{"id":27382,"date":"2020-07-23T00:01:49","date_gmt":"2020-07-23T04:01:49","guid":{"rendered":"http:\/\/beyondpesticides.org\/dailynewsblog\/?p=27382"},"modified":"2020-07-22T16:46:14","modified_gmt":"2020-07-22T20:46:14","slug":"pesticide-use-linked-to-increased-risk-of-lung-cancer","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/","title":{"rendered":"Pesticide Use Linked to Increased Risk of Lung Cancer"},"content":{"rendered":"\n

\"\"(Beyond Pesticides<\/em>, July 23, 2020) Chronic pesticide use, and subsequent exposure, elevate a person\u2019s risk of developing lung cancer, according to a study published in\u00a0F1000Research<\/em><\/a>\u00a0by researchers at the Nakhon Sawan Provincial Public Health Office and Naresuan University, Thailand. Globally,\u00a0cancer<\/a>\u00a0is one of the leading causes of death, with over 8 million people succumbing to the disease every year. Notably, the International Agency for Cancer Research<\/a>\u00a0(IARC) predicts new cancer cases to rise 67.4% by 2030.<\/p>\n

Although there is a vast amalgamation of research linking cancer risk to genetic and external factors (i.e., cigarette smoke), there is increasing evidence that pesticide exposure augments the risk of developing lung cancer, as well. This study highlights the importance of understanding how pesticide use can increase the risk of latent diseases, which do not readily develop upon initial exposure. \u00a0Study researchers state, \u201cTo our knowledge, the association between lung cancer and pesticides has never been studied before among [Thai] people. The objective of this study was to investigate associations between pesticide exposure and lung cancer among people [living in Nakhon Sawan province, Thailand]. The results can be used for the prevention of lung cancer, and to support the global literature.\u201d<\/p>\n

Lung cancer is one of the most common and deadliest types of cancer, afflicting millions of people across the globe annually. The first scientific study associating pesticide exposure with lung cancer occurred\u00a050 years ago<\/a>\u00a0and, ever since, epidemiological studies present increasing evidence that pesticide exposure increases the risk of developing lung cancer. A\u00a02004 study<\/a>\u00a0demonstrates a positive association between lung cancer and seven widely used agricultural pesticides (e.g., dicamba, metolachlor, pendimethalin, carbofuran, chlorpyrifos, diazinon, and dieldrin). Likewise,\u00a0a U.S. study<\/a>\u00a0finds that the risk of developing lung cancer increases with the number of years working as a pesticide applicator. This study adds to the growing body of research linking pesticide use and exposure to various forms of cancer.<\/p>\n

To assess the relationship between pesticide use and lung cancer, researchers compared a lifetime pesticide exposure of lung cancer cases to healthy neighbors of the same gender, from January 1, 2014, to March 31, 2017. Additionally, researchers gathered related data, including age, demographic, and pesticide exposure, via a face-to-face interview questionnaire.<\/p>\n

Data analysis used\u00a0IBM SPSS Statistics<\/a>\u00a0and linear regression models to evaluate links between lung cancer incidents and types of pesticides, as well as individual pesticides, adjusting for gender, age, cigarette smoking, occupation, and air pollution exposure. Individual pesticides exhibiting a significant correlation with lung cancer are\u00a0chlorpyrifos<\/a>, as well as legacy<\/a>\u00a0pesticides carbofuran<\/a>\u00a0and dieldrin<\/a>. Lastly, researchers categorized the number of cumulative pesticide exposure days into quartiles (Q1-Q4), with Q1 being the lowest exposure and Q4 the highest. Researchers placed participants who used pesticides for less than 160 days in Q1 and participants who used pesticides for more than 530 days in Q4. According to the study, the use of pesticides, including herbicides, insecticides, and fungicides have a positive association with lung cancer development, with Q4 exposure participants displaying elevated risk of lung cancer compared to Q1 exposure participants.<\/p>\n

Although exposure to insecticides and herbicides increases the risk of developing lung cancer for participants in Q2 through Q4, only Q4 exposure (the highest exposure level) significantly increases the risk of lung cancer for fungicide use. From a research perspective, the higher exposure effects for Q2 through Q4 are a function of high acute toxicity for insecticides and herbicides.<\/p>\n

The connection between pesticides and associated cancer risks is nothing new, as a\u00a0plethora of studies<\/a>\u00a0links pesticide use and residue to various cancers, from more prevalent forms like\u00a0breast cancer<\/a>\u00a0to rare forms like\u00a0kidney cancer nephroblastoma<\/a>\u00a0<\/em>(Wilms\u2019 tumor). The connection between lung cancer and pesticides is of specific concern, as etiological studies often attribute lung cancer to genetics or cigarette smoke and overlook the lung cancer risks associated with pesticide exposure via inhalation of powders, airborne droplets, or vapors. Some studies attribute pesticides\u2014labeled hazardous to inhale\u2014sprayed on tobacco plants to lung cancer, and the related mechanisms that cause lung cancer. Upon inhalation, pesticide particles enter the respiratory tract, and the lungs readily absorb the particles into the bloodstream.<\/p>\n

Past research demonstrates the mechanism by which cancer can develop after pesticides enter the bloodstream. In 2013, an\u00a0experimental study<\/a>\u00a0showed that exposure to pesticides produces reactive oxygen species (ROS), which are highly unstable and cause potential DNA and cell damage that propagates the development of cancer. Additionally, pesticides can increase cancer risk via\u00a0alternate mechanisms<\/a>, including genotoxicity (gene damage), epigenetics (gene expression), immunotoxicity, tumors, and endocrine disruption. A\u00a02008 study<\/a>\u00a0showed that a substance other than tobacco smoke, most likely pesticides, was causing gene mutations that prompt lung cancer.\u00a0Additional research<\/a>\u00a0finds that exposure to cigarette smoke, pesticides, and wood dust increases lung cancer incidents. The evidence, associating lung cancer and pesticides, in this study and others like it, highlights the need for better long-term risk assessment of pesticide use on human health as current evaluations fail to capture chronic (long-term) risks fully.<\/p>\n

Studies like this one demonstrate the implications that extensive pesticide use has on future human health, as lung cancer develops among those who use pesticides more frequently. Of all the pesticides investigated, dieldrin, carbofuran, and chlorpyrifos show the greatest association with lung cancer incidents. The U.S. and many other countries banned some forms of the legacy pesticides dieldrin and carbofuran due to their adverse health effects on humans, wildlife, and the environment. Both dieldrin and carbofuran are persistent organic pollutants, which not only accumulate in soil and water, but in the fatty tissue and brains of humans as well. The organochlorine pesticide dieldrin causes kidney\/liver damage, disrupts normal endocrine function, and increases six-fold the risk of\u00a0Parkinson\u2019s disease<\/a>\u00a0by preventing the body from eliminating the chemicals that prompt degenerative neurological disorder development. Carbofuran is the most toxic carbamate pesticide and is highly toxic upon inhalation and ingestion. The World Health Organization (WHO) and the U.S. Environmental Protection Agency (EPA) classify carbofuran\u2019s acute effects as highly hazardous\/toxic. Furthermore, the chemical can cause\u00a0endocrine disruption<\/a>, and depress the nervous system and neurological function. Although the U.S. banned granular carbofuran use due to the concerns about bird ingestion, liquid formulas are still available as restricted use pesticides (RUPs). Since liquid pesticide formulas have particles that are easier to inhale, carbofuran poisoning remains a concern.<\/p>\n

Chlorpyrifos is an insecticide in the organophosphate chemical family, which originated from World War II nerve agents. In addition to being highly toxic to terrestrial and aquatic organisms, human exposure to\u00a0chlorpyrifos<\/a>\u00a0can induce endocrine disruption, reproductive dysfunction, fetal defects, neurotoxic damage, and kidney\/liver damage. Recently, the European Union banned chlorpyrifos use, and\u00a0Thailand<\/a>\u00a0announced a ban on all chlorpyrifos imports, yet it remains in use in the United States. However, states, including Hawaii, California, New York, and Maryland, plans to phase out most of its agricultural uses after EPA negotiated chlorpyrifos\u2019s withdrawal from most of the residential market because of neurotoxic effects to children in 2000.<\/p>\n

Cancer is becoming the leading cause of death worldwide, it is essential to know and understand the implications pesticide use and exposure has on human health. Studies related to pesticides and cancer can aid in future cancer research to understand the underlying mechanisms that cause cancer. With the Trump administration\u00a0dismantling many environmental regulations<\/a>, it is vital to understand how exposure to environmental pollutants like pesticides can increase the risk of developing chronic disease, especially if theses regulatory rollbacks increase the persistence of environmental pollutants. Beyond Pesticides tracks the most recent studies related to pesticide exposure through our\u00a0Pesticide Induced Diseases Database (PIDD)<\/a>. This database supports the clear need for strategic action to shift away from pesticide dependency. For more information on the multiple harms, pesticides can cause, see PIDD pages on\u00a0sexual and reproductive dysfunction<\/a>,\u00a0endocrine disruption<\/a>,\u00a0cancer<\/a>, and other diseases. Additionally,\u00a0buying<\/a>,\u00a0growing<\/a>, and supporting organic can help eliminate the extensive use of pesticides in the environment. Organic agriculture has many\u00a0health<\/a>\u00a0and\u00a0environmental<\/a>\u00a0benefits, which curtail the need for chemical-intensive agricultural practices.\u00a0Regenerative organic agriculture<\/a>\u00a0revitalizes soil health through organic carbon sequestration while reducing pests and generating a higher return than chemical-intensive agriculture. For more information on how organic is the right choice for both consumers and the farmworkers who grow our food, see Beyond Pesticides webpage,\u00a0Health Benefits of Organic Agriculture<\/a>.\u00a0<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: F1000Research<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, July 23, 2020) Chronic pesticide use, and subsequent exposure, elevate a person\u2019s risk of developing lung cancer, according to a study published in\u00a0F1000Research\u00a0by researchers at the Nakhon Sawan Provincial Public Health Office and Naresuan University, Thailand. Globally,\u00a0cancer\u00a0is one of the leading causes of death, with over 8 million people succumbing to the disease every year. Notably, the International Agency for Cancer Research\u00a0(IARC) predicts new cancer cases to rise 67.4% by 2030. Although there is a vast amalgamation of research linking cancer risk to genetic and external factors (i.e., cigarette smoke), there is increasing evidence that pesticide exposure augments the risk of developing lung cancer, as well. This study highlights the importance of understanding how pesticide use can increase the risk of latent diseases, which do not readily develop upon initial exposure. \u00a0Study researchers state, \u201cTo our knowledge, the association between lung cancer and pesticides has never been studied before among [Thai] people. The objective of this study was to investigate associations between pesticide exposure and lung cancer among people [living in Nakhon Sawan province, Thailand]. The results can be used for the prevention of lung cancer, and to support the global literature.\u201d Lung cancer is one of the […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[196,128,33,27,374],"tags":[],"class_list":["post-27382","post","type-post","status-publish","format-standard","hentry","category-cancer","category-carbofuran","category-chlorpyrifos","category-dieldrin","category-fungicides"],"yoast_head":"\nPesticide Use Linked to Increased Risk of Lung Cancer - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pesticide Use Linked to Increased Risk of Lung Cancer - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, July 23, 2020) Chronic pesticide use, and subsequent exposure, elevate a person\u2019s risk of developing lung cancer, according to a study published in\u00a0F1000Research\u00a0by researchers at the Nakhon Sawan Provincial Public Health Office and Naresuan University, Thailand. Globally,\u00a0cancer\u00a0is one of the leading causes of death, with over 8 million people succumbing to the disease every year. Notably, the International Agency for Cancer Research\u00a0(IARC) predicts new cancer cases to rise 67.4% by 2030. Although there is a vast amalgamation of research linking cancer risk to genetic and external factors (i.e., cigarette smoke), there is increasing evidence that pesticide exposure augments the risk of developing lung cancer, as well. This study highlights the importance of understanding how pesticide use can increase the risk of latent diseases, which do not readily develop upon initial exposure. \u00a0Study researchers state, \u201cTo our knowledge, the association between lung cancer and pesticides has never been studied before among [Thai] people. The objective of this study was to investigate associations between pesticide exposure and lung cancer among people [living in Nakhon Sawan province, Thailand]. 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By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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Globally,\u00a0cancer\u00a0is one of the leading causes of death, with over 8 million people succumbing to the disease every year. Notably, the International Agency for Cancer Research\u00a0(IARC) predicts new cancer cases to rise 67.4% by 2030. Although there is a vast amalgamation of research linking cancer risk to genetic and external factors (i.e., cigarette smoke), there is increasing evidence that pesticide exposure augments the risk of developing lung cancer, as well. This study highlights the importance of understanding how pesticide use can increase the risk of latent diseases, which do not readily develop upon initial exposure. \u00a0Study researchers state, \u201cTo our knowledge, the association between lung cancer and pesticides has never been studied before among [Thai] people. The objective of this study was to investigate associations between pesticide exposure and lung cancer among people [living in Nakhon Sawan province, Thailand]. The results can be used for the prevention of lung cancer, and to support the global literature.\u201d Lung cancer is one of the […]","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2020-07-23T04:01:49+00:00","og_image":[{"url":"http:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2020\/07\/Lung-X-Ray.jpg","type":"","width":"","height":""}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"Pesticide Use Linked to Increased Risk of Lung Cancer","datePublished":"2020-07-23T04:01:49+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/"},"wordCount":1412,"commentCount":2,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/#primaryimage"},"thumbnailUrl":"http:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2020\/07\/Lung-X-Ray.jpg","articleSection":["Cancer","Carbofuran","Chlorpyrifos","Dieldrin","Fungicides"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2020\/07\/pesticide-use-linked-to-increased-risk-of-lung-cancer\/","name":"Pesticide Use Linked to Increased Risk of Lung Cancer - 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By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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