{"id":31947,"date":"2022-11-25T00:01:59","date_gmt":"2022-11-25T05:01:59","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=31947"},"modified":"2022-11-23T09:09:11","modified_gmt":"2022-11-23T14:09:11","slug":"hormone-mimicking-properties-of-glyphosate-weed-killer-and-related-compounds-increase-breast-cancer-risk","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/11\/hormone-mimicking-properties-of-glyphosate-weed-killer-and-related-compounds-increase-breast-cancer-risk\/","title":{"rendered":"Hormone Mimicking Properties of Glyphosate Weed Killer and Related Compounds Increase Breast Cancer Risk"},"content":{"rendered":"

(Beyond Pesticides, <\/em>November 25, 2022) A study published in\u00a0Chemosphere<\/em><\/a>\u00a0<\/em>adds to the growing body of research demonstrating the endocrine (hormone) disrupting effects of glyphosate play in breast cancer development. Exposure to the herbicide glyphosate and other glyphosate-based herbicides (GBHs) at high concentrations mimics the estrogen-like cellular effects of 17\u03b2-estradiol (E2), altering binding activity to estrogen receptor \u03b1 (ER\u03b1) sites, thus causing fundamental changes in breast cancer cell proliferation (abundance).\u00a0<\/p>\n

Glyphosate<\/a>\u00a0is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer\u2019s (formerly Monsanto) Roundup\u00ae. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human,\u00a0biotic<\/a>, and ecosystem\u00a0harm<\/a>.\u00a0Therefore, advocates point to the need for national policies to reassess hazards associated with disease development and diagnosis upon exposure to chemical pollutants. The researchers note, \u201cThe results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. Additionally, these findings suggest that glyphosate at high concentrations may have strong significance in tamoxifen resistance and breast cancer progression. [F]urther studies in animal models must confirm these effects on organ systems.\u201d<\/p>\n

The study evaluated the cytotoxic (toxic to cells) effect of analytical grade glyphosate and GBHs to evaluate its estrogenic activity. The literature shows that significant exposure to these GBHs can cause cell death from the active ingredient glyphosate, as well as other ingredients in the formulations. These ingredients can have detergent-like properties (e.g., adjuncts) that can amplify the cytotoxic effects of glyphosate. The researchers aim to clarify the molecular mechanism involved in glyphosate-induced estrogen production and breast cancer cells. The Chilean researchers in the study find exposure to glyphosate at high concentrations induces estrogen-like effects through binding to estrogen receptor \u03b1 (ER\u03b1) sites, mimicking the cell effects of 17\u03b2-estradiol (E2), attaching a phosphate group to the zinc (Zn) II ion (phosphorylation), thus causing fundamental changes to estrogen in breast cancer cells. Like past studies, this study demonstrates that glyphosate mimics the effect of E2 through Er\u03b1 phosphorylation.<\/p>\n

Breast cancer is the most common cancer among women, causing the second most cancer-related deaths in the United States. Past studies suggest genetic inheritance factors influence breast cancer occurrence. However, genetic factors only play a\u00a0minor role<\/a>\u00a0in breast cancer incidents, while exposure to external environmental factors (i.e., chemical exposure) may play a more notable role. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Most common forms of breast cancer have receptors on the cell surface that can increase cancer growth when activated by estrogen, progesterone, or too much of the protein called\u00a0HER2<\/a>. Hormones generated by the endocrine system greatly influence hormone cancer incidents among humans (e.g., breast, prostate, and thyroid cancers). Several\u00a0studies and reports<\/a>, including U.S. Environmental Protection Agency (EPA) data, identify hundreds of chemicals as influential factors associated with breast cancer risk. One in ten women will receive a breast cancer diagnosis, and genetics\u00a0<\/em>can only account for five to ten percent of cases. There are grave concerns over exposure to endocrine (hormone) disrupting chemicals and pollutants that produce adverse health effects. Considering not only glyphosate but over\u00a0296 chemicals in consumer products can increase breast cancer risk through endocrine disruption<\/a>, it is essential to understand how chemical exposure impacts chronic disease occurrence.\u00a0<\/p>\n

Glyphosate has been the subject of a great deal of public advocacy and regulatory attention and is the target of thousands of lawsuits. Beyond Pesticides has covered the glyphosate tragedy extensively;\u00a0see its litigation archives for multiple articles on glyphosate lawsuits<\/a>. Almost five decades of extensive glyphosate-based herbicide use has put human, animal, and environmental health at risk. The chemical’s ubiquity threatens\u00a093 percent<\/a>\u00a0of all U.S. endangered species,\u00a0resulting<\/a>\u00a0in biodiversity loss and ecosystem disruption (e.g.,\u00a0soil erosion<\/a>\u00a0and loss of services<\/a>). Exposure to GBHs can cause specific alterations in\u00a0microbial gut composition<\/a>\u00a0and\u00a0trophic cascades<\/a>. Similar to this paper, past studies find a strong association between glyphosate exposure and\u00a0the development of various health anomalies,<\/a>\u00a0including\u00a0cancer<\/a>,\u00a0Parkinson’s disease<\/a>, and\u00a0autism<\/a>. The\u00a0risk assessment process<\/a>\u00a0used by EPA for its pesticide registration process is\u00a0substantially inadequate to protect human health<\/a>. Although EPA classifies glyphosate herbicides as “not likely to be carcinogenic to humans, “stark evidence<\/a>\u00a0demonstrates links to various cancers, including non-Hodgkin lymphoma. Moreover, EPA\u00a0fails<\/a>\u00a0to adequately consider exposure effects on mammary gland development in its review of animal studies related to pesticide impacts. Thus, EPA’s classification perpetuates environmental injustice among individuals disproportionately exposed to chemicals, like farmworkers, especially in marginalized communities.<\/p>\n

Several studies<\/a>\u00a0link pesticide use and residue to various cancers, from more prevalent forms like\u00a0breast cancer<\/a>\u00a0to rare ones like kidney cancer nephroblastoma\u00a0<\/em>(Wilms\u2019 tumor). Although the connection between pesticides and associated cancer risks is nothing new, past\u00a0studies<\/a>\u00a0suggest glyphosate and GBHs act as endocrine disruptors, affecting the development and regulation of estrogen hormones that promote breast cancer. However, this study is one of the few to evaluate the molecular mechanisms involved in toxicological changes initiating breast cancer events. Phosphorylation with a Zn (II) ion stabilized the bond between the estrogen-imitating activity of glyphosate and GBHs to the Er\u03b1. Therefore, the bond promotes the overexpression of estrogen-sensitive genes, increasing consequences on breast cancer cell activity. The study concludes, \u201cThe results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. \u201d<\/p>\n

Cancer is a leading cause of death worldwide. Much pesticide use and exposure are associated with cancer effects. Studies concerning pesticides and cancer help future epidemiologic research understand the underlying mechanisms that cause cancer. Although the link between agricultural practices and pesticide-related illnesses is stark, over\u00a063 percent<\/a>\u00a0of commonly used lawn pesticides and\u00a070 percent<\/a>\u00a0of commonly used school pesticides have\u00a0links<\/a>\u00a0to cancer. Advocates argue that global leaders must fully understand the cause of pesticide-induced diseases before the chemicals enter the environment. Policy reform and practices that eliminate toxic pesticide use can end the uncertainty surrounding potential harm. For more information on the harms of pesticides, see Beyond Pesticides\u2019\u00a0Pesticide-Induced Diseases Database<\/a>\u00a0pages on\u00a0breast cancer<\/a>,\u00a0endocrine disruption<\/a>, and other diseases. This database supports the need for strategic action to shift away from pesticide dependency.<\/p>\n

Prevention<\/a>\u00a0of the causes of breast cancer, not just awareness, is critical to solving this disease. In 1985, Imperial Chemical Industries and the American Cancer Society declared October \u201cBreast Cancer Awareness Month<\/a>\u201d as part of a campaign to promote\u00a0mammograms<\/a>\u00a0for the early\u00a0detection<\/a>\u00a0of breast cancer. Unfortunately, most people are all too\u00a0aware<\/a>\u00a0of breast cancer. Detection and treatment of cancers do not solve the problem.\u00a0EPA should evaluate and ban endocrine-disrupting pesticides and make organic food production and land management the standard that legally establishes toxic pesticide use as \u201cunreasonable.\u201d<\/a><\/p>\n

Moreover, proper prevention practices, like\u00a0buying<\/a>,\u00a0growing<\/a>, and supporting organics, can eliminate exposure to toxic pesticides. Organic agriculture has many\u00a0health<\/a>\u00a0and\u00a0environmental<\/a>\u00a0benefits that curtail the need for chemical-intensive agricultural practices.\u00a0Regenerative organic agriculture<\/a>\u00a0nurtures soil health through organic carbon sequestration while preventing pests and generating a higher return than chemical-intensive agriculture. For more information on how organic is the right choice, see the Beyond Pesticides webpage,\u00a0Health Benefits of Organic Agriculture<\/a>.\u00a0<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Chemosphere<\/em><\/a>\u00a0<\/em><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, November 25, 2022) A study published in\u00a0Chemosphere\u00a0adds to the growing body of research demonstrating the endocrine (hormone) disrupting effects of glyphosate play in breast cancer development. Exposure to the herbicide glyphosate and other glyphosate-based herbicides (GBHs) at high concentrations mimics the estrogen-like cellular effects of 17\u03b2-estradiol (E2), altering binding activity to estrogen receptor \u03b1 (ER\u03b1) sites, thus causing fundamental changes in breast cancer cell proliferation (abundance).\u00a0 Glyphosate\u00a0is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer\u2019s (formerly Monsanto) Roundup\u00ae. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human,\u00a0biotic, and ecosystem\u00a0harm.\u00a0Therefore, advocates point to the need for national policies to reassess hazards associated with disease development and diagnosis upon exposure to chemical pollutants. The researchers note, \u201cThe results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. Additionally, […]<\/p>\n","protected":false},"author":2,"featured_media":29580,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[84,196,85,41],"tags":[],"class_list":["post-31947","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-breast-cancer","category-cancer","category-endocrine-disruption","category-glyphosate"],"yoast_head":"\nHormone Mimicking Properties of Glyphosate Weed Killer and Related Compounds Increase Breast Cancer Risk - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2022\/11\/hormone-mimicking-properties-of-glyphosate-weed-killer-and-related-compounds-increase-breast-cancer-risk\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hormone Mimicking Properties of Glyphosate Weed Killer and Related Compounds Increase Breast Cancer Risk - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, November 25, 2022) A study published in\u00a0Chemosphere\u00a0adds to the growing body of research demonstrating the endocrine (hormone) disrupting effects of glyphosate play in breast cancer development. Exposure to the herbicide glyphosate and other glyphosate-based herbicides (GBHs) at high concentrations mimics the estrogen-like cellular effects of 17\u03b2-estradiol (E2), altering binding activity to estrogen receptor \u03b1 (ER\u03b1) sites, thus causing fundamental changes in breast cancer cell proliferation (abundance).\u00a0 Glyphosate\u00a0is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer\u2019s (formerly Monsanto) Roundup\u00ae. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human,\u00a0biotic, and ecosystem\u00a0harm.\u00a0Therefore, advocates point to the need for national policies to reassess hazards associated with disease development and diagnosis upon exposure to chemical pollutants. The researchers note, \u201cThe results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. 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Exposure to the herbicide glyphosate and other glyphosate-based herbicides (GBHs) at high concentrations mimics the estrogen-like cellular effects of 17\u03b2-estradiol (E2), altering binding activity to estrogen receptor \u03b1 (ER\u03b1) sites, thus causing fundamental changes in breast cancer cell proliferation (abundance).\u00a0 Glyphosate\u00a0is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer\u2019s (formerly Monsanto) Roundup\u00ae. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human,\u00a0biotic, and ecosystem\u00a0harm.\u00a0Therefore, advocates point to the need for national policies to reassess hazards associated with disease development and diagnosis upon exposure to chemical pollutants. The researchers note, \u201cThe results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. 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