{"id":631,"date":"2008-09-22T07:19:31","date_gmt":"2008-09-22T11:19:31","guid":{"rendered":"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=631"},"modified":"2008-09-22T07:19:31","modified_gmt":"2008-09-22T11:19:31","slug":"pyrethroid-pesticide-affects-puberty-at-low-levels","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/","title":{"rendered":"Pyrethroid Pesticide Affects Puberty at Low Levels"},"content":{"rendered":"<p><font size=\"2\">(<em>Beyond Pesticides<\/em>, September 22, 2008) A study published in the September issue of <em><a href=\"http:\/\/www.ehponline.org\/members\/2008\/11119\/11119.html\">Environmental Health Perspectives<\/a><\/em> finds that low-dose, short-term exposure to esfenvalerate, a synthetic pyrethroid pesticide, delays the onset of puberty in rats at doses two times lower than U.S. EPA\u2019s stated no observable effect level (NOEL) of 2.0 mg\/kg\/day. Synthetic pyrethroids are used for everything from lawn care and household insecticides, to mosquito control and agriculture. There are currently <a href=\"http:\/\/www.pesticideinfo.org\/List_Products.jsp?Rec_Id=PC33172&#038;Chem_Name=Esfenvalerate&#038;PC_Code=109303\">348 pesticide products<\/a> registered by the U.S. EPA. <\/p>\n<p>The researchers conclude:<\/p>\n<p>&#8220;Although the exact mechanism of action is unknown at this time, we observed the effects at dosage levels below the NOEL established through chronic dietary exposure studies in rats. The U.S. EPA (1998) http:\/\/www.epa.gov\/fedrgstr\/EPA-PEST\/1998\/April\/Day-29\/p11372.htm stated that \u201d\u02dcThere is no evidence of additional sensitivity to young rats or rabbits following pre- or postnatal exposure to esfenvalerate.\u2019 The present study shows that immature female rats exposed to 1.0 mg\/kg\/day are sensitive to this pesticide, as evidenced by their delay in the onset of puberty. Delayed pubertal onset in humans has been associated with low bone mass density (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16261454?ordinalpos=369&#038;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\">Ho and Kung 2005<\/a>), and estrogen is necessary for bone mineral acquisition in both girls and boys (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16261455?ordinalpos=17&#038;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\">Yilmaz et al. 2005<\/a>). Importantly, a lowered endogenous estrogen level in females is one factor associated with bone fragility (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14724768?ordinalpos=193&#038;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\">Hoffman and Bradshaw 2003<\/a>).<\/p>\n<p>\u201cThis could potentially affect current established exposure levels for humans, because the reference dose for [esfenvalerate] of 0.02 mg\/kg\/day is based directly on the rodent NOEL of 2.0 mg\/kg\/day.\u201d <\/p>\n<p>With the phase-out of most residential uses of the common organophosphate insecticides, chlorpyrifos and diazinon, home use of pyrethroids has increased. Pesticide products containing synthetic pyrethroids are often described by pest control operators and community mosquito management bureaus as \u201csafe as chrysanthemum flowers.\u201d While pyrethroids are a synthetic version of an extract from the chyrsanthemum plant, they are chemically engineered to be more toxic, take longer to breakdown, and are often formulated with synergists, increasing potency and compromising the human body\u2019s ability to detoxify the pesticide. Pyrethroids may affect neurological development, disrupt hormones, induce cancer, and suppress the immune system. Researchers at Emory University and the Centers for Disease Control and Prevention (CDC) find that residential pesticide use represents the most important risk factor for <a href=\"http:\/\/www.ehponline.org\/members\/2006\/9043\/9043.html\">children&#8217;s exposure to pyrethroid insecticides<\/a>. <\/p>\n<p>According to Ohio State University, esfenvalerate is one of over 75 commonly used pesticides that are highly or moderately toxic to bees. It has also been used on Christmas trees in North Carolina. Esfenvalerate has replaced fenvalerate, whose uses were voluntarily withdrawn from the market by varfious manufacturers, including The Scotts Company, from 2003 to 2008, although existing supplies can be sold off. <\/p>\n<p>For more information, see Beyond Pesticides\u2019 factsheet on <a href=\"https:\/\/www.beyondpesticides.org\/pesticides\/factsheets\/Synthetic%20Pyrethroids.pdf\">synthetic pyrethroids<\/a>. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Beyond Pesticides, September 22, 2008) A study published in the September issue of Environmental Health Perspectives finds that low-dose, short-term exposure to esfenvalerate, a synthetic pyrethroid pesticide, delays the onset of puberty in rats at doses two times lower than U.S. EPA\u2019s stated no observable effect level (NOEL) of 2.0 mg\/kg\/day. Synthetic pyrethroids are used for everything from lawn care and household insecticides, to mosquito control and agriculture. There are currently 348 pesticide products registered by the U.S. EPA. The researchers conclude: &#8220;Although the exact mechanism of action is unknown at this time, we observed the effects at dosage levels below the NOEL established through chronic dietary exposure studies in rats. The U.S. EPA (1998) http:\/\/www.epa.gov\/fedrgstr\/EPA-PEST\/1998\/April\/Day-29\/p11372.htm stated that \u201d\u02dcThere is no evidence of additional sensitivity to young rats or rabbits following pre- or postnatal exposure to esfenvalerate.\u2019 The present study shows that immature female rats exposed to 1.0 mg\/kg\/day are sensitive to this pesticide, as evidenced by their delay in the onset of puberty. Delayed pubertal onset in humans has been associated with low bone mass density (Ho and Kung 2005), and estrogen is necessary for bone mineral acquisition in both girls and boys (Yilmaz et al. 2005). Importantly, a [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,85,190],"tags":[],"class_list":["post-631","post","type-post","status-publish","format-standard","hentry","category-childrenschools","category-endocrine-disruption","category-esfenvalerate"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pyrethroid Pesticide Affects Puberty at Low Levels - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pyrethroid Pesticide Affects Puberty at Low Levels - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, September 22, 2008) A study published in the September issue of Environmental Health Perspectives finds that low-dose, short-term exposure to esfenvalerate, a synthetic pyrethroid pesticide, delays the onset of puberty in rats at doses two times lower than U.S. EPA\u2019s stated no observable effect level (NOEL) of 2.0 mg\/kg\/day. Synthetic pyrethroids are used for everything from lawn care and household insecticides, to mosquito control and agriculture. There are currently 348 pesticide products registered by the U.S. EPA. The researchers conclude: &#8220;Although the exact mechanism of action is unknown at this time, we observed the effects at dosage levels below the NOEL established through chronic dietary exposure studies in rats. The U.S. EPA (1998) http:\/\/www.epa.gov\/fedrgstr\/EPA-PEST\/1998\/April\/Day-29\/p11372.htm stated that \u201d\u02dcThere is no evidence of additional sensitivity to young rats or rabbits following pre- or postnatal exposure to esfenvalerate.\u2019 The present study shows that immature female rats exposed to 1.0 mg\/kg\/day are sensitive to this pesticide, as evidenced by their delay in the onset of puberty. Delayed pubertal onset in humans has been associated with low bone mass density (Ho and Kung 2005), and estrogen is necessary for bone mineral acquisition in both girls and boys (Yilmaz et al. 2005). Importantly, a [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/\" \/>\n<meta property=\"og:site_name\" content=\"Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/beyondpesticides\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/beyondpesticides\/\" \/>\n<meta property=\"article:published_time\" content=\"2008-09-22T11:19:31+00:00\" \/>\n<meta name=\"author\" content=\"Beyond Pesticides\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ByondPesticides\" \/>\n<meta name=\"twitter:site\" content=\"@ByondPesticides\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Beyond Pesticides\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/\"},\"author\":{\"name\":\"Beyond Pesticides\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#\/schema\/person\/1b5c0a0981b549cc5b628770073031f4\"},\"headline\":\"Pyrethroid Pesticide Affects Puberty at Low Levels\",\"datePublished\":\"2008-09-22T11:19:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/\"},\"wordCount\":465,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/#organization\"},\"articleSection\":[\"Children\/Schools\",\"Endocrine Disruption\",\"esfenvalerate\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/\",\"url\":\"https:\/\/beyondpesticides.org\/dailynewsblog\/2008\/09\/pyrethroid-pesticide-affects-puberty-at-low-levels\/\",\"name\":\"Pyrethroid Pesticide Affects Puberty at Low Levels - 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The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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