A recently completed study (available in preprint before peer review) identifies the development of what the authors term Toxicant-Induced Loss of Tolerance (TILT), the constellation of symptoms associated with chemical exposures.
(Beyond Pesticides, November 3, 2021) With a significant and increasing share of the U.S. population reporting sensitivities to certain chemicals, a team of researchers at University of California (Irvine), University of Texas (San Antonio), and the Massachusetts Institute of Technology is working to better understand how these symptoms develop. Although referred to by several names over the years, including Multiple Chemical Sensitivity (MCS) and Idiopathic Environmental Illness, medical professionals are now referring to the disease as Chemical Intolerance, or Toxicant Induced Loss of Tolerance (TILT), to better represent the disease process and range of nervous system symptoms that individuals develop to low level chemical exposures. â€śWe established evidence of this previously understudied disease process,â€ť said Shahir Masri, Sc.D, at University of California, Irvine. â€śOur insights will help public health scientists, physicians and policymakers better understand how to minimize harmful exposures and prevent future disease.â€ť TILT is characterized by a two-step process. First, there is an â€śinitiation exposure event,â€ť whereby an individual is either repeatedly exposed to low levels of certain chemicals, or experiences a major exposure incident. In the second stage, affected individuals are â€śtriggeredâ€ť even by minute exposures, not only to the chemical that affected them in the first […]