{"id":34461,"date":"2024-02-06T00:01:43","date_gmt":"2024-02-06T05:01:43","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=34461"},"modified":"2024-02-07T13:25:23","modified_gmt":"2024-02-07T18:25:23","slug":"the-link-between-ovarian-cancer-and-pesticides-increases-among-female-farmers","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2024\/02\/the-link-between-ovarian-cancer-and-pesticides-increases-among-female-farmers\/","title":{"rendered":"The Link Between Ovarian Cancer and Pesticides Increases Among Female Farmers"},"content":{"rendered":"

(Beyond Pesticides, <\/em>February\u00a0 6, 2024) A study published in Occupational and Environmental Medicine<\/em><\/a> finds that pesticide exposure, especially during puberty, can play a role in ovarian cancer<\/a> development among female farmers. Although there are many studies<\/a> that evaluate the risk for cancers among farmers, very few pieces of literature cover the risk of ovarian cancer from pesticide exposure. Additionally, this study notes suggests the role of hormones in ovarian cancer prognosis and development, highlighting an association with endocrine disruption. Exposure to past and current-use endocrine-disrupting chemicals (EDCs), like pesticides, has a long history of severe adverse\u00a0human health<\/a>\u00a0effects. Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem) present in nearly all organisms and ecosystems. The World Health Organization (WHO),\u00a0European Union (EU), and endocrine disruptor expert (deceased) Theo Colborn<\/a>, Ph.D., classify over 55 to 177 chemical compounds as endocrine disruptors, including various\u00a0household products<\/a>\u00a0like detergents, disinfectants, plastics, and pesticides. Endocrine disruption can lead to several\u00a0health problems<\/a>, including hormone-related cancer development (e.g.,\u00a0thyroid<\/a>,\u00a0breast<\/a>,\u00a0ovarian<\/a>, prostate<\/a>, testicular<\/a>),\u00a0reproductive dysfunction<\/a>, and\u00a0diabetes<\/a>\/obesity<\/a>\u00a0that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause cancer, among other health issues.<\/p>\n

The study evaluates a group of 59,391 female farmers with lifelong exposure to pesticides through agriculture and reproductive health. The participants are from an AGRIculture and CANcer (AGRICAN) cohort, a large prospective cohort of subjects in agriculture with links to cancer among active and retired males and females, farm owners and workers, living in areas with a population-based cancer registry. The study investigates the role that hormonal factors (e.g., endocrine disruption) from pesticide exposure plays in reproductive health issues, including ovarian cancer, during specifically sensitive exposure windows (i.e., children, puberty, menopause). The results find 262 incidences of ovarian cancer over a 10-to-12-year period. Women in agriculture working with pigs have the highest risk of ovarian cancer, followed by women growing fruit and women applying potato seed treatments. Exposure during puberty does have a positive association with ovarian cancer risk. Although the risk of ovarian cancer is reduced among women born on farms growing grain cereal or breeding pigs, the risk of other cancer and health issues remains.\u00a0<\/p>\n

The connection between pesticides and associated cancer risks is not a new finding. Many pesticides are\u00a0\u201cknown or probable\u201d<\/a>\u00a0carcinogens (cancer-causing agents), and widespread uses only amplify chemical hazards, adversely affecting human health.\u00a0Several studies<\/a>\u00a0link pesticide use and residue to various cancers, from the more prevalent\u00a0breast cancer<\/a>\u00a0to the rare\u00a0kidney cancer, nephroblastoma<\/a>\u00a0<\/em>(Wilms\u2019 tumor).\u00a0Sixty-six percent<\/a>\u00a0of all cancers have links to environmental factors, especially in occupations of high chemical use. At least\u00a045 different cancers<\/a>\u00a0have associations with work-related chemical exposure. Although the link between agricultural practices and pesticide-related illnesses is stark, over\u00a063 percent<\/a>\u00a0of commonly used lawn pesticides and\u00a070 percent<\/a>\u00a0of commonly used school pesticides have\u00a0links<\/a>\u00a0to cancer. U.S. National Institutes of Health\u2019s\u00a0National Cancer Institute<\/a>\u00a0also finds many cancer-causing substances are endocrine disruptors. The entire endocrine system directly affects traditional endocrine glands and their\u00a0hormones and receptors<\/a>\u00a0(i.e., estrogens, anti-androgens, thyroid hormones), greatly influencing hormone cancer incidents among humans (e.g., breast, prostate, and thyroid cancers). Several\u00a0studies and reports<\/a>, including U.S. Environmental Protection Agency (EPA) data,\u00a0identify<\/a>\u00a0hundreds of chemicals as influential factors associated with hormone-related cancer risk. There are grave concerns over exposure to endocrine (hormone) disrupting chemicals and pollutants that produce adverse health effects. Over\u00a0296 chemicals in consumer products can increase breast cancer risk through endocrine disruption<\/a>, so it is essential to understand how chemical exposure impacts chronic disease occurrence.\u00a0<\/p>\n

This study is one of the first to comprehensively assess the association between specific agricultural exposures among female farmers and ovarian cancer. Adding data on agricultural exposure, including duration and intensity of exposure, adds a new perspective on how these chemicals impact female farmers\u2019 health. The study also points to hormonal factors (i.e., endocrine disruption) increasing ovarian cancer risk. \u00a0The connection between cancers and EDCs is historically established by the International Agency for Research on Cancer (IARC) and the U.S. National Toxicology Program (NTP), classifies many EDCs as\u00a0possible carcinogens<\/a>\u00a0based on epidemiological studies. Despite women in agriculture using fewer pesticides than men, the risk of pesticide exposure remains significant enough to call for further investigation of how these chemical exposures increase the risk of all health issues.<\/p>\n

There is a lack of understanding of the etiology of pesticide-induced diseases, including predictable lag time between chemical exposure, health impacts, and epidemiological data. Exposure to pesticides can increase the risk of developing chronic illnesses that may be rare and disproportionately impact various populations.\u00a0Cancer<\/a>\u00a0is one of the leading causes of death worldwide, with over eight million people succumbing to the disease every year. Notably,\u00a0\u00a0IARC predicts an increase<\/a>\u00a0in new cancer cases from 19.3 million to 30.2 million per year by 2040. Therefore, studies related to pesticides and cancer will aid in understanding the underlying mechanisms that cause the disease.<\/p>\n

Understanding the health implications of pesticide use and exposure for humans is essential, particularly when pesticides increase chronic disease risk. Beyond Pesticides tracks the most recent news and studies on pesticides and related topics through the\u00a0Daily News Blog<\/a>\u00a0and\u00a0Pesticide-Induced Diseases Database (PIDD)<\/a>. For more information on the adverse effects of pesticides on human health, see PIDD pages on\u00a0cancer<\/a> (including ovarian cancer<\/a>),\u00a0endocrine disruption<\/a>, and other diseases.<\/p>\n

Moreover, proper prevention practices, like\u00a0buying<\/a>,\u00a0growing<\/a>, and supporting organics, can eliminate exposure to toxic pesticides. Organic agriculture has many\u00a0health<\/a>\u00a0and\u00a0environmental<\/a>\u00a0benefits, as it curtails the need for chemical-intensive agricultural practices.\u00a0Regenerative organic agriculture<\/a>\u00a0nurtures soil health through organic carbon sequestration, preventing pests and generating a higher return than chemical-intensive agriculture. For more information on why organic is the right choice, see the Beyond Pesticides webpage,\u00a0Health Benefits of Organic Agriculture<\/a>.\u00a0<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n

Source:\u00a0Occupational and Environmental Medicine<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, February\u00a0 6, 2024) A study published in Occupational and Environmental Medicine finds that pesticide exposure, especially during puberty, can play a role in ovarian cancer development among female farmers. Although there are many studies that evaluate the risk for cancers among farmers, very few pieces of literature cover the risk of ovarian cancer from pesticide exposure. Additionally, this study notes suggests the role of hormones in ovarian cancer prognosis and development, highlighting an association with endocrine disruption. Exposure to past and current-use endocrine-disrupting chemicals (EDCs), like pesticides, has a long history of severe adverse\u00a0human health\u00a0effects. Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem) present in nearly all organisms and ecosystems. The World Health Organization (WHO),\u00a0European Union (EU), and endocrine disruptor expert (deceased) Theo Colborn, Ph.D., classify over 55 to 177 chemical compounds as endocrine disruptors, including various\u00a0household products\u00a0like detergents, disinfectants, plastics, and pesticides. Endocrine disruption can lead to several\u00a0health problems, including hormone-related cancer development (e.g.,\u00a0thyroid,\u00a0breast,\u00a0ovarian, prostate, testicular),\u00a0reproductive dysfunction, and\u00a0diabetes\/obesity\u00a0that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause cancer, among other health issues. The study evaluates a […]<\/p>\n","protected":false},"author":2,"featured_media":34475,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[249,196,85,215,275,1,527],"tags":[446,444,865,609,1306,850,779],"class_list":["post-34461","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-agriculture","category-cancer","category-endocrine-disruption","category-farmworkers","category-reproductive-health","category-uncategorized","category-womens-health","tag-cancer","tag-endocrine-disruption","tag-farmer","tag-farmworkers","tag-ovarian-cancer","tag-reproductive-health","tag-womens-health"],"yoast_head":"\nOvarian Cancer and Pesticide Link Increases Among Female Farmers<\/title>\n<meta name=\"description\" content=\"Pesticide exposure, especially during puberty, can play a role in ovarian cancer development among female farmers. 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