toxic effect.\u2019\u201d <a href=\"https:\/\/www.forbes.com\/sites\/jennysplitter\/2019\/10\/14\/the-epa-is-changing-how-it-tests-agricultural-pesticides\/#785bd7d82c14\">Dr. Sass argues<\/a> that animal testing works to protect public health, and says that the organization endorses a more-precautionary approach to the use of chemicals that would proscribe approval of any that show evidence of harm in animals.<\/p>\n<p><a href=\"https:\/\/www.ehn.org\/epa-lab-animals-chemical-testing-2640450647.html\">Drs. Vandenberg and Zoeller point out<\/a> that EPA could alter its approach to regulating chemicals in order to use these emerging non-animal technologies sensibly: \u201cInstead of requiring overt evidence that a chemical\u00a0causes harm\u00a0in animals or people, they could use the results from cell-based tests to identify chemicals that interact with biological systems. Because there would be no information about how these cell-based tests quantitatively relate to humans, they would have to move to a \u2018hazard-based\u2019 approach.\u201d<\/p>\n<p><a href=\"https:\/\/www.beyondpesticides.org\/assets\/media\/documents\/infoservices\/pesticidesandyou\/documents\/PrecautionCited.pdf\">The Precautionary Principle, as set out in 1998, says<\/a>: \u201cWhen an activity raises threats of harm to human health or the environment, precautionary measures should be taken even if some cause and effect relationships are not fully established scientifically. In this context the proponent of an activity, rather than the public, should bear the burden of proof. The process of applying the precautionary principle must be open, informed and democratic and must include potentially affected parties. It must also involve an examination of the full range of alternatives, including no action.\u201d<\/p>\n<p>It is staggering to recognize <a href=\"https:\/\/www.beyondpesticides.org\/assets\/media\/documents\/Scientific%20Findings%20Support%20Replacing%20Poisons%20with%20Precaution%20PAY%20Spring%202019.pdf\">the reality that our nation and world are saturated with human-made chemicals<\/a> \u2014 80,000 on the market in the U.S. alone, and most synthesized only in the past 50 years. The majority of those compounds have not been evaluated for effects other than acute toxicity, and 95% have not been reviewed for potential impacts on children. Given these circumstances, Beyond Pesticides advocates for a Precautionary approach to permitting of all pesticides, and for the <a href=\"https:\/\/www.beyondpesticides.org\/about\/our-mission\">transition to a world free of them<\/a>. Join us: <a href=\"https:\/\/beyondpesticides.org\/join\/sign-me-up\">https:\/\/beyondpesticides.org\/join\/sign-me-up<\/a>.<\/p>\n<p><em>All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n<p>Sources: <a href=\"https:\/\/www.forbes.com\/sites\/jennysplitter\/2019\/10\/14\/the-epa-is-changing-how-it-tests-agricultural-pesticides\/#785bd7d82c14\">https:\/\/www.forbes.com\/sites\/jennysplitter\/2019\/10\/14\/the-epa-is-changing-how-it-tests-agricultural-pesticides\/#785bd7d82c14<\/a> and <a href=\"https:\/\/www.nrdc.org\/experts\/jennifer-sass\/epa-attack-science-targets-critical-animal-tests\">https:\/\/www.nrdc.org\/experts\/jennifer-sass\/epa-attack-science-targets-critical-animal-tests<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Beyond Pesticides, October 18, 2019)\u00a0The U.S. Environmental Protection Agency (EPA) issued a directive in September, under Administrator Andrew Wheeler, that changes its pesticide approval process and aims to reduce (mammalian) animal testing significantly by 2035. The agency also announced awards totaling $4.25 million to four universities for development of alternative methods to evaluate chemicals, including pesticides. The move will likely be seen both as an advancement of animal rights, and as a setback for the kinds of testing that can have important implications for human health. Resolution of this issue could be found in a shift away from chemical agriculture and to organic and regenerative practices, which eschew toxic chemicals and synthetic fertilizers, and obviate need for them. The directive affects not only the agency\u2019s own research, but also, as the memo says, EPA will \u201ccome as close as possible to excluding from its approval process any reliance on mammal studies conducted after January 1, 2035, including those performed by third parties.\u201d The schools receiving EPA funds to work on alternative testing are Johns Hopkins University, Vanderbilt University and Vanderbilt\u2019s Medical Center, Oregon State University, and the University of California-Riverside. President of the International Science Consortium for People for the [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[354,10,1],"tags":[],"class_list":["post-25787","post","type-post","status-publish","format-standard","hentry","category-environmental-protection-agency-epa","category-pesticide-regulation","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>EPA Directive to End Animal Testing of Pesticides Welcomed and Challenged as Not Addressing Inadequate Reviews of Adverse Effects - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2019\/10\/epa-directive-to-end-animal-testing-of-pesticides-welcomed-and-challenged-as-not-addressing-inadequate-reviews-of-adverse-effects\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EPA Directive to End Animal Testing of Pesticides Welcomed and Challenged as Not Addressing Inadequate Reviews of Adverse Effects - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, October 18, 2019)\u00a0The U.S. Environmental Protection Agency (EPA) issued a directive in September, under Administrator Andrew Wheeler, that changes its pesticide approval process and aims to reduce (mammalian) animal testing significantly by 2035. The agency also announced awards totaling $4.25 million to four universities for development of alternative methods to evaluate chemicals, including pesticides. The move will likely be seen both as an advancement of animal rights, and as a setback for the kinds of testing that can have important implications for human health. Resolution of this issue could be found in a shift away from chemical agriculture and to organic and regenerative practices, which eschew toxic chemicals and synthetic fertilizers, and obviate need for them. The directive affects not only the agency\u2019s own research, but also, as the memo says, EPA will \u201ccome as close as possible to excluding from its approval process any reliance on mammal studies conducted after January 1, 2035, including those performed by third parties.\u201d The schools receiving EPA funds to work on alternative testing are Johns Hopkins University, Vanderbilt University and Vanderbilt\u2019s Medical Center, Oregon State University, and the University of California-Riverside. 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