{"id":4604,"date":"2010-12-06T00:01:42","date_gmt":"2010-12-06T04:01:42","guid":{"rendered":"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=4604"},"modified":"2010-12-06T00:28:18","modified_gmt":"2010-12-06T04:28:18","slug":"single-exposure-to-dioxin-can-cause-problems-for-future-generations","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2010\/12\/single-exposure-to-dioxin-can-cause-problems-for-future-generations\/","title":{"rendered":"Single Exposure to Dioxin Can Cause Problems for Future Generations"},"content":{"rendered":"<p><font size=\"2\">(<em>Beyond Pesticides<\/em>, December 6, 2010) A new study finds that exposure to dioxin in the womb can affect female reproduction for generations, reducing fertility and increasing the chance for premature delivery. Scientists from the Women&#8217;s Reproductive Health Research Center at Vanderbilt University School of Medicine examined the effects of a specific variety of dioxin on female mice and found that subsequent generations of the mice exposed to dioxin are at risk. The study, entitled \u201c<a href=\"http:\/\/www.sciencedirect.com\/science?_ob=ArticleURL&#038;_udi=B6TC0-517YN5D-4&#038;_user=10&#038;_coverDate=10%2F16%2F2010&#038;_rdoc=1&#038;_fmt=high&#038;_orig=search&#038;_origin=search&#038;_sort=d&#038;_docanchor=&#038;view=c&#038;_acct=C000050221&#038;_version=1&#038;_urlVersion=0&#038;_userid=10&#038;md5=f857302e32976989abd4fc70c1c9672e&#038;searchtype=a\">Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations<\/a>,\u201d was published in the journal <em>Reproductive Toxicology<\/em>.  <\/p>\n<p>Dioxin refers to a family of chemicals linked to <a href=\"https:\/\/www.beyondpesticides.org\/news\/daily_news_archive\/2001\/01_26_01.htm\">cancer<\/a>, endocrine disruption, weakened immune systems and reproductive problems. They are persistent organic pollutants that bioaccumulate in humans and other animals, especially in fatty tissue, meaning that concentrations of dioxin in the body generally increase with age. So, even in very low doses, dioxins can cause health problems. <\/p>\n<p>Scientists in this study specifically looked at the variety of dioxin that is considered the most toxic, known as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a well-known contaminant of the herbicide <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/24d.htm\">2,4-D<\/a>, which was originally a part of the deadly chemical weapon <a href=\"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=189 during the Vietnam War\">Agent Orange<\/a>. As such, TCDD is still found in soil samples from Central Vietnam in levels that are 200 times what is considered \u201cacceptable&#8221; to the U.S. Environmental Protection Agency (EPA). <\/p>\n<p>The mice in the study were exposed either once, twice or three times to 10 micrograms of TCDD per kilogram (10 parts per billion). The fertility rates of these mice and their offspring were compared to that of unexposed mice. For the single exposure, pregnant female mice were fed the chemical on day 15.5 of pregnancy to expose the fetus. For animals treated twice, some of the females that were exposed in the womb were fed the chemical right before puberty at four weeks. For mice that were exposed three times, the females exposed in the womb and at four weeks were also fed the chemical at nine weeks, or right after puberty. Researchers then mated the exposed females at 10-12 weeks with normal male mice. If the females became pregnant, some of their female offspring were bred with normal males at age 10-12 weeks. This was repeated for four generations. <\/p>\n<p>Researchers found that mice exposed to 10 micrograms per kilogram of TCDD while in the womb had reduced fertility rates. Only 44% of these mice were able to get pregnant and many of the pregnancies that did come to term were prematurely delivered with a high mortality rate. This pattern was repeated in subsequent generations (the \u201cgranddaughter\u201d and \u201cgreat-granddaughter\u201d mice, if you will).<\/p>\n<p>Not surprisingly, results were much bleaker for those mice that were exposed twice or three times. Only about 66% of the mice that were exposed twice became pregnant and only 29% of their female offspring could conceive, with effects repeating for three more generations. None of the mice that were exposed three times could conceive, compared to all of the unexposed control mice reproductive outcomes.<br \/>\n<em><br \/>\nSource: <a href=\"http:\/\/www.environmentalhealthnews.org\/ehs\/newscience\/prenatal-dioxin-affects-female-mouse-fertility-for-generations#do\">Environmental Health News<\/a><\/em>  <\/font><\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Beyond Pesticides, December 6, 2010) A new study finds that exposure to dioxin in the womb can affect female reproduction for generations, reducing fertility and increasing the chance for premature delivery. Scientists from the Women&#8217;s Reproductive Health Research Center at Vanderbilt University School of Medicine examined the effects of a specific variety of dioxin on female mice and found that subsequent generations of the mice exposed to dioxin are at risk. The study, entitled \u201cDevelopmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations,\u201d was published in the journal Reproductive Toxicology. Dioxin refers to a family of chemicals linked to cancer, endocrine disruption, weakened immune systems and reproductive problems. They are persistent organic pollutants that bioaccumulate in humans and other animals, especially in fatty tissue, meaning that concentrations of dioxin in the body generally increase with age. So, even in very low doses, dioxins can cause health problems. Scientists in this study specifically looked at the variety of dioxin that is considered the most toxic, known as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a well-known contaminant of the herbicide 2,4-D, which was originally a part of the deadly chemical weapon Agent Orange. As such, TCDD is still found [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[89,119,156],"tags":[],"class_list":["post-4604","post","type-post","status-publish","format-standard","hentry","category-24-d","category-infertility","category-miscarriage"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Single Exposure to Dioxin Can Cause Problems for Future Generations - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2010\/12\/single-exposure-to-dioxin-can-cause-problems-for-future-generations\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Single Exposure to Dioxin Can Cause Problems for Future Generations - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, December 6, 2010) A new study finds that exposure to dioxin in the womb can affect female reproduction for generations, reducing fertility and increasing the chance for premature delivery. Scientists from the Women&#8217;s Reproductive Health Research Center at Vanderbilt University School of Medicine examined the effects of a specific variety of dioxin on female mice and found that subsequent generations of the mice exposed to dioxin are at risk. The study, entitled \u201cDevelopmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations,\u201d was published in the journal Reproductive Toxicology. Dioxin refers to a family of chemicals linked to cancer, endocrine disruption, weakened immune systems and reproductive problems. They are persistent organic pollutants that bioaccumulate in humans and other animals, especially in fatty tissue, meaning that concentrations of dioxin in the body generally increase with age. So, even in very low doses, dioxins can cause health problems. Scientists in this study specifically looked at the variety of dioxin that is considered the most toxic, known as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a well-known contaminant of the herbicide 2,4-D, which was originally a part of the deadly chemical weapon Agent Orange. 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The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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