{"id":8811,"date":"2012-12-10T00:01:15","date_gmt":"2012-12-10T04:01:15","guid":{"rendered":"https:\/\/www.beyondpesticides.org\/dailynewsblog\/?p=8811"},"modified":"2012-12-10T10:47:13","modified_gmt":"2012-12-10T14:47:13","slug":"study-reveals-organophosphate-pesticides-cause-lasting-damage-to-brain-and-nervous-system","status":"publish","type":"post","link":"https:\/\/beyondpesticides.org\/dailynewsblog\/2012\/12\/study-reveals-organophosphate-pesticides-cause-lasting-damage-to-brain-and-nervous-system\/","title":{"rendered":"Study Reveals: Organophosphate Pesticides Cause Lasting Damage to Brain and Nervous System"},"content":{"rendered":"

(Beyond Pesticides<\/em>, December 10, 2012) Long-term low-level exposure to organophosphate pesticides produces lasting damage to neurological and cognitive functions, according to researchers at University College London (UCL). This research pulls data from 14 studies over the past 20 years, including more than 1,600 participants, in order to provide a quantitative analysis of the current literature on these dangerous chemicals. Lead author of the study, Sarah Mackenzie Ross, Ph.D., notes, \u201cThis is the first time anyone has analyzed the literature concerning the neurotoxicity of organophosphate pesticides, using the statistical technique of meta-analysis.\u201d<\/p>\n

UCL\u2019s systematic review, published in the journal Critical Reviews in Toxicology<\/em><\/a>, comes to an unsettling conclusion about the hazards of constant low-level occupational exposure to organophosphates. The study notes, \u201cThe majority of well designed studies found a significant association between low-level exposure to [organophosphates] and impaired neurobehavioral function which is consistent, small to moderate in magnitude and concerned primarily with cognitive functions such as psychomotor speed, executive function, visuospatial ability, working and visual memory.\u201d In other words, low-level exposure had significant detrimental effect on working memory and information processing.<\/p>\n

The researchers are hopeful that the results of their analysis will be used to inform governments performing reviews on the neurotoxicity of low level exposure to organophosphates. Co-author of the study, Professor Christopher McManus, M.D., Ph.D., explains, \u201cThis is considered to be the method of choice in situations where research findings may be used to inform public policy.\u201d Although the study was directed at apprising the UK government, Beyond Pesticides would like to see this research affect registration reviews performed by the U.S. Environmental Protection Agency (EPA). <\/p>\n

Organophosphates, derived from World War II nerve agents, are a common class of chemicals used as pesticides. Several are already banned or highly restricted in several European countries and in the U.S., where most are still widely used. In addition to being potent neurotoxins, organophosphates pesticides are extremely harmful to the nervous system, as they are cholinesterase inhibitors and bind irreversibly to the active site of an enzyme essential for normal nerve impulse transmission. Despite numerous organophosphate poisonings of farmworkers, homeowners, and children, EPA has allowed the continued registration of many of these products. In some cases, such as those of chlorpyrifos<\/a> and diazinon<\/a>, household uses of the products have been cancelled because of the extreme health risks to children, but agricultural, golf course, and \u201cpublic health\u201d (mosquito control) uses remain on the market. Furthermore, the cancellation of household uses does not restrict the use of remaining stocks, meaning homeowners who purchased diazinon, for example, before the 2004 phase-out, may still use this product. Malathion<\/a>, another common organophosphate, is still permitted for residential use as an insecticide and nematicide, even though all organophosphates have the same mode of action in damaging the nervous system. According to EPA, approximately one million pounds of malathion are applied annually for residential uses. After a protracted battle with farm worker and environmental groups, EPA acted to phase out<\/a> all uses of the dangerous organophoshate azinphos-methyl (AZM)<\/a>, however the agency has allowed growers to use their remaining stocks through September 30, 2013. <\/p>\n

Through our Pesticide Induced Diseases Database (PIDD)<\/a> Beyond Pesticides keeps track of the most recent studies related to pesticide exposure. For more information on the cognitive harms pesticides can cause, see our PIDD page on Learning\/Developmental Disorders<\/a>. <\/p>\n

Source<\/em>: Alpha Galileo Foundation [News Release] <\/a>
\n
\nAll unattributed positions and opinions in this piece are those of Beyond Pesticides.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

(Beyond Pesticides, December 10, 2012) Long-term low-level exposure to organophosphate pesticides produces lasting damage to neurological and cognitive functions, according to researchers at University College London (UCL). This research pulls data from 14 studies over the past 20 years, including more than 1,600 participants, in order to provide a quantitative analysis of the current literature on these dangerous chemicals. Lead author of the study, Sarah Mackenzie Ross, Ph.D., notes, \u201cThis is the first time anyone has analyzed the literature concerning the neurotoxicity of organophosphate pesticides, using the statistical technique of meta-analysis.\u201d UCL\u2019s systematic review, published in the journal Critical Reviews in Toxicology, comes to an unsettling conclusion about the hazards of constant low-level occupational exposure to organophosphates. The study notes, \u201cThe majority of well designed studies found a significant association between low-level exposure to [organophosphates] and impaired neurobehavioral function which is consistent, small to moderate in magnitude and concerned primarily with cognitive functions such as psychomotor speed, executive function, visuospatial ability, working and visual memory.\u201d In other words, low-level exposure had significant detrimental effect on working memory and information processing. The researchers are hopeful that the results of their analysis will be used to inform governments performing reviews on the […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21,293,3,274,242,244],"tags":[],"class_list":["post-8811","post","type-post","status-publish","format-standard","hentry","category-chemicals","category-developmental-disorders","category-diseasehealth-effects","category-learning-disabilities","category-nervous-system-effects","category-organophosphate"],"yoast_head":"\nStudy Reveals: Organophosphate Pesticides Cause Lasting Damage to Brain and Nervous System - Beyond Pesticides Daily News Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/beyondpesticides.org\/dailynewsblog\/2012\/12\/study-reveals-organophosphate-pesticides-cause-lasting-damage-to-brain-and-nervous-system\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study Reveals: Organophosphate Pesticides Cause Lasting Damage to Brain and Nervous System - Beyond Pesticides Daily News Blog\" \/>\n<meta property=\"og:description\" content=\"(Beyond Pesticides, December 10, 2012) Long-term low-level exposure to organophosphate pesticides produces lasting damage to neurological and cognitive functions, according to researchers at University College London (UCL). 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The founders, who established Beyond Pesticides (originally as National Coalition Against the Misuse of Pesticides) as a nonprofit membership organization in 1981, felt that without the existence of such an organized, national network, local, state and national pesticide policy would become, under chemical industry pressure, increasingly unresponsive to public health and environmental concerns. Beyond Pesticides believes that people must have a voice in decisions that affect them directly. We believe decisions should not be made for us by chemical companies or by decision-makers who either do not have all of the facts or refuse to consider them. Learn more about our work, read A Year in Review\u20142021, our accomplishments are your victories! Beyond Pesticides seeks to protect healthy air, water, land, and food for ourselves and future generations. By forging ties with governments, nonprofits, and people who rely on these natural resources, we reduce the need for unnecessary pesticide use and protect public health and the environment. Beyond Pesticides provides hands-on services to the public and supports local action by: identifying and interpreting hazards; and, designing safe pest management programs. With the information provided by Beyond Pesticides, people may not only be able to make informed choices and adopt practices that protect themselves and their families from unnecessary exposure to pesticides, but they will be able to effect changes on community-wide pest management decisions and policies that govern pesticide use, such as pesticide uses in parks, schools, for community insect control and along roadsides. 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