{"id":31867,"date":"2022-11-10T00:01:41","date_gmt":"2022-11-10T05:01:41","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=31867"},"modified":"2022-11-08T09:17:27","modified_gmt":"2022-11-08T14:17:27","slug":"kids-and-kidney-cancer-implication-for-prenatal-pesticide-exposure","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/11\/kids-and-kidney-cancer-implication-for-prenatal-pesticide-exposure\/","title":{"rendered":"Kids and Kidney Cancer: Implication for Prenatal Pesticide Exposure"},"content":{"rendered":"

(Beyond Pesticides, <\/em>November 10, 2022) A meta-analysis<\/a>\u00a0by the University Alberta Hospital, Edmonton, AB, Canada, adds to the plethora of research linking prenatal (before birth\/during pregnancy) pesticide exposure to carcinogenic (cancer) tumor development. The analysis, published in\u00a0Human & Experimental Toxicology<\/em><\/a>, finds parental exposure to pesticides during the preconception (before pregnancy) or pregnancy period increases the risk of Wilms\u2019 tumor (a type of kidney cancer) occurrence among children. Already,\u00a0studies<\/a>\u00a0find\u00a0low<\/a>\u00a0levels of pesticide exposure during pregnancy or childhood cause adverse health effects, from metabolic disorders to mental and physical disabilities. Although medical advancements in disease survival are more prominent nowadays, childhood cancer remains the\u00a0leading cause of death<\/a>\u00a0from disease among children. Furthermore, childhood cancer survivors can suffer from chronic or long-term health complications that may be life-threatening.<\/p>\n

Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, a mother\u2019s pesticide exposure can have a\u00a0stronger association<\/a>\u00a0with cancer among a child than childhood exposure, and a newborn can still encounter pesticides. Therefore, it is essential to understand how pesticides impact the health and well-being of individuals during critical developmental periods, especially for latent diseases (e.g., cancers).<\/p>\n

The researchers performed a systematic review and meta-analysis on case-control studies to determine a link between pesticide exposure (e.g., insecticides, herbicides) and Wilms\u2019 tumor occurrence in children. To establish the connection, researchers used monographs (commentary studies) on specific organophosphate insecticides and herbicides from the International Association for the Research on Cancer (IARC) of the World Health Organization (WHO). Researchers systematically reviewed PUBMED, SCOPUS, and Google Scholar studies (1960\u20132021) following the Preferred Reporting Items for Systematic reviews and Meta-Analyses<\/a> (PRISMA) guidelines.<\/p>\n

The report also examines occupational versus residential exposure and before-birth (prenatal) versus after-birth (postnatal) exposure. These results strengthen the finding that parental pesticide exposure before or during pregnancy correlates with increased risk for Wilms\u2019 tumor in a child. The IRAC\/WHO monographs support this conclusion and policies to stop specific pesticide use to prevent future cases of cancer.<\/p>\n

The connection between pesticides and cancer is significant as\u00a0several studies<\/a>\u00a0link pesticide use and residues to various cancers (e.g.,\u00a0breast cancer<\/a>, prostate cancer, lung cancer).\u00a0Sixty-six percent<\/a>\u00a0of all cancers have links to environmental factors, especially in occupations of high chemical use. In addition to\u00a0links<\/a> between agricultural practices and pesticide-related illnesses, over\u00a065 percent<\/a>\u00a0of commonly used lawn pesticides and\u00a070 percent<\/a>\u00a0of commonly used school pesticides have\u00a0links<\/a>\u00a0to cancer. Although general pesticide exposure can increase susceptibility to cancer, prenatal and early-life exposure to environmental toxicants can increase cancer risk.<\/p>\n

Exposure to the now-banned insecticide DDT increases the risk of developing breast cancer later in life. Moreover, a\u00a02021 study<\/a>\u00a0finds previous maternal exposure to the chemical compound during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three times in successive generations.\u00a0<\/p>\n

This study reinforces concepts around \u201ccritical windows of exposure,\u201d which suggests that prenatal and early-life exposure to environmental toxicants increase susceptibility to health impacts. Thus, a\u00a0parent\u2019s exposure<\/a>\u00a0to pesticides during these critical periods is indicative of increased childhood disease risk. While Wilms\u2019 tumor generally afflicts children under ten years of age, other early life exposures can take years and even decades before adverse health effects arise. Although 90 percent of kidney tumors among children are Wilms tumors, co-occurring diseases may arise from weakened immune function. Similar to this study, previous research demonstrates that even pregnant mothers\u2019 exposure to\u00a0household cleaners<\/a>, many of which are pesticides, can increase\u00a0nephroblastoma<\/a>\u00a0(kidney cancer) and brain tumor risk in children. The etiology or cause of childhood cancer involves the interaction of multiple components including lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects.\u00a0The study concludes, \u201cPesticide exposure in household\/residential settings seems to contribute to Wilms\u2019 tumor etiology. Additional investigations with an extensive sample size are required to conclude more confidently, probably involving low-\/middle-income and high-income countries. This may be considered important in the post-pandemic era. In our opinion, there is some compelling evidence to robustly educate parents and\/or guardians more regarding the appropriate use of chemical compounds and take necessary precautions to minimize the potential risks associated with their application.\u201d<\/p>\n

There is a\u00a0strong consensus among pediatricians<\/a>\u00a0that pregnant mothers and young children should avoid pesticide exposure during critical windows of development. However, the general population should follow this advice as the effects of pesticide exposure can affect every individual. Fortunately, the\u00a0wide availability of non-pesticidal alternative strategies<\/a>\u00a0allows for choices in residential and agricultural management to promote a safe and healthy environment, especially among chemically vulnerable individuals. For instance,\u00a0buying<\/a>,\u00a0growing<\/a>, and\u00a0supporting organic<\/a>\u00a0land management reduces human and environmental contamination from pesticides. Organic agriculture has many\u00a0health<\/a>\u00a0and\u00a0environmental<\/a>\u00a0benefits, which curtail the need for chemical-intensive agricultural practices. Numerous studies find that\u00a0pesticide metabolite levels in urine significantly decrease<\/a>\u00a0when switching to an all-organic diet. For more information on how organic is the right choice for both consumers and the farmworkers that grow our food, see the Beyond Pesticides webpage on\u00a0the Health Benefits of Organic Agriculture<\/a>.<\/p>\n

Beyond Pesticides tracks the most recent news and studies on pesticides through the\u00a0Daily News Blog<\/a>\u00a0and\u00a0Pesticide-Induced Diseases Database (PIDD)<\/a>. This database supports the need for strategic action to shift away from pesticide dependency. For more information on the adverse effects of pesticides on human health, see PIDD pages on\u00a0cancer<\/a>,\u00a0birth\/fetal defects<\/a>, and other diseases. Additionally, since pesticides can have multi-generation impacts on our health, you can learn more about the hazards posed to children\u2019s health through Beyond Pesticide\u2019s\u00a0Pesticide and You<\/em><\/a>\u00a0Journal article, \u201cChildren and Pesticides Don\u2019t Mix<\/a>.\u201d<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Human & Experimental Toxicology<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, November 10, 2022) A meta-analysis\u00a0by the University Alberta Hospital, Edmonton, AB, Canada, adds to the plethora of research linking prenatal (before birth\/during pregnancy) pesticide exposure to carcinogenic (cancer) tumor development. The analysis, published in\u00a0Human & Experimental Toxicology, finds parental exposure to pesticides during the preconception (before pregnancy) or pregnancy period increases the risk of Wilms\u2019 tumor (a type of kidney cancer) occurrence among children. Already,\u00a0studies\u00a0find\u00a0low\u00a0levels of pesticide exposure during pregnancy or childhood cause adverse health effects, from metabolic disorders to mental and physical disabilities. Although medical advancements in disease survival are more prominent nowadays, childhood cancer remains the\u00a0leading cause of death\u00a0from disease among children. Furthermore, childhood cancer survivors can suffer from chronic or long-term health complications that may be life-threatening. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, a mother\u2019s pesticide exposure can have a\u00a0stronger association\u00a0with cancer among a child than childhood exposure, and a newborn can still encounter pesticides. Therefore, it is essential to understand how pesticides impact the health and well-being of individuals during critical developmental periods, especially for latent diseases (e.g., cancers). The researchers performed a systematic review and meta-analysis on case-control studies […]<\/p>\n","protected":false},"author":2,"featured_media":31869,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[144,196,371],"tags":[],"class_list":["post-31867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-birth-defects","category-cancer","category-children"],"yoast_head":"\nKids and Kidney Cancer: Implication for Prenatal Pesticide Exposure - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/11\/kids-and-kidney-cancer-implication-for-prenatal-pesticide-exposure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kids and Kidney Cancer: Implication for Prenatal Pesticide Exposure - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, November 10, 2022) A meta-analysis\u00a0by the University Alberta Hospital, Edmonton, AB, Canada, adds to the plethora of research linking prenatal (before birth\/during pregnancy) pesticide exposure to carcinogenic (cancer) tumor development. The analysis, published in\u00a0Human & Experimental Toxicology, finds parental exposure to pesticides during the preconception (before pregnancy) or pregnancy period increases the risk of Wilms\u2019 tumor (a type of kidney cancer) occurrence among children. Already,\u00a0studies\u00a0find\u00a0low\u00a0levels of pesticide exposure during pregnancy or childhood cause adverse health effects, from metabolic disorders to mental and physical disabilities. Although medical advancements in disease survival are more prominent nowadays, childhood cancer remains the\u00a0leading cause of death\u00a0from disease among children. Furthermore, childhood cancer survivors can suffer from chronic or long-term health complications that may be life-threatening. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. 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Moreover, a mother\u2019s pesticide exposure can have a\u00a0stronger association\u00a0with cancer among a child than childhood exposure, and a newborn can still encounter pesticides. Therefore, it is essential to understand how pesticides impact the health and well-being of individuals during critical developmental periods, especially for latent diseases (e.g., cancers). 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