Gateway on Pesticide Hazards and Safe Pest Management

Beyond Pesticides offers resources below to evaluate the health and ecological effects of specific chemical exposure from ACTIVE INGREDIENTS in pesticide products, as well as regulatory information and supporting scientific documents. Because various pesticide products can contain more than one active ingredient, it is important to READ the LABEL to determine chemical components.

With 192 different active ingredients and counting, it is essential to establish the connection between the use of these chemicals and their respective hazards.

View the step-by-step guide on how to search for the active ingredient(s) in pesticide products below:

1. Go to U.S. EPA's Pesticide Product and Label System and enter the product name. The generic product name may vary.
   
2. After searching, click on the chemical ingredients tab or the link for the most recent label to find Active Ingredients.
                Chemical List                                            Label List 
   
   If one selects the chemical ingredients tab, skip to Step 4 . If not, proceed to step number 3
   
   
3. To find the active ingredient(s) on the label, search for the page in the document containing the date of registration. Usually, the active ingredients section occurs within the first few pages of the label document.
   
   
4. Return to the Beyond Pesticides Gateway and search for the active ingredient name in the yellow box to the right or from the list below. 
   
   

Cyantraniliprole

General Information

• Product Names:

  Zyrox® Fly Granular Bait
  Exirel Insect Control
  Benevia® Insect Control
  Cynt 200 Sc Mup
  Ference®
  Cyantraniliprole 200sc Mup
  Mainspring Gnl
  Verimark Insect Control
  Fortenza® Red
  Fortenza®
  Lumiderm Insecticide Seed Treatment
  Cyazypyr Technical

• Chemical Class: diamide (carboxamide)
• Uses: a broad-spectrum insecticide used to control a wide range of pests in agriculture, horticulture, and on ornamental plants.
• Alternatives: Organic Agriculture, ManageSafe™
• Beyond Pesticides rating: Toxic

Health and Environmental Effects

• Cancer: Not documented
• Endocrine Disruption: Not documented
• Reproductive Effects: Not documented
• Neurotoxicity: Not documented
• Kidney/Liver Damage: Not documented
• Sensitizer/ Irritant: Not documented
• Birth/Developmental: Not documented
• Detected in Groundwater: Not documented
• Potential Leacher: Not documented
• Toxic to Birds: Not documented
• Toxic to Fish/Aquatic Organisms: Yes (27)
• Toxic to Bees: Not documented

Additional Information

• Regulatory Status:
  • EPA Pesticide Tolerances (2024)
  • EPA Releases Draft Biological Evaluation of Cyantraniliprole’s Effects on Endangered Species (2023)
• Supporting information:
  • PAN Pesticides Database: Cyantraniliprole (Pesticide Action Network)
  • Xerces Society: Cyantraniliprole
  • Center for Biological Diversity Press Release - Legal Victory: Court Orders EPA to Protect Endangered Wildlife From Toxic Pesticide (2022)
• Studies:
• Cyantraniliprole impairs reproductive parameters by inducing oxidative stress in adult female wistar rats. da Silva Scarton, S. R., Tsuzuki, F., Guerra, M. T., Dos Santos, D. P., Dos Santos, A. C., Guimarães, A. T. B., Simão, A. N. C., Beu, C. C. L., & Fernades, G. S. A. (2022). Cyantraniliprole impairs reproductive parameters by inducing oxidative stress in adult female wistar rats. Reproductive toxicology (Elmsford, N.Y.), 107, 166–174. https://doi.org/10.1016/j.reprotox.2021.12.009
• Assessment of acute and chronic toxicity of cyantraniliprole and sulfoxaflor on honey bee (Apis mellifera) larvae. Kim, J., Chon, K., Kim, B. S., Oh, J. A., Yoon, C. Y., & Park, H. H. (2022). Assessment of acute and chronic toxicity of cyantraniliprole and sulfoxaflor on honey bee (Apis mellifera) larvae. Pest management science, 78(12), 5402–5412. https://doi.org/10.1002/ps.7162
• Growth, DNA damage and biochemical toxicity of cyantraniliprole in earthworms (Eisenia fetida). Qiao, Z., Zhang, F., Yao, X., Yu, H., Sun, S., Li, X., Zhang, J., & Jiang, X. (2019). Growth, DNA damage and biochemical toxicity of cyantraniliprole in earthworms (Eisenia fetida). Chemosphere, 236, 124328. https://doi.org/10.1016/j.chemosphere.2019.07.059
• Residue and toxicity of cyantraniliprole and its main metabolite J9Z38 in soil-earthworm microcosms. Zhang, X., Wang, X., Liu, Y., Fang, K., & Liu, T. (2020). Residue and toxicity of cyantraniliprole and its main metabolite J9Z38 in soil-earthworm microcosms. Chemosphere, 249, 126479. https://doi.org/10.1016/j.chemosphere.2020.126479
• Digging below the surface: Hidden risks for ground-nesting bees. Rondeau, S. (2024) Digging below the surface: Hidden risks for ground-nesting bees, Science. Available at: https://www.science.org/doi/10.1126/science.adt8998.
• Quantifying exposure of bumblebee (Bombus spp.) queens to pesticide residues when hibernating in agricultural soils. Rondeau, S. et al. (2022) Quantifying exposure of bumblebee (Bombus spp.) queens to pesticide residues when hibernating in agricultural soils, Environmental Pollution. Available at: https://pubmed.ncbi.nlm.nih.gov/35809712/.
• Bumblebee (Bombus impatiens) queens prefer pesticide-contaminated soils when selecting underground hibernation sites. Rondeau, S. and Raine, N. (2024) Bumblebee (Bombus impatiens) queens prefer pesticide-contaminated soils when selecting underground hibernation sites, The Science of the Total Environment. Available at: https://pubmed.ncbi.nlm.nih.gov/39332727/.
• Size-dependent responses of colony-founding bumblebee (Bombus impatiens) queens to exposure to pesticide residues in soil during hibernation. Rondeau, S. and Raine, N. (2024) Size-dependent responses of colony-founding bumblebee (Bombus impatiens) queens to exposure to pesticide residues in soil during hibernation, The Science of the Total Environment. Available at: https://pubmed.ncbi.nlm.nih.gov/39029756/.