{"id":29125,"date":"2021-04-22T00:01:54","date_gmt":"2021-04-22T04:01:54","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=29125"},"modified":"2024-08-15T10:27:42","modified_gmt":"2024-08-15T14:27:42","slug":"grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/","title":{"rendered":"Grandmothers’ Exposure to DDT Increases Granddaughters’ Breast Cancer and Cardiometabolic Disorder Risk"},"content":{"rendered":"

(Beyond Pesticides<\/em>, April 22, 2021) Past maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three successive generations, according to a new study published in\u00a0Cancer Epidemiology, Biomarkers & Prevention<\/em><\/a>. Although previous studies<\/a> highlight early life or in utero<\/em> exposure to DDT increasing breast cancer risk later in life, this study is the first to note generational effects on grandchildren’s health. DDT continues to adversely affect the health of the U.S. population, nearly 50 years after its ban. However, this ban is not global, as many countries still use or manufacture the chemical compound. Furthermore, residues of DDT metabolite, DDE, continue to readily contaminate food and water worldwide. Therefore, studies like these highlight the need to investigate how first-generation pesticide exposure can impact future generational health in order to prevent adverse health outcomes, especially during sensitive developmental periods<\/a> (i.e., in utero<\/em>, infancy\/childhood). The study researchers note, “Discovery of actionable biomarkers of response to ancestral environmental exposures in young women may provide opportunities for breast cancer prevention.”<\/p>\n

To assess the association between multi-generational health risks and chemical exposure, researchers used the Public Health Institute’s Child Health and Development Studies (CHDS). CHDS has been following a cohort of 20,000 pregnant women since the 1960s and examines how diseases can pass from one generation to the next. Researchers gathered archived blood serum samples from pregnant grandmothers (F0) during and after pregnancy to measure\u00a0o,p\u2019<\/em>-DDT,\u00a0p,p\u2019<\/em>-DDT and\u00a0p,p\u2019<\/em>-DDE concentrations. After adjusting for body mass index (BMI) and health effects among daughters (F1), researchers estimated granddaughter (F2) health outcomes, including waist circumference, weight, height, via log-linear models. Health outcomes like obesity and early menstruation are risk factors for breast cancer later in life.\u00a0<\/p>\n

The results find obesity risk increases two to three-fold in granddaughter when grandmothers have high\u00a0o,p\u2019<\/em>-DDT levels, especially among grandmothers of average weight. There is also a positive association between grandmother\u00a0o,p\u2019<\/em>-DDT levels, and early-onset menstruation among granddaughters, regardless of grandmother\u2019s BMI. (See \u201dPesticides and the Obesity Epidemic<\/a>.\u201d)<\/p>\n

DDT,\u00a0an organochlorine<\/a>\u00a0(OC) insecticide, was widely used to control mosquitoes and in agriculture. However, a massive environmental movement spurred by Rachel Carson\u2019s\u00a0\u00a0Silent Spring\u00a0<\/em>resulted in the chemical ban in 1972. DDT, and its major metabolite DDE, still remain in the environment decades after use ended, with the U.S. Environmental Protection Agency (EPA) finding<\/a> chemical concentrations that exceed acceptable levels. DDT\/DDE are persistent organic pollutants (POPs) resistant to environmental degradation through chemical, biological, and photolytic processes. These POPs persist in\u00a0soil and water sediments<\/a>,\u00a0glacier meltwater runoff<\/a>,\u00a0U.S. national parks<\/a>, and\u00a0food webs<\/a>. Additionally, these compounds readily dissolve into body fat and linger for many years, adversely affecting the hormonal system, metabolic function, and brain development. Exposure to DDT, as an endocrine (hormone) disruptor, increases the risk associated with\u00a0diabetes<\/a>,\u00a0early onset menopause<\/a>,\u00a0reduced sperm count<\/a>,\u00a0endometriosis<\/a>, birth defects<\/a>, autism<\/a>, vitamin D<\/a>\u00a0deficiency, non-Hodgkin\u2019s Lymphoma<\/a>, and\u00a0obesity<\/a>. Past studies indicate DDE exposure has multi-generational health effects on\u00a0obesity and diabetes<\/a>, with DDE uniquely augmenting multi-generational\u00a0breast cancer<\/a>\u00a0occurrences. Climate change only threatens to exacerbate residual DDT\/DDE exposure, as warming may affect chemical movement and concentration in the environment. Therefore, animals and humans may experience a weakened ability to tolerate those chemicals.<\/p>\n

Many studies have long demonstrated that\u00a0childhood<\/a>\u00a0and\u00a0in utero<\/a>\u00a0exposure to DDT increases the risk of developing breast cancer later in life. However, studies find many current-use pesticides and chemical contaminants play a role in similar disease prognosis, including mammary tumor formation. Recent research from the Silent Spring Institute links\u00a028 different EPA registered pesticides<\/a>\u00a0with the development of mammary gland tumors in animal studies. Many of these said chemicals are endocrine disruptors, thus have implications for breast cancer risk. Even\u00a0household cleaners<\/a>, most of which are pesticides, contain endocrine-disrupting chemicals that increase breast cancer risk.\u00a0Furthermore, long-term exposure to organophosphate (OP) pesticides\u00a0increases<\/a>\u00a0adverse health and cancer risk, specifically among women. Like DDT, exposure to other POPs like per- and polyfluoroalkyl substances (PFAS) during pregnancy can increase\u00a0cardiometabolic disorders<\/a>\u00a0like obesity, diabetes, and cardiovascular diseases among offspring. Since DDT\/DDE residues, current-use pesticides, and other chemical pollutants contaminate the environment, exposure to these chemical mixtures can\u00a0synergize<\/a>\u00a0to increase toxicity and disease effects.<\/p>\n

Inheritance of health issues spanning generations relating to hereditary influence is a familiar phenomenon. However, this study represents the first study to demonstrate multi-generational health problems from DDT exposure, a non-genetic factor. Therefore, exposure to pesticides poses just as much of a multi-generational health risk as hereditary illnesses. A plethora of research links pesticide exposure to endocrine disruption with epigenetic (non-genetic influence on gene expression) effects. As far back as 15 years ago,\u00a0a Washington State University study<\/a>\u00a0linked pesticide exposure to multi-generational impacts on male fertility in rodents. According to multiple studies,\u00a0glyphosate<\/a>\u00a0exposure has adverse multi-generational effects causing negligible observable effects on pregnant rodents but severe effects on the two subsequent generations. These impacts include reproductive (prostate and ovarian) and kidney diseases, obesity, and birth anomalies. New findings suggest exposure to the pesticide\u00a0atrazine<\/a>\u00a0causes multi-generation resistance to the chemical in\u00a0wasps<\/a>\u00a0by altering gut bacteria composition. Moreover, chemical byproducts made during the pesticide manufacturing process, such as\u00a0dioxin<\/a>, have multi-generational consequences on reproductive health.<\/p>\n

Researchers note that past studies investigating DDT exposure measured bodily DDE concentration, as the metabolite stays in the body longer than the parent chemical itself. However, this study finds\u00a0o,p’<\/em>-DDT, rather than DDE, is the most sensitive biomarker for DDT exposure, indicating exposure during pregnancy many decades ago. The compound metabolizes much quicker than the main ingredient for DDT (p,p’<\/em>-DDT) that breakdowns to DDE. Furthermore, studies find\u00a0less<\/a>\u00a0endocrine disruption potential associated with breast cancer risk for DDE compared to\u00a0o,p’<\/em>-DDT. Lastly, the study\u2019s researchers note that higher rates of obesity among granddaughters are most likely due to grandmother\u2019s DDT exposure rather than exposure to present-day obesogenic chemicals from diet or other means. DDT-associated compounds are commonly detectable in\u00a0most<\/a>\u00a0of the U.S. population, especially among\u00a0people of color (POC) communities<\/a>. Therefore, it is essential to understand the impacts these residual compounds, and others like them, have on the future of human, animal, and environmental health.<\/p>\n

Study co-author and scientist at Public Health Institute Barbara Cohn, Ph.D.,\u00a0stresses<\/a>, “In combination with our on-going studies of DDT effects in the grandmother’s and mother’s generations, our work suggests we should take precautionary action on the use of other endocrine-disrupting chemicals, given their potential to affect generations to come in ways we cannot anticipate today\u2026We don’t want to wait [for] the next three generations to find out the chemicals that are in use now cause breast cancer.”<\/p>\n

It is essential to understand the effects that endocrine-disrupting pesticides may have on the health of current and future generations. There is a lack of understanding behind the etiology of pesticide-induced diseases, including predictable lag time between chemical exposure, health impacts, and epidemiological data. Therefore, lawmakers and regulators should consider taking a more precautionary approach before introducing these chemicals into the environment. With far too many diseases in the U.S. associated with pesticide exposure, reducing pesticide use is a critically important aspect of safeguarding public health and addressing cost burdens for local communities.<\/p>\n

Learn more about the effects of pesticides on human health by visiting Beyond Pesticides\u2019\u00a0Pesticide-Induced Diseases Database<\/a>, supporting a shift away from pesticide dependency. This database is a fantastic resource for additional scientific literature, documenting elevated rates of\u00a0Endocrine Disruption<\/a>,\u00a0Cancer<\/a>,\u00a0Body Burdens<\/a>, and other chronic diseases and illnesses among people exposed to pesticides. Beyond Pesticides believes that we must mitigate the multi-generational impacts pesticides pose on human and animal health. Adopting\u00a0regenerative-organic practices<\/a>\u00a0and using\u00a0least-toxic pest control<\/a>\u00a0can reduce harmful exposure to pesticides. Solutions like\u00a0buying<\/a>,\u00a0growing<\/a>, and supporting organic can help eliminate the extensive use of pesticides in the environment. Learn more about the multi-generation impacts of pesticides on our health via Beyond Pesticide\u2019s journal\u00a0Pesticides and You<\/a>. Additionally, read more and help spread the word about the hazards pesticides pose to children through our\u00a0Children and Pesticides Don\u2019t Mix<\/a>\u00a0fact sheet.<\/p>\n

Help Beyond Pesticides educate and build the movement that will bring long-needed protection to humans, animals, and the entire environment by attending the National Pesticide Forum this spring.\u00a0Cultivating Healthy Communities<\/a>\u00a0will bring together expert scientists, farmers, policymakers, and activists to discuss strategies to eliminate harms from toxic chemical use in favor of non-toxic organic solutions. It begins with a pre-conference session on Monday, May 24, and continues every Tuesday beginning May 25, June 1, June 8, and ending June 15, 2021.\u00a0Registration is open today and available through the webpage on this link.<\/a> It starts with US.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Cancer Epidemiology, Biomarkers & Prevention<\/em><\/a>, Environmental Health News<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, April 22, 2021) Past maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three successive generations, according to a new study published in\u00a0Cancer Epidemiology, Biomarkers & Prevention. Although previous studies highlight early life or in utero exposure to DDT increasing breast cancer risk later in life, this study is the first to note generational effects on grandchildren’s health. DDT continues to adversely affect the health of the U.S. population, nearly 50 years after its ban. However, this ban is not global, as many countries still use or manufacture the chemical compound. Furthermore, residues of DDT metabolite, DDE, continue to readily contaminate food and water worldwide. Therefore, studies like these highlight the need to investigate how first-generation pesticide exposure can impact future generational health in order to prevent adverse health outcomes, especially during sensitive developmental periods (i.e., in utero, infancy\/childhood). The study researchers note, “Discovery of actionable biomarkers of response to ancestral environmental exposures in young women may provide opportunities for breast cancer prevention.” To assess the association between multi-generational health risks and chemical exposure, researchers used the Public Health Institute’s Child […]<\/p>\n","protected":false},"author":2,"featured_media":29127,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[199,84,371,350,26,484,417,343,527],"tags":[],"class_list":["post-29125","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biomonitoring","category-breast-cancer","category-children","category-contamination-2","category-ddt","category-epigenetic","category-multi-generational-effects","category-pesticide-residues","category-womens-health"],"yoast_head":"\nGrandmothers' Exposure to DDT Increases Granddaughters' Breast Cancer and Cardiometabolic Disorder Risk - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Grandmothers' Exposure to DDT Increases Granddaughters' Breast Cancer and Cardiometabolic Disorder Risk - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, April 22, 2021) Past maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three successive generations, according to a new study published in\u00a0Cancer Epidemiology, Biomarkers & Prevention. Although previous studies highlight early life or in utero exposure to DDT increasing breast cancer risk later in life, this study is the first to note generational effects on grandchildren’s health. DDT continues to adversely affect the health of the U.S. population, nearly 50 years after its ban. However, this ban is not global, as many countries still use or manufacture the chemical compound. Furthermore, residues of DDT metabolite, DDE, continue to readily contaminate food and water worldwide. Therefore, studies like these highlight the need to investigate how first-generation pesticide exposure can impact future generational health in order to prevent adverse health outcomes, especially during sensitive developmental periods (i.e., in utero, infancy\/childhood). 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The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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Although previous studies highlight early life or in utero exposure to DDT increasing breast cancer risk later in life, this study is the first to note generational effects on grandchildren’s health. DDT continues to adversely affect the health of the U.S. population, nearly 50 years after its ban. However, this ban is not global, as many countries still use or manufacture the chemical compound. Furthermore, residues of DDT metabolite, DDE, continue to readily contaminate food and water worldwide. Therefore, studies like these highlight the need to investigate how first-generation pesticide exposure can impact future generational health in order to prevent adverse health outcomes, especially during sensitive developmental periods (i.e., in utero, infancy\/childhood). The study researchers note, “Discovery of actionable biomarkers of response to ancestral environmental exposures in young women may provide opportunities for breast cancer prevention.” To assess the association between multi-generational health risks and chemical exposure, researchers used the Public Health Institute’s Child […]","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2021-04-22T04:01:54+00:00","article_modified_time":"2024-08-15T14:27:42+00:00","og_image":[{"width":620,"height":340,"url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2021\/04\/Copy-of-Untitled.png","type":"image\/png"}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"Grandmothers’ Exposure to DDT Increases Granddaughters’ Breast Cancer and Cardiometabolic Disorder Risk","datePublished":"2021-04-22T04:01:54+00:00","dateModified":"2024-08-15T14:27:42+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/"},"wordCount":1508,"commentCount":0,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/#primaryimage"},"thumbnailUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2021\/04\/Copy-of-Untitled.png","articleSection":["Biomonitoring","Breast Cancer","Children","contamination","DDT","Epigenetic","multi-generational effects","Pesticide Residues","Women's Health"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/04\/grandmothers-exposure-to-banned-pesticide-ddt-increases-breast-cancer-and-cardiometabolic-disorder-risk-in-granddaughters\/","name":"Grandmothers' Exposure to DDT Increases Granddaughters' Breast Cancer and Cardiometabolic Disorder Risk - 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By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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