{"id":31438,"date":"2022-08-03T00:01:49","date_gmt":"2022-08-03T04:01:49","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=31438"},"modified":"2022-08-03T12:46:32","modified_gmt":"2022-08-03T16:46:32","slug":"scientific-literature-connects-pesticides-and-male-fertility-problems","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/08\/scientific-literature-connects-pesticides-and-male-fertility-problems\/","title":{"rendered":"Scientific Literature Review Again Connects Pesticides and Male Fertility Problems"},"content":{"rendered":"

(Beyond Pesticides<\/em>, August 3, 2022) A systematic review of scientific studies on pesticides and fertility finds exposure associated with lower semen quality, DNA fragmentation, and chromosomal abnormalities. Published in the journal Andrology,<\/a> the review is yet another warning from a long string of researchers sounding the alarm over the connection between global fertility and toxic chemical exposure. With data from the U.S. Centers for Disease Control and Prevention (CDC)\u00a0 indicating roughly 1 in 5 couples are unable to conceive after a year of trying, and trends continuing to slope downwards, it is critical that contributing factors be identified so that protective changes can be made. \u00a0<\/p>\n

After screening over 1,300 studies, researchers narrowed their review down to 64 papers assessing semen parameters and DNA integrity after pesticide exposure. Each study is analyzed for its design, the pesticide investigated, \u00a0the population studied, controls, and reproductive effects determined.<\/p>\n

Pesticides are evaluated for their impacts to sperm quality and DNA integrity based on their chemical class. Organochlorine insecticides, which are all banned but still persistent in soil, air, water, and food in the United States, include a range of impacts to sperm quality. Higher levels of DDT or its breakdown metabolite DDE are associated with lower semen count, and motility and morphology below normal threshold values established by the World Health Organization (WHO). (Under WHO threshold values, a sub-fertile condition is defined by values lower than the fifth percentile of the general population.) Several studies find that as organochlorine concentrations increase in individual males, sperm parameters also fall. In addition to sperm quality, organochlorines are associated with chromosomal aberrations in several studies, including effects such as sperm disomy, where sperm have extra or missing chromosomes. This can result in viable offspring, but those offspring are at greater risk of abnormalities. \u00a0<\/p>\n

Organophosphate, the class of insecticides that replaced the organochlorines as they were phased out, also present a range of deleterious impacts. These chemicals include pesticides like malathion<\/a>, still widely used, and chlorpyrifos<\/a>, which is only now being phased out of agricultural use. Effects on sperm parameters are particularly pronounced for individuals in farming regions or with a history of occupational pesticide work. However, studies on the general population also show cause for concern, finding total sperm count and concentrations inversely related to urinary metabolites of organophosphate insecticides. Apart from sperm quality, the literature reveals several studies showing organophosphate exposure resulting in missing or extra chromosomes in sperm, with particular attention paid to diethyl phosphate, a non-specific organophosphate metabolite.<\/p>\n

Synthetic pyrethroids are also singled out in the scientific literature for their links to sperm damage. These are the insecticides that are replacing the organophosphates, as they are being phased out for their myriad health hazards. Unfortunately, the game of whack-a-mole played by the pesticide industry with EPA\u2019s allowance has not resulted in chemicals that are safer for long-term human fertility. Like organophosphates, occupationally exposed individuals are particularly affected, with pyrethroid factory workers showing higher rates of sperm abnormalities and lower motility than non-exposed individuals. Factory workers are also more likely to exhibit DNA fragmentation in their sperm. Another concentration-dependent relationship is found, with individuals reporting higher levels of urinary 3-phenoxybenzoic acid (3-PBA), a non-specific pyrethroid metabolite, having a lower sperm counts, disomy, and a greater chance of exhibiting sperm morphology below WHO thresholds.<\/p>\n

Beyond these three classes, scientists did find evidence of negative associations with carbamate class insecticides, fungicides, and herbicides, but the low number of studies does not allow for extensive analysis. Mixtures of various pesticides are cited as having similar effects to the three main pesticide classes investigated though firm results were difficult to specify due to lack of complete information. In general, occupationally exposed workers are most at risk, with chronic exposure being associated with greater sperm defects.<\/p>\n

The results of the study are concerning in light of steadily declining sperm counts. A 2017 study<\/a> found that sperm counts since 1973 have fallen by nearly 60%. \u00a0One author of that study, Shanna Swan, PhD, captured public attention regarding sperm declines through her book Countdown<\/a>, which goes into great depth regarding the impact of environmental chemicals on human fertility.\u00a0 Watch Dr. Swan’s talk, Modern Life and the Threat to the Future<\/a>, at Beyond Pesticides’ 2021 National Forum, Cultivating Healthy Communities<\/em>.<\/p>\n

Researchers have been sounding the alarm on the impact of pesticides on fertility for decades. In 2013, a previous literature review evaluating pesticide impacts on fertility found pesticides strongly associated with declines in sperm count. <\/a>As she recounted in a presentation at Beyond Pesticides\u2019 2021 National Pesticide Forum Dr. Swan\u2019s own work is borne out of efforts to try to disprove a paper published in 1992 by Carlsen et al.,<\/a> which highlights significant declines in sperm quality since the late 1930s.<\/p>\n

As the human civilization grapples with a range of cascading crises, from climate change to the insect apocalypse and global biodiversity crisis, we may be missing the chance to address one of the most critical aspects to the continuation of humanity as we now know it. For more information on the fertility crisis, see Dr. Swan\u2019s presentation to the National Pesticide Forum on Beyond Pesticides\u2019 Youtube page.<\/a><\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Andrology<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, August 3, 2022) A systematic review of scientific studies on pesticides and fertility finds exposure associated with lower semen quality, DNA fragmentation, and chromosomal abnormalities. Published in the journal Andrology, the review is yet another warning from a long string of researchers sounding the alarm over the connection between global fertility and toxic chemical exposure. With data from the U.S. Centers for Disease Control and Prevention (CDC)\u00a0 indicating roughly 1 in 5 couples are unable to conceive after a year of trying, and trends continuing to slope downwards, it is critical that contributing factors be identified so that protective changes can be made. \u00a0 After screening over 1,300 studies, researchers narrowed their review down to 64 papers assessing semen parameters and DNA integrity after pesticide exposure. Each study is analyzed for its design, the pesticide investigated, \u00a0the population studied, controls, and reproductive effects determined. Pesticides are evaluated for their impacts to sperm quality and DNA integrity based on their chemical class. Organochlorine insecticides, which are all banned but still persistent in soil, air, water, and food in the United States, include a range of impacts to sperm quality. Higher levels of DDT or its breakdown metabolite DDE are […]<\/p>\n","protected":false},"author":2,"featured_media":31363,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[416,119,392,244,381,1],"tags":[],"class_list":["post-31438","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-centers-for-disease-control-and-prevention","category-infertility","category-organochlorines","category-organophosphate","category-synthetic-pyrethroid","category-uncategorized"],"yoast_head":"\nScientific Literature Review Again Connects Pesticides and Male Fertility Problems - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/08\/scientific-literature-connects-pesticides-and-male-fertility-problems\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientific Literature Review Again Connects Pesticides and Male Fertility Problems - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, August 3, 2022) A systematic review of scientific studies on pesticides and fertility finds exposure associated with lower semen quality, DNA fragmentation, and chromosomal abnormalities. Published in the journal Andrology, the review is yet another warning from a long string of researchers sounding the alarm over the connection between global fertility and toxic chemical exposure. With data from the U.S. Centers for Disease Control and Prevention (CDC)\u00a0 indicating roughly 1 in 5 couples are unable to conceive after a year of trying, and trends continuing to slope downwards, it is critical that contributing factors be identified so that protective changes can be made. \u00a0 After screening over 1,300 studies, researchers narrowed their review down to 64 papers assessing semen parameters and DNA integrity after pesticide exposure. Each study is analyzed for its design, the pesticide investigated, \u00a0the population studied, controls, and reproductive effects determined. Pesticides are evaluated for their impacts to sperm quality and DNA integrity based on their chemical class. 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