{"id":32234,"date":"2023-01-19T00:01:50","date_gmt":"2023-01-19T05:01:50","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=32234"},"modified":"2023-01-17T16:03:03","modified_gmt":"2023-01-17T21:03:03","slug":"neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/","title":{"rendered":"Neonicotinoid Insecticides Adversely Affect Nervous System Health, According to Study"},"content":{"rendered":"

(Beyond Pesticides<\/em>, January 19, 2023) Research published in\u00a0Environmental Health Perspectives<\/em><\/a>\u00a0finds the presence of nine various neonicotinoids (neonics) and six neonic metabolites within human cerebrospinal fluid (CSF). CSF is an essential part of the central nervous system (CNS), especially for CNS development. Specific chemical biomarkers (measurable indicators of biological state), like pesticides, found in CSF are useful for diagnosing and evaluating numerous neurological diseases.<\/p>\n

The nervous system is an integral part of the human body and includes the brain, spinal cord, a vast network of nerves and neurons, all of which are responsible for many of our bodily functions\u2014from sensed to movement. However, mounting evidence over the past years shows that chronic exposure to\u00a0sublethal (low) levels<\/a>\u00a0of pesticides can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. The impacts of pesticides on the nervous system, including the brain, are hazardous, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Researchers identify the role agricultural chemicals play in CNS impacts causing neurological diseases, like\u00a0amyotrophic lateral sclerosis<\/a>\u00a0(ALS) and\u00a0Parkinson\u2019s disease<\/a>,\u00a0dementia<\/a>-like diseases such as\u00a0Alzheimer\u2019s<\/a>, and other effects on\u00a0cognitive function<\/a>.<\/p>\n

Over\u00a0300 environmental contaminants<\/a>\u00a0and their byproducts, including pesticides, are chemicals commonly present in human blood and urine samples and can increase neurotoxicity risk when crossing the brain barrier. Therefore, studies like this highlight the importance of understanding how chemical accumulation in the body can impact long-term health and disease prognosis.<\/p>\n

The study explores whether the presence of neonics and their metabolites in CSF is an indicator of adverse CNS effects. From April 2019 to January 2021, researchers gathered 314 CSF samples from patients aged one month to 89 years in the First Affiliated Hospital of Shantou University, Shantou, China using a clinical lumbar puncture. Researchers collected CSF samples from patients experiencing similar symptoms with a different disease\/clinical diagnosis (i.e., \u201cmostly viral encephalitis, encephalitis other than viral encephalitis, leukemia, cerebral hemorrhage, cerebral laceration, urinary tract infection, respiratory failure, pulmonary tuberculosis, and posterior circulation ischemia\u201d). To analyze the presence of neonics and their metabolites in CSF, researchers used acidification, solid phase extraction, and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS\/MS). Ninety-nine percent of the 314 CSF samples contain at least one neonic. Of the 314 CSF samples, nine percent (28) have a single neonic compound, 84 percent (265) have between 2 and 6, and six percent (19) have between 7 and 10 neonic compounds. Nine of these neonics in CSF samples are nitenpyram (NIT), thiamethoxam, imidacloprid, acetamiprid (ACE), thiacloprid, clothianidin, flonicamid, imidaclothiz, and sulfoxaflor. Additionally, six neonic metabolites are present in CSF: N-desmethyl-thiamethoxam, olefin-imidacloprid, 5-hydroxy-imidacloprid, N-desmethyl-acetamiprid (N-dm-ACE), thiacloprid-amide, and 6-chloronicotinic acid.<\/p>\n

Over the past 20 years,\u00a0neonicotinoids<\/a> served as an alternative for four major chemical classes of insecticides in the global market (organophosphates, carbamates, phenyl-pyrazoles, and pyrethroids).\u00a0These<\/a> systemic agricultural pesticides are highly toxic, resembling nicotine, and affect the central nervous system of insects, resulting in paralysis and death, even at low doses. Like other pesticides, neonics readily contaminate\u00a0water<\/a>\u00a0and\u00a0food<\/a>\u00a0resources as traditional water waste treatments typically fail to remove the chemical from tap water, and the systemic nature of neonics allows the chemical to accumulate within plant products. According to the Centers for Disease Control and Prevention (CDC), nearly\u00a0half the U.S. population<\/a>\u00a0encounters at least one type of neonic daily, with children ages three to five having the highest exposure risk. Health impacts of exposure to neonics can include\u00a0neurotoxicity<\/a>,\u00a0reproductive anomalies, hepatic and renal damage,<\/a>\u00a0and an\u00a0increase in gene expression linked to hormone-dependent breast cancer<\/a>. Additionally, researchers\u00a0identified<\/a>\u00a0that some neonicotinoids play a role in enzyme (aromatase) production that stimulates excess estrogen production, a known event in hormone-dependent cancer development.<\/p>\n

Beyond its link to human health effects, neonicotinoids are infamous for their well-documented role in driving mass pollinator declines. However, pollinators are far from the only victims of ubiquitous neonicotinoid contamination. In a recent avian risk assessment, EPA scientists found that neonicotinoids levels in treated seeds exceed the agency\u2019s threshold of concern for certain birds by as much as 200-fold. A\u00a02017 study<\/a>\u00a0by researchers at the University of Saskatchewan confirmed that tiny amounts of neonicotinoids \u2013 the equivalent of just four treated canola seeds, for example \u2013 are enough to cause migrating songbirds to lose their sense of direction and become emaciated.\u00a0Recent research<\/a>\u00a0uncovered the endocrine-disrupting health impacts of imidacloprid on white-tailed deer, adding to the concern of the same effect in humans.<\/p>\n

This study adds to the growing research on pesticides and neurotoxic consequences. Although past studies on neonic toxicity focus on neurotoxicity among insects and aquatic invertebrates, emerging evidence demonstrates these compounds also adversely impact the nervous system of animals, including humans as well. Not only does research find exposure to sublethal doses of chemicals affect hormone receptors (endocrine disruption), but neural receptors, such as connections between nerves, the brain, enzymes, and DNA are affected as well. In addition to this research,\u00a0several studies<\/a>\u00a0demonstrate\u00a0autism<\/a>, mood disorders (e.g.,\u00a0depression<\/a>), and degenerative neurological conditions among aquatic and terrestrial animals, including humans, exposed to pesticides. Pesticides themselves, mixtures of chemicals such as the defoliant Agent Orange (2,4-D and 2,4,5-T) and its \u00a0dioxin contaminants and therapeutic hormones in pharmaceutical products, possess the ability to disrupt neurological function. Furthermore,\u00a0studies suggest<\/a>\u00a0that pesticides formulants (adjuvants) such as POEA (polyoxyethylene tallow amine) have both neurological and endocrine-disrupting activity. POEA is present in some\u00a0glyphosate<\/a>-based herbicides like Roundup and has higher nervous system toxicity than the active ingredient (glyphosate). Although the biological function and mechanism of neurotoxicity related to pesticide exposure is ambiguous, scientists note synchronized communication within and between cells that have a mechanism of action of \u201cspamming\u201d communication signals. The study concludes, \u201cFor continued global use of NEOs [neonics], mechanisms of toxicity, especially to the CNS in humans, need to be more rigorously investigated.\u201d<\/p>\n

The nervous system is integral to everyday human activities and the body\u2019s ability to function normally. Pesticides themselves can possess the ability to disrupt neurological function. Pesticides\u2019 impact on the nervous system, including the\u00a0brain<\/a>, are hazardous, especially for chronically exposed individuals or during critical windows of vulnerability and development. Therefore, studies related to pesticides and neurological disorders can help scientists understand the underlying mechanisms that cause neurodegenerative diseases. As captured by epidemiologic studies in Beyond Pesticides\u2019\u00a0Pesticide-Induced Diseases Database<\/a>\u00a0(PIDD) and\u00a0Daily News Blog<\/a>, the adverse health effects of pesticides, exposure, and the aggregate risk of pesticides showcase a need for more precise research on pesticide exposure. Existing information, including this study, supports the clear need for a strategic shift away from pesticide dependency. For more information on the effects of pesticide exposure on neurological health, see Beyond Pesticides\u2019 PIDD pages on\u00a0brain and nervous system disorders<\/a>, including\u00a0dementia<\/a>-like diseases, such as\u00a0Alzheimer\u2019s<\/a>, and other impacts on\u00a0cognitive function<\/a>.\u00a0<\/p>\n

Beyond Pesticides advocates for organic<\/a>\u00a0land<\/a>\u00a0and\u00a0agriculture<\/a>\u00a0management as\u00a0precautionary approach<\/a>\u00a0to pest prevention and management.\u00a0Buying<\/a>,\u00a0growing<\/a>, and supporting organic can help eliminate the extensive use of pesticides in the environment and from your diet. For more information on why organic is the right choice for consumers and the farmworkers who grow our food, see Beyond Pesticides webpage,\u00a0Health Benefits of Organic Agriculture<\/a>.\u00a0<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Environmental Health Perspectives<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, January 19, 2023) Research published in\u00a0Environmental Health Perspectives\u00a0finds the presence of nine various neonicotinoids (neonics) and six neonic metabolites within human cerebrospinal fluid (CSF). CSF is an essential part of the central nervous system (CNS), especially for CNS development. Specific chemical biomarkers (measurable indicators of biological state), like pesticides, found in CSF are useful for diagnosing and evaluating numerous neurological diseases. The nervous system is an integral part of the human body and includes the brain, spinal cord, a vast network of nerves and neurons, all of which are responsible for many of our bodily functions\u2014from sensed to movement. However, mounting evidence over the past years shows that chronic exposure to\u00a0sublethal (low) levels\u00a0of pesticides can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. The impacts of pesticides on the nervous system, including the brain, are hazardous, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Researchers identify the role agricultural chemicals play in CNS impacts causing neurological diseases, like\u00a0amyotrophic lateral sclerosis\u00a0(ALS) and\u00a0Parkinson\u2019s disease,\u00a0dementia-like diseases such as\u00a0Alzheimer\u2019s, and other effects on\u00a0cognitive function. Over\u00a0300 environmental contaminants\u00a0and their byproducts, including pesticides, are chemicals commonly present in human blood […]<\/p>\n","protected":false},"author":2,"featured_media":32236,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[328,242],"tags":[],"class_list":["post-32234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-neonicotinoids","category-nervous-system-effects"],"yoast_head":"\nNeonicotinoid Insecticides Adversely Affect Nervous System Health, According to Study - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neonicotinoid Insecticides Adversely Affect Nervous System Health, According to Study - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, January 19, 2023) Research published in\u00a0Environmental Health Perspectives\u00a0finds the presence of nine various neonicotinoids (neonics) and six neonic metabolites within human cerebrospinal fluid (CSF). CSF is an essential part of the central nervous system (CNS), especially for CNS development. Specific chemical biomarkers (measurable indicators of biological state), like pesticides, found in CSF are useful for diagnosing and evaluating numerous neurological diseases. The nervous system is an integral part of the human body and includes the brain, spinal cord, a vast network of nerves and neurons, all of which are responsible for many of our bodily functions\u2014from sensed to movement. However, mounting evidence over the past years shows that chronic exposure to\u00a0sublethal (low) levels\u00a0of pesticides can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. The impacts of pesticides on the nervous system, including the brain, are hazardous, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Researchers identify the role agricultural chemicals play in CNS impacts causing neurological diseases, like\u00a0amyotrophic lateral sclerosis\u00a0(ALS) and\u00a0Parkinson\u2019s disease,\u00a0dementia-like diseases such as\u00a0Alzheimer\u2019s, and other effects on\u00a0cognitive function. 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CSF is an essential part of the central nervous system (CNS), especially for CNS development. Specific chemical biomarkers (measurable indicators of biological state), like pesticides, found in CSF are useful for diagnosing and evaluating numerous neurological diseases. The nervous system is an integral part of the human body and includes the brain, spinal cord, a vast network of nerves and neurons, all of which are responsible for many of our bodily functions\u2014from sensed to movement. However, mounting evidence over the past years shows that chronic exposure to\u00a0sublethal (low) levels\u00a0of pesticides can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. The impacts of pesticides on the nervous system, including the brain, are hazardous, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Researchers identify the role agricultural chemicals play in CNS impacts causing neurological diseases, like\u00a0amyotrophic lateral sclerosis\u00a0(ALS) and\u00a0Parkinson\u2019s disease,\u00a0dementia-like diseases such as\u00a0Alzheimer\u2019s, and other effects on\u00a0cognitive function. Over\u00a0300 environmental contaminants\u00a0and their byproducts, including pesticides, are chemicals commonly present in human blood […]","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2023-01-19T05:01:50+00:00","og_image":[{"width":600,"height":340,"url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2023\/01\/CSF-DN-11923.png","type":"image\/png"}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"Neonicotinoid Insecticides Adversely Affect Nervous System Health, According to Study","datePublished":"2023-01-19T05:01:50+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/"},"wordCount":1219,"commentCount":0,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/#primaryimage"},"thumbnailUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2023\/01\/CSF-DN-11923.png","articleSection":["neonicotinoids","Nervous System Effects"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/01\/neonicotinoid-insecticides-adversely-affect-nervous-system-health-according-to-study\/","name":"Neonicotinoid Insecticides Adversely Affect Nervous System Health, According to Study - 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