{"id":30990,"date":"2022-04-28T00:01:59","date_gmt":"2022-04-28T04:01:59","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=30990"},"modified":"2023-04-02T22:27:44","modified_gmt":"2023-04-03T02:27:44","slug":"implications-for-human-health-glyphosate-breakdown-product-ampa-associated-with-oxidative-stress-and-dna-damage-among-children","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/04\/implications-for-human-health-glyphosate-breakdown-product-ampa-associated-with-oxidative-stress-and-dna-damage-among-children\/","title":{"rendered":"Glyphosate Breakdown Product Associated with Oxidative Stress and DNA Damage Among Children"},"content":{"rendered":"

(Beyond Pesticides, <\/em>April 28, 2022) A study in\u00a0Environmental Research<\/em><\/a>\u00a0finds that glyphosate’s primary metabolite (breakdown product), aminomethylphosphonic acid (AMPA), induces DNA damage through oxidative stress among subpopulations of primary school children. Although pyrethroid and chlorpyrifos metabolites can induce oxidative stress, this study is the first to investigate AMPA’s association with adverse health effects, rather than solely the effects of the active ingredient, glyphosate, in Roundup and other formulations.<\/p>\n

Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulations, readily contaminating soil, water, food, and other resources. Chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is among the most prevalent pesticide contributors to human, biotic, and ecosystem\u00a0harm<\/a>.\u00a0According to research, herbicide toxicity to invertebrates has\u00a0double<\/a>d\u00a0since 2004. Although research links glyphosate exposure to cancer, specifically non-Hodgkin lymphoma, much less research considers the effects that metabolites have on children who are more vulnerable to chemical exposure. Ecological and health risk assessments primarily focus on active ingredients in pesticide products, overlooking the potential impacts of metabolites. Thus, studies like these highlight the need to assess the implications of metabolite exposure to protect human, animal, and environmental health. The study notes, “Our results indicate that [Cypriot] children are co-exposed to a mixture of pesticides likely originating from both dietary and non-dietary sources. On average, these pesticide exposures appear at higher levels than those typically measured in other EU populations. The population health risk associated with such mixture exposures needs to be further investigated.”<\/p>\n

The researchers in this study investigated the health of children aged 10 to 11 in Cyprus, using the European Human Biomonitoring Initiative (HBM4EU) to measure urinary concentrations of glyphosate, AMPA, and pyrethroid and chlorpyrifos metabolites. Using an immunological assay, researchers identified oxidative stress using biological markers to assess lipid and DNA damage. Additionally, parents filled out questionnaires gathering data on demographic characteristics, pesticide usage, and diet.<\/p>\n

The results find that AMPA, but not glyphosate, has a positive association with DNA damage via oxidation. Moreover, the metabolites of pyrethroids (3-PBA) and chlorpyrifos (TCPy) are also associated with DNA damage and oxidative stress. Lipid damage from oxidative stress did not occur among these pesticides. However, the results suggest parental education levels influence urinary pyrethroid levels.<\/p>\n

Decades of extensive glyphosate herbicide use (e.g., Roundup) have put human, animal, and environmental health at risk. The chemical\u2019s ubiquity threatens\u00a093 percent<\/a>\u00a0of all U.S. endangered species,\u00a0resulting<\/a>\u00a0in biodiversity loss and ecosystem disruption (e.g.,\u00a0soil erosion<\/a>,\u00a0loss of services<\/a>, and\u00a0trophic cascades<\/a>). Exposure to glyphosate has implications for\u00a0the development of various health anomalies,<\/a>\u00a0including\u00a0cancer<\/a>,\u00a0Parkinson\u2019s disease<\/a>, and\u00a0autism<\/a>. Although the U.S. Environmental Protection Agency (EPA) classifies glyphosate herbicides as \u201cnot likely to be carcinogenic to humans,\u201d\u00a0stark evidence<\/a>\u00a0demonstrates links to various cancers, including non-Hodgkin lymphoma. EPA\u2019s classification perpetuates adverse impacts, especially among vulnerable individuals, like pregnant women, infants, children, and the elderly. Not only do health officials warn that continuous use of glyphosate will perpetuate adverse health effects, but that use also highlights recent concerns over\u00a0antibiotic resistance<\/a>. Agrochemical company Bayer\/Monsanto patents glyphosate as an antibiotic. Exposure hinders enzymatic pathways in many bacteria and parasites. However, studies\u00a0find<\/a>\u00a0glyphosate exposure disrupts the microbial composition in both soil and animals\u2014including humans\u2014discerningly eliminating beneficial bacteria while preserving unhealthy microbes. Moreover, resistance to pesticides is also growing at similar rates among genetically engineered (GE) and non-GE conventionally grown crops. This increase in resistance is evident among\u00a0herbicide-tolerant<\/a>\u00a0GE crops, including seeds genetically engineered to be\u00a0glyphosate-tolerant<\/a>.<\/p>\n

This study is one of the first to identify oxidative stress from AMPA exposure among children in a nonoccupational setting. However, glyphosate and its formulations have long been associated with oxidative stress and\u00a0strong evidence<\/a> of genotoxicity. Moreover, glyphosate degrades relatively quickly in the environment, between five and 20 days, leaving behind AMPA, which is highly persistent with a half-life of 151 days. Therefore, researchers attribute higher rates of AMPA concentration in children\u2019s bodies to relative availability in the environment compared to glyphosate. Additional\u00a0studies<\/a>\u00a0find that 100 percent of adults and children have detectable levels of AMPA in urine samples, with children exhibiting a five times higher bodily concentration than adults. Therefore, researchers suggest that a shift to organic can mitigate exposure to these toxic chemicals, especially among vulnerable populations like children.\u00a0\u00a0<\/p>\n

It is essential to understand the effects widely used pesticides and their breakdown products may have on the health of current and future generations. Beyond Pesticides\u00a0challenges the EPA registration of chemicals like glyphosate in court<\/a>\u00a0due to their impacts on soil, air, water, and our health. However, emphasis on converting to\u00a0regenerative-organic systems<\/a>\u00a0and using\u00a0least-toxic pest control<\/a>\u00a0can mitigate harmful exposure concerns. Public policy must advance this shift rather than continue to allow unnecessary reliance on pesticides. Considering\u00a0glyphosate<\/a>\u00a0levels in the human body can decrease by\u00a070%<\/a>\u00a0through a one-week switch to an organic diet,\u00a0purchasing organic food whenever possible<\/a>\u2014which never allows glyphosate use\u2014can help curb exposure and resulting adverse health effects. Learn more about pesticides’ impacts on human health by visiting Beyond Pesticides’\u00a0Pesticide-Induced Diseases Database<\/a>. This database supports the clear need for strategic action to shift away from pesticide dependency. Moreover, Beyond Pesticides provides tools, information, and support to take local action: check out our\u00a0factsheet on glyphosate\/Roundup<\/a>\u00a0and our report,\u00a0Monsanto\u2019s Roundup (Glyphosate) Exposed<\/a>. Contact us for help with local efforts and stay informed of developments through our\u00a0Daily News Blog<\/a>\u00a0and our journal,\u00a0Pesticides and You<\/em><\/a>. Additionally, check out\u00a0Carey Gillam\u2019s talk on Monsanto\u2019s corruption<\/a>\u00a0on glyphosate\/Roundup at Beyond Pesticides\u2019 36th National Pesticide Forum.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Environmental Research<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, April 28, 2022) A study in\u00a0Environmental Research\u00a0finds that glyphosate’s primary metabolite (breakdown product), aminomethylphosphonic acid (AMPA), induces DNA damage through oxidative stress among subpopulations of primary school children. Although pyrethroid and chlorpyrifos metabolites can induce oxidative stress, this study is the first to investigate AMPA’s association with adverse health effects, rather than solely the effects of the active ingredient, glyphosate, in Roundup and other formulations. Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulations, readily contaminating soil, water, food, and other resources. Chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is among the most prevalent pesticide contributors to human, biotic, and ecosystem\u00a0harm.\u00a0According to research, herbicide toxicity to invertebrates has\u00a0doubled\u00a0since 2004. Although research links glyphosate exposure to cancer, specifically non-Hodgkin lymphoma, much less research considers the effects that metabolites have on children who are more vulnerable to chemical exposure. Ecological and health risk assessments primarily focus on active ingredients in pesticide products, overlooking the potential impacts of metabolites. Thus, studies like these highlight the need to assess the implications of metabolite exposure to protect human, animal, and environmental health. The study notes, “Our […]<\/p>\n","protected":false},"author":2,"featured_media":30992,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[371,41,528,399],"tags":[],"class_list":["post-30990","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-children","category-glyphosate","category-metabolites","category-oxidative-stress"],"yoast_head":"\nGlyphosate Breakdown Product Associated with Oxidative Stress and DNA Damage Among Children - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/04\/implications-for-human-health-glyphosate-breakdown-product-ampa-associated-with-oxidative-stress-and-dna-damage-among-children\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Glyphosate Breakdown Product Associated with Oxidative Stress and DNA Damage Among Children - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, April 28, 2022) A study in\u00a0Environmental Research\u00a0finds that glyphosate’s primary metabolite (breakdown product), aminomethylphosphonic acid (AMPA), induces DNA damage through oxidative stress among subpopulations of primary school children. Although pyrethroid and chlorpyrifos metabolites can induce oxidative stress, this study is the first to investigate AMPA’s association with adverse health effects, rather than solely the effects of the active ingredient, glyphosate, in Roundup and other formulations. Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulations, readily contaminating soil, water, food, and other resources. Chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is among the most prevalent pesticide contributors to human, biotic, and ecosystem\u00a0harm.\u00a0According to research, herbicide toxicity to invertebrates has\u00a0doubled\u00a0since 2004. Although research links glyphosate exposure to cancer, specifically non-Hodgkin lymphoma, much less research considers the effects that metabolites have on children who are more vulnerable to chemical exposure. Ecological and health risk assessments primarily focus on active ingredients in pesticide products, overlooking the potential impacts of metabolites. Thus, studies like these highlight the need to assess the implications of metabolite exposure to protect human, animal, and environmental health. 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By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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Although pyrethroid and chlorpyrifos metabolites can induce oxidative stress, this study is the first to investigate AMPA’s association with adverse health effects, rather than solely the effects of the active ingredient, glyphosate, in Roundup and other formulations. Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulations, readily contaminating soil, water, food, and other resources. Chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is among the most prevalent pesticide contributors to human, biotic, and ecosystem\u00a0harm.\u00a0According to research, herbicide toxicity to invertebrates has\u00a0doubled\u00a0since 2004. Although research links glyphosate exposure to cancer, specifically non-Hodgkin lymphoma, much less research considers the effects that metabolites have on children who are more vulnerable to chemical exposure. Ecological and health risk assessments primarily focus on active ingredients in pesticide products, overlooking the potential impacts of metabolites. Thus, studies like these highlight the need to assess the implications of metabolite exposure to protect human, animal, and environmental health. 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