{"id":33183,"date":"2023-07-11T00:01:56","date_gmt":"2023-07-11T04:01:56","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=33183"},"modified":"2023-07-12T16:12:39","modified_gmt":"2023-07-12T20:12:39","slug":"high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/","title":{"rendered":"High Frequency of Household Pesticide Exposure Can Double the Risk of Parkinson\u2019s Disease Among the General Population"},"content":{"rendered":"

(Beyond Pesticides, <\/em>July 11, 2023) A study published in\u00a0Parkinsonism & Related Disorders<\/em><\/a>\u00a0finds high exposure to household pesticides increases the risk of developing Parkinson\u2019s disease (PD) two-fold. There is a multitude of epidemiologic research on Parkinson\u2019s disease demonstrating several risk factors, including specific genetic mutations and external\/environmental triggers (i.e., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the\u00a0nervous system<\/a>. Past studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides have on the risk of PD, although many studies demonstrate the association between PD onset via occupational (work-related) pesticide exposure patterns.<\/p>\n

Parkinson\u2019s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. Alzheimer\u2019s ranks first. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD incidents are genetic, PD is quickly becoming the world\u2019s fastest-growing brain disease. Therefore, research like this highlights the need to examine alternate risk factors for disease development, especially if disease triggers are overwhelmingly nonhereditary.<\/p>\n

Using an observational cross-sectional study, the researchers explored the association between household pesticide exposure and PD risk. The researchers selected patients with PD from the Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD), and specialists evaluated movement disorders associated with PD. The study extracted data on sex, age at evaluation (for all participants), age at onset for patients with PD, and lifetime smoking history (at least 100 cigarettes during lifetime). To determine household pesticide exposure, researchers asked participants whether they used chemicals to kill various types of pests (e.g., insects, weeds, fungi) in or around the house\/apartment during their lifetime (four categories of answers: 1\u20135 days\/year, 6\u201310 days\/year, 11\u201330 days\/year, more than 30 days\/year). The study categorizes high exposure to household pesticides as more than 30 days per. Men tend to have higher instances of PD relative to household pesticide exposure. After adjusting for sex, age, smoking, or region of origin, researchers find the risk of PD is independent of these factors, and the odds of developing PD increase two-fold upon from (>30 days\/year) household pesticide exposure.<\/p>\n

Parkinson\u2019s disease occurs when there is damage to dopaminergic nerve cells (i.e., those activated by or sensitive to dopamine) in the brain responsible for dopamine production, one of the primary neurotransmitters mediating motor function. Although the cause of dopaminergic cell damage remains unknown,\u00a0evidence<\/a>\u00a0suggests that pesticide exposure, especially chronic exposure, may be the culprit. Occupational exposure poses a unique risk, as pesticide exposure is direct via handling and application. A\u00a02017 study<\/a>\u00a0finds that occupational use of pesticides (i.e., fungicides, herbicides, or insecticides) increases PD risk by 110 to 211 percent. Even more concerning, some personal protection equipment (PPE) may not adequately protect workers from chemical exposure during application. However,\u00a0indirect nonoccupational (residential) exposure to pesticides, such as proximity to pesticide-treated areas, can also increase the risk of PD<\/a>. A\u00a0Louisiana State University study<\/a>\u00a0finds that residents living adjacent to pesticide-treated pasture and forest land by the agriculture and timber industry have higher incidence of PD. Furthermore, pesticide residues in waterways and on produce present an alternate route for residential pesticide exposure to increase the risk for PD via ingestion. In addition to PD, pesticide exposure can cause severe health problems even at low residue levels, including\u00a0endocrine disruption<\/a>,\u00a0cancers<\/a>,\u00a0reproductive dysfunction<\/a>,\u00a0respiratory problems<\/a>\u00a0(e.g., asthma, bronchitis), and other\u00a0neurological impacts<\/a>. Nevertheless,\u00a0direct occupational and indirect nonoccupational pesticide exposure can increase the risk of PD<\/a>.\u00a0<\/p>\n

This study adds to the research that associates pesticide exposure with PD.\u00a0<\/em>A history of high exposure to household pesticides increases the risk of PD regardless of the age at PD onset. Insecticides are the most commonly used household pesticides, particularly synthetic pyrethroids, and organophosphates. Several studies identify various pesticides as involved in the pathology of PD, including the insecticides\u00a0rotenone<\/a>\u00a0and\u00a0chlorpyrifos<\/a>\u00a0and herbicides\u00a02,4-D<\/a>,\u00a0glyphosate<\/a>, and\u00a0paraquat<\/a>. A\u00a0Washington State University study<\/a>\u00a0determined that residents living near areas treated with glyphosate\u2014the most widely used herbicides in the U.S.\u2014are one-third more likely to die prematurely from Parkinson\u2019s disease. In the\u00a0Louisiana State University study<\/a>, exposure to 2,4-D, chlorpyrifos, and paraquat from pasture land, forestry, or woodland operations, as prominent risk factors for PD, with the highest risk in areas where chemicals quickly percolate into drinking water sources. Overall, research finds exposure to pesticides increases the risk of developing PD from 33 percent to 80 percent, with some pesticides prompting a higher risk than others.<\/p>\n

This study adds to the\u00a0large body of scientific studies<\/a>\u00a0strongly implicating pesticide involvement in Parkinson\u2019s disease development. In addition to this research,\u00a0several studies<\/a>\u00a0demonstrate\u00a0autism<\/a>, mood disorders (e.g.,\u00a0depression<\/a>), and degenerative neurological conditions (e.g.,\u00a0ALS<\/a>,\u00a0Alzheimer\u2019s<\/a>,\u00a0Parkinson\u2019s<\/a>) among aquatic and terrestrial animals, including humans exposed to pesticides. Pesticides themselves, mixtures of chemicals such as Agent Orange (2,4-D and 2,4,5-T) or dioxins, and therapeutic hormones or pharmaceutical products can possess the ability to disrupt neurological function. Therefore, the impacts of pesticides on the nervous system, including the\u00a0brain<\/a>, are hazardous, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Considering health officials expect Parkinson\u2019s\u00a0disease diagnosis to double<\/a>\u00a0over the next 20 years, mitigating preventable exposure from disease-inducing pesticides becomes increasingly essential.<\/p>\n

Parkinson\u2019s disease has no cure, but preventive practices, like organic agriculture<\/a> or Parks for a Sustainable Future<\/a>, can eliminate exposure to toxic PD-inducing pesticides. Organic agriculture represents a safer, healthier approach to crop production that does not necessitate toxic pesticide use. Beyond Pesticides encourages farmers to embrace\u00a0regenerative, organic<\/a>\u00a0practices and consumers to purchase organically grown food. A complement to buying organic is contacting\u00a0various organic farming organizations<\/a>\u00a0to learn more about what you can do. Those affected by pesticide drift can refer to Beyond Pesticides\u2019 webpage on\u00a0What to Do in a Pesticide Emergency<\/a>\u00a0and contact the organization for additional information. Furthermore, see Beyond Pesticides\u2019\u00a0Parkinson\u2019s Disease article<\/a>\u00a0from the Spring 2008 issue of\u00a0Pesticides and You<\/em>.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Parkinsonism & Related Disorders<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, July 11, 2023) A study published in\u00a0Parkinsonism & Related Disorders\u00a0finds high exposure to household pesticides increases the risk of developing Parkinson\u2019s disease (PD) two-fold. There is a multitude of epidemiologic research on Parkinson\u2019s disease demonstrating several risk factors, including specific genetic mutations and external\/environmental triggers (i.e., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the\u00a0nervous system. Past studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides have on the risk of PD, although many studies demonstrate the association between PD onset via occupational (work-related) pesticide exposure patterns. Parkinson\u2019s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. Alzheimer\u2019s ranks first. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and […]<\/p>\n","protected":false},"author":2,"featured_media":28180,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[397,145],"tags":[702,738,737,736,600],"class_list":["post-33183","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-household-use","category-parkinsons","tag-chemical-exposure","tag-household-pesticides","tag-neurotoxicity","tag-parkinsons","tag-pesticides"],"yoast_head":"\nHigh Frequency of Household Pesticide Exposure Can Double the Risk of Parkinson\u2019s Disease Among the General Population - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High Frequency of Household Pesticide Exposure Can Double the Risk of Parkinson\u2019s Disease Among the General Population - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, July 11, 2023) A study published in\u00a0Parkinsonism & Related Disorders\u00a0finds high exposure to household pesticides increases the risk of developing Parkinson\u2019s disease (PD) two-fold. There is a multitude of epidemiologic research on Parkinson\u2019s disease demonstrating several risk factors, including specific genetic mutations and external\/environmental triggers (i.e., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the\u00a0nervous system. Past studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides have on the risk of PD, although many studies demonstrate the association between PD onset via occupational (work-related) pesticide exposure patterns. 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There is a multitude of epidemiologic research on Parkinson\u2019s disease demonstrating several risk factors, including specific genetic mutations and external\/environmental triggers (i.e., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the\u00a0nervous system. Past studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides have on the risk of PD, although many studies demonstrate the association between PD onset via occupational (work-related) pesticide exposure patterns. Parkinson\u2019s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. Alzheimer\u2019s ranks first. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and […]","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2023-07-11T04:01:56+00:00","article_modified_time":"2023-07-12T20:12:39+00:00","og_image":[{"width":2000,"height":1600,"url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2020\/11\/Untitled-design.jpg","type":"image\/jpeg"}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"High Frequency of Household Pesticide Exposure Can Double the Risk of Parkinson\u2019s Disease Among the General Population","datePublished":"2023-07-11T04:01:56+00:00","dateModified":"2023-07-12T20:12:39+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/"},"wordCount":1132,"commentCount":0,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/#primaryimage"},"thumbnailUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2020\/11\/Untitled-design.jpg","keywords":["chemical exposure","household pesticides","neurotoxicity","Parkinson's","pesticides"],"articleSection":["Household Use","Parkinson's"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/07\/high-frequency-of-household-pesticide-exposure-can-double-the-risk-of-parkinsons-disease-among-the-general-population\/","name":"High Frequency of Household Pesticide Exposure Can Double the Risk of Parkinson\u2019s Disease Among the General Population - 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