{"id":5781,"date":"2011-08-11T00:01:01","date_gmt":"2011-08-11T04:01:01","guid":{"rendered":"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=5781"},"modified":"2015-11-30T10:04:14","modified_gmt":"2015-11-30T14:04:14","slug":"research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/","title":{"rendered":"Research Shows Commonly Used Pesticides Produce Greater Toxic Effect When Mixed"},"content":{"rendered":"<p><span style=\"font-size: small;\">(<em>Beyond Pesticides<\/em>, August 11, 2011) A combination of eleven different kinds of commonly used pyrethroids were tested on mice in a new study which found that, at real-world exposure levels, the insecticides can produce heightened toxicity that is equal to the sum of each insecticide\u2019s individual effect. The mixture of similar-acting insecticides works by over-stimulating electronic channels in the mouse\u2019s brain cells and eventually causing death. This study adds to the growing body of research on the toxicity of pesticide combinations in nature and showcases the need for policy change because the current risk assessment approach to regulating pesticides fails to look at chemical mixtures and <a href=\"https:\/\/www.beyondpesticides.org\/infoservices\/pesticidesandyou\/Winter%2003-04\/Synergy.pdf\">synergistic effects<\/a>. <\/span><\/p>\n<p>The U.S. Environmental Protection Agency (EPA) currently regulates on a chemical-by-chemical basis, but as this study demonstrates, interacting chemicals can have synergistic effects at very low levels, where a \u201cchemical cocktail\u201d of multiple interacting chemicals combine to have greater effects than expected. Pesticides can also have a cumulative &#8220;toxic loading&#8221; effect both in the immediate and long term.<\/p>\n<p>Researchers exposed mice brain cells to eleven different food-use pyrethroid insecticides either singly or in a mixture in the study entitled \u201d<a href=\"http:\/\/www.environmentalhealthnews.org\/ehs\/newscience\/2011\/07\/pyrethroids-increased-toxicity\/\">Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.<\/a>\u201d The pyrethroid compounds tested include: <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/deltamethrin.htm\">deltamethrin<\/a>, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/cyfluthrin.htm\">\u00ce\u00b2-cyfluthrin<\/a>, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/cypermethrin.htm\">cypermethrin<\/a>, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/permethrin.htm\">permethrin<\/a>, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/bifenthrin.htm\">bifenthrin<\/a>, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/esfenvalerate.htm\">esfenvalerate<\/a>, \u00ce\u00bb-cyhalothrin, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/tefluthrin.htm\">tefluthrin<\/a>, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/fenpropathrin.htm\">fenpropathrin<\/a>, <a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/resmethrin.htm\">resmethrin<\/a> and S-bioallethrin. They are mainly used to control pests on food crops, and are toxic to insects and humans in the same way. They work by targeting vital electrical channels in certain types of brain cells. The chemicals stimulate the electrical signals moving into the cells, which changes neuron function and ultimately leading to paralysis and death.<\/p>\n<p><a href=\"https:\/\/www.beyondpesticides.org\/gateway\/pesticide\/pyrethrins.htm\">Pyrethroids<\/a> are synthetic versions of pyrethrin, a natural insecticide found in certain species of chrysanthemum. Pyrethroids are suspected endocrine disruptors, have been linked to certain cancers, and are particularly dangerous to aquatic life even at low concentrations. Despite the fact that there are plenty of <a href=\"https:\/\/www.beyondpesticides.org\/alternatives\/factsheets\/index.htm\">effective pest control methods<\/a> that are not nearly as toxic, these insecticides are some of the most popular household pesticides, available in the form of powders and sprays to control ants, mosquitoes, fleas, flies, and cockroaches. As research unfurls, particularly on the combined effects that these insecticides have, the high-volume uses of pyrethroids are major cause for concern to <a href=\"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=407\">human and environmental health<\/a>.<\/p>\n<p><em>Source: <a href=\"http:\/\/www.environmentalhealthnews.org\/ehs\/newscience\/2011\/07\/pyrethroids-increased-toxicity\/\">Environmental Health News<\/a> <\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Beyond Pesticides, August 11, 2011) A combination of eleven different kinds of commonly used pyrethroids were tested on mice in a new study which found that, at real-world exposure levels, the insecticides can produce heightened toxicity that is equal to the sum of each insecticide\u2019s individual effect. The mixture of similar-acting insecticides works by over-stimulating electronic channels in the mouse\u2019s brain cells and eventually causing death. This study adds to the growing body of research on the toxicity of pesticide combinations in nature and showcases the need for policy change because the current risk assessment approach to regulating pesticides fails to look at chemical mixtures and synergistic effects. The U.S. Environmental Protection Agency (EPA) currently regulates on a chemical-by-chemical basis, but as this study demonstrates, interacting chemicals can have synergistic effects at very low levels, where a \u201cchemical cocktail\u201d of multiple interacting chemicals combine to have greater effects than expected. Pesticides can also have a cumulative &#8220;toxic loading&#8221; effect both in the immediate and long term. Researchers exposed mice brain cells to eleven different food-use pyrethroid insecticides either singly or in a mixture in the study entitled \u201dAdditivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.\u201d [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[226,286,254,258,190,242,38],"tags":[],"class_list":["post-5781","post","type-post","status-publish","format-standard","hentry","category-bifenthrin","category-cyfluthrin","category-cypermethrin","category-deltamethrin","category-esfenvalerate","category-nervous-system-effects","category-permethrin"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research Shows Commonly Used Pesticides Produce Greater Toxic Effect When Mixed - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Shows Commonly Used Pesticides Produce Greater Toxic Effect When Mixed - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, August 11, 2011) A combination of eleven different kinds of commonly used pyrethroids were tested on mice in a new study which found that, at real-world exposure levels, the insecticides can produce heightened toxicity that is equal to the sum of each insecticide\u2019s individual effect. The mixture of similar-acting insecticides works by over-stimulating electronic channels in the mouse\u2019s brain cells and eventually causing death. This study adds to the growing body of research on the toxicity of pesticide combinations in nature and showcases the need for policy change because the current risk assessment approach to regulating pesticides fails to look at chemical mixtures and synergistic effects. The U.S. Environmental Protection Agency (EPA) currently regulates on a chemical-by-chemical basis, but as this study demonstrates, interacting chemicals can have synergistic effects at very low levels, where a \u201cchemical cocktail\u201d of multiple interacting chemicals combine to have greater effects than expected. Pesticides can also have a cumulative &#8220;toxic loading&#8221; effect both in the immediate and long term. Researchers exposed mice brain cells to eleven different food-use pyrethroid insecticides either singly or in a mixture in the study entitled \u201dAdditivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.\u201d [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/\" \/>\n<meta property=\"og:site_name\" content=\"Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/beyondpesticides\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/beyondpesticides\/\" \/>\n<meta property=\"article:published_time\" content=\"2011-08-11T04:01:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-11-30T14:04:14+00:00\" \/>\n<meta name=\"author\" content=\"Beyond Pesticides\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ByondPesticides\" \/>\n<meta name=\"twitter:site\" content=\"@ByondPesticides\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Beyond Pesticides\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/\"},\"author\":{\"name\":\"Beyond Pesticides\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4\"},\"headline\":\"Research Shows Commonly Used Pesticides Produce Greater Toxic Effect When Mixed\",\"datePublished\":\"2011-08-11T04:01:01+00:00\",\"dateModified\":\"2015-11-30T14:04:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/\"},\"wordCount\":396,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization\"},\"articleSection\":[\"Bifenthrin\",\"Cyfluthrin\",\"cypermethrin\",\"Deltamethrin\",\"esfenvalerate\",\"Nervous System Effects\",\"Permethrin\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/\",\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2011\/08\/research-shows-commonly-used-pesticides-produce-greater-toxic-effect-when-mixed\/\",\"name\":\"Research Shows Commonly Used Pesticides Produce Greater Toxic Effect When Mixed - 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The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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