{"id":29797,"date":"2021-09-01T00:01:50","date_gmt":"2021-09-01T04:01:50","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=29797"},"modified":"2021-08-31T14:45:41","modified_gmt":"2021-08-31T18:45:41","slug":"in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/","title":{"rendered":"In Utero and Childhood Pesticide Exposure Increases Childhood Cancer Risk"},"content":{"rendered":"

(Beyond Pesticides<\/em>, September 1, 2021) A study published in\u00a0Environmental Pollution<\/em><\/a>\u00a0finds the risk of acute childhood leukemia (AL) increases with prenatal and newborn exposure to pesticides (i.e., insecticides and herbicides). The study results support the hypothesis that chronic environmental pesticide exposure increases childhood leukemia risk up to two times. Maternal exposure has a stronger association with leukemia than childhood exposure. Insecticides and herbicides are of particular significance in increasing leukemia risk, especially for acute lymphoblastic leukemia. Although medical advancements in disease survival are more prominent nowadays, childhood AL remains the secondary cause of child mortality following physical injury. Furthermore, childhood leukemia survivors can suffer from chronic or long-term health complications that may be life-threatening.<\/p>\n

Although the etiology or cause of childhood AL involves the interaction of multiple components like lifestyle and genetics, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Already,\u00a0studies<\/a>\u00a0find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic disorders to mental and physical disabilities. Moreover, several studies demonstrate an association between environmental or occupational pesticide exposure and the risk of childhood cancer, specifically focusing on\u00a0leukemia<\/a>.<\/p>\n

Acute leukemia<\/a>\u00a0is the most common type of childhood cancer, affecting one out of three individuals, ages 0 to 14 years. Although the disease is rare, incidents are steadily increasing among adolescents and have been over the last 30 years. Therefore, studies like these highlight the importance of understanding how pesticide use can increase the risk of latent diseases (e.g., cancers) among vulnerable populations, such as children\/infants. The authors note, \u201c\u2026[T]he findings of the present meta-analysis provide some evidence that low-dose long-term exposure to pesticides, mainly during pregnancy, increases the risk of childhood AL, especially among infants, supporting the still harmful role of pesticides\u2026Moreover, mechanistic studies are deemed necessary to shed light into potentially relevant molecular pathways that underlie these associations, if replicated in future research.\u201d<\/p>\n

Despite several scientific studies demonstrating an association between pesticide exposure and adverse health outcomes like acute childhood leukemia (AL), methodological evidence remains inconclusive. The researchers evaluate the currently available, peer-reviewed literature on the association between pesticide exposure and different types of childhood AL, including acute lymphoblastic (ALL), acute myeloid (AML), and infant leukemia. The literature review focuses on studies published until January 2021 with specific attention to methodology. Researchers categorize effects by pesticide type, exposure-outcome (e.g., leukemia type), window\/timeframe of exposure, and exposed population in evaluating the vast array of current studies.<\/p>\n

The study results identify 55 studies from over 30 countries pertaining to over 200 different pesticide exposures from over 160,000 participants. Regardless of pesticide type, leukemia type, exposure timeframe, and population group, methodological studies demonstrate pesticide exposure increases the risk of childhood leukemia, particularly for infants. Maternal exposure to pesticides during gestation results in a more elevated leukemia risk for children than childhood (postnatal) exposure. Whether pesticide exposure is occupational or mixed, parental exposure to pesticides has the highest association with AL risk, including paternal (father) exposure. Exposure during pregnancy results in a 1.5 times greater risk of developing AL, with a 2.5 times increase in risk for acute lymphoblastic leukemia. When assessing pesticide subtypes, maternal exposure to insecticides and herbicides augments AL risk by a ratio of 1.6 and 1.4, respectively. Infant leukemia incidents depend on maternal pesticide exposure during pregnancy, with a higher risk for acute lymphoblastic and the highest risk for infant acute myeloid leukemia.<\/p>\n

Environmental contaminants like pesticides are ubiquitous in the environment, with\u00a090 percent<\/a>\u00a0of Americans having at least one pesticide compound in their body. This bodily contamination has implications for human health, especially during vulnerable life stages like childhood, puberty, pregnancy, and old age. Pesticide exposure during pregnancy is of specific concern as health effects for all life stages can be long-lasting. A\u00a02020 study<\/a>\u00a0finds the first few weeks of pregnancy are the most vulnerable periods during which prenatal pesticide exposure can increase the risk of the rare fetal disorder holoprosencephaly. This disorder prevents the embryonic forebrain from developing into two separate hemispheres. Moreover, women living near agricultural areas experience higher exposure rates that\u00a0increase the risk<\/a>\u00a0of birthing a baby with abnormalities. Just as nutrients are transferable between mother and fetus, so are chemical contaminants. Studies\u00a0find<\/a>\u00a0pesticide compounds present in the mother\u2019s blood can transfer to the fetus via the umbilical cord. Therefore, pesticide exposure during pregnancy has implications for both mother and child\u2019s health.\u00a0<\/p>\n

Many studies indicate prenatal and early-life exposure to environmental toxicants increase susceptibility to diseases. For decades, studies have long demonstrated that\u00a0childhood<\/a>\u00a0and\u00a0in utero<\/a>\u00a0exposure to the U.S. banned insecticide DDT increases the risk of developing breast cancer later in life. Moreover, a\u00a02021 study<\/a>\u00a0finds previous maternal exposure to the chemical compound during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three successive generations. However, studies find numerous current-use pesticides and chemical contaminants play a role in similar disease outcomes, including mammary tumor formation. Recent research from the Silent Spring Institute links\u00a028 different EPA registered pesticides<\/a>\u00a0with the development of mammary gland tumors in animal studies. Many of these said chemicals are endocrine disruptors, thus have implications for breast cancer risk. Even\u00a0household cleaners<\/a>, many of which are pesticides, can increase\u00a0nephroblastoma<\/a>\u00a0(kidney cancer) and brain tumor risk in children. Furthermore, long-term exposure to organophosphate (OP) pesticides\u00a0increases<\/a>\u00a0adverse health and cancer risk, specifically among women. Since DDT and its metabolite DDE residues, current-use pesticides, and other chemical pollutants contaminate the environment, exposure to these chemical mixtures can\u00a0synergize<\/a>\u00a0to increase toxicity and disease effects.<\/p>\n

The scientific connection between pesticides and associated cancer risks is nothing new.\u00a0Several studies<\/a>\u00a0link pesticide use and residues to various cancers, from more prevalent forms like\u00a0breast cancer<\/a>\u00a0to rare forms like kidney cancer nephroblastoma\u00a0<\/em>(Wilms\u2019 tumor).\u00a0Sixty-six percent<\/a>\u00a0of all cancers have links to environmental factors, especially in occupations of high chemical use. In addition to the link between agricultural practices and pesticide-related illnesses being robust<\/a>, over\u00a063 percent<\/a>\u00a0of commonly used lawn pesticides and\u00a070 percent<\/a>\u00a0commonly used school pesticides have\u00a0links<\/a>\u00a0to cancer. U.S. National Institutes of Health\u2019s\u00a0National Cancer Institute<\/a>\u00a0also finds many cancer-causing substances are endocrine disruptors. Globally,\u00a0cancer<\/a>\u00a0is one of the leading causes of death, with over 8 million people succumbing to the disease every year. Notably,\u00a0the International Agency for Cancer Research<\/a>\u00a0(IARC) predicts new cancer cases to rise 67.4% by 2030. Therefore, it is essential to understand how external stimuli\u2014like environmental pollution from pesticides\u2014can drive cancer development to avoid exposure and lessen potential cancer risks.<\/p>\n

Although pesticides products are subject to an extensive toxicological assessment before registration, current regulatory guideline studies fail to assess genotoxicity and carcinogenicity\u00a0in utero<\/em>\u00a0that induces infant leukemia incidents. Children are more susceptible to the toxic effect of pesticide exposure as their endocrine and metabolic systems cannot adequately detoxify and excrete chemical compounds. Moreover, pesticides can hinder childhood development making children more vulnerable to acute health effects like asthma\/respiratory issues, gut dysbiosis, cardiovascular diseases, and other physical and mental birth abnormalities.<\/p>\n

Cancer is a leading cause of death worldwide. Hence,\u00a0studies<\/a>\u00a0concerning pesticides and cancer help future epidemiologic research understand the underlying mechanisms that cause the disease. There is a serious deficiency in understanding the etiology of pesticide-induced diseases, including predictable lag time between chemical exposure, health impacts, and epidemiologic data. Therefore, advocates maintain that lawmakers and regulators should take a more precautionary approach before introducing these chemicals into the environment. With far too many diseases in the U.S. associated with pesticide exposure, eliminating pesticide use is a critically important aspect of safeguarding public health and addressing cost burdens for local communities. Beyond Pesticides’\u00a0Pesticide-Induced Diseases Database<\/a>\u00a0(PIDD) is a vital resource for additional scientific literature that documents elevated cancer rates and other chronic diseases and illnesses among people exposed to pesticides. This database supports the clear need for strategic action to shift away from pesticide dependency. For more information on pesticide exposure’s multiple harms, see PIDD pages on\u00a0leukemia<\/a>\u00a0and other\u00a0cancers<\/a>,\u00a0birth\/fetal defects<\/a>,\u00a0endocrine disruption<\/a>, and other diseases.<\/p>\n

One way to reduce human and environmental contamination from pesticides is\u00a0buying<\/a>,\u00a0growing<\/a>, and\u00a0supporting organic<\/a> land management. Organic agriculture has many\u00a0health<\/a>\u00a0and\u00a0environmental<\/a>\u00a0benefits, which curtail the need for chemical-intensive agricultural practices. Numerous studies find that\u00a0levels of pesticide metabolites in urine drop greatly<\/a>\u00a0when switching to an all-organic diet. Furthermore, given the\u00a0wide availability of non-pesticidal alternative strategies<\/a>, families and agricultural industry workers alike can apply these methods to promote a safe and healthy environment, especially among chemically vulnerable individuals. For more information on how organic is the right choice for both consumers and the farmworkers that grow our food, see Beyond Pesticides webpage,\u00a0Health Benefits of Organic Agriculture<\/a>.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Environmental Pollution<\/em><\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, September 1, 2021) A study published in\u00a0Environmental Pollution\u00a0finds the risk of acute childhood leukemia (AL) increases with prenatal and newborn exposure to pesticides (i.e., insecticides and herbicides). The study results support the hypothesis that chronic environmental pesticide exposure increases childhood leukemia risk up to two times. Maternal exposure has a stronger association with leukemia than childhood exposure. Insecticides and herbicides are of particular significance in increasing leukemia risk, especially for acute lymphoblastic leukemia. Although medical advancements in disease survival are more prominent nowadays, childhood AL remains the secondary cause of child mortality following physical injury. Furthermore, childhood leukemia survivors can suffer from chronic or long-term health complications that may be life-threatening. Although the etiology or cause of childhood AL involves the interaction of multiple components like lifestyle and genetics, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Already,\u00a0studies\u00a0find low levels of pesticide exposure during […]<\/p>\n","protected":false},"author":2,"featured_media":29769,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[144,371,494,92,527],"tags":[],"class_list":["post-29797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-birth-defects","category-children","category-herbicides","category-leukemia","category-womens-health"],"yoast_head":"\nIn Utero and Childhood Pesticide Exposure Increases Childhood Cancer Risk - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"In Utero and Childhood Pesticide Exposure Increases Childhood Cancer Risk - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, September 1, 2021) A study published in\u00a0Environmental Pollution\u00a0finds the risk of acute childhood leukemia (AL) increases with prenatal and newborn exposure to pesticides (i.e., insecticides and herbicides). The study results support the hypothesis that chronic environmental pesticide exposure increases childhood leukemia risk up to two times. Maternal exposure has a stronger association with leukemia than childhood exposure. Insecticides and herbicides are of particular significance in increasing leukemia risk, especially for acute lymphoblastic leukemia. Although medical advancements in disease survival are more prominent nowadays, childhood AL remains the secondary cause of child mortality following physical injury. Furthermore, childhood leukemia survivors can suffer from chronic or long-term health complications that may be life-threatening. Although the etiology or cause of childhood AL involves the interaction of multiple components like lifestyle and genetics, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. 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The study results support the hypothesis that chronic environmental pesticide exposure increases childhood leukemia risk up to two times. Maternal exposure has a stronger association with leukemia than childhood exposure. Insecticides and herbicides are of particular significance in increasing leukemia risk, especially for acute lymphoblastic leukemia. Although medical advancements in disease survival are more prominent nowadays, childhood AL remains the secondary cause of child mortality following physical injury. Furthermore, childhood leukemia survivors can suffer from chronic or long-term health complications that may be life-threatening. Although the etiology or cause of childhood AL involves the interaction of multiple components like lifestyle and genetics, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Already,\u00a0studies\u00a0find low levels of pesticide exposure during […]","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2021-09-01T04:01:50+00:00","og_image":[{"width":640,"height":320,"url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2021\/08\/leukemia.png","type":"image\/png"}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"In Utero and Childhood Pesticide Exposure Increases Childhood Cancer Risk","datePublished":"2021-09-01T04:01:50+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/"},"wordCount":1532,"commentCount":0,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/#primaryimage"},"thumbnailUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2021\/08\/leukemia.png","articleSection":["Birth defects","Children","Herbicides","Leukemia","Women's Health"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2021\/09\/in-utero-and-childhood-pesticide-exposure-increases-childhood-cancer-risk\/","name":"In Utero and Childhood Pesticide Exposure Increases Childhood Cancer Risk - 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By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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