{"id":38020,"date":"2025-03-25T00:01:35","date_gmt":"2025-03-25T04:01:35","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=38020"},"modified":"2025-03-21T12:41:55","modified_gmt":"2025-03-21T16:41:55","slug":"research-finds-triazole-fungicides-induce-cardiotoxicity-threatening-cardiovascular-health","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2025\/03\/research-finds-triazole-fungicides-induce-cardiotoxicity-threatening-cardiovascular-health\/","title":{"rendered":"Research Finds Triazole Fungicides Induce Cardiotoxicity, Threatening Cardiovascular Health"},"content":{"rendered":"<p><span data-contrast=\"none\">(<\/span><i><span data-contrast=\"none\">Beyond Pesticides<\/span><\/i><span data-contrast=\"none\">, March 25, 2025) An editorial in <\/span><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14779072.2025.2476124\"><i><span data-contrast=\"none\">Expert Review of Cardiovascular Therapy<\/span><\/i><\/a> <span data-contrast=\"auto\">finds that <\/span><span data-contrast=\"none\">triazole fungicides pose a significant risk of cardiotoxicity with \u201cgrowing concerns regarding their safety for human health, especially in long-term exposure,\u201d the authors share. After analyzing the known mechanisms of cardiotoxicity of <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/tag\/triazole\/\"><span data-contrast=\"none\">triazole pesticides<\/span><\/a><span data-contrast=\"none\"> in mammals, they conclude that \u201cthe most effective approach to mitigating triazole-induced cardiotoxicity lies in prevention.\u201d<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Triazoles, a class of fungicides, target fungi by inhibiting the biosynthesis of ergosterol, an essential component of their cell membranes. As the researchers share, \u201cCompounds such as <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-gateway?pesticideid=282\"><span data-contrast=\"none\">tebuconazole<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-gateway?pesticideid=253\"><span data-contrast=\"none\">propiconazole<\/span><\/a><span data-contrast=\"none\">, and <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-gateway?pesticideid=135\"><span data-contrast=\"none\">difenoconazole<\/span><\/a><span data-contrast=\"none\"> are among the most used triazoles in agriculture.\u201d Triazoles are utilized as antifungal medications, despite the rise of <\/span><a href=\"https:\/\/ehp.niehs.nih.gov\/doi\/10.1289\/EHP7484\"><span data-contrast=\"none\">resistant infections<\/span><\/a><span data-contrast=\"none\">, in addition to their use as systemic pesticides on many fruit and vegetable crops, including grapes, wheat, corn, and soybeans.\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">As Beyond Pesticides\u2019 <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2025\/03\/study-finds-spermiotoxicity-and-impacts-on-male-mammal-fertility-with-ipconazole-fungicide-exposure\/\"><span data-contrast=\"none\">previous coverage<\/span><\/a><span data-contrast=\"auto\"> indicates<\/span><span data-contrast=\"none\">, many triazole fungicides in the U.S. are registered for use despite <\/span><a href=\"https:\/\/www.beyondpesticides.org\/assets\/media\/documents\/Feature%20--%20Endocrine%20disruptor%20review%2039.2.pdf\"><span data-contrast=\"none\">evidence of endocrine disruption<\/span><\/a><span data-contrast=\"auto\"> established over a decade ago in a U.S. Geological Survey <\/span><a href=\"https:\/\/pubs.usgs.gov\/publication\/ofr20121213\"><span data-contrast=\"none\">report<\/span><\/a><span data-contrast=\"auto\">. <\/span><span data-contrast=\"none\">These pesticides exhibit common mechanisms of toxicity often disregarded in U.S. Environmental Protection Agency (EPA) risk assessments, with a <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-induced-diseases-database\/overview\"><span data-contrast=\"none\">multitude of studies<\/span><\/a><span data-contrast=\"none\"> showcasing the myriads of health threats that the agency does not consider in its chemical registration processes. (See more on EPA failures and regulatory deficiencies <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/category\/environmental-protection-agency-epa\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)\u00a0\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Within the editorial, the authors examine the scientific literature linking triazole exposure to cardiotoxicity, including heart damage and cardiovascular system impacts, tying together the mechanisms of toxicity between chemicals within this class of pesticides. They report:<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"none\">The toxicity of triazoles, while classically defined due to their ability to impact ergosterol biosynthesis, \u201carises from the ability of the fungicide to <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33102531\/\"><span data-contrast=\"none\">bind to distinct proteins<\/span><\/a><span data-contrast=\"none\"> of off-target organisms, including humans.\u201d<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"none\">\u201cTriazole pesticides can induce cardiotoxicity through various mechanisms: <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/category\/diseasehealth-effects\/oxidative-stress\/\"><span data-contrast=\"none\">oxidative stress<\/span><\/a><span data-contrast=\"none\">, mitochondrial dysfunction, inflammation, and electrophysiological alterations in the heart.\u201d (See studies <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38556154\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32798748\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36463339\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37633639\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35202779\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"none\">\u201c[I]n vivo exposure of rats to <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/category\/chemicals\/tebuconazole\/\"><span data-contrast=\"none\">tebuconazole<\/span><\/a><span data-contrast=\"none\"> induces cardiac toxicity through oxidative stress.\u201d (See studies <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38556154\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\"> and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32980069\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)\u00a0<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"none\">Exposure to triazoles, confirmed with <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38185363\/\"><span data-contrast=\"none\">urine analyses in humans<\/span><\/a><span data-contrast=\"none\">, is associated with oxidative stress.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"none\">A <\/span><a href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2024.1255918\/full\"><span data-contrast=\"none\">study<\/span><\/a><span data-contrast=\"none\">, using the U.S. Food and Drug Administration&#8217;s Adverse Event Reporting System (FAERS) from 2004 to 2022, finds 53,864 adverse effects attributed to triazole antifungal agents, 6,174 of which were cardiac adverse effects.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"6\" data-aria-level=\"1\"><span data-contrast=\"none\">\u201cExposure to triazoles can compromise mitochondrial function. In vivo studies in rats have demonstrated that tebuconazole modulates the mitochondrial pathway of apoptosis [cell death].\u201d (See studies <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32798748\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33848738\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32006631\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"7\" data-aria-level=\"1\"><span data-contrast=\"none\">\u201c[I]n vitro and in vivo exposure to triazoles can trigger inflammatory responses in cardiac tissue, resulting in the release of pro-inflammatory cytokines. Chronic inflammation can cause adverse cardiac remodeling, fibrosis, and heart failure.\u201d (See studies <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36463339\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\"> and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26567492\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"8\" data-aria-level=\"1\"><span data-contrast=\"none\">In triazoles <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36410676\/\"><span data-contrast=\"none\">changing mitochondrial function<\/span><\/a><span data-contrast=\"none\">, it can result in \u201cdecreased ATP production, release of pro-apoptotic factors, increased reactive oxygen species (ROS) production, and intracellular calcium dysregulation.\u201d These impacts, especially involving ROS production in cardiac cells, can lead \u201cto oxidative stress, which can damage proteins, lipids, and DNA, resulting in cellular dysfunction and programmed cell death (apoptosis), as observed in rats orally in vivo treated with triazole (tebuconazole).\u201d (See studies <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38556154\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32798748\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32006631\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32980069\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"9\" data-aria-level=\"1\"><span data-contrast=\"none\">Triazoles \u201ccan directly interfere with ion channels in mammal cardiac cells, altering the action potential and electrical conduction in the heart, leading to arrhythmias, which are potentially fatal disturbances in heart rhythm, as shown in studies conducted in vitro and ex vivo.\u201d (See studies <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38556154\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37633639\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">, and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35202779\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"1\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"10\" data-aria-level=\"1\"><span data-contrast=\"none\">Tebuconazole <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32006631\/\"><span data-contrast=\"none\">exposure in <\/span><\/a><span data-contrast=\"none\">rats<\/span><span data-contrast=\"none\"> results in increased heart weight, which indicates cardiac hypertrophy that makes it harder for the heart to pump blood.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"none\">Aside from cardiotoxicity, scientific literature links triazole pesticides to numerous health threats. <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2024\/03\/study-provides-first-combined-assessment-of-multiple-classes-of-pesticides-in-human-blood\/\"><span data-contrast=\"none\">Previous coverage<\/span><\/a><span data-contrast=\"none\"> of a study in <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0269749123020717\"><i><span data-contrast=\"none\">Environmental Pollution<\/span><\/i><\/a> <span data-contrast=\"auto\">highlights f<\/span><span data-contrast=\"none\">our triazoles pesticides, detected in blood, that can cross the blood-brain barrier and infiltrate cerebrospinal fluid due to their ability to affect a steroid synthesis pathway. Research finds <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-gateway?pesticideid=198\"><span data-contrast=\"none\">ipconazole<\/span><\/a><span data-contrast=\"none\">, in a recent <\/span><a href=\"https:\/\/www.mdpi.com\/2305-6304\/13\/3\/176\"><i><span data-contrast=\"none\">Toxics<\/span><\/i><\/a><span data-contrast=\"none\"> study, to cause spermiotoxicity through significantly reduced sperm viability, as well as alterations in enzyme and gene expression related to fertility. (See Beyond Pesticides\u2019 coverage <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2025\/03\/study-finds-spermiotoxicity-and-impacts-on-male-mammal-fertility-with-ipconazole-fungicide-exposure\/\"><span data-contrast=\"none\">here<\/span><\/a><span data-contrast=\"none\">.)<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The solution to adverse health impacts from pesticide exposure, as the <\/span><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14779072.2025.2476124\"><i><span data-contrast=\"none\">Expert Review of Cardiovascular Therapy<\/span><\/i><\/a><span data-contrast=\"none\"> article authors state, is prevention. By transitioning away from the use of petrochemical pesticides and synthetic fertilizers in land management, the threats to health and the environment are mitigated. Adopting organic practices, and relying on an <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2025\/02\/study-demonstrates-health-benefits-of-organic-diet-over-that-consumed-with-toxic-pesticides\/\"><span data-contrast=\"none\">organic diet<\/span><\/a><span data-contrast=\"none\">, provides numerous health benefits and has a significantly lower environmental impact than conventional food production, as <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2024\/05\/study-shows-value-of-organic-practices-in-lowering-environmental-impact-of-agriculture\/\"><span data-contrast=\"none\">Beyond Pesticides has reported<\/span><\/a><span data-contrast=\"none\">.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Research finds that organic diets can also promote heart health. A study in the <\/span><a href=\"https:\/\/academic.oup.com\/eurjpc\/advance-article\/doi\/10.1093\/eurjpc\/zwaf057\/8003732\"><i><span data-contrast=\"none\">European Journal of Preventive Cardiology<\/span><\/i><\/a><span data-contrast=\"none\"> states that organic food consumption lowers the risk of developing cardiovascular disease. These findings reinforce scientific understanding that negative effects on the heart from pesticide exposure are preventable and eliminating toxic chemicals within food can play an important role in reducing a major public health threat.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.beyondpesticides.org\/programs\/organic-agriculture\/overview\"><span data-contrast=\"none\">Organic agriculture<\/span><\/a><span data-contrast=\"none\"> lowers <\/span><a href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/category\/diseasehealth-effects\/cardiovascular-disease\/\"><span data-contrast=\"none\">cardiovascular disease<\/span><\/a><span data-contrast=\"none\"> risks, as well as <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-induced-diseases-database\/brain-and-nervous-system-disorders\"><span data-contrast=\"none\">brain and nervous system disorders<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-induced-diseases-database\/cancer\"><span data-contrast=\"none\">cancer<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/www.beyondpesticides.org\/resources\/pesticide-induced-diseases-database\/endocrine-disruption\"><span data-contrast=\"none\">endocrine disruption<\/span><\/a><span data-contrast=\"none\">, and many more. Be part of the organic solution by <\/span><a href=\"https:\/\/www.beyondpesticides.org\/programs\/organic-agriculture\/buying-organic-products\"><span data-contrast=\"none\">buying organic products<\/span><\/a><span data-contrast=\"none\">, <\/span><a href=\"https:\/\/www.beyondpesticides.org\/programs\/organic-agriculture\/growing-your-own-organic-food\"><span data-contrast=\"none\">growing your own organic food<\/span><\/a><span data-contrast=\"none\">, and <\/span><a href=\"https:\/\/www.beyondpesticides.org\/action-of-the-week\"><span data-contrast=\"none\">advocating<\/span><\/a><span data-contrast=\"none\"> for the advancement of organic, sustainable, and regenerative practices and policies.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"none\">All unattributed positions and opinions in this piece are those of Beyond Pesticides.\u00a0<\/span><\/i><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Source<\/span><\/b><span data-contrast=\"none\">:<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Souza, D. and Roman-Campos, D. (2025) Cardiotoxicity and triazole pesticides: therapeutic options for a neglected heart disease, <\/span><i><span data-contrast=\"auto\">Expert Review of Cardiovascular Therapy<\/span><\/i><span data-contrast=\"auto\">. Available at: <\/span><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14779072.2025.2476124\"><span data-contrast=\"none\">https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14779072.2025.2476124<\/span><\/a><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Beyond Pesticides, March 25, 2025) An editorial in Expert Review of Cardiovascular Therapy finds that triazole fungicides pose a significant risk of cardiotoxicity with \u201cgrowing concerns regarding their safety for human health, especially in long-term exposure,\u201d the authors share. After analyzing the known mechanisms of cardiotoxicity of triazole pesticides in mammals, they conclude that \u201cthe most effective approach to mitigating triazole-induced cardiotoxicity lies in prevention.\u201d\u00a0 Triazoles, a class of fungicides, target fungi by inhibiting the biosynthesis of ergosterol, an essential component of their cell membranes. As the researchers share, \u201cCompounds such as tebuconazole, propiconazole, and difenoconazole are among the most used triazoles in agriculture.\u201d Triazoles are utilized as antifungal medications, despite the rise of resistant infections, in addition to their use as systemic pesticides on many fruit and vegetable crops, including grapes, wheat, corn, and soybeans.\u00a0\u00a0 As Beyond Pesticides\u2019 previous coverage indicates, many triazole fungicides in the U.S. are registered for use despite evidence of endocrine disruption established over a decade ago in a U.S. Geological Survey report. These pesticides exhibit common mechanisms of toxicity often disregarded in U.S. Environmental Protection Agency (EPA) risk assessments, with a multitude of studies showcasing the myriads of health threats that the agency does [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":38022,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290,625,85,374,399,168,272],"tags":[2042,1445,721,444,875,720,2043,1827,1269,1398],"class_list":["post-38020","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiovascular-disease","category-difenoconazole","category-endocrine-disruption","category-fungicides","category-oxidative-stress","category-propiconazole","category-tebuconazole","tag-cardiotoxicity","tag-cardiovascular","tag-cardiovascular-disease","tag-endocrine-disruption","tag-fungicide","tag-heart","tag-heart-health","tag-organic-diet","tag-oxidative-stress","tag-triazole"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Finds Triazole Fungicides Induce Cardiotoxicity, Threatening 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