{"id":34253,"date":"2024-01-03T00:01:53","date_gmt":"2024-01-03T05:01:53","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=34253"},"modified":"2024-01-03T11:29:59","modified_gmt":"2024-01-03T16:29:59","slug":"loss-of-chromosome-y-in-male-farmers-genotoxic-implications-for-cancer","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2024\/01\/loss-of-chromosome-y-in-male-farmers-genotoxic-implications-for-cancer\/","title":{"rendered":"Loss of Chromosome Y in Male Farmers Genotoxic Implications for Cancer"},"content":{"rendered":"

(Beyond Pesticides, <\/em>January 3, 2024) A study published in Environmental Health Perspectives<\/em><\/a> finds elevated, chronic exposure to glyphosate throughout one\u2019s lifetime increases the risk of mosaic loss of chromosome Y (loss of chromosome Y occurs to many men in some cells due to aging [mLOY]) that impacts a noticeable fraction of cells. Although the loss of this sex chromosome does not cause cell death, like the loss of autosomal chromosomes, the risk of mLOY is a biomarker for genotoxicity (the damage of genetic information within a cell causing mutations from chemical exposure, which may lead to cancer) and expansion of cellular response to glyphosate, resulting in the precursor for hematological (blood) cancers. This study is one of the first to identify sex-specific chromosome degradation, with stark evidence<\/a>\u00a0demonstrating links to various cancers, including\u00a0non-Hodgkin lymphoma<\/a>. The\u00a0International Agency for Research on Cancer (IARC) has classified the glyphosate as a probable carcinogen<\/a> or cancer-causing chemical. However, the U.S. Environmental Protection Agency\u2019s (EPA) allowance of widespread use of glyphosate allows for adverse impacts<\/a>, especially among vulnerable individuals, like pregnant women, infants, children, and the elderly. Glyphosate exposure levels and resulting residues in urine has been documented with recent data showing that\u00a0four out of five (81.6%) U.S. residents have detectable levels of glyphosate in their bodies<\/a>. Despite these concerning data, evidence of widespread exposure to a carcinogen has\u00a0so far failed to influence regulators at EPA<\/a>, which puts increasing responsibility on local elected officials and consumers, according to advocates, to stop glyphosate use in their community\u2019s land mana<\/a>gement.<\/p>\n

The study notes, \u201cAlthough future studies are needed to confirm the observed associations, our findings for glyphosate add to the limited literature on occupational and environmental exposures as contributors to mLOY, the most common acquired chromosomal alteration in men, and provide novel mechanistic evidence supporting the potential carcinogenicity of this widely used herbicide.\u201d<\/p>\n

The study analyzes blood-derived DNA from 1,606 farmers to detect mLOY using genotype assessments of the sex chromosomes in the cells. Researchers gathered self-reported pesticide exposure from the farmers and estimated the association between mLOY and glyphosate use, employing a multivariable logistic regression. The results find that mLOY is detectable in 21.4 percent of farmers, with mLOY expanding throughout most cells in 9.8 percent of farmers. Most farmers with mLOY expanding throughout most cells are older in age, with a greater lifetime exposure and intensity of exposure to glyphosate. However, these individuals are non-smokers and non-obese, which are other risk factors for mLOY.<\/p>\n

Glyphosate<\/a>\u00a0is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, including Bayer\u2019s (formerly Monsanto) Roundup\u00ae. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. Glyphosate is often promoted by industry as a \u201clow toxicity\u201d chemical and \u201csafer\u201d than other chemicals, yet it has been shown to have\u00a0detrimental impacts<\/a> on humans and the environment. The toxic herbicide readily contaminates the ecosystem, with residues pervasive in food and water commodities. In addition to this study, decades of accumulated scientific literature commonly associates glyphosate with human, biotic, and ecosystem\u00a0harm<\/a>. Additionally, glyphosate\u2019s ubiquity threatens\u00a093 percent<\/a>\u00a0of all U.S. endangered species,\u00a0resulting<\/a>\u00a0in biodiversity loss and ecosystem disruption (e.g.,\u00a0soil erosion<\/a>,\u00a0loss of services<\/a>, and\u00a0trophic cascades<\/a>). Moreover, chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. Not only do health officials warn that continuous use of glyphosate will perpetuate adverse health and ecological effects, but that use also highlights recent concerns over\u00a0antibiotic resistance<\/a>. Thus, glyphosate has been extensively controversial about its safety for humans, nonhuman organisms, and ecosystems.\u00a0For instance, the presence of glyphosate in human bodies has risen dramatically during the past three decades.\u00a0Research at the University of California San Diego found<\/a>\u00a0that, between two data collection periods (1993\u20131996 and 2014\u20132016), the percentage of people testing positive for the presence of glyphosate (or its metabolites) in urine rose by an average of 500 percent, peaking at 1,208 percent.<\/p>\n

Although the EPA classifies glyphosate herbicides as \u201cnot likely to be carcinogenic to humans, glyphosate exposure has implications for\u00a0the development of various health anomalies,<\/a>\u00a0including the distortion of DNA function, leading to several chronic diseases<\/a> like cancer<\/a>, Parkinson\u2019s disease<\/a>, metabolic disorders<\/a>, gut dysbiosis<\/a>, nervous system disorders<\/a>, and neurodevelopment disorders like\u00a0autism<\/a>. In recent years,\u00a0numerous lawsuits have targeted Monsanto<\/a>\u00a0(now Bayer), which contains glyphosate, alleging that the herbicide contributes to the plaintiffs\u2019 cancers. Beyond Pesticides has reported<\/a>\u00a0on EPA\u2019s ongoing failures to protect people and the environment from glyphosate-based herbicide (GBH) compounds. Therefore, advocates say it is crucial to comprehend the full spectrum of glyphosate\u2019s effects on human health from its potential carcinogenicity.<\/p>\n

This study is one of the first to investigate mLOY as a biomarker for genomic instability (loss of sex chromosome), providing new insight into the biological mechanism involved in carcinogenicity beyond general genotoxicity (i.e., DNA damage) and oxidative stress. However, considering the co-occurring effects of glyphosate exposure, including the chemical\u2019s breakdown product AMPA, is essential. Since glyphosate and its formulations have long been associated with oxidative stress<\/a> and\u00a0strong evidence\u00a0of genotoxicity, multiple biological mechanisms can work synergically (together) to increase the risk, time of onset, or disease severity.<\/p>\n

It is essential to understand the effects of widely used pesticides and their breakdown products on the health of current and future generations. Beyond Pesticides challenges the EPA registration of chemicals like glyphosate in court<\/a>\u00a0due to their impacts on soil, air, water, and health. However, emphasis on converting to\u00a0regenerative-organic systems<\/a>\u00a0and using\u00a0least-toxic pest control<\/a>\u00a0can mitigate harmful exposure concerns. Public policy must advance this shift rather than allow unnecessary reliance on pesticides. Considering\u00a0glyphosate<\/a>\u00a0levels in the human body can decrease by\u00a070%<\/a>\u00a0through a one-week switch to an organic diet,\u00a0purchasing organic food whenever possible<\/a>\u2014which never allows glyphosate use\u2014can help curb exposure and adverse health effects. Learn more about pesticides\u2019 impacts on human health by visiting Beyond Pesticides\u2019\u00a0Pesticide-Induced Diseases Database<\/a>. This database supports the clear need for strategic action to shift away from pesticide dependency. Moreover, Beyond Pesticides provides tools, information, and support to take local action: check out our\u00a0factsheet on glyphosate\/Roundup<\/a>\u00a0and our report,\u00a0Monsanto\u2019s Roundup (Glyphosate) Exposed<\/a>. Contact us for help with local efforts and stay informed of developments through our\u00a0Daily News Blog<\/a>\u00a0and our journal,\u00a0Pesticides and You<\/em><\/a>. Additionally, check out\u00a0Carey Gillam\u2019s talk on Monsanto\u2019s corruption<\/a>\u00a0on glyphosate\/Roundup at Beyond Pesticides\u2019 36th National Pesticide Forum.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source: Environmental Health Perspectives<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, January 3, 2024) A study published in Environmental Health Perspectives finds elevated, chronic exposure to glyphosate throughout one\u2019s lifetime increases the risk of mosaic loss of chromosome Y (loss of chromosome Y occurs to many men in some cells due to aging [mLOY]) that impacts a noticeable fraction of cells. Although the loss of this sex chromosome does not cause cell death, like the loss of autosomal chromosomes, the risk of mLOY is a biomarker for genotoxicity (the damage of genetic information within a cell causing mutations from chemical exposure, which may lead to cancer) and expansion of cellular response to glyphosate, resulting in the precursor for hematological (blood) cancers. This study is one of the first to identify sex-specific chromosome degradation, with stark evidence\u00a0demonstrating links to various cancers, including\u00a0non-Hodgkin lymphoma. The\u00a0International Agency for Research on Cancer (IARC) has classified the glyphosate as a probable carcinogen or cancer-causing chemical. However, the U.S. Environmental Protection Agency\u2019s (EPA) allowance of widespread use of glyphosate allows for adverse impacts, especially among vulnerable individuals, like pregnant women, infants, children, and the elderly. Glyphosate exposure levels and resulting residues in urine has been documented with recent data showing that\u00a0four out of five (81.6%) […]<\/p>\n","protected":false},"author":2,"featured_media":34258,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[577,196,1200,484,41,291,494,1199,497,399,275],"tags":[1206,446,1205,1204,1201,1202,470,1210,1196,1203],"class_list":["post-34253","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blood-disorders","category-cancer","category-dna-damage","category-epigenetic","category-glyphosate","category-hematological-malignancies","category-herbicides","category-mens-health","category-occupational-health","category-oxidative-stress","category-reproductive-health","tag-blood-cancer","tag-cancer","tag-cellular-health","tag-chromosome","tag-dna","tag-dna-damage","tag-glyphosate","tag-glyphosate-based-herbicides","tag-mens-health","tag-y-chromosome"],"yoast_head":"\nLoss of Chromosome Y in Male Farmers Genotoxic Implications for Cancer<\/title>\n<meta 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