{"id":31509,"date":"2022-08-18T00:01:57","date_gmt":"2022-08-18T04:01:57","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=31509"},"modified":"2022-08-16T16:31:06","modified_gmt":"2022-08-16T20:31:06","slug":"parents-exposure-to-pesticides-indicative-of-childhood-cancer-risk-among-offspring","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/08\/parents-exposure-to-pesticides-indicative-of-childhood-cancer-risk-among-offspring\/","title":{"rendered":"Parents\u2019 Exposure to Pesticides Indicative of Childhood Cancer Risk among Offspring"},"content":{"rendered":"

(Beyond Pesticides,<\/em> August 18, 2022) A study published in\u00a0Environmental Research<\/em><\/a>\u00a0suggests occupational (work-related) exposure to pesticides among nonpregnant women and men may increase childhood cancer risk for offspring. Already,\u00a0studies<\/a>\u00a0find\u00a0low<\/a>\u00a0levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic disorders to mental and physical disabilities. However, few assess parental exposure’s impact on childhood disease risk outside critical development periods (e.g., pregnancy). Although medical advancements in disease survival are more prominent nowadays, childhood cancer remains the\u00a0leading cause of death<\/a>\u00a0from disease among children. Furthermore, childhood cancer survivors can suffer from chronic or long-term health complications that may be life-threatening.<\/p>\n

The etiology or cause of childhood cancer involves the interaction of multiple components like lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, several studies demonstrate an association between environmental or occupational pesticide exposure and the risk of childhood cancer. Considering maternal pesticide exposure can have a\u00a0stronger association<\/a>\u00a0with cancer among children than childhood exposure, and newborns can still encounter pesticides, it is important to understand how pesticide accumulation and co-occurrence can increase the risk of latent diseases (e.g., cancers) among vulnerable populations, such as children\/infants.<\/p>\n

There is a lack of understanding of cancer risk from parental exposure to pesticides via occupation. The study examines whether parents\u2019 exposure to pesticides has an association with childhood cancer development among offspring. The\u00a0International Classification of Childhood Cancer<\/a>\u00a0classifies childhood cancers as leukemias, lymphomas, and central nervous system (CNS) tumors\/gliomas.\u00a0<\/p>\n

Using a Swedish register-based case-control study spanning 1960 to 2015, researchers compare juvenile cancer cases from the Cancer Register that are less than 20 years old to healthy (control) children born in the same year. The study investigates parental employment history around the time of the offspring\u2019s birth and evaluates whether there is any exposure to herbicides, insecticides, and fungicides.\u00a0 Logistic regression analyses estimate the risk for cancers, including leukemia, lymphoma, CNS and other solid tumors. Although work-related maternal and paternal exposure to pesticides does not have an increased association with childhood cancer risk overall, exposure indicates a 42 percent higher risk of lymphoma (primarily Hodgkin lymphoma) and a 30 percent increased risk of solid non-CNS tumors in children. Additionally, paternal pesticide exposure can indicate a 15 percent risk for myeloid leukemia. The researchers detect that even low levels of pesticide exposure may lead to a higher risk of childhood cancers.<\/p>\n

There is a significant scientific connection between pesticides and cancer as\u00a0several studies<\/a>\u00a0link pesticide use and residues to various cancers, from prevalent forms like\u00a0breast cancer<\/a>\u00a0to rare like kidney cancer nephroblastoma\u00a0<\/em>(Wilms\u2019 tumor).\u00a0Sixty-six percent<\/a>\u00a0of all cancers have links to environmental factors, especially in occupations of high chemical use. In addition to the\u00a0robust<\/a>\u00a0links between agricultural practices and pesticide-related illnesses, over\u00a065 percent<\/a>\u00a0of commonly used lawn pesticides and\u00a070 percent<\/a> of commonly used school pesticides have\u00a0links<\/a>\u00a0to cancer. Although general pesticide exposure can increase susceptibility to cancer, prenatal and early-life exposure to environmental toxicants can increase cancer risk. For decades, studies have long demonstrated that\u00a0childhood<\/a>\u00a0and\u00a0in utero<\/a>\u00a0exposure to the U.S. banned insecticide DDT increases the risk of developing breast cancer later in life. Moreover, a\u00a02021 study<\/a>\u00a0finds previous maternal exposure to the chemical compound during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three successive generations.\u00a0<\/p>\n

Both current and past-use pesticides and chemical contaminants play a role in similar disease outcomes as several of these chemicals are endocrine disruptors, thus having implications for specific cancer risks (e.g., breast cancer). Even pregnant mothers’ exposure to\u00a0household cleaners<\/a>, many of which are pesticides, can increase\u00a0nephroblastoma<\/a>\u00a0(kidney cancer) and brain tumor risk in children. Furthermore, long-term exposure to organophosphate (OP) pesticides\u00a0increases<\/a>\u00a0adverse health and cancer risks, specifically among women. Since DDT and its metabolite DDE residues, current-use pesticides, and other chemical pollutants contaminate the environment, exposure to these chemical mixtures can\u00a0synergize<\/a>\u00a0to increase toxicity and disease effects. Globally,\u00a0cancer<\/a>\u00a0is one of the leading causes of death, with over eight million people succumbing to the disease every year. Notably,\u00a0the International Agency for Cancer Research<\/a>\u00a0(IARC) predicts a 67.4 percent rise in new cancer cases by 2030. Therefore, it is essential to understand how external stimuli\u2014like environmental pollution from pesticides\u2014can drive cancer development to avoid exposure and lessen potential cancer risks.<\/p>\n

Although this study does not identify a definitive association between increased risk of all childhood cancer among children and parental occupational exposure to pesticides, maternal occupational exposure indicates a higher risk for specific cancers like lymphoma (i.e., non-Hodgkin lymphoma) and solid non-CNS tumors. Moreover, children of fathers with occupational insecticide exposure have a higher risk of myeloid leukemia. The likely reason for occupational pesticide exposure to indicate potential cancer risk is due to genetic mutation or damage that may occur and passed down to offspring. This alteration makes the offspring more susceptible to other factors that may increase cancer risk. For instance, the risk of developing lymphoma is slightly higher if a close relative (e.g., parent, sibling, offspring) has\/had lymphoma or another type of blood cancer. As the rate of chronic diseases like cancer\u00a0continues to increase in the U.S.<\/a>, and\u00a0additional studies find these diseases to be pesticide-induced<\/a>, the public must increase pressure on regulators and lawmakers to enact meaningful measures that eliminate pesticide use and the hazards. The study concludes, \u201cAlthough these findings merit further investigation, they indicate that parental exposure to pesticides may lead to higher risks of childhood cancer even in settings of low exposure.\u201d<\/p>\n

There is a\u00a0strong consensus among pediatricians<\/a>\u00a0that pregnant mothers and young children should avoid pesticide exposure during critical windows of development. However, the general population should follow this advice as the effects of pesticide exposure span every individual. Fortunately, the\u00a0wide availability of non-pesticidal alternative strategies<\/a>\u00a0allows families and agricultural industry workers to apply these methods to promote a safe and healthy environment, especially among chemically vulnerable individuals. For instance,\u00a0buying<\/a>,\u00a0growing<\/a>, and\u00a0supporting organic<\/a>\u00a0land management can reduce human and environmental contamination from pesticides. Organic agriculture has many\u00a0health<\/a>\u00a0and\u00a0environmental<\/a>\u00a0benefits, which curtail the need for chemical-intensive agricultural practices. Numerous studies find that\u00a0pesticide metabolite levels in urine significantly decrease<\/a>\u00a0when switching to an all-organic diet. For more information on how organic is the right choice for both consumers and the farmworkers that grow our food, see the Beyond Pesticides webpage on\u00a0Health Benefits of Organic Agriculture<\/a>.<\/p>\n

Both government officials and the public must comprehend the health implications of pesticide use and exposure on humans, especially when pesticides increase chronic disease risk. Beyond Pesticides tracks the most recent news and studies on pesticides through the\u00a0Daily News Blog<\/a>\u00a0and\u00a0Pesticide-Induced Diseases Database (PIDD)<\/a>. This database supports the need for strategic action to shift away from pesticide dependency. For more information on the adverse effects of pesticides on human health, see PIDD pages on\u00a0cancer<\/a>\u00a0(lymphoma<\/a>,\u00a0multiple myeloma<\/a>),\u00a0birth\/fetal defects<\/a>, and other diseases. Additionally, since pesticides can have multi-generation impacts on our health, you can learn more about the hazards posed to children\u2019s health through Beyond Pesticide\u2019s\u00a0Pesticide and You<\/em><\/a>\u00a0Journal article, \u201cChildren and Pesticides Don\u2019t Mix<\/a>.\u201d<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Environmental Research<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, August 18, 2022) A study published in\u00a0Environmental Research\u00a0suggests occupational (work-related) exposure to pesticides among nonpregnant women and men may increase childhood cancer risk for offspring. Already,\u00a0studies\u00a0find\u00a0low\u00a0levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic disorders to mental and physical disabilities. However, few assess parental exposure’s impact on childhood disease risk outside critical development periods (e.g., pregnancy). Although medical advancements in disease survival are more prominent nowadays, childhood cancer remains the\u00a0leading cause of death\u00a0from disease among children. Furthermore, childhood cancer survivors can suffer from chronic or long-term health complications that may be life-threatening. The etiology or cause of childhood cancer involves the interaction of multiple components like lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, several studies demonstrate an association between environmental or occupational pesticide exposure and the risk of childhood cancer. Considering maternal pesticide […]<\/p>\n","protected":false},"author":2,"featured_media":31511,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[196,371,417,497],"tags":[],"class_list":["post-31509","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-children","category-multi-generational-effects","category-occupational-health"],"yoast_head":"\nParents\u2019 Exposure to Pesticides Indicative of Childhood Cancer Risk among Offspring - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/08\/parents-exposure-to-pesticides-indicative-of-childhood-cancer-risk-among-offspring\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Parents\u2019 Exposure to Pesticides Indicative of Childhood Cancer Risk among Offspring - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, August 18, 2022) A study published in\u00a0Environmental Research\u00a0suggests occupational (work-related) exposure to pesticides among nonpregnant women and men may increase childhood cancer risk for offspring. 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Already,\u00a0studies\u00a0find\u00a0low\u00a0levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic disorders to mental and physical disabilities. However, few assess parental exposure’s impact on childhood disease risk outside critical development periods (e.g., pregnancy). Although medical advancements in disease survival are more prominent nowadays, childhood cancer remains the\u00a0leading cause of death\u00a0from disease among children. Furthermore, childhood cancer survivors can suffer from chronic or long-term health complications that may be life-threatening. The etiology or cause of childhood cancer involves the interaction of multiple components like lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, several studies demonstrate an association between environmental or occupational pesticide exposure and the risk of childhood cancer. 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