{"id":41562,"date":"2026-05-11T00:01:52","date_gmt":"2026-05-11T04:01:52","guid":{"rendered":"https:\/\/beyondpesticides.org\/dailynewsblog\/?p=41562"},"modified":"2026-05-11T00:19:25","modified_gmt":"2026-05-11T04:19:25","slug":"public-health-advocates-call-for-review-of-adverse-synergistic-effects-of-pesticides-ignored-by-regulators","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/05\/public-health-advocates-call-for-review-of-adverse-synergistic-effects-of-pesticides-ignored-by-regulators\/","title":{"rendered":"Public Health Advocates Call for Review of Adverse Synergistic Effects of Pesticides, Ignored by Regulators  \u00a0"},"content":{"rendered":"\r\n<p>(<em>Beyond Pesticides<\/em>, May 11, 2026) As studies stack up on adverse synergistic effects of chemical mixtures, serious deficiencies in the regulatory review of pesticides have come into sharp focus. As the hazards are shown to escalate and the regulatory review process is shown to fall short, public health advocates are telling Congress, the U.S. Environmental Protection Agency, and the Department of Health and Human Services that they <strong><a href=\"https:\/\/secure.everyaction.com\/SiWXvv8E00GkI8wKVJ6aAA2##anchor\">must consider the effects of pesticides in the context in which they are used and with reference to the organic alternative.<\/a><\/strong>\u00a0<\/p>\r\n<p>A\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.mdpi.com%2F2305-6304%2F14%2F5%2F373&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275182704%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=bt4F6u2dta6RbVrFnLSxOMSnuwuoyg%2F%2FyRs7D9lkE3g%3D&amp;reserved=0\">recent study in\u00a0<em>Toxics<\/em><\/a>\u00a0reviewed the current literature on pesticides, microplastics, or metal exposure in combination with per- and polyfluoroalkyl substances (PFAS) on aquatic vertebrates and invertebrates, finding that\u00a0PFAS can\u00a0modify, including intensify, the toxicity of co-occurring pollutants.\u00a0\u00a0<\/p>\r\n<p>A commentary in\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.frontiersin.org%2Fjournals%2Ftoxicology%2Farticles%2F10.3389%2Fftox.2024.1444024%2Ffull&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275142818%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=6QQTWBTikzmyEjn3giuKcFXe6GnTqnSMTsVEtFAGI%2BY%3D&amp;reserved=0\"><em>Frontiers in Toxicolog<\/em>y<\/a>, by \u00a0Maricel Maffini, PhD, and Laura Vandenberg, PhD, \u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2024%2F09%2Fhuman-health-disregarded-with-obsolete-regulations-and-risk-management-researchers-find%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275093116%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=9cnBi3VOZXRb9ONLpuZjR8QZRTmU8xZJYWR4tPOn0xg%3D&amp;reserved=0\">notes<\/a>, \u201cCurrent approaches also rely on the assumption that testing chemicals one at a time is\u00a0appropriate to\u00a0understand how chemicals act under real-world conditions. Numerous mixture studies, including ones that\u00a0demonstrated\u00a0cumulative effects, have disproven this assumption.\u201d\u00a0\u00a0<\/p>\r\n<p>As noted by the naturalist, writer, and conservationist John Muir, known as the \u201cFather of the National Parks,\u201d and those before and after him, including the English poet John Donne, who wrote \u201cNo Man is an Island\u201d in 1624, all life is interconnected. As a result, synergism is the rule, rather than the exception. John Muir put it succinctly: \u201cWhen we try to pick out anything by itself, we find it hitched to everything else in the universe.\u201d\u00a0\u00a0<\/p>\r\n<p><u>Examples of synergistic effects of pesticides abound<\/u>.\u00a0\u00a0<\/p>\r\n<ul>\r\n\t<li>The presence of Varroa mites in combination with the\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fchemicals%2Fneonicotinoids%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275212476%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Kk5BiopEOQ6oEfkf0psvCmou5EVy2FzNdMDwBEX9omI%3D&amp;reserved=0\">neonicotinoid<\/a>\u00a0insecticide imidacloprid increases the risk of bee mortality and disrupts the larval\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Ftag%2Fgut-microbiome%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275239003%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=ZqbPancJdoy2ThnDB25up2la8Kj56Fj4u%2F5fSmVBLG4%3D&amp;reserved=0\">gut microbiome<\/a>, according to a\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F08%2Fstudy-shows-synergistic-effects-of-pesticides-and-mites-in-bees-adding-to-science-on-colony-decline%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275267005%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=EIQXLqd%2BWJJp%2BmuTChh8CWkgV4xNb4cAshL7o9uZftk%3D&amp;reserved=0\">study<\/a>\u00a0of the\u00a0synergy\u00a0between the parasitic mite\u00a0<em>Varroa destructor<\/em>\u00a0and imidacloprid. An\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2024%2F07%2Fneonicotinoid-insecticides-contribute-to-honey-bee-vulnerability-to-parasitic-varroa-mites%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275291198%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=TXdB6HQ4mfSdtN89APCeeCLETd7YZ6YV81l5UWJ1wd0%3D&amp;reserved=0\">article<\/a>\u00a0in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fentomologytoday.org%2F2024%2F06%2F20%2Fneonicotinoid-exposure-worsens-varroa-mite-infestations-honey-bees-study%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275321149%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=18A%2FzJkB4WP0t5EcaCzS0GXy7MGMDEXttyegEnn4Y2U%3D&amp;reserved=0\">Entomology Today<\/a><\/em>, a publication of the Entomological Society of America, highlights the important findings of a study published earlier this year in the\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Facademic.oup.com%2Fjinsectscience%2Farticle%2F24%2F3%2F20%2F7683866&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275356557%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=gQldYlxj22uQgTSh1E9OQ6CKyHZL1pTrnKn9d%2B6zvYE%3D&amp;reserved=0\"><em>Journal of Insect Science<\/em>.<\/a>\u00a0While there has been debate on whether\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2014%2F05%2Fpesticides-not-mites-or-pathogens-cause-honey-bee-decline%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275389550%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=qDOtyQWiOIXmiw%2BEyJt%2B3Z1XDYm9c1ZIFeEP3zt04%2B0%3D&amp;reserved=0\">neonicotinoid<\/a>\u00a0(neonic) insecticides or\u00a0Varroa\u00a0mites\u00a0are more detrimental to the survival of bees, evidence suggests that neonicotinoids are not only harmful individually but can increase vulnerability to parasitism from mites in western honey bees (<em>Apis mellifera<\/em>).\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>A review in\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.imrpress.com%2Fjournal%2FCEOG%2F52%2F8%2F10.31083%2FCEOG39882%2Fhtm&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275422990%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=RDoHlIbs%2B6BIrC3Eb23wIlngRNXXSJi6iBx4SCpvEUg%3D&amp;reserved=0\"><em>Clinical and Experimental Obstetrics &amp; Gynecolog<\/em>y<\/a>\u00a0analyzes studies linking exposure to environmental contaminants with adverse effects to women&#8217;s reproductive health. The chemical classes within the review include plasticizers,\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fchemicals%2Fpfas%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275447067%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=nRkpugy9AeBRjDSgZpiJEr46c2KRj5mBJ8pur3geabQ%3D&amp;reserved=0\">PFAS<\/a>, heavy metals, pesticides, organophosphate flame retardants (OPFRs), polychlorinated biphenyls (PCBs),\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fvolatile-organic-compounds%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275468247%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=gmSQHdrU1ZG92eI2VTH4mLh6VeFVn8pjzZzLrfs5uj8%3D&amp;reserved=0\">volatile organic compounds<\/a>\u00a0(VOCs),\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Ftag%2Fmicroplastic%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275494655%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=PKJJWDLNUOTFHSzfTBYGOpfPZNGGQEzqU%2FipqvoUPhY%3D&amp;reserved=0\">microplastics<\/a>,\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fassets%2Fmedia%2Fdocuments%2FFactsheet%2520-%2520Quaternary%2520Ammonium%2520Compounds.pdf&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275526036%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=sS2wEvyy1qsUU8EDuY42EjdlGY23Zhm882ncxMHJ9y0%3D&amp;reserved=0\">quaternary ammonium compounds<\/a>\u00a0(QACs), and polycyclic aromatic hydrocarbons (PAHs), many of which are related to chemical-intensive land management and can exacerbate health effects through additive or\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fsynergistic-effects%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275569916%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=aoG5vEz2gQmGmpKKg945Fad8NB98eUyCxCcTzjo3Ffo%3D&amp;reserved=0\">synergistic effects<\/a>, like\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F02%2Finteractions-between-microplastics-and-pesticides-exacerbate-their-environmental-health-threat-studies-find%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275633747%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=lbkHoLhwDA8HMbO0ndy0BugdIjqSJQvy6GSgq%2FPx0Hk%3D&amp;reserved=0\">microplastics<\/a>\u00a0when in contact with petrochemical pesticides and synthetic fertilizers.<br \/>\r\n\u00a0<\/li>\r\n\t<li>The scientific literature shows that microplastics (MPs) and pesticides, both ubiquitous throughout the environment, have\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F07%2Fresearch-finds-heightened-toxicity-to-aquatic-organisms-from-microplastic-pesticide-interactions%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275708571%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=xWClRNcEQFcitEAo25UR9KmdXzY7hFPZsQhR4Ux54CA%3D&amp;reserved=0\">synergistic effects<\/a>\u00a0that threaten aquatic organisms. The most recent study to\u00a0demonstrate\u00a0this, published in\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs10646-025-02909-5&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275776375%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=ffch8ww5oAmclbSCDq%2FohnjmPIIYokeT4xzHA6Uln4A%3D&amp;reserved=0\"><em>Ecotoxicolog<\/em>y<\/a>, focuses on the impacts of MPs and\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fresources%2Fpesticide-gateway%3Fpesticideid%3D17&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275833699%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=gyGx5QLQPh2%2FQqtHWUF4dI2ZYq7ZlBE9%2FE1GaydoH18%3D&amp;reserved=0\">chlorpyrifos<\/a>\u00a0(CPF), a widely used organophosphate insecticide, on\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedirect.com%2Ftopics%2Fearth-and-planetary-sciences%2Fcladocera&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275890613%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=IaSefeg52hlE2cS4qTle4mfkiySBKF%2Ba6tm4BJ%2FDcE8%3D&amp;reserved=0\">cladocerans<\/a>, a group of\u00a0microcrustaceans.\u00a0A\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F02%2Finteractions-between-microplastics-and-pesticides-exacerbate-their-environmental-health-threat-studies-find%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871275958520%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=z2psOWAKkMfwM%2BFpBNGc1FDXRLa0y63iI5kpXd0HZP0%3D&amp;reserved=0\">literature review of over 90 scientific articles<\/a>\u00a0in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.mdpi.com%2F2077-0472%2F15%2F4%2F356&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276015357%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=EYcti78lfLd952ss3spcUVCXJXqUdhpoS8IWBvlQBas%3D&amp;reserved=0\">Agriculture<\/a><\/em>\u00a0documents that MPs increase the bioavailability, persistence, and toxicity of pesticides used in agriculture. In\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2024%2F07%2Fenhanced-bioavailability-and-contamination-of-neonicotinoid-pesticides-linked-to-microplastics-in-soil%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276071507%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=W4ciBcLEa7a6JudxbOGJcQUwKgsAMuiAxpS9KuB8BJA%3D&amp;reserved=0\">analyzing the interactions<\/a>\u00a0between neonicotinoid pesticides (NNPs) and MPs, a recent study in\u00a0<em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38972406\/\">The Science of The Total Environment<\/a><\/em>\u00a0finds that neonicotinoids, such as thiacloprid (THI), become more bioavailable in soils containing traditional and biodegradable plastics. Increased bioavailability, which quantifies the extent to which organisms are exposed to chemicals in soil or sediment, puts\u00a0<a href=\"https:\/\/www.beyondpesticides.org\/programs\/wildlife\/soil-biota\">soil microbiota<\/a>\u00a0at risk, and leaves all consumers susceptible to adverse effects in contaminated\u00a0<a href=\"https:\/\/www.beyondpesticides.org\/resources\/eating-with-a-conscience\/overview\">food crops<\/a>.<br \/>\r\n\u00a0<\/li>\r\n\t<li>A study in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Froyalsocietypublishing.org%2Fdoi%2F10.1098%2Frsos.250281&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276367009%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=lmbvJ4WGVXRkOxrCaD3s8PV%2F2ePI2DXJ%2BHaW8A0wLs4%3D&amp;reserved=0\">Royal Society Open Science<\/a><\/em>\u00a0shows intraspecific differences (between individuals of a species) in wild\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fprograms%2Fbee-protective-pollinators-and-pesticides%2Fwhat-the-science-shows&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276406067%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=WfZHRLxakVkBUUXhNqhz4I5j4q6iSYoK4DZHpdQ8Iic%3D&amp;reserved=0\">bumblebees<\/a>\u00a0(<em>Bombus\u00a0vosnesenskii<\/em>) exposed to an herbicide (<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fresources%2Fpesticide-gateway%3Fpesticideid%3D37&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276458414%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=1lpvHOx700C6OpleVa97WLf4vlQ1gf36sxN5urXY8DA%3D&amp;reserved=0\">glyphosate<\/a>), a fungicide (<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fresources%2Fpesticide-gateway%3Fpesticideid%3D282&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276519902%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=soTGbWyRWUVnxQ63nzfeILdPs9Qf9DKzPuoi08hHdNQ%3D&amp;reserved=0\">tebuconazole<\/a>), and an insecticide (<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fresources%2Fpesticide-gateway%3Fpesticideid%3D39&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276573955%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=P0u7LY%2FdBIuQpYWd5uUSRrQ8YcvapK5vJk5gkoCNt2c%3D&amp;reserved=0\">imidacloprid<\/a>), with gut microbiome health as a factor. The authors conclude, \u201cThese findings suggest that site-specific factors influence pesticide sensitivity and should be considered in ecotoxicological studies of wild bees.\u201d\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>Researchers\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F07%2Fmass-kill-of-monarch-butterflies-in-california-linked-to-pesticide-residues-in-their-bodies%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276636397%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Pq7RquuP6P6BeUMHFFnv%2BRgrXnEqahN7Sca%2FSqzN%2F64%3D&amp;reserved=0\">studying a mass mortality event<\/a>\u00a0of approximately 200\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Ftag%2Fmonarch-butterfly%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276688358%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=2O8nciMcACM5f1Eid98MIiZjMi1dnBwc9mDQUIOT24M%3D&amp;reserved=0\">monarch butterflies<\/a>\u00a0(<em>Danaus\u00a0plexippus\u00a0plexippus<\/em>) in Pacific Grove, California, point out that there are\u00a0additional\u00a0issues in assessing risks to species since \u201cavailable toxicity values are based on exposure to a single active ingredient, whereas all the sampled monarchs contained residues of multiple pesticides.\u201d Exposure to multiple pesticides can result in\u00a0additive\u00a0or\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fsynergistic-effects%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276736920%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=ZuEwFB4Uctut0uGLj7Y41j%2FR7Vv1sL9arKTqXhzD1U4%3D&amp;reserved=0\">synergistic effects<\/a>, which then enhance toxicity, as has been\u00a0demonstrated\u00a0in many studies of pollinator species.\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>A common soil arthropod has\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F05%2Fstudy-finds-synergistic-convergence-of-global-warming-pesticide-toxicity-and-antibiotic-resistance%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276787798%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=lvKS2PkOSFAPriU4GApVHkh%2Bunav95u%2BLZ4hA3vQwUc%3D&amp;reserved=0\">clearly illustrated<\/a>\u00a0how this convergence creates synergistic effects: warming increases pesticide toxicity; pesticide toxicity triggers antibiotic resistance; antibiotic resistance spreads through\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fassets%2Fmedia%2Fdocuments%2Fjournal%2Fbp-36.4-w17-Antibiotics-Cited2.pdf&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276831490%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Sl5z3qklR%2B%2BYvOky0B0frNZpIwAvO1wjDIe9Agog0K8%3D&amp;reserved=0\">horizontal gene transfer<\/a>\u00a0(movement through the environment to people), and predation.\u00a0\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>Published in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0269749125007729&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276875418%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=B5d0696xc5ttmsvPRGWGCkpSEMLN%2BPm%2FI2A4LMScLgw%3D&amp;reserved=0\">Environmental Pollution<\/a><\/em>, a\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F06%2Fpesticide-residues-in-pet-food-threaten-health-of-companion-animals-regulatory-deficiencies-cited%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276924559%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=D52IO9r4ajEeDsqaAtcFjlP%2BvecfN2ZGiIrz%2Fe%2FXAv4%3D&amp;reserved=0\">study<\/a>\u00a0of commercial dry pet products finds dietary pesticide residues in dog and cat food, \u201chighlighting the urgent need for improved regulatory frameworks to address the presence of non-approved pesticides in pet food.\u201d Additionally, the researchers point out: \u201cCurrent regulatory frameworks primarily assess the toxicity of individual pesticide compounds, yet real-world exposure involves complex mixtures that may lead to additive or\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fsynergistic-effects%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871276964458%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=oZwm4g2aSNrXjyWP7tyRh7HmONHSOYs0buyrcuStWeU%3D&amp;reserved=0\">synergistic effects<\/a>. The presence of multiple residues in a single sample suggests that companion animals may be subjected to combined toxicological burdens that are not yet fully understood.\u201d\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>A\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F04%2Fwidely-used-fungicide-mixed-with-natural-mycotoxins-increases-toxicity-of-treated-food-crops%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277000851%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=8d4CNRWAHzglQhIgJUzpnIVlSoUMTuVpfz2LXuv8naY%3D&amp;reserved=0\">recent study<\/a>\u00a0published in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.mdpi.com%2F2304-8158%2F14%2F7%2F1226&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277041266%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=zsOkB7CXewNkQbtIEbUzMZhiz4n%2FsftH0WhFIG%2FGoOE%3D&amp;reserved=0\">Foods<\/a><\/em>\u00a0assesses the ability of the fungicide\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fresources%2Fpesticide-gateway%3Fpesticideid%3D95&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277096200%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=qT6T%2BoNrg9aqrodhrLnJfpNO5JYB8%2FSGy0%2BKUTCVR8Q%3D&amp;reserved=0\">azoxystrobin<\/a>\u00a0(AZX) and naturally occurring toxins produced by certain fungi, known as mycotoxins, to display effects of cytotoxicity (cell damage). These effects were evaluated using three common mycotoxins found in food, including ochratoxin A, deoxynivalenol, and T-2 toxin as mixtures with AZX within human hepatocarcinoma cell cultures. In analyzing combinations of these compounds at sublethal concentrations, the authors find modified toxicological behavior and\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fassets%2Fmedia%2Fdocuments%2Finfoservices%2Fpesticidesandyou%2FWinter%252003-04%2FSynergy.pdf&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277153464%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Yp23ryT0hbi1fA17PAnkwKvJvsepAhN5%2F3igy8R3SCs%3D&amp;reserved=0\">synergistic effects<\/a>\u00a0that highlight the complexities of chemical mixtures, and potential threats to liver health\u00a0through dietary exposure to both toxicants and toxins, which are not adequately regulated for their interactions.\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F03%2Fstudy-of-pesticide-mixtures-and-intestinal-barrier-dysfunction-further-highlights-regulatory-deficiencies%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277212575%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=mBFYQ3fOhb9TB7AKkpNpBRwguIoYmYCDtdPzu3z3w%2BQ%3D&amp;reserved=0\">Study results<\/a>\u00a0published in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fabs%2Fpii%2FS0048357525000690&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277272272%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=9ZNUnEBRhSEX7DGrj2xRn28PYNKnCDNzpLfmTDJtzS8%3D&amp;reserved=0\">Pesticide Biochemistry and Physiology<\/a><\/em>\u00a0\u201csuggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.\u201d\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>A\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2025%2F03%2Fchildrens-health-threatened-as-rates-of-pediatric-cancers-are-linked-to-agricultural-pesticide-mixtures%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277323774%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=bst7tJU%2FoZIUJQyTjTAAqC%2FMgQbzuhKMr%2FX1MhKzsFM%3D&amp;reserved=0\">study<\/a>\u00a0in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fagupubs.onlinelibrary.wiley.com%2Fdoi%2F10.1029%2F2024GH001236&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277378341%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=QnxSYnoqEA73eezCAz0QPYfAvITFi6dHc1SNyL1K6Go%3D&amp;reserved=0\">GeoHealth<\/a><\/em>\u00a0of pediatric cancers in Nebraska links exposure to agricultural mixtures with the occurrence of these diseases. The authors find statistically significant positive associations between pesticide usage rates and children with\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fdiseasehealth-effects%2Fcancer%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277438521%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=m2NdWCZ6STOgMcMiF%2FJGmZufrelB40fuzmdMxrW2DYw%3D&amp;reserved=0\">cancer<\/a>, specifically brain and central nervous system (CNS) cancers and leukemia.\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>A\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2024%2F11%2Fglyphosate-and-mixtures-in-test-animals-show-lethal-and-sublethal-effects-to-embryos-highlights-regulatory-deficiencies%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277489594%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Z7Ox%2FnaXIiwzS09nPBVTXjKItyU0kPLJ1%2BuvpdQkJv8%3D&amp;reserved=0\">study<\/a>\u00a0in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0045653524025244&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277534293%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=AuCihfXhr%2FpbeAWxk4HnvPBoAqkUeZqpI%2FpGU%2FiAsms%3D&amp;reserved=0\">Chemosphere<\/a><\/em>, conducted by researchers from the Institute of Biochemistry and Molecular Biology in Germany, reveals the varied lethal and sublethal effects of different mixtures\u00a0of the weed killer glyphosate\u00a0through tests on the South African clawed frog,\u00a0<em>Xenopus laevis<\/em>. After exposing embryos to four glyphosate formulations, mortality, morphological defects, altered heartbeat rate, and impaired heart-specific gene expression are\u00a0observed.\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>In\u00a0their\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2024%2F10%2Fstudy-shows-climate-change-exacerbates-synergistic-effects-of-synthetic-pyrethroid-pesticide-threatens-biodiversity%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277590238%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=jKqADrpMX0fS42EP%2BJ1xtAt3z8nv2sCTooZrEO7zVNw%3D&amp;reserved=0\">recent publication<\/a>\u00a0in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0269749124018268&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277645282%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Liyk1bOg95UtgWoRylj8yuMPredeEh%2FcCecfs6FOHgY%3D&amp;reserved=0\">Environmental Pollution<\/a><\/em>, researchers from the\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.ufz.de%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277700089%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=RUNDdmWQWncpCoaeXvKOymfJ2umUKWsUlQiyadMOcmA%3D&amp;reserved=0\">Helmholtz Centre for Environmental Research<\/a>\u00a0in Leipzig, Germany, find the greatest\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fsynergistic-effects%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871277962656%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=v5d14rf4VODGHSRk%2Baix%2F6iymIBGaFuTZC9cvTMfyQM%3D&amp;reserved=0\">synergistic effects<\/a>\u00a0when\u00a0<em>Daphnia magna<\/em>\u00a0are subjected to the insecticide\u00a0esfenvalerate\u00a0under conditions experienced with climate change.\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>In a\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2024%2F06%2Fstudy-shows-importance-of-testing-pesticide-mixtures-to-determine-adverse-ecosystem-effects%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278015798%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=EH3VimNrOwTVO7vIYD1iYK%2Fuyvw%2B3gcs8bKzUO1nGss%3D&amp;reserved=0\">study<\/a>\u00a0published in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.mdpi.com%2F2227-9059%2F12%2F6%2F1176&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278068864%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=pjLMSHIpZL3Uu93I8PVpH52WeEV8mzJNLGfk1fm1Z9w%3D&amp;reserved=0\">Biomedicines<\/a><\/em>, the authors conduct a multi-behavioral evaluation of the effects of three pesticides, both individually and as mixtures, on larvae. The authors state, \u201cEven at low concentrations, pesticides can negatively affect organisms, altering important behaviors that can have repercussions at the population level.\u201d By analyzing effects on individual zebrafish with single compounds and\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2023%2F09%2Fepas-failure-to-assess-multiple-chemical-exposure-threat-creates-environmental-injustice-says-inspector-general%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278122407%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=AZ%2FmLhSAfVBm9AJ7clIVwSImR8BwtNJIDULvpgNsEog%3D&amp;reserved=0\">mixtures<\/a>, this study shows the dangers of pesticides in aquatic systems regarding\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2Fcategory%2Fsynergistic-effects%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278172047%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=gb9D%2FvhllVBiISeTCbkUgc5XX0XOr4WaGEq%2Ff8JzzI8%3D&amp;reserved=0\">synergy<\/a>\u00a0and the\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.beyondpesticides.org%2Fassets%2Fmedia%2Fdocuments%2FPAY.Summer.2018.pdf&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278222833%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Ic5Y76tOQtS3RRT3YmjTojEXSx5ICR3KmqrXwroAtMo%3D&amp;reserved=0\">ripples created throughout entire ecosystems<\/a>.\u00a0<\/li>\r\n<\/ul>\r\n<p><u>Other studies highlight the need for a broader overhaul of the current regulatory review to address critical flaws in EPA&#8217;s current ecological risk assessment process<\/u>.<\/p>\r\n<ul>\r\n\t<li>A November 2023 European\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41586-023-06773-3&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278269232%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=PRYLh29KopDiVU8lhknxi9e6XTXlAYQEjvSHPfrZLjA%3D&amp;reserved=0\">study<\/a>\u00a0published in\u00a0<em><a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41586-023-06773-3&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278305018%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=xYz68gaMqAT1fq67C1I%2FgM92o%2BGnqVBcZ6HFmDVF88c%3D&amp;reserved=0\">Nature<\/a><\/em>\u00a0demonstrates that relying on testing one active ingredient in a laboratory setting misses real-world impacts of pesticides on bees, nontarget pollinators;\u00a0and, a \u201clandscape-level\u201d study finds that typical risk assessment reviews used by EPA and European regulators fail to \u201csafeguard bees and other pollinators that support agricultural production and wild plant pollination.\u201d The authors&#8217; conclusions challenge \u201cthe current assumption of pesticide regulation\u2014that chemicals that individually pass laboratory tests and\u00a0semifield\u00a0[contained outdoors] trials are considered environmentally benign\u201d and call into question EPA&#8217;s current regulatory assessments based on the western honey bee and its failure to adequately regulate mixtures of chemicals to which organisms are exposed in the real world as well as the actual devastating impacts to pollinators from the ubiquitous neonicotinoids.\u00a0<br \/>\r\n\u00a0<\/li>\r\n\t<li>A<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fconbio.onlinelibrary.wiley.com%2Fdoi%2Ffull%2F10.1111%2Fconl.13022&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278330771%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=hXt0Rb35vofT3lAZ3vGzbdmZK59AqEc9k7%2BvtBmcYLQ%3D&amp;reserved=0\">\u00a0study<\/a>\u00a0published in\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fconbio.onlinelibrary.wiley.com%2Fdoi%2Ffull%2F10.1111%2Fconl.13022&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278361271%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=PMyM5UlxkiwxsRClx%2BCCD%2FeqMSm0NwcNL2u0eVfq4cM%3D&amp;reserved=0\"><em>Conservation Letters<\/em><\/a>, a journal of the Society for Conservation Biology, exposes critical shortcomings in the U.S. Environmental Protection Agency&#8217;s (EPA)\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.epa.gov%2Frisk%2Fecological-risk-assessment&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278382610%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=%2FmLyhUtFXBQ1YAUUwIPhPe%2FkohCPhikwHWyof3yqf9E%3D&amp;reserved=0\">ecological risk assessment (ERA)<\/a>\u00a0process for modeling the risks that pesticides pose to bees and other pollinators. For the study, \u201cRisk assessments underestimate threat of pesticides to wild bees,\u201d researchers conducted a meta-analysis of toxicity data in EPA&#8217;s\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.epa.gov%2Fcomptox-tools%2Fecotoxicology-ecotox-knowledgebase-resource-hub&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278404835%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=W6b4zqu4vvEPD40fxOoyvP9YiK8veHXgyKXALcJ5mHE%3D&amp;reserved=0\">ECOTOX knowledgebase<\/a>\u00a0(ECOTOX), an EPA-hosted, publicly available resource with information on adverse effects of single chemical stressors to certain aquatic and terrestrial species. The meta-analysis found that the agency&#8217;s approach, which relies heavily on\u00a0honey bee\u00a0data from controlled laboratory studies, drastically underestimates the real-world threats from neonicotinoid insecticides (and\u00a0likely other\u00a0pesticides) to native bees and other pollinators. The\u00a0<a href=\"https:\/\/nam10.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fbeyondpesticides.org%2Fdailynewsblog%2F2024%2F06%2Fstudy-confirms-serious-flaws-in-epas-ecological-risk-assessments-threatening-bees-and-other-pollinators%2F&amp;data=05%7C02%7CJFeldman%40beyondpesticides.org%7C44da13116bf14b2418a408deac81f142%7Cc752d38fe68a46fc83ee8e12479e74ad%7C0%7C0%7C639137871278427019%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C4000%7C%7C%7C&amp;sdata=Ydple7LxB5oyu1IjHYG21Oi2S1ks8l6jzFzu%2BPmkWG4%3D&amp;reserved=0\">study<\/a>\u00a0\u201cchallenges the reliability of surrogate species as predictors when extrapolating pesticide toxicity data to wild pollinators and recommends solutions to address the (a)biotic interactions occurring in nature that make such extrapolations unreliable in the ERA process.\u201d\u00a0\u00a0<\/li>\r\n<\/ul>\r\n<p>Since interactions and synergism are the rule, pesticides cannot be evaluated on the basis of single-chemical, single-species tests. Public health advocates maintain that they must be evaluated in context\u2014that is, the system of chemical-dependent management of crops, landscapes, and structures must itself be questioned. They also point to the availability of an alternative system\u2014regenerative organic production and land management\u2014that is both successful and a suitable standard of comparison, saying the only way to truly protect pollinators, insects, birds, and other species, as well as the biosphere as a whole, is to stop the use of toxic pesticides completely. Continuing, they say that converting the world&#8217;s agricultural systems to organic would have a tremendous positive impact on threatened populations.\u00a0<\/p>\r\n<p>Beyond Pesticides is urging the public to:\u00a0<strong><a href=\"https:\/\/secure.everyaction.com\/SiWXvv8E00GkI8wKVJ6aAA2##anchor\">Tell EPA, FDA, and Congress that regulations must consider the effects of pesticides in the context in which they are used and with reference to the organic alternative<\/a><a href=\"https:\/\/secure.everyaction.com\/SiWXvv8E00GkI8wKVJ6aAA2##anchor\"><em>.<\/em><\/a><\/strong><\/p>\r\n<p><span style=\"text-decoration: underline;\">Letter to the U.S. Congress<\/span><br \/>\r\nPlease urge EPA and FDA to use their registration and tolerance-setting authority, respectively, to set regulatory standards with an assessment of pesticide mixtures, considering their additive and synergistic effects. A recent study in Toxics reviewed the current literature on pesticides, microplastics, or metal exposure in combination with per- and polyfluoroalkyl substances (PFAS) on aquatic vertebrates and invertebrates, finding that PFAS can modify, including intensify, the toxicity of co-occurring pollutants.\u00a0<\/p>\r\n<p>Varroa mites in combination with a neonicotinoid insecticide increases the risk of bee mortality and disrupts the larval gut microbiome, suggesting that neonicotinoids are not only harmful individually but can increase vulnerability to parasitism from mites in western honey bees.<\/p>\r\n<p>Women\u2019s reproductive health is adversely affected by exposure to environmental contaminants, many of which are related to chemical-intensive land management and can exacerbate health effects through additive or synergistic effects.<\/p>\r\n<p>Microplastics (MPs) and pesticides have synergistic effects that threaten aquatic organisms. MPs increase the bioavailability, persistence, and toxicity of pesticides used in agriculture, putting soil microbiota and consumers at elevated risk.<\/p>\r\n<p>Individual wild bumblebees differ in their response when exposed to an herbicide (glyphosate), a fungicide (tebuconazole), and an insecticide (imidacloprid), with gut microbiome health as a factor.\u00a0<\/p>\r\n<p>A mass mortality event of about 200 monarch butterflies in Pacific Grove points to additional issues in assessing risks to species since \u201cavailable toxicity values are based on exposure to a single active ingredient, whereas all the sampled monarchs contained residues of multiple pesticides.\u201d\u00a0<\/p>\r\n<p>A common soil arthropod demonstrates synergistic effects: warming increases pesticide toxicity; pesticide toxicity triggers antibiotic resistance; antibiotic resistance spreads through horizontal gene transfer and predation.\u00a0<\/p>\r\n<p>The presence of multiple residues in a single sample of dog or cat food suggests that they are subjected to combined toxicological burdens that are not fully regulated.<\/p>\r\n<p>The interaction of a fungicide and naturally occurring mycotoxins shows synergistic effects, highlighting the complexities of chemical mixtures and potential threats to liver health through dietary exposure to both toxicants and toxins that are not regulated for their interactions.<\/p>\r\n<p>Combined pesticide exposure may further amplify the toxicity and compromise the intestinal barrier.<\/p>\r\n<p>Agricultural mixtures are linked to the occurrence of pediatric cancers, specifically brain and central nervous system cancers and leukemia.<\/p>\r\n<p>Different glyphosate mixtures produce varied lethal and sublethal effects&#8211;mortality, morphological defects, altered heartbeat rate, and impaired heart-specific gene expression\u2014on the South African clawed frog.<\/p>\r\n<p>Daphnia magna experienced synergistic effects when subjected to the insecticide esfenvalerate under conditions of climate change.<\/p>\r\n<p>Studies highlight the need for a broad overhaul of EPA\u2019s risk assessment process. A November 2023 European study published in Nature challenges \u201cthe current assumption of pesticide regulation\u2014that chemicals that individually pass laboratory tests and semifield trials are considered environmentally benign.\u201d<\/p>\r\n<p>Since interactions and synergism are the rule, pesticides cannot be evaluated based on single-chemical, single-species tests. They must be evaluated in context\u2014that is, the system of chemical-dependent management must itself be questioned. Fortunately, there is an alternative system\u2014regenerative organic production and land management\u2014that is a suitable successful standard of comparison.\u00a0<\/p>\r\n<p>Please ensure that EPA and FDA consider effects of pesticides in the context in which they are used and with reference to the available organic alternative.<\/p>\r\n<p>Thank you.<\/p>\r\n<p><u>Letter to the Administrator of Environmental Protection Agency<br \/>\r\n<\/u>To adequately protect public health and the environment in pesticide registration review, the agency must consider the effects of chemical mixtures. A recent study in Toxics reviewed the current literature on pesticides, microplastics, or metal exposure in combination with per- and polyfluoroalkyl substances (PFAS) on aquatic vertebrates and invertebrates, finding that PFAS can modify, including intensify, the toxicity of co-occurring pollutants.\u00a0<\/p>\r\n<p>The presence of Varroa mites in combination with a neonicotinoid insecticide<\/p>\r\n<p>the risk of bee mortality and disrupts the larval gut microbiome, suggesting that neonicotinoids are not only harmful individually but can increase vulnerability to parasitism from mites in western honey bees.<\/p>\r\n<p>Women\u2019s reproductive health is adversely affected by exposure to environmental contaminants, many of which are related to chemical-intensive land management and can exacerbate health effects through additive or synergistic effects.<\/p>\r\n<p>Microplastics (MPs) and pesticides have synergistic effects that threaten aquatic organisms. MPs increase the bioavailability, persistence, and toxicity of pesticides used in agriculture, putting soil microbiota and consumers at elevated risk.<\/p>\r\n<p>Individual wild bumblebees differ in their response when exposed to an herbicide (glyphosate), a fungicide (tebuconazole), and an insecticide (imidacloprid), with gut microbiome health as a factor.\u00a0<\/p>\r\n<p>Researchers studying a mass mortality event of about 200 monarch butterflies in Pacific Grove point to additional issues in assessing risks to species since \u201cavailable toxicity values are based on exposure to a single active ingredient, whereas all the sampled monarchs contained residues of multiple pesticides.\u201d\u00a0<\/p>\r\n<p>A common soil arthropod demonstrates synergistic effects: warming increases pesticide toxicity; pesticide toxicity triggers antibiotic resistance; antibiotic resistance spreads through horizontal gene transfer and predation.\u00a0<\/p>\r\n<p>The presence of multiple residues in a single sample of dog or cat food suggests that companion animals may be subjected to combined toxicological burdens that are not yet fully understood.<\/p>\r\n<p>The interaction of a fungicide and naturally occurring mycotoxins shows synergistic effects, highlighting the complexities of chemical mixtures and potential threats to liver health through dietary exposure to both toxicants and toxins that are not regulated for their interactions.<\/p>\r\n<p>Combined pesticide exposure may further amplify the toxicity and compromise the intestinal barrier.<\/p>\r\n<p>Agricultural mixtures are linked to the occurrence of pediatric cancers, specifically brain and central nervous system cancers and leukemia.<\/p>\r\n<p>Different mixtures of the weed killer glyphosate produce varied lethal and sublethal effects&#8211;mortality, morphological defects, altered heartbeat rate, and impaired heart-specific gene expression\u2014on the South African clawed frog.<\/p>\r\n<p>Daphnia magna experienced synergistic effects when subjected to the insecticide esfenvalerate under conditions of climate change.<\/p>\r\n<p>Studies highlight the need for a broad overhaul of EPA\u2019s risk assessment process. A November 2023 European study published in Nature challenges \u201cthe current assumption of pesticide regulation\u2014that chemicals that individually pass laboratory tests and semifield trials are considered environmentally benign.\u201d<\/p>\r\n<p>Since interactions and synergism are the rule, pesticides cannot be evaluated based on single-chemical, single-species tests. They must be evaluated in context\u2014that is, the system of chemical-dependent management must itself be questioned. Fortunately, there is an alternative system\u2014regenerative organic production and land management\u2014that is a suitable successful standard of comparison.\u00a0<\/p>\r\n<p>EPA must consider effects of pesticides in the context in which they are used and with reference to the organic alternative.<\/p>\r\n<p>Thank you.<\/p>\r\n<p><u>Letter to Secretary of Health and Human Servicess<br \/>\r\n<\/u>Under your tolerance-setting authority to protect public health from pesticide residues in food, it is critical that pesticide mixtures are evaluated, an area of health concern not currently considered. A recent study in Toxics reviewed the current literature on pesticides, microplastics, or metal exposure in combination with per- and polyfluoroalkyl substances (PFAS) on aquatic vertebrates and invertebrates, finding that PFAS can modify, including intensify, the toxicity of co-occurring pollutants.\u00a0<\/p>\r\n<p>Study results published in Pesticide Biochemistry and Physiology \u201csuggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.\u201d The researchers found that the insecticides abamectin and spirodiclofen, and the fungicide fluazinam, individually and in combination, cause serious disruption of intestinal functions caused by the interaction of pesticides in mixtures. These findings highlight the need to assess potential synergistic effects of pesticide mixtures as a part of the regulatory review process. Under memorandums of understanding with EPA, please instruct FDA to recommend tolerances based on combined exposure when pesticides are used together.<\/p>\r\n<p>\u201cCurrently, most studies investigating the effects of pesticide residues on the barrier function of Caco-2 cells [human colorectal adenocarcinoma cells used as a model of the intestinal epithelial barrier] concentrate on the exposure to a single residue, while the potential toxic effects arising from the concurrent presence of multiple pesticide residues remain largely overlooked,\u201d the authors say. This study exposes a mechanism for the synergistic effects of concurrent exposure to a combination of pesticides and highlights the importance of considering synergy in risk assessments and the setting of pesticide tolerance to protect health.\u00a0<\/p>\r\n<p>Additional research referenced in the study supports the findings of intestinal damage from pesticide exposure, including disruption of the intestinal epithelial barrier by imidacloprid, enhancing the toxicity of zinc oxide to gut microbiota; disrupting the integrity of the gut barrier in mice by chlorpyrifos, resulting in increased entry of lipopolysaccharides into the body, and synergistic effects of carbendazim combined with epoxiconazole or fluazinam in Caco-2 cells.\u00a0<\/p>\r\n<p>The findings are very troubling, since pesticide residues in food are introduced directly to the intestines. As the researchers note, \u201cThe intestinal tract functions as a congenital barrier for homeostasis, preventing pathogenic bacteria, toxins, and other harmful substances from entering the body.\u201d They continue: \u201cPesticides ingested through the diet are absorbed and transported into the human body, directly interacting with intestinal epithelial cells. This exposure results in alterations to cell permeability and integrity, ultimately compromising the barrier function of these cells.\u201d<\/p>\r\n<p>The complex interactions among pesticide mixtures are not fully understood but represent a significant threat to human health. EPA fails to adequately regulate mixtures of chemicals to which organisms are exposed in the real world. Risk assessments have been highly criticized as inadequate in addressing the full range of adverse effects that put human health at risk. Since establishing tolerances for pesticide residues is the responsibility of FDA. I ask you to require FDA to set tolerances based on combined exposure when pesticides are used together.<\/p>\r\n<p>Given both the known and still unevaluated effects of pesticides, including the impact of mixtures and synergistic effects, petrochemical pesticides can be better regulated through the setting of tolerances and replaced by organic land management practices, which are commercially viable and effective in both agricultural and nonagricultural uses.<\/p>\r\n<p>Thank you.<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>(Beyond Pesticides, May 11, 2026) As studies stack up on adverse synergistic effects of chemical mixtures, serious deficiencies in the regulatory review of pesticides have come into sharp focus. As the hazards are shown to escalate and the regulatory review process is shown to fall short, public health advocates are telling Congress, the U.S. Environmental Protection Agency, and the Department of Health and Human Services that they must consider the effects of pesticides in the context in which they are used and with reference to the organic alternative.\u00a0 A\u00a0recent study in\u00a0Toxics\u00a0reviewed the current literature on pesticides, microplastics, or metal exposure in combination with per- and polyfluoroalkyl substances (PFAS) on aquatic vertebrates and invertebrates, finding that\u00a0PFAS can\u00a0modify, including intensify, the toxicity of co-occurring pollutants.\u00a0\u00a0 A commentary in\u00a0Frontiers in Toxicology, by \u00a0Maricel Maffini, PhD, and Laura Vandenberg, PhD, \u00a0notes, \u201cCurrent approaches also rely on the assumption that testing chemicals one at a time is\u00a0appropriate to\u00a0understand how chemicals act under real-world conditions. Numerous mixture studies, including ones that\u00a0demonstrated\u00a0cumulative effects, have disproven this assumption.\u201d\u00a0\u00a0 As noted by the naturalist, writer, and conservationist John Muir, known as the \u201cFather of the National Parks,\u201d and those before and after him, including the English poet John Donne, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":41583,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[350,2041,354,403,488,10,421,276,1],"tags":[],"class_list":["post-41562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-contamination-2","category-department-of-health-and-human-services","category-environmental-protection-agency-epa","category-food-and-drug-administration-fda","category-pesticide-mixtures","category-pesticide-regulation","category-synergistic-effects","category-take-action","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Public Health Advocates Call for Review of Adverse Synergistic Effects of Pesticides, Ignored by Regulators \u00a0 - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2026\/05\/public-health-advocates-call-for-review-of-adverse-synergistic-effects-of-pesticides-ignored-by-regulators\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Public Health Advocates Call for Review of Adverse Synergistic Effects of Pesticides, Ignored by Regulators \u00a0 - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, May 11, 2026) As studies stack up on adverse synergistic effects of chemical mixtures, serious deficiencies in the regulatory review of pesticides have come into sharp focus. As the hazards are shown to escalate and the regulatory review process is shown to fall short, public health advocates are telling Congress, the U.S. Environmental Protection Agency, and the Department of Health and Human Services that they must consider the effects of pesticides in the context in which they are used and with reference to the organic alternative.\u00a0 A\u00a0recent study in\u00a0Toxics\u00a0reviewed the current literature on pesticides, microplastics, or metal exposure in combination with per- and polyfluoroalkyl substances (PFAS) on aquatic vertebrates and invertebrates, finding that\u00a0PFAS can\u00a0modify, including intensify, the toxicity of co-occurring pollutants.\u00a0\u00a0 A commentary in\u00a0Frontiers in Toxicology, by \u00a0Maricel Maffini, PhD, and Laura Vandenberg, PhD, \u00a0notes, \u201cCurrent approaches also rely on the assumption that testing chemicals one at a time is\u00a0appropriate to\u00a0understand how chemicals act under real-world conditions. 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The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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