(Beyond Pesticides, November 13, 2025) A study in Environmental Science & Technology shows that maternal exposure to organophosphate (OP) and pyrethroid insecticides adversely affects newborn health. Through amino acid and acylcarnitine metabolomics (the study of small molecules known as metabolites) with over 400 mother-infant pairs, this research analyzes metabolic pathways linking pesticide exposure to negative birth outcomes. “To our knowledge, this study is the first to reveal the effect of OP and pyrethroid insecticide exposure on neonatal metabolic signatures, which may elucidate a key role of metabolites in insecticide exposure and birth outcomes,” the authors state. In collecting maternal urine samples in the first and third trimesters, as well as neonatal blood samples after birth, OP and pyrethroid metabolites and metabolomic biomarkers are assessed. Notably, the authors report: “Results indicated that third-trimester maternal urinary levels of 3- phenoxybenzoic acid (3-PBA) and diethyl dithiophosphate (DEDTP) were negatively associated with birth weight. Specifically, a one-unit increase in their ln-transformed [natural logarithm form] concentrations was associated with a 1.508% decrease in birth weight for 3-PBA and a 1.366% decrease for DEDTP.” Additionally, the analyses show that OP and pyrethroid exposure is associated with “disrupted neonatal amino acids and acylcarnitine profiles, with patterns varying […]

(Beyond Pesticides, November 7, 2025) There is little dispute that modern industrial culture has produced a constellation of related chronic conditions contributing powerfully to human disease. In recent decades, attention has begun to focus on the developmental origins of health and disease—prenatal exposures to pesticides, for example, that contribute to diseases in adulthood, such as cardiovascular and metabolic problems, along with the combination, known as cardiometabolic syndrome. Cardiometabolic disorders include obesity, hypertension, cholesterol imbalances, and insulin resistance. The usual suspects blamed for the syndrome are poor diet, physical inactivity, and genetic predisposition. These are all well-established risk factors, but they fail to fully account for the sharp rise in cardiometabolic syndrome globally. Obesity prevalence has doubled and diabetes quadrupled over the last 40 years, according to the Non-Communicable Diseases (NCD) Risk Factor Collaboration. In a study on early life exposure to a pesticide mixture, researchers analyze sex differences in cardiometabolic outcomes from prenatal and early life. The study was conducted by an international team of scientists led by Ana M. Mora, M.D., of the Center for Environmental Research and Community Health at the University of California, Berkeley, using data from the Center for the Health Assessment of Mothers and Children of […]

(Beyond Pesticides, November 6, 2025) The report, Designed to Kill: Who Profits from Paraquat, and accompanying interactive storymap, unpacks the supply chain of the infamous herbicide paraquat and underscores the true costs of pesticide products, from manufacturing to use in the fields. This report is part of a larger initiative, the Pesticide Mapping Project—“a collaborative research series that illustrates the health and climate harms of pesticides across their toxic lifecycle: including fossil fuel extraction, manufacturing, international trade, and application on vast areas of U.S. land.” Top Highlights This report highlights, among other notable points, “that every stage of the paraquat supply chain—which spans the globe—emits greenhouse gases and toxic air pollutants.” With SinoChem as the lead producer and player in the paraquat market, the Chinese government-owned pesticide company’s supply chain “includes fossil fuel extraction in Equatorial Guinea and Saudi Arabia, chemical manufacturing in India, Germany, and the United Kingdom, international chemical shipping, and final formulation and distribution in the United States.” Paraquat is not currently manufactured in the U.S., accounting for imports of “between 40 and 156 million pounds of paraquat each year, according to the last eight years of pesticide import records available from the private database.” Despite the […]

(Beyond Pesticides, October 29, 2025) A study published in Environment International evaluates residues of individual and mixtures of endocrine-disrupting chemicals (EDCs), including pesticides, and finds an association between exposure and hyperactive behavior in children. The researchers evaluated urine samples from over 800 preschoolers, identifying and statistically analyzing concentrations of 22 EDCs, and finding that nine of these chemicals are significantly associated with hyperactivity trajectories and EDC mixtures are positively associated with hyperactive behavior, noting the strongest association in girls.  “The current study indicates the adverse health effects of exposure to mixtures of EDCs among preschoolers, and suggests gender specificity in these effects,” the researchers state. They continue, “This highlights the importance of focusing on multi-pollutant exposure in early childhood.”  Study Importance  “Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children, which has become one of the main factors leading to the burden of disease in children and adolescents worldwide.” The authors continue: “Its core symptoms are high levels of inattention and/or hyperactivity/impulsivity during the preschool period. A meta-analysis showed that the overall prevalence of ADHD in children in China over the past 15 years was as high as 6.2%, and has been increasing over recent years.”  In comparison, according […]

(Beyond Pesticides, October 29, 2025) The latest research on bats and beavers, ecosystem services, and biodiversity adds to a wide body of science on the importance of a balanced ecosystem. In both the Bulletin of the National Research Centre and Journal of Animal Ecology, the researchers highlight the interconnectedness not only between wildlife species but to broader ecosystem functioning and human health implications. Researchers in the Journal article add to the growing body of science connecting an abundance of bat species in areas with established beaver dams, highlighting how interconnected wildlife is. The reporting on this recent research coincides with Beyond Pesticides’ 42nd National Forum, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature, scheduled for today, October 29. As the author of the article in the Bulletin of the National Research Centre, entitled “The complex web between environmental disruption, pesticide use, and human health: lessons from the bat crisis,” states: “The close relationship between environmental balance, biodiversity, and human health has long been a concern of science and public policy. Disruptions in ecosystems often trigger cascading effects that extend far beyond the original ecological imbalance, affecting agricultural practices, food security, and public health.” Bat Declines and […]

(Beyond Pesticides, October 28, 2025) A California-based population study published in BMC Public Health finds that “7.5 [percent] of all pregnant people in California who gave birth in 2021 lived within 1 km [kilometer] of agricultural fields where OP pesticides [organophosphates] had been used during their pregnancy. . .” Despite a 54 percent decrease in overall use of the neurotoxic insecticide chlorpyrifos in the state between 2016 and 2021, after a statewide ban on the organophosphate insecticide in 2016, researchers found that in one California county, “more than 50 [percent] of pregnant people lived within 1 km of OP pesticide use.” Significant disparities were found in terms of elevated exposure to pesticides, “with Hispanic/Latine, young people, and residents of the predominantly fruit and vegetable growing Central Coast region being most likely to live near OP pesticide applications during pregnancy.” The authors suggest that “regulatory changes to limit use or restrict applications in close proximity to residential areas could have a substantial public health benefit on children’s brain development.” These findings add to the existing scientific literature on perinatal and maternal pesticide exposure associated with adverse long-term health effects for children and mothers. They also serve as a reminder to public […]

(Beyond Pesticides, October 23, 2025) A global literature review of pesticide residues in marine seaweed, published in Marine Pollution Bulletin, highlights the widespread presence of pesticides in bioindicator species. As vital coastal primary producers, seaweed acts as a key indicator for regional pesticide contamination patterns. The bioaccumulation within seaweed species also threatens consumers, including humans, as the chemicals can biomagnify as they move through the food web. Pesticide contamination in waterways allows residues to bioaccumulate in seaweed species, presenting risks to public health, biodiversity, and ecosystem functioning. In addition to the support seaweeds provide for ecosystems, they provide food sources for a multitude of organisms and are of growing socioeconomic importance. “This systematic review identifies, critically evaluates, and synthesizes recent global literature (2015–2024) on pesticide residues detected in seaweeds to delineate contamination patterns,” the authors share. The findings highlight the harmful impacts of petrochemical pesticides on multiple species. Many aquatic species rely on seaweed as a food source, including fish, sea urchins, crabs, snails, brittle stars, and marine mammals such as manatees and sea turtles. Even bacteria and filter feeders consume seaweed when it is decomposed. Birds and land mammals also consume seaweed, including humans who utilize seaweed in various […]

(Beyond Pesticides, October 21, 2025) A study, published in International Journal of Hygiene and Environmental Health, calculates cumulative dietary pesticide exposure and finds a significant positive association between pesticide residues in food and urine when analyzing over 40 produce types. The research uses data for 1,837 individuals from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) and compares them to biomonitoring samples of the participants. According to the researchers, “Here we show that consumption of fruits and vegetables, weighted by pesticide load, is associated with increasing levels of urinary pesticide biomarkers.” They continue, “When excluding potatoes, consumption of fruits and vegetables weighted by pesticide contamination was associated with higher levels of urinary pesticide biomarkers for organophosphate, pyrethroid, and neonicotinoid insecticides.” The NHANES data is derived from a national biomonitoring survey from the U.S. Centers for Disease Control and Prevention (CDC), which collects information about consumption of fruits and vegetables as well as urine samples. Background As the study authors explain: “Hundreds of millions of pounds of synthetic pesticide active ingredients are used every year in the United States, and pesticide exposure can occur through food, drinking water, residential proximity to agricultural spraying, household pesticide use, and occupational use. Pesticide […]

(Beyond Pesticides, October 7, 2025) Published in Environment International, a study utilizing silicone wristbands provides a snapshot of chemical exposure in over 600 participants across 10 European countries. Using the wristbands as passive and noninvasive samplers, the researchers find that organic farmers’ wristbands contain lower pesticide levels than other groups, offering insight into the benefits of organic and disproportionate risks to farmers using chemical-intensive methods. The results further reveal prevalent environmental pesticide mixtures, in addition to highlighting exposure to current-use pesticides (CUPs) and legacy (banned) pesticides that occurs through multiple exposure routes to workers, residents, and consumers. “Our study offers a comprehensive analysis of non-dietary pesticide exposure patterns among various populations across the EU [European Union], underscoring its widespread prevalence and identifying significant occupational and residential predictors,” the authors explain. As pesticide exposure occurs through both dietary and nondietary routes, such as through dermal (skin) contact and inhalation of contaminated air, there “is a growing need for aggregated [total; combined] exposure estimates across occupationally and nonoccupationally exposed populations.” The study includes testing for 193 pesticides, both legacy pesticides and CUPs, captured in silicone wristbands worn by farmers, residents living close to treated fields (neighbors), and the general population (consumers) in […]

(Beyond Pesticides, October 1, 2025) A novel study in Scientific Reports combines computational analyses with toxicological data to identify pathways affected by exposure to the weed killer glyphosate. The analyses identify glyphosate targets that correlate with kidney injury and kidney cancer, revealing pathways with significant glyphosate-induced alterations, including the dysregulation of nitrogen metabolism that leads to ammonia accumulation and oxidative stress, both of which contribute to renal (kidney) damage and carcinogenesis (development of cancer). “This study provides a comprehensive investigation into the molecular mechanisms by which glyphosate may contribute to kidney injury and kidney cancer, employing an array of bioinformatics tools for target prediction, toxicity assessment, pathway enrichment analysis, molecular docking and molecular dynamics simulation,” the researchers state. The results of the analyses and simulations highlight the molecular mechanisms underlying glyphosate’s nephrotoxic (damaging to kidneys) and carcinogenic (cancer-causing) effects. Study Importance and Background Glyphosate, known as a broad-spectrum systemic herbicide, has been used for agricultural and nonagricultural purposes for decades and is the most extensively used herbicide worldwide. This widespread use is largely due to its application to genetically engineered, glyphosate-tolerant crops. Both glyphosate and its main metabolite (breakdown product), aminomethylphosphonic acid (AMPA), are detected in water, soil, and food, […]

(Beyond Pesticides, September 24, 2025) A novel study of chronic toxicity of the neonicotinoid insecticide thiamethoxam to honey bees (Apis mellifera), published in Insects, finds sublethal effects that threaten the survival of bee larvae and the health of bee colonies. “We evaluated the effects of thiamethoxam on the entire larval development cycle of reproductive bees and conducted a comparative analysis, demonstrating that thiamethoxam significantly alters ecdysone [a hormone that controls molting in insects] and juvenile hormone titers [hormones for insect growth] in both queen and drone larvae, impairing metamorphosis and reproductive development,” the authors state. Risk assessments and scientific literature focus primarily on honey bee workers, rarely including how pesticides can impact queen and drone bees that are necessary for stable colonies. In focusing on this data gap, the researchers reveal that the survival rate of bee larvae decreases gradually with increasing doses of thiamethoxam, adding to the wide body of science on pesticide-related threats to honey bee health. (See Beyond Pesticides’ What the Science Shows on Biodiversity page for more information, as well as Daily News coverage on risk assessments here, here, and here.) Honey bees provide crucial ecosystem services as pollinating insects and play a vital role in […]

(Beyond Pesticides, September 16, 2025) As reported in the Daily News on August 28, the U.S. Environmental Protection Agency (EPA) announced that it “will hold a public webinar [today], September 16, 2025, at 2:00 PM ET to provide information on the ecological runoff/erosion and spray drift mitigation measures that can be used to protect endangered species from pesticides.” This follows closely behind an earlier announcement of a newly released Pesticide App for Label Mitigations (PALM) mobile tool to assist in implementing these mitigation measures. Despite boasting that the PALM tool is a “one-stop shop” for farmers to use EPA’s mitigation menu, which the agency claims helps to protect nontarget species, environmental critics say that self-directed mitigation without a rigorous reporting and enforcement apparatus fails to meet the level of protection that is necessary under the Endangered Species Act (ESA). As Beyond Pesticides has often reported, mitigation measures are not enforced through recordkeeping, inspections, and certification, and require no accountability from farmers and pesticide applicators. At the same time, EPA assumes compliance with mitigation measures as the basis for meeting statutory standards of reasonable risk from harmful chemicals, despite documented health and environmental harm. As a Daily News article earlier this […]

(Beyond Pesticides, September 10, 2025) After being criticized by the chemical industry and allied agribusiness and service industry groups on the Make America Healthy Again (MAHA) report in May, the strategy document, released yesterday, has tamped down efforts to reform government programs that regulate pesticides. There are no specific recommendations on improving the regulation of pesticides. Rather, the strategy appears to embrace business-as-usual and could even ramp up government efforts to tout the need for pesticides and claims that current regulatory reviews are effective and comprehensive. In a section of the strategy entitled “Increasing Public Awareness and Knowledge,” the document says: “EPA, partnering with food and agricultural stakeholders, will work to ensure that the public has awareness and confidence in EPA’s pesticide robust review procedures and how that relates to the limiting of risk for users and the general public and informs continual improvement.” This is at odds with the earlier MAHA assessment report which identified pesticides as substances of concern that, citing deficiencies in chemical reviews, “may be neglecting potential synergistic effects and cumulative burdens, thereby missing opportunities to translate cumulative risk assessment into the clinical environment in meaningful ways.” While the earlier report, Make Our Children Healthy Again: Assessment, […]

(Beyond Pesticides, September 10, 2025) Published earlier this year, a review of over 1,700 studies in Nature Communications finds pesticides affect a diverse range of nontarget organisms and contribute to global biodiversity loss. The authors* reveal “negative responses of the growth, reproduction, behaviour and other physiological biomarkers within terrestrial and aquatic systems” for nontarget plants, animals, and microorganisms. “To our knowledge, there has been no systematic and overarching synthesis of how different types of pesticides affect the diversity of multiple non-target eukaryotic and prokaryotic organisms across all trophic levels,” the researchers write. They continue, “Furthermore, current syntheses have not considered how the impacts of pesticides differ globally across climatic zones or for major mechanisms of exposure, such as those acting in aquatic or terrestrial environments.” In particular, pesticide regulatory risk assessments analyze a limited range of model species, including rats, zebrafish, clawed frogs, honeybees, and earthworms, among others. As such, they are unlikely to capture the variety of responses to pesticide exposure seen across the diversity of species and communities found in both managed and natural systems,” the authors state. *Authors include Beyond Pesticides 2023 National Forum speaker Dave Goulson—see the Daily News on his keynote address here. Research Results […]

(Beyond Pesticides, September 9, 2025) SprayDays California, the pesticide notification and mapping tool run by the California Department of Pesticide Regulation (DPR), was updated in late August after public backlash (including from farmworkers), which identified inadequate notice of pesticide use to those who work in or live in proximity to agricultural fields. According to a DPR press release from August 28, these changes include attempts to bring down barriers for users so that, in the words of DPR Director Karen Morrison, the department can “provide Californians with access to information and services.” While public health advocates view notification as a step that may allow people to leave a treatment area or take shelter to reduce exposure, groups continue to express concerns about a focus on notification to the exclusion of addressing the root causes of exposure—chemical-intensive agriculture, despite the viability of organic compatible practices and products. The groups criticize the continuous registration of pesticide active ingredients and product formulations without considering widely available practices and nonchemical and nature-based alternatives to pest management. These include regenerative organic principles and practices that draw inspiration from Indigenous land management and agroecological systems that have thrived in coexistence with nature. Recent Updates There are […]

(Beyond Pesticides, September 5, 2025) A study in Journal of Agricultural and Food Chemistry finds permethrin, a commonly used synthetic pyrethroid insecticide, to be disruptive to the gut microbiome, altering microbiota and leading to increased formation of fat cells (adipogenesis) and metabolic disorders. With an aim to “comprehensively elucidate the effects of permethrin on gut microbiota, lipogenesis, and the associated molecular mechanisms,” the study explores the adverse effects of permethrin exposure in adult mice through multiple experiments. “Our study provides the first in vivo [in a living organism] evidence suggesting a potentially causal relationship between permethrin exposure and the development of obesity, potentially mediated by specific gut microbiota-derived metabolites,” the researchers explain. They continue, “Notably, this work is the first to define a distinct microbiota−metabolite−host axis as a critical mediator of environmental toxicant-induced metabolic dysfunction.” Permethrin is widely used as an insecticide on crops, such as cotton, corn, and wheat, as well as on livestock, in indoor and outdoor areas, and for treating lice and scabies. Mosquito abatement programs often utilize permethrin, further adding to the various exposure routes of this neurotoxic chemical. (See additional uses and health effects of permethrin in Beyond Pesticides’ Gateway on Pesticide Hazards and Safe […]

(Beyond Pesticides, September 3, 2025) A study in Environmental Entomology shows that habitat and open space near agricultural fields become a killing field of pesticides, threatening biodiversity due to contamination from toxic drift. The study detected 42 pesticides, including several neonicotinoids, which are among the most lethal threats to pollinators. The research reveals the complexity of pesticide flow through the environment and the inadequacy of current methods of protecting nontarget organisms, including honey bees, bumblebees, and hundreds of other species of native bees worldwide. Their catastrophic declines is tied to pesticides in large part and highlights the inadequacy of current pesticide reduction strategies, such as integrated pest management (IPM) and now other loosely defined concepts like “regenerative,” in an attempt to protect the environment and nontarget organisms in chemical-dependent land management and agriculture. (See What the Science Shows on Biodiversity.) The researchers on the study, from the U.S. Department of Agriculture, Cornell University and Michigan State University, put silicone bands on fence posts in open areas adjacent to highbush blueberry fields on 15 farms in western Michigan. Silicone takes up chemicals in the atmosphere which can then be extracted and analyzed. The fence posts were placed at seven intervals ranging […]

(Beyond Pesticides, August 29 – September 1, 2025) It is recognized, especially on Labor Day, that the adverse effects of pesticides, with the preponderance of science accumulating every day, put workers (those who handle pesticides and are exposed through inhalation and skin absorption) at elevated risk above rates in the general population. The harm to workers is exacerbated by additional and cumulative exposure to pesticides that occurs through daily life—residues in food, water, and landscapes. Beyond Pesticides is reaching out to its network and urging people and organizations to: On Labor Day, ask your Mayor to lead a transition to practices and product procurement that protect workers with criteria that meet organic standards in landscaping and food purchasing.  With the dismantling of federal government programs charged with establishing protections and ramping up deregulation of the chemical, agribusiness, and allied industries, safety strategies for workers who are the backbone of society fall to local governments and people whose decisions should not result in hazardous worker exposure to toxic pesticides. Municipality and school district purchasing of food grown with toxic chemicals results in poisoning of farmworkers, their children, and their communities. Purchasing and applying toxic lawn care products or contract services results in […]

(Beyond Pesticides, August 28, 2025) The U.S. Environmental Protection Agency (EPA) on August 12, 2025, released a statement, “EPA Announces Action to Protect Endangered Species from Insecticide Methomyl,” in which the agency announced label changes for methomyl, a carbamate insecticide, with mitigation measures that are being criticized as allowing great risks to biodiversity and human health. The label changes, following the National Marine Fisheries Service’s (NMFS) final biological opinion issued on January 1, 2024, actually establish mitigation measures to be determined by applicators using the Bulletins Live! Two website prior to use. EPA claims that this grower determined action will meet the standards of the Endangered Species Act (ESA) by “reduc[ing] runoff and spray drift from treated areas into species’ habitats.” However, the process does not include monitoring and oversight to determine whether the rigorous standards of ESA are being met. The agency says that mitigation tracking is “at the field or farm level,” but it is not required to be submitted to the agency. EPA announced on August 20 that it is holding a 90-minute public webinar on September 16, 2025, at 2:00 PM ET to provide information on the ecological runoff/erosion and spray drift mitigation measures that can […]

(Beyond Pesticides, August 26, 2025) A scientific review in World’s Poultry Science Journal highlights the adverse health effects on avian species from exposure to the widely used weed killer glyphosate (Roundupᵀᴹ) throughout the process of poultry production. The herbicide enters the poultry production system through residues in genetically engineered feed. An earlier article in Scientific Reports concludes that glyphosate’s (GLP) “widespread application on feed crops leaves residues in the feed,” while residues are “found to be common in conventional eggs acquired from grocery stores.” In analyzing the biochemical, toxicological, and ecological impacts of glyphosate on poultry, particularly chickens, the authors find a wide body of evidence linking glyphosate and its metabolite (breakdown product) aminomethylphosphonic acid (AMPA) to debilitating hazards that extend beyond mortality. These sublethal effects include disruption of the gut microbiome and gastrointestinal disease; decreased productivity and diminished reproductive health; hepatic and kidney toxicity; growth and developmental impacts, including teratogenicity and embryotoxicity; endocrine disruption and oxidative stress; and impaired immune functions. The effects of glyphosate, as have long been documented in the scientific literature and covered by Beyond Pesticides here, range from negative impacts on biodiversity and the environment to food safety risks and human health implications. Residues of […]

(Beyond Pesticides, August 22, 2025) Legislative language moving through Congress—intended to prevent farmers, consumers, and workers from holding pesticide manufacturers accountable for the harm caused by their toxic products—is being opposed by a broad coalition of farmers, beekeepers, consumers, environmentalists, and workers with the release today of a joint statement opposing a dramatic change in a fundamental legal right. The document, Protect the Right of Farmers, Consumers, and Workers to Hold Pesticide Companies Accountable for Their Harmful Products, is joined by 51 organizations, coalitions, businesses, and leaders representing tens of thousands of members and communities. The legislation at issue is hidden in a provision of the Appropriations bill (Section 453) that has passed through the Appropriations Committee in the U.S. House of Representatives and is headed for a vote of the full House in the next couple of weeks, followed by the U.S. Senate. The Appropriations provision is being pushed by chemical companies in the wake of extraordinary jury verdicts against Bayer/Monsanto, amounting to billions of dollars in compensatory and punitive damages, for “failure-to-warn” liability claims involving glyphosate (Roundupᵀᴹ) weed killer products. The pesticide has been classified as cancer-causing by the International Agency for Research on Cancer (a part of […]

(Beyond Pesticides, August 15, 2025) In analyzing the data present in an article in Data in Brief, concerning levels of pesticide biomarkers are present in the urine of adolescents and young adults that are linked to numerous health implications. The biomonitoring data, collected at two time points from participants in a longitudinal cohort study in the agricultural county of Pedro Moncayo, Ecuador, encompasses a total of 23 compounds used as herbicides, insecticides, and fungicides and their associated metabolites (breakdown products), which include organophosphates, pyrethroids, and neonicotinoids. The results highlight the disproportionate risks to a Latin American population that occur as a result of living in areas with heavy chemical-intensive agriculture. “This article presents urinary pesticide metabolite concentrations for 665 participants in the ‘Study of Secondary Exposure to Pesticides among Children, Adolescents, and Adults’ (ESPINA), which were collected during two follow-up assessments,” the authors describe. The first sampling period from July to October 2016, referred to as Follow-up Year [FUY]-8b, includes 529 of the participants, while the second sampling period from July to September 2022 (FUY-14a) includes 505 of the participants. All participants are within the agricultural community of Pedro Moncayo. As the authors note, “The ESPINA study aimed to include […]

(Beyond Pesticides, August 14, 2025) A review in Clinical and Experimental Obstetrics & Gynecology links various classes of environmental pollutants including pesticides and per- and polyfluoroalkyl substances (PFAS), both of which Beyond Pesticides has extensively covered, to adverse effects on the female reproductive system and common mechanisms of toxicity. These chemicals “disrupt the hypothalamic-pituitary-gonadal axis (HPG), impair ovarian function, and contribute to reproductive dysfunction through mechanisms such as oxidative stress, hormonal disruption, and epigenetic [gene expression or behavior] modifications,” the authors say. This leads to menstrual irregularities, infertility, and pregnancy complications, as well as increases in the risk of reproductive system disorders such as endometriosis, polycystic ovary syndrome (PCOS), and ovarian cancer, among others. “Additionally, transgenerational effects mediated by epigenetic modifications, germ cell damage, and placental transfer may adversely affect offspring health, increasing the risk of reproductive dysfunction, neurodevelopmental disorders, metabolic diseases, and cancer,” the researchers explain. This study, integrating recent epidemiological and experimental findings, provides an overview of major chemical classes that threaten women’s health and highlights the need for immediate action. As the authors point out, female reproductive health is important not only for those who choose to plan for a family but also for the overall well-being […]