{"id":41245,"date":"2026-03-25T00:01:29","date_gmt":"2026-03-25T04:01:29","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=41245"},"modified":"2026-03-23T14:27:29","modified_gmt":"2026-03-23T18:27:29","slug":"review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/","title":{"rendered":"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases"},"content":{"rendered":"

(Beyond Pesticides<\/em>, March 25, 2026) A literature review, published in Diseases<\/em><\/a>, showcases the wide body of scientific literature linking pesticide exposure to liver disease through both apoptotic (programmed cell death without triggering inflammation) and non-apoptotic (regulated cell death with an inflammatory response) pathways. \u201cIn summary, our study confirms that pesticides carry significant health risks and sheds light on the underreported mechanisms that can drive their overall toxicity as a whole and hepatotoxicity [liver] in particular,\u201d the researchers state.<\/p>\n

\u00a0In addition to analyzing the science on pesticide-induced apoptosis, the researchers \u201csystematically illustrated an underappreciated mechanism of pesticide-induced overall and hepatic toxicity, i.e., the ability to induce non-apoptotic regulated cell death (RCD) pathways such as ferroptosis, necroptosis, and pyroptosis.\u201d They continue, saying, \u201cImportantly, our review stresses the contribution of pesticide-induced cell death modes to inflammation and immunity regulation in hepatic pathology.\u201d<\/p>\n

Background<\/strong><\/p>\n

Pesticides, as a comprehensive group, can be subdivided into classes based on their targets: rodenticides (rodents), herbicides (weeds), insecticides (insects), fungicides (fungi), nematicides (nematodes), acaricides (mites and ticks), and bactericides (bacteria). The use of these pesticides, particularly in agriculture, has skyrocketed over recent decades. As the authors state: \u201cIn 2019, the total pesticide market size was estimated to approach $85 billion. The constant growth of this market is emphasized by the fact that its size is expected to increase to $280 billion by 2030.\u201d This expansive market, however, causes social and economic burdens, particularly with the wide range of subsequent adverse health effects that occur with pesticide exposure.<\/p>\n

The pesticide classes can further be identified by their chemical composition, which in turn indicates \u201cthe cellular and molecular targets for the biological action of pesticides,\u201d the researchers note. They continue: \u201cInsecticides primarily target the nervous system, acting as acetylcholinesterase inhibitors, nicotine receptor agonists, voltage-gated sodium channel inhibitors, gamma-aminobutyric acid inhibitors, etc. Rodenticides can act as anticoagulants or mitochondrial oxidative phosphorylation uncouplers. Fungicides can inhibit energy metabolism, microtubule assembly, or synthesis of fungal sterols. Likewise, herbicides target specific plant metabolic pathways, for instance, inhibiting photosynthetic processes, as well as amino acid or lipid synthesis.\u201d<\/p>\n

Despite these varying mechanisms of action and molecular targets, many pesticides could share common cytotoxic (damaging living cells) mechanisms. One of the main mechanisms that has been widely documented is oxidative stress<\/a>. This is \u201ctriggered by excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)\u201d and can be a driving force of pesticide-induced cytotoxicity. (See study here<\/a>.) Research (see here<\/a> and here<\/a>) also shows that inflammation can lead to pesticide-induced toxicity.<\/p>\n

This toxicity is linked to liver diseases, which is a large group of disorders that include nonalcoholic fatty liver disease (NAFLD), hepatitis, fibrosis<\/a>, cirrhosis, liver cancer (hepatocellular carcinoma), and more. Liver disease is a leading cause of death globally, causing about 2 million deaths<\/a> per year.<\/p>\n

Understanding the effects of pesticides on liver cells is complex, as multiple mechanisms linked to liver disease are also linked to pesticide exposure. One study<\/a> shows: \u201csimultaneous involvement of oxidative stress, mitochondrial dysfunction, impaired glucose and lipid metabolism in liver damage. Therefore, the hepatotoxicity of pesticides might be multifaceted and suggests involvement of a wide array of cellular and molecular events.\u201d<\/p>\n

As the authors state, \u201cA compelling body of evidence clearly demonstrates that a wide spectrum of pesticides might facilitate the development and progression of liver diseases through altering lipid and carbohydrate metabolism, triggering oxidative stress, ER [endoplasmic reticulum] stress, and mitochondrial dysfunction in liver cells, stimulating apoptosis, promoting fibrosis, and inflammation… Although the links between pesticides, non-apoptotic RCDs, and inflammation in the liver are well-established, there is a lack of studies that directly investigate non-apoptotic RCD-mediated effects on inflammation.\u201d This literature review aims to fill that research gap and \u201cexpand the landscape of the hepatotoxicological [liver damage caused by chemical substances] mechanisms associated with pesticides.\u201d<\/p>\n

Apoptotic Regulated Cell Death<\/strong><\/p>\n

A multitude of studies show how pesticides elicit hepatotoxicity through apoptosis. This research indicates that pesticide exposure is linked to \u201cthe increased risk of NAFLD, hepatocellular carcinoma, hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and elevation of circulating liver function markers,\u201d among others.<\/p>\n

Impaired lipid metabolism and lipogenesis (the process of synthesizing fatty acids and triglycerides) is attributed to pesticide exposure. Scientific literature finds organochlorines (such as dieldrin<\/a>), neonicotinoids (imidacloprid<\/a>), and pyrethroids (permethrin<\/a>) can alter lipid metabolism. The fungicides carbendazim<\/a> and propamocarb<\/a> can also alter gene expression within the liver, disrupting critical processes. \u201cIn addition to lipid metabolism, pesticides affect carbohydrate metabolism in liver cells, which also impairs the functions of hepatocytes [main functional cells of the liver],\u201d the researchers say. Exposure to the organophosphates dichlorvos<\/a>, monocrotophos<\/a>, and malathion<\/a> can impact these cells, elevating risks for liver disorders.<\/p>\n

Mitochondrial dysfunction<\/a> also plays a role in pesticide-induced hepatotoxicity, which one study connects to exposure of chlorpyrifos<\/a>, endosulfan<\/a>, fenpyroximate<\/a>, paraquat<\/a>, pendimethalin<\/a>, rotenone<\/a>, and tebufenpyrad<\/a>. Another study<\/a> finds that the neonicotinoid insecticides dinotefuran<\/a>, nitenpyram<\/a>, and acetamiprid<\/a> promotes mitochondrial dysfunction of liver cells and oxidative stress.<\/p>\n

The link between oxidative stress and pesticide-induced apoptosis \u201chas been clearly shown,\u201d according to the authors. (See additional Daily News<\/em> coverage here<\/a>.) Research also documents the role of pesticides in triggering hepatic inflammation. One study<\/a> notes morphological signs of inflammation in rat livers following exposure to imidacloprid, while another study<\/a> finds similar results in mice administered chlorpyrifos. \u201cThus, a wide spectrum of pesticides triggers hepatic inflammation, which aggravates their hepatotoxic effects,\u201d the researchers write.<\/p>\n

Non-Apoptotic Regulated Cell Death<\/strong><\/p>\n

Stress-induced cell death can create an inflammatory immune response, such as those documented in pesticide-induced non-apoptotic RCD. In explaining the difference, the authors say, \u201cApoptosis is a non-inflammatory, caspase-dependent programmed cell death, while necroptosis, pyroptosis, and ferroptosis are pro-inflammatory, regulated lytic<\/a> cell deaths.\u201d<\/p>\n

These three types of non-apoptotic RCD are \u201cthe most documented and widely studied RCD pathways in liver pathology, contributing to a broad spectrum of liver diseases,\u201d highlighting the various mechanisms through which pesticides can cause liver damage. The researchers state, \u201cIncreasing evidence summarized in Table 1<\/a> suggests that induction of non-apoptotic cell death pathways like necroptosis, ferroptosis, and pyroptosis is a common mechanism of pesticide-induced toxicity.\u201d<\/p>\n

Ferroptosis<\/em><\/p>\n

This type of cell death incorporates ferrous iron, with the hallmarks of ferroptosis, including alterations in the levels of iron, as well as changes in lipid and redox metabolism. Oxidative stress, impaired lipid metabolism, and ferroptosis are all linked to liver disease, with ferroptosis particularly promoting liver fibrosis<\/a>.<\/p>\n

\u201cOur analysis reveals that ferroptosis-mediated detrimental health effects of pesticides are currently the most studied, and ferroptosis contributes to pesticide-mediated nephrotoxicity (kidney), pulmonary toxicity, neurological damage, cardiotoxicity, reproductive dysfunction, intestinal injury, and immunotoxicity,\u201d the authors share. \u201cTaken together, oxidative stress mediated by the generation of ROS and lipid peroxides is crucial for pesticide-induced ferroptosis.\u201d<\/p>\n

Necroptosis<\/em><\/p>\n

Necroptosis is similar to and connected with apoptosis, as both pathways involve death receptor signaling. Usually, necroptosis is considered a backup mechanism if cells fail to die by apoptosis, but this process can also occur in isolation. Necroptosis can \u201cpromote progression of steatosis [fatty liver disease] to fibrosis and then to hepatocellular carcinoma\u201d (see study here<\/a>) and \u201caccumulating evidence demonstrates that necroptosis triggered by pesticides might be involved in neurotoxicity and neurodegeneration, renal injury, cardiac dysfunction, and immunotoxicity.\u201d Some of the pesticides that induce necroptosis include rotenone, chlorothalonil<\/a>, paraquat, dichlorvos, imidacloprid, and lambda-cyhalothrin<\/a>, with ROS and oxidative stress acting as a major contributor to the regulated cell death.<\/p>\n

Pyroptosis<\/em><\/p>\n

Pyroptosis is another inflammation-promoting cell death pathway, with a growing body of evidence that supports the significant impact of pyroptosis on liver diseases. \u201cRecent studies on pesticide-induced pyroptosis have unveiled its impact on kidney damage, neurological diseases, intestinal and pancreatic disorders, and immunotoxicity,\u201d the researchers state. Pesticides, including imidacloprid, fenpropathrin<\/a>, thiacloprid<\/a>, paraquat, malathion, rotenone, and propisochlor<\/a>, are documented as triggering pyroptosis. Similar to the other non-apoptotic RCD pathways, oxidative stress plays a role in pyroptosis.<\/p>\n

Literature Review Outcomes<\/strong><\/p>\n

In analyzing the well-documented connection between apoptosis and pesticides, as well as the smaller body of existing literature on ferroptosis, necroptosis, and pyroptosis in the liver, the authors find that ROS and oxidative stress act as key drivers of pesticide-induced cell death. This connects the role of inflammation in liver diseases to stress-induced environmental contaminants.<\/p>\n

The authors state: \u201cThe current experimental evidence clearly indicates that a wide spectrum of pesticides can trigger non-apoptotic RCDs in different tissues, which underscores the importance of this mechanism. In this review, we have focused on the role of RCDs, e.g., ferroptosis, necroptosis, and pyroptosis, in the emergence and progression of liver diseases associated with pesticide exposure. Accumulating evidence summarized in this review suggests that these emerging forms of RCD might be involved in promoting and orchestrating inflammation, liver tissue remodeling, steatosis, and fibrosis.\u201d While the mechanisms of pesticide toxicity are highly complex, this literature reviews adds to the mounting scientific evidence linking pesticide exposure to elevated disease risks.<\/p>\n

Beyond Pesticides\u2019 Resources<\/strong><\/p>\n

To learn more about liver damage and liver failure, see Daily News<\/em> coverage here<\/a> and here<\/a>. The Pesticide-Induced Diseases Database<\/a>, containing nearly 3,000 studies, documents elevated rates of additional chronic diseases among people exposed to pesticides, with increasing numbers of studies associated with both specific illnesses and a range of illnesses. The Gateway on Pesticide Hazards and Safe Pest Management<\/a> also provides information on specific pesticide active ingredients, with links to factsheets, health and environmental effects, regulatory status, key studies, alternatives, and more.<\/p>\n

Beyond Pesticides\u2019 mission<\/a> is to protect public health and the environment by leading the transition to a world free of toxic chemicals. This can be accomplished through the elimination of petrochemical pesticides and synthetic fertilizers use in agriculture and land management with the adoption of organic systems<\/a>. Learn more about the health and environmental benefits of organic methods, as widely documented and supported by science (see here<\/a>, here<\/a>, and here<\/a>), and take action<\/a> to advance the organic movement.<\/p>\n

All unattributed positions and opinions in this piece are those of Beyond Pesticides. <\/em><\/p>\n

Source<\/strong>:<\/p>\n

Khairullina, Z. et al<\/em>. (2026) Pesticides Drive Liver Diseases Through Non-Apoptotic Regulated Cell Death Pathways, Diseases<\/em>. Available at: https:\/\/www.mdpi.com\/2079-9721\/14\/3\/96<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, March 25, 2026) A literature review, published in Diseases, showcases the wide body of scientific literature linking pesticide exposure to liver disease through both apoptotic (programmed cell death without triggering inflammation) and non-apoptotic (regulated cell death with an inflammatory response) pathways. \u201cIn summary, our study confirms that pesticides carry significant health risks and sheds light on the underreported mechanisms that can drive their overall toxicity as a whole and hepatotoxicity [liver] in particular,\u201d the researchers state. \u00a0In addition to analyzing the science on pesticide-induced apoptosis, the researchers \u201csystematically illustrated an underappreciated mechanism of pesticide-induced overall and hepatic toxicity, i.e., the ability to induce non-apoptotic regulated cell death (RCD) pathways such as ferroptosis, necroptosis, and pyroptosis.\u201d They continue, saying, \u201cImportantly, our review stresses the contribution of pesticide-induced cell death modes to inflammation and immunity regulation in hepatic pathology.\u201d Background Pesticides, as a comprehensive group, can be subdivided into classes based on their targets: rodenticides (rodents), herbicides (weeds), insecticides (insects), fungicides (fungi), nematicides (nematodes), acaricides (mites and ticks), and bactericides (bacteria). The use of these pesticides, particularly in agriculture, has skyrocketed over recent decades. As the authors state: \u201cIn 2019, the total pesticide market size was estimated to approach $85 […]<\/p>\n","protected":false},"author":2,"featured_media":41247,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[196,374,494,2370,582,399,313],"tags":[700,2525,2071,2526,2047,1270,989,2529,1188,2527,1269,2528],"class_list":["post-41245","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-fungicides","category-herbicides","category-insecticides","category-liver-damage","category-oxidative-stress","category-rodenticide","tag-apoptosis","tag-cell-death","tag-cytotoxicity","tag-ferroptosis","tag-hepatotoxicity","tag-inflammation","tag-liver","tag-liver-cancer","tag-liver-disease","tag-necroptosis","tag-oxidative-stress","tag-pyroptosis"],"yoast_head":"\nReview Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"description\" content=\"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/beyondpesticides\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/beyondpesticides\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-25T04:01:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Beyond Pesticides\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ByondPesticides\" \/>\n<meta name=\"twitter:site\" content=\"@ByondPesticides\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Beyond Pesticides\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/\"},\"author\":{\"name\":\"Beyond Pesticides\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4\"},\"headline\":\"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases\",\"datePublished\":\"2026-03-25T04:01:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/\"},\"wordCount\":1665,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization\"},\"image\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg\",\"keywords\":[\"apoptosis\",\"cell death\",\"cytotoxicity\",\"ferroptosis\",\"hepatotoxicity\",\"inflammation\",\"liver\",\"liver cancer\",\"liver disease\",\"necroptosis\",\"oxidative stress\",\"pyroptosis\"],\"articleSection\":[\"Cancer\",\"Fungicides\",\"Herbicides\",\"Insecticides\",\"Liver Damage\",\"Oxidative Stress\",\"Rodenticide\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/\",\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/\",\"name\":\"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases - Beyond Pesticides Daily News Blog\",\"isPartOf\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg\",\"datePublished\":\"2026-03-25T04:01:29+00:00\",\"description\":\"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases.\",\"breadcrumb\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage\",\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg\",\"contentUrl\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg\",\"width\":1920,\"height\":1080,\"caption\":\"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#website\",\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/\",\"name\":\"Beyond Pesticides Daily News Blog\",\"description\":\"News on Pesticide Science, Policy and Activism\",\"publisher\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization\",\"name\":\"Beyond Pesticides\",\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2023\/05\/BeyondPesticides-Logo-Stacked-scaled.jpg\",\"contentUrl\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2023\/05\/BeyondPesticides-Logo-Stacked-scaled.jpg\",\"width\":2560,\"height\":2501,\"caption\":\"Beyond Pesticides\"},\"image\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/beyondpesticides\",\"https:\/\/x.com\/ByondPesticides\",\"https:\/\/www.instagram.com\/beyondpesticides\/?hl=en\",\"https:\/\/www.linkedin.com\/company\/beyond-pesticides\",\"https:\/\/www.youtube.com\/user\/bpncamp\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4\",\"name\":\"Beyond Pesticides\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/e26b7558fcb265e244c6e159abe5f0aab551822dc82fd0b1607e809bdfbed20a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/e26b7558fcb265e244c6e159abe5f0aab551822dc82fd0b1607e809bdfbed20a?s=96&d=mm&r=g\",\"caption\":\"Beyond Pesticides\"},\"description\":\"Beyond Pesticides is a 501(c)3 nonprofit organization headquartered in Washington, D.C., which works with allies in protecting public health and the environment to lead the transition to a world free of toxic pesticides. The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. Beyond Pesticides believes that people must have a voice in decisions which affect them directly.\",\"sameAs\":[\"https:\/\/www.beyondpesticides.org\",\"https:\/\/www.facebook.com\/beyondpesticides\/\",\"https:\/\/www.instagram.com\/beyondpesticides\/\",\"https:\/\/www.linkedin.com\/company\/beyond-pesticides\/\",\"https:\/\/x.com\/ByondPesticides\",\"https:\/\/www.youtube.com\/user\/bpncamp\/\"],\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/author\/beyond-pesticides\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases - Beyond Pesticides Daily News Blog","description":"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/","og_locale":"en_US","og_type":"article","og_title":"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases - Beyond Pesticides Daily News Blog","og_description":"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases.","og_url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/","og_site_name":"Beyond Pesticides Daily News Blog","article_publisher":"https:\/\/www.facebook.com\/beyondpesticides","article_author":"https:\/\/www.facebook.com\/beyondpesticides\/","article_published_time":"2026-03-25T04:01:29+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg","type":"image\/jpeg"}],"author":"Beyond Pesticides","twitter_card":"summary_large_image","twitter_creator":"@ByondPesticides","twitter_site":"@ByondPesticides","twitter_misc":{"Written by":"Beyond Pesticides","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#article","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/"},"author":{"name":"Beyond Pesticides","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4"},"headline":"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases","datePublished":"2026-03-25T04:01:29+00:00","mainEntityOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/"},"wordCount":1665,"commentCount":0,"publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage"},"thumbnailUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg","keywords":["apoptosis","cell death","cytotoxicity","ferroptosis","hepatotoxicity","inflammation","liver","liver cancer","liver disease","necroptosis","oxidative stress","pyroptosis"],"articleSection":["Cancer","Fungicides","Herbicides","Insecticides","Liver Damage","Oxidative Stress","Rodenticide"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/","name":"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases - Beyond Pesticides Daily News Blog","isPartOf":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage"},"thumbnailUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg","datePublished":"2026-03-25T04:01:29+00:00","description":"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases.","breadcrumb":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#primaryimage","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg","contentUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2026\/03\/DN-3.25.26.jpg","width":1920,"height":1080,"caption":"In a literature review of pesticide-induced liver diseases, researchers find multiple types of cell death contribute to the diseases."},{"@type":"BreadcrumbList","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/03\/review-links-pesticide-induced-mechanisms-of-cell-death-to-increased-risks-of-liver-diseases\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/beyondpesticides.org\/dailynewsblog\/"},{"@type":"ListItem","position":2,"name":"Review Links Pesticide-Induced Mechanisms of Cell Death to Increased Risks of Liver Diseases"}]},{"@type":"WebSite","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#website","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/","name":"Beyond Pesticides Daily News Blog","description":"News on Pesticide Science, Policy and Activism","publisher":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/beyondpesticides.org\/dailynewsblog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization","name":"Beyond Pesticides","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/logo\/image\/","url":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2023\/05\/BeyondPesticides-Logo-Stacked-scaled.jpg","contentUrl":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-content\/uploads\/2023\/05\/BeyondPesticides-Logo-Stacked-scaled.jpg","width":2560,"height":2501,"caption":"Beyond Pesticides"},"image":{"@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/beyondpesticides","https:\/\/x.com\/ByondPesticides","https:\/\/www.instagram.com\/beyondpesticides\/?hl=en","https:\/\/www.linkedin.com\/company\/beyond-pesticides","https:\/\/www.youtube.com\/user\/bpncamp"]},{"@type":"Person","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4","name":"Beyond Pesticides","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/e26b7558fcb265e244c6e159abe5f0aab551822dc82fd0b1607e809bdfbed20a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/e26b7558fcb265e244c6e159abe5f0aab551822dc82fd0b1607e809bdfbed20a?s=96&d=mm&r=g","caption":"Beyond Pesticides"},"description":"Beyond Pesticides is a 501(c)3 nonprofit organization headquartered in Washington, D.C., which works with allies in protecting public health and the environment to lead the transition to a world free of toxic pesticides. The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. Beyond Pesticides believes that people must have a voice in decisions which affect them directly.","sameAs":["https:\/\/www.beyondpesticides.org","https:\/\/www.facebook.com\/beyondpesticides\/","https:\/\/www.instagram.com\/beyondpesticides\/","https:\/\/www.linkedin.com\/company\/beyond-pesticides\/","https:\/\/x.com\/ByondPesticides","https:\/\/www.youtube.com\/user\/bpncamp\/"],"url":"https:\/\/beyondpesticides.org\/dailynewsblog\/author\/beyond-pesticides\/"}]}},"_links":{"self":[{"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/posts\/41245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/comments?post=41245"}],"version-history":[{"count":1,"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/posts\/41245\/revisions"}],"predecessor-version":[{"id":41246,"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/posts\/41245\/revisions\/41246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/media\/41247"}],"wp:attachment":[{"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/media?parent=41245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/categories?post=41245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/beyondpesticides.org\/dailynewsblog\/wp-json\/wp\/v2\/tags?post=41245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}