{"id":34130,"date":"2023-12-13T07:10:36","date_gmt":"2023-12-13T12:10:36","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=34130"},"modified":"2023-12-13T09:11:32","modified_gmt":"2023-12-13T14:11:32","slug":"with-endometrial-uterine-cancer-on-the-rise-the-science-points-to-an-association-with-pesticides","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/12\/with-endometrial-uterine-cancer-on-the-rise-the-science-points-to-an-association-with-pesticides\/","title":{"rendered":"With Endometrial (Uterine) Cancer on the Rise, the Science Points to an Association with Pesticides"},"content":{"rendered":"\r\n

(Beyond Pesticides<\/em>, December 13, 2023) A study published in Environmental Health<\/em><\/a> finds occupational (work-related) exposure to pesticides increases the risk of endometrial (uterine) cancer development. Endometrial cancer is the most common cancer of the female reproductive system<\/a> and the fourth most common cancer among women, primarily affecting the uterine lining rather than the uterus itself, like uterine sarcoma. Despite data predicting the disease rate to increase<\/a>, few studies evaluate the connection environmental contaminants have on endometrial cancer occurrence. Like most cancers<\/a>, non-genetic factors account for a majority of endometrial cancer risk, including diabetes, age, contraceptive (birth-control) use, and hormone (endocrine) disruption. However, three percent of all cases are hereditary, primarily from Lynch syndrome. The study notes, \u201cIdentifying other modifiable risk factors may help develop strategies to reduce the expected increasing incidence of these neoplasms.\u201d<\/p>\r\n

Many pesticides have a long history associated with endocrine-disrupting properties that induce various molecular changes, prompting disease development. The International Agency for Research on Cancer\u00a0(IARC) classifies many of these chemicals<\/a>\u00a0as potent carcinogens in animal studies. Cancer development also depends on genetic susceptibility, as impaired genes responsible for xenobiotic detoxification (elimination) increase disease risk sensitivity. Adding to the science, a review published in\u00a0Environmental Exposure, Biomonitoring, and Exposure Assessment<\/em><\/a>\u00a0highlights how specific estrogen-mimicking pesticides increase the risk of disease, particularly hormone-related cancers among women (e.g., breast, ovarian, endometrial cancer) and men (e.g., testicular, prostate cancer). Endocrine disruptors, including many pesticides, are xenobiotic (i.e., chemical substances foreign to an organism or ecosystem).\u00a0Many reports<\/a>\u00a0demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal\u2014and thus environmental\u2014health by altering the natural bodily hormones responsible for conventional reproductive, physical, and mental development. Endocrine disruption can lead to several\u00a0health problems<\/a>, including hormone-related cancer development (e.g., thyroid<\/a>, breast<\/a>, ovarian<\/a>, prostate<\/a>, testicular<\/a>, reproductive dysfunction<\/a>, and diabetes<\/a>\/obesity<\/a> that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause cancer, among other health issues.<\/p>\r\n

Using a questionnaire and job-exposure matrix (JEM) in the Screenwide case-control study, the study analyzed the association between occupational exposure to pesticides and endometrial cancer. The data includes 174 consecutive incidents of endometrial cancer cases and 216 controls of the individuals occupationally exposed to pesticides, whether fungicides, herbicides, or insecticides; there is a positive association with endometrial cancer. Although past exposure shows a higher occurrence of endometrial cancer, this can be explained through the latency (delayed) development of cancer, as the illness is primarily chronic. As for occupation, agricultural jobs have a higher association with cancer prognosis than custodial jobs (e.g., disinfectants).<\/p>\r\n

The connection between pesticides and associated cancer risks is not a new finding. Many pesticides are\u00a0\u201cknown or probable\u201d<\/a>\u00a0carcinogens (cancer-causing agents), and widespread uses only amplify chemical hazards, adversely affecting human health.\u00a0Several studies<\/a>\u00a0link pesticide use and residue to various cancers, from the more prevalent\u00a0breast cancer<\/a>\u00a0to the rare\u00a0kidney cancer, nephroblastoma<\/a>\u00a0<\/em>(Wilms\u2019 tumor).\u00a0Sixty-six percent<\/a>\u00a0of all cancers have links to environmental factors, especially in occupations of high chemical use. At least\u00a045 different cancers<\/a>\u00a0have associations with work-related chemical exposure. Although the link between agricultural practices and pesticide-related illnesses is stark, over\u00a063 percent<\/a>\u00a0of commonly used lawn pesticides and\u00a070 percent<\/a>\u00a0of commonly used school pesticides have\u00a0links<\/a>\u00a0to cancer. Many cancer-causing substances<\/a> are endocrine disruptors, directly affecting traditional endocrine glands and their\u00a0hormones and receptors<\/a>\u00a0(e.g., estrogens, anti-androgens, thyroid hormones) while greatly influencing hormone cancer incidents among humans (e.g., unrein, breast, prostate, and thyroid cancers). Moreover, several\u00a0studies and reports<\/a>, including U.S. Environmental Protection Agency (EPA) data,\u00a0identify<\/a>\u00a0hundreds of chemicals as influential factors associated with hormone-related cancer risk.\u00a0<\/p>\r\n

This study is one of the first to evaluate the association between work-related exposure to pesticides and endometrial cancer, accounting for confounding factors like age, comorbidities (presence of multiple health conditions), and medication. Additionally, the study highlights potential mechanisms involved in disease development, including oxidative stress, disruption of enzymatic activity, and epigenetic changes from pesticide exposure. However, the specific molecular pathway needs further investigation. Similarly, external factors such as exposure rate, pesticide type, and pesticide (including breakdown product) persistence in the organism can play a role in carcinogenicity (cancer development).<\/p>\r\n

There is a lack of understanding of the etiology of pesticide-induced diseases, including predictable lag time between chemical exposure, health impacts, and epidemiological data. Exposure to pesticides can increase the risk of developing chronic illnesses.\u00a0Cancer<\/a>\u00a0is one of the leading causes of death worldwide, with over eight million people succumbing to the disease every year. Notably,\u00a0IARC predicts an increase<\/a>\u00a0in new cancer cases from 19.3 million to 30.2 million per year by 2040. Therefore, studies related to pesticides and cancer will aid in understanding the underlying mechanisms that cause the disease. Consequently, it is essential to understand the health implications of pesticide use and exposure for humans, particularly when pesticides increase chronic disease risk. Beyond Pesticides tracks the most recent news and studies on pesticides and related topics through the\u00a0Daily News Blog<\/a>\u00a0and\u00a0Pesticide-Induced Diseases Database (PIDD)<\/a>. For more information on the adverse effects of pesticides on human health, see PIDD pages on\u00a0cancer<\/a>,\u00a0endocrine disruption<\/a>, and other diseases.<\/p>\r\n

Moreover, proper prevention practices, like\u00a0buying<\/a>,\u00a0growing<\/a>, and supporting organics, can eliminate exposure to toxic pesticides. Organic agriculture has many health<\/a> and environmental<\/a>, benefits, as it curtails the need for chemical-intensive agricultural practices. Regenerative organic agriculture<\/a>\u00a0nurtures soil health through organic carbon sequestration, preventing pests and generating a higher return than chemical-intensive agriculture. For more information on why organic is the right choice, see the Beyond Pesticides webpage,\u00a0Health Benefits of Organic Agriculture<\/a>.\u00a0<\/p>\r\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\r\n

Source: Environmental Health<\/em><\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, December 13, 2023) A study published in Environmental Health finds occupational (work-related) exposure to pesticides increases the risk of endometrial (uterine) cancer development. Endometrial cancer is the most common cancer of the female reproductive system and the fourth most common cancer among women, primarily affecting the uterine lining rather than the uterus itself, like uterine sarcoma. Despite data predicting the disease rate to increase, few studies evaluate the connection environmental contaminants have on endometrial cancer occurrence. Like most cancers, non-genetic factors account for a majority of endometrial cancer risk, including diabetes, age, contraceptive (birth-control) use, and hormone (endocrine) disruption. However, three percent of all cases are hereditary, primarily from Lynch syndrome. The study notes, \u201cIdentifying other modifiable risk factors may help develop strategies to reduce the expected increasing incidence of these neoplasms.\u201d Many pesticides have a long history associated with endocrine-disrupting properties that induce various molecular changes, prompting disease development. The International Agency for Research on Cancer\u00a0(IARC) classifies many of these chemicals\u00a0as potent carcinogens in animal studies. Cancer development also depends on genetic susceptibility, as impaired genes responsible for xenobiotic detoxification (elimination) increase disease risk sensitivity. Adding to the science, a review published in\u00a0Environmental Exposure, Biomonitoring, and Exposure […]<\/p>\n","protected":false},"author":2,"featured_media":34150,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[196,1159,1],"tags":[446,1160,600,850,779],"class_list":["post-34130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-endometrial-uterine-cancer","category-uncategorized","tag-cancer","tag-endometrial","tag-pesticides","tag-reproductive-health","tag-womens-health"],"yoast_head":"\nWith Endometrial (Uterine) Cancer on the Rise, the Science Points to an Association with Pesticides - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"description\" content=\"A study published in Environmental Health finds occupational (work-related) exposure to pesticides increases the risk of endometrial (uterine) cancer development.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2023\/12\/with-endometrial-uterine-cancer-on-the-rise-the-science-points-to-an-association-with-pesticides\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"With Endometrial (Uterine) Cancer on the Rise, the Science Points to an Association with Pesticides - 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