{"id":31103,"date":"2022-05-26T00:01:06","date_gmt":"2022-05-26T04:01:06","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=31103"},"modified":"2022-05-25T16:29:37","modified_gmt":"2022-05-25T20:29:37","slug":"neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/","title":{"rendered":"Neurotoxic Pesticides Disrupt Gut Function Linked to Parkinson\u2019s Disease Development"},"content":{"rendered":"

(Beyond Pesticides<\/em>, May 26, 2022) A study published in\u00a0The International Journal of Biochemistry & Cell Biology<\/em><\/a>\u00a0finds environmental exposure to neurotoxic pesticides increases Parkinson\u2019s Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the\u00a0nervous system<\/a>. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD.<\/p>\n

Parkinson\u2019s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only 10 to 15 percent of PD incidents are genetic, PD is quickly becoming the fastest-growing brain disease due to nongenetic factors. Therefore, research like this highlights the need to examine alternate risk factors for disease development, especially if disease triggers are overwhelmingly nonhereditary. The study notes, \u201cOverall, our study demonstrates that mitochondrial dysfunction in EGCs can induce autophagic dysregulation and a proinflammatory response, thereby affecting gut motility.\u201d<\/p>\n

The researchers investigated how EGCs respond to environmental pesticide exposure using cellular and animal models to understand the mechanisms driving gastrointestinal abnormalities. The pesticides implicated in the study include rotenone and tebufenpyrad. Both pesticides induce cell death via mitochondrial dysfunction among neurotransmitters that release, activate, or involve dopamine, also known as dopaminergic cell damage. Mitochondrial stress impairs molecular gradient function in EGCs, increasing inflammation of these cells consistent with GI cellular inflammation from neurotoxic pesticide exposure. Pesticide-induced mitochondrial dysfunction adversely affects smooth muscle motion and kinetic energy of the enteric nervous system (ENS) in the GI tract.<\/p>\n

The gut, also known as the \u201csecond brain<\/a>,\u201d share similar structural and chemical parallels to the brain. The microbiota in the gut plays a crucial role in lifelong digestion, immune and central nervous system regulation, as well as other bodily functions. Through the gut biome, pesticide exposure can enhance or exacerbate the adverse effects of additional environmental toxicants on the body. Since the gut microbiome shapes metabolism, it can mediate some toxic effects of environmental chemicals. However, with prolonged exposure to various environmental contaminants, critical chemical-induced changes may occur in the gut microbes, influencing adverse health outcomes. The impacts of pesticides on the human gut microbiome represent another pesticide assault on human health. Because the biome harbors between 10 and 100 trillion symbiotic microbes, pesticide exposure has effects on some of those bacteria. The human gastrointestinal tract and its digestive processes (aka, the \u201cgut\u201d) mediate the function of several systems. Dysfunction of the gut microbiome is associated with a host of diseases, including cardiovascular disease, some cancers, multiple sclerosis, diabetes, asthma, Crohn\u2019s disease, Parkinson\u2019s disease, and inflammatory bowel disease, as well as allergies, autism, depression, obesity, and other disorders or syndromes.<\/p>\n

Parkinson\u2019s disease occurs when there is damage to the dopaminergic nerve cells (i.e., those activated by or sensitive to dopamine) in the brain responsible for dopamine production, one of the primary neurotransmitters mediating motor function. Although the cause of dopaminergic cell damage remains unknown, evidence suggests that pesticide exposure, especially chronic exposure, may be the culprit. Several studies identify various pesticides involved in the pathology of PD, including insecticides,\u00a0rotenone<\/a>\u00a0and\u00a0chlorpyrifos<\/a>, and herbicides\u00a02,4-D<\/a>,\u00a0glyphosate<\/a>, and\u00a0paraquat<\/a>. Literature comprehensively documents the neurotoxic properties of paraquat and rotenone as laboratory experiments reproduce features of Parkinson\u2019s in the brain of animals. A\u00a0Washington State University study<\/a>\u00a0determined that residents living near areas treated with glyphosate\u2014the most widely used herbicides in the U.S.\u2014are one-third more likely to die prematurely from Parkinson\u2019s disease. In the\u00a0Louisiana State University study<\/a>, exposure to 2,4-D, chlorpyrifos, and paraquat from pasture land, forestry, or woodland operations are prominent risk factors for PD, with the highest risk in areas where chemicals quickly percolate into drinking water sources. Overall, research finds exposure to pesticides increases the risk of developing PD from 33 percent to 80 percent, with some pesticides prompting a higher risk than others. Another\u00a0study<\/a>\u00a0finds a 2.5-fold increase in PD risk among users of each chemical compared to non-users.<\/p>\n

Occupational pesticide exposure poses a unique risk through direct handling and application. A\u00a02017 study<\/a>\u00a0finds that occupational use of pesticides (i.e., fungicides, herbicides, or insecticides) increases PD risk by 110 to 211 percent. Even more concerning is that some personal protection equipment (PPE) may not adequately protect workers from chemical exposure during application. However,\u00a0indirect nonoccupational exposure to pesticides can also increase the risk of PD<\/a>. For instance,\u00a090 percent<\/a>\u00a0of Americans have at least one pesticide compound in their body, primarily stemming from dietary exposure, like\u00a0food<\/a>\u00a0and\u00a0drinking water<\/a>. These compounds have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. Thus, exposure to these toxicants can cause several adverse environmental and biological health effects. With the increasing ubiquity of pesticides, current measures safeguarding against pesticide use must adequately detect and assess total chemical contaminants.<\/p>\n

This study is the first to demonstrate that exposure to environmental neurotoxic pesticides impairs mitochondrial transformation of energy in living organisms, causing inflammation in EGCs. The mitochondrial dysfunction and inflammatory events induce gut dysfunction. Mitochondrial dysfunction is a significant aspect of PD pathology. Research demonstrates acute and chronic exposure to pesticides, like rotenone, organophosphates, and organochlorines, can inhibit the mitochondrial brain function responsible for cell regeneration and induce oxidative stress. Although many countries, including Europe and Canada, ban the use of chemicals like rotenone and organochlorines due to concerns about links to Parkinson\u2019s, among other illnesses, the U.S. merely restricts use as the U.S. Environmental Protection Agency (EPA) permits the use of rotenone to kill invasive fish species. Considering research demonstrates that a multitude of pesticides presenting a risk of developing PD belong to various pesticide classes and have a differing mode of action, advocates say that government officials must evaluate all health effects related to chemical exposure equally regardless of chemical composition. The study concludes, \u201cOur findings have major implications in understanding the GI-related pathogenesis and progression of environmentally linked PD.\u201d<\/p>\n

This study adds to the\u00a0large body of scientific studies<\/a>\u00a0strongly implicating pesticide\u2019s involvement in Parkinson\u2019s disease development. However, indirect health effects from pesticide exposure are not a new phenomenon as pesticide exposure can cause severe\u00a0human health<\/a>\u00a0(i.e., endocrine disruption, cancer, reproductive\/birth problems, neurotoxicity, loss of biodiversity, etc.) and\u00a0wildlife<\/a>\u00a0and\u00a0biodiversity<\/a>\u00a0issues, even at low residue levels. Although the exact cause of PD remains unknown,\u00a0studies\u00a0<\/a>continuously identify exposure to pesticides and specific gene-pesticide interactions as significant adverse risk factors. Environmental triggers like occupational exposure to pesticides can prompt PD in individuals with or without the genetic precursor. However, PD can develop regardless of whether an individual is a carrier of\u00a0<\/em>the PD gene mutation. Pesticides themselves can possess the ability to disrupt neurological function. Therefore, the impacts of pesticides on the nervous system, including the\u00a0brain<\/a>, are hazardous, especially for chronically exposed individuals (e.g., farm workers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Considering that health officials expect Parkinson\u2019s\u00a0disease diagnosis to double<\/a>\u00a0over the next 20 years, it is essential to mitigate preventable exposure to disease-inducing pesticides. For more information on the effects of pesticide exposure on neurological health, see Beyond Pesticides\u2019\u00a0Pesticide-Induced Diseases Database<\/a>\u00a0pages on\u00a0Parkinson\u2019s disease<\/a>,\u00a0dementia<\/a>-like diseases, such as\u00a0Alzheimer\u2019s<\/a>, and other impacts on\u00a0cognitive function<\/a>.\u00a0<\/p>\n

Parkinson\u2019s disease may have no cure, but prevention practices like organics can eliminate exposure to toxic PD-inducing pesticides. Organic agriculture represents a safer, healthier approach to crop production that does not necessitate toxic pesticide use. Beyond Pesticides encourages farmers to embrace\u00a0regenerative, organic<\/a>\u00a0practices. A compliment to buying organic is contacting\u00a0various organic farming organizations<\/a>\u00a0to learn more about what you can do. Those impacted by pesticide drift can refer to Beyond Pesticides\u2019 webpage on\u00a0What to Do in a Pesticide Emergency<\/a>\u00a0and contact the organization for additional information. Furthermore, see Beyond Pesticides\u2019\u00a0Parkinson\u2019s Disease article<\/a>\u00a0from the Spring 2008 issue of\u00a0Pesticides and You<\/em>.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source:\u00a0The International Journal of Biochemistry & Cell<\/em><\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, May 26, 2022) A study published in\u00a0The International Journal of Biochemistry & Cell Biology\u00a0finds environmental exposure to neurotoxic pesticides increases Parkinson\u2019s Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the\u00a0nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinson\u2019s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only […]<\/p>\n","protected":false},"author":2,"featured_media":31105,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[400,369,370,242,145,37],"tags":[],"class_list":["post-31103","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-effects","category-microbiata","category-microbiome","category-nervous-system-effects","category-parkinsons","category-rotenone"],"yoast_head":"\nNeurotoxic Pesticides Disrupt Gut Function Linked to Parkinson\u2019s Disease Development - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neurotoxic Pesticides Disrupt Gut Function Linked to Parkinson\u2019s Disease Development - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, May 26, 2022) A study published in\u00a0The International Journal of Biochemistry & Cell Biology\u00a0finds environmental exposure to neurotoxic pesticides increases Parkinson\u2019s Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the\u00a0nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinson\u2019s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. 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Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the\u00a0nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinson\u2019s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only […]","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2022-05-26T04:01:06+00:00","og_image":[{"width":640,"height":320,"url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2022\/05\/parkinson-and-gut.png","type":"image\/png"}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"Neurotoxic Pesticides Disrupt Gut Function Linked to Parkinson\u2019s Disease Development","datePublished":"2022-05-26T04:01:06+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/"},"wordCount":1467,"commentCount":0,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/#primaryimage"},"thumbnailUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2022\/05\/parkinson-and-gut.png","articleSection":["Brain Effects","Microbiata","Microbiome","Nervous System Effects","Parkinson's","Rotenone"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/05\/neurotoxic-pesticides-disrupt-gut-function-linked-to-parkinsons-disease-development\/","name":"Neurotoxic Pesticides Disrupt Gut Function Linked to Parkinson\u2019s Disease Development - 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By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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