[X] CLOSEMAIN MENU

  • Archives

  • Categories

    • Announcements (582)
    • Antibacterial (115)
    • Antibiotic Resistance (2)
    • Aquaculture (22)
    • Beneficials (22)
    • Biodiversity (19)
    • Biofuels (6)
    • Biological Control (11)
    • Biomonitoring (28)
    • Canada (4)
    • Cannabis (17)
    • Children (3)
    • Children/Schools (215)
    • Climate Change (30)
    • contamination (47)
    • Environmental Justice (105)
    • Environmental Protection Agency (EPA) (60)
    • Events (82)
    • Farm Bill (1)
    • Farmworkers (107)
    • Fracking (1)
    • Fungicides (1)
    • Goats (1)
    • Golf (11)
    • Health care (31)
    • Holidays (24)
    • Integrated and Organic Pest Management (53)
    • International (278)
    • Invasive Species (28)
    • Label Claims (46)
    • Lawns/Landscapes (181)
    • Litigation (278)
    • Microbiata (2)
    • Microbiome (2)
    • Nanotechnology (53)
    • National Politics (381)
    • Pesticide Drift (122)
    • Pesticide Regulation (657)
    • Pesticide Residues (137)
    • Pets (17)
    • Preemption (4)
    • Resistance (69)
    • Rodenticide (21)
    • Take Action (376)
    • Uncategorized (181)
    • Wildlife/Endangered Sp. (309)
    • Wood Preservatives (21)
  • Most Viewed Posts

Daily News Blog

Archive for the 'Parkinson’s' Category


09
Nov

Veterans’ Coverage of Agent Orange-Related Diseases Delayed

(Beyond Pesticides, November 9, 2017) Vietnam veterans suffering from certain Agent Orange-related health conditions will continue to wait for compensation. U.S. Department of Veteran Affairs (VA) Secretary David Shulkin announced last week he intends to delay a decision to expand coverage to new illnesses. Despite a robust review by the National Academy of Medicine, which recommended expanding disability compensation for bladder cancer, hyopothyroidism, high blood pressure, and Parkinson’s-like tremors due to past exposure to the toxic herbicide cocktail, the VA decided to take no action. “After thoroughly reviewing the National Academy of Medicine (NAM)’s latest report regarding Veterans and Agent Orange, and associated data and recommendations from the NAM Task Force, I have made a decision to further explore new presumptive conditions for service connection that may ultimately qualify for disability compensation,”  Secretary Shulkin said in a press release last week.  “I appreciate NAM’s work and the commitment and expertise of VA’s NAM Task Force, and look forward to working with the Administration on the next steps in the process.” Given a promise from VA Secretary Shulkin to provide a decision on the new ailments by November 1st, Veterans groups are crying foul, and placing blame on the Trump administration, […]

Share

11
Dec

Increased Risk of Parkinson’s Disease Linked to Consumption of Heptachlor Contaminated Milk

(Beyond Pesticides, December 11, 2015) Milk contaminated with the long-banned and toxic organochlorine pesticide heptachlor in Hawaii has been found  in the brains of men that were more likely to develop Parkinson’s disease, according to a new study. This study adds to a large body of evidence linking pesticide exposure to Parkinson’s disease. Researchers of the study, titled “Midlife milk consumption and substantia nigra neuron density at death” and published in the journal Neurology, collected milk intake data from 1965 to 1968 for 449 men aged 45-68 years withpostmortem examinations from 1992 to 2004. Neuron density was measured in an area of the brain called substantia nigra (SN). As Parkinson’s develops, cells are destroyed in certain parts of the brain stem, particularly in the SN, a crescent-shaped cell mass. Measurements of brain residues of heptachlor epoxide, a heptachlor metabolite that is persistent and more toxic than its parent chemical, were also taken. “Among those who drank the most milk, residues of heptachlor epoxide were found in 9 of 10 brains as compared to 63.4%…for those who consumed no milk,” the researchers wrote. Neuron density was lowest in subjects who consumed the highest amounts of milk. The researchers looked at milk […]

Share

23
Jun

Air Force Veterans Who Used Agent Orange Contaminated Aircraft May Be Compensated

(Beyond Pesticides, June 23, 2015) After years of denial and obstruction, Air Force and Air Force Reserve veterans now have the chance to receive compensation for their exposure to the highly toxic herbicide Agent Orange on contaminated aircraft used after the Vietnam War. Affected veteran’s health issues stem from their time spent on UC-123 transport planes, which during the war were outfitted with spray equipment in the American military’s attempt to eliminate forest cover for Vietcong fighters. After the war, these aircraft were returned to use in the United States for basic transport operations such as cargo shipping and medical evacuation missions. However, these planes never underwent any form of decontamination or testing before being repurposed. Though the Agent Orange Act of 1991 stipulated medical care and disability coverage for sick veterans who  served in the Vietnam War and were exposed to Agent Orange, those who flew in contaminated post-war planes were deemed ineligible. Prior to this recent announcement from the Department of Veteran’s affairs, government officials asserted that the “dried residues” of Agent Orange were not likely to pose a health threat to aircraft crew. However, a study published by the National Academy of Sciences Institute of Medicine in […]

Share

23
Dec

USDA Reports Pesticide Residues on Over Half of Food Tested

(Beyond Pesticides, December 23, 2014) The U.S. Department of Agriculture’s (USDA) Agricultural Marketing Service (AMS) has posted a report on its data from the 2013 Pesticide Data Program (PDP) Annual Summary, concluding that although over half of the food tested by the agency for pesticide residues last year showed detectable levels of pesticides, these levels are below the tolerances established by the Environmental Protection Agency (EPA) and do not pose a safety concern. The residues reflect a pesticide use and exposure pattern that raises hazard scenarios that are not fully evaluated by EPA for chemical mixtures, synergistic effects, impacts  on  people and environments  with high risk factors, and certain critical health endpoints, such as endocrine disruption  . Excluding water, of the 9,990 samples analyzed, 23.5 percent had one pesticide detected and 36 percent had more than one pesticide. Residues exceeding tolerances were detected in 0.23 percent (23 samples out of 9,990) of the samples tested. Of these 23 samples, 17 were imported and 6 were domestic. Residues with no established tolerances were found in 3.0 percent of samples, of which 50.2 percent were domestic and 49.2 percent imported. According to USDA, “The Pesticide Data Program provides reliable data through rigorous […]

Share

10
Dec

Flight Attendant Links Airline Insecticide Use to His Parkinson’s

(Beyond Pesticides, December 10, 2013) A former steward for Australian-based Quantas airlines is suing the Australian government claiming that frequent insecticide use in airplane cabins resulted in his Parkinson’s disease diagnosis. Australia is among 49 countries that require pesticide spraying on some or all flights. Pesticide use on flights into the United States is not required, but is permitted under international law. (See here for a breakdown of pesticide use in American-based airlines, and here for information from the U.S. Department of Transportation on pesticide use in aircrafts.) Brett Vollus, former Quantas airline steward, worked for the company for 27 years until this past May when he was diagnosed with Parkinson’s and a malignant brain tumor. “He [my doctor] asked me what I did for living and when I told him he just nodded and said: ‘Another one, I am seeing a lot of you’,” Mr. Vollus said to The Australian. “This is a nightmare that has ruined my life. I am very keen to start a legal action and if it can help others I am happy to lead the way.” This case puts an international spotlight on growing evidence that pesticide use is linked to Parkinson’s disease. Parkinson’s […]

Share

06
Dec

Gene Mutation Increases Risk of Parkinson’s Disease from Pesticide Exposure

(Beyond Pesticides, December 6, 2013) In a new study exploring gene-environment interactions, researchers find that individuals with a genetic mutation linked to Parkinson’s disease are more likely to develop the neurodegenerative disease if they are exposed to pesticides. The study, Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF 2-PGC1α Transcription, identifies the molecule that protects neurons from pesticides, ties genetic mutation to pesticide exposure, and demonstrates that low dose exposure can cause Parkinson’s disease. The study, conducted by researchers at the Massachusetts Institute of Technology and the Sanford-Burnham Medical Research Institute in La Jolla, CA, supports previous epidemiological and animal studies that demonstrate the link between pesticide exposure and neurological damage, using human stem cells as a model. “For the first time, we have used human stem cells derived from Parkinson’s disease patients to show that a genetic mutation combined with exposure to pesticides creates a ‘double hit’ scenario, producing free radicals in neurons that disable specific molecular pathways that cause nerve-cell death,” says lead author Stuart Lipton, M.D., Ph.D., professor and director at the Sanford-Burnham’s Medical Research Institute. Using skin cells from Parkinson’s patient who already possess the genetic mutation linked to the disease, researchers transformed […]

Share

30
May

Study Shows Pesticides Dramatically Increase Risk of Developing Parkinson’s Disease

(Beyond Pesticides, May 30, 2013) New research published in the journal Neurology further supports the causative link between pesticide exposure and Parkinson’s disease. Emanuel Cereda, M.D., Ph.D., of the IRCCS university Hospital San Matteo Foundation in Pavia, Italy, and coauthor Gianni Pezzoli, M.D., analyzed 104 studies published between 1975 and 2011 to determine the link between pesticides and solvents to Parkinson’s disease. The researchers analyzed exposure using information on proximity to large farms likely to use pesticides, likelihood of well water consumption, and occupations that cause greater exposure to pesticides and solvents used to kill weeds, insects, fungus, and rodents. Overall, researchers found exposure to pesticides increased the risk of developing the disease by 33%  to 80%.   Some pesticides were considered to be of higher risk than others, with weed killers like paraquat and fungicides maneb and mancozeb causing twice the risk for development of Parkinson’s disease. While risk increased the longer people were exposed to pesticides, researchers indicate there is still a need for further research on the chemical threshold for harm to the brain. The study builds on recent research that has linked Parkinson’s disease to pesticide exposure. In a 2011 article published in the journal Molecular […]

Share

09
May

Review Highlights Dangerous Health Effects of Glyphosate

(Beyond Pesticides, May 9, 2013) A review of the scientific literature of the toxic effects of glyphosate, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, links the herbicide  to a wide range of diseases and suggests  that more research is needed. The review, conducted by a scientist at Massachusetts Institute of Technology (MIT), looks at the mechanisms through which the adverse effects may be happening and points to  the chemical’s inhibition of cytochrome P450 (CYP) enzymes, which plays the crucial role of detoxifying xenobiotics. Thus, glyphosate can enhance the negative effects of other environmental toxicants on the body. Authors argue that this has been a critically overlooked component in research on glyphosates’ toxicity to mammals. We “have hit upon something very important that needs to be taken seriously and further investigated,” Stephanie Seneff, PhD, lead author and research scientist at MIT, told Reuters. Not surprisingly, Monsanto, the developer of Roundup, the leading product containing glyphosate, has attempted to discredit the study, claiming that its product has a long track record of being safe – read Another Bogus “Study.” However, Beyond Pesticides has assembled  extensive documentation on the human health and environmental risks […]

Share

08
Jan

Researchers Find Further Proof of a Link between Pesticides and Parkinson’s

(Beyond Pesticides, January 8, 2013) Neurologists at the University of California, Los Angeles (UCLA) have published their latest research linking pesticide exposure to Parkinson’s disease. Appearing in the online edition of PNAS, the UCLA scientists’ work details the series of events that can occur after individuals are exposed to the pesticide benomyl, which was phased out in 2001. Researchers believe their findings on the series of events the pesticide sets in motion could be applicable even to Parkinson’s patients who have not been exposed to benomyl. According to scientists, exposure to benomyl prevents the enzyme aldehyde dehydrogenase (ALDH) from keeping in check a naturally occurring toxin in the brain called 3,4-Dihydroxyphenylacetaldehyde (DOPAL). Without ALDH regulating DOPAL, the toxin accumulates, damages neurons, and increases an individual’s risk of developing Parkinson’s disease. Researchers postulate that this process may be occurring in people with Parkinson’s who were never exposed to pesticides. The findings of this research provide insight into possible treatments to slow the disease, such as developing new drugs to protect ALDH activity. Although the exact cause of Parkinson’s is still unknown, until this research scientists were focusing in on the protein a-synuclein as a pathway to the disease. The protein, present […]

Share

14
Nov

Head Injury and Pesticide Exposure Increases Risk for Parkinson’s Disease

(Beyond Pesticides, November 14, 2012) For years, scientists have shown that pesticide exposures are linked to the onset of Parkinson’s disease. Now a new study by researchers at University of California, Los Angeles, (UCLA) finds that exposure to pesticides and suffering a head injury are associated with a three-fold increase in one’s chances of developing Parkinson’s disease. Parkinson’s disease is the second most common neurodegenerative disease, and occurs when nerve cells in the substantia nigra region of the brain are damaged or destroyed and can no longer produce dopamine, a nerve-signaling molecule that helps control muscle movement. People with Parkinson’s disease have a variety of symptoms, including loss of muscle control, trembling and lack of coordination. Over time, symptoms intensify. At least one million Americans have Parkinson’s and about 50,000 new cases are diagnosed each year. The study, “Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease,” published in the journal Neurology surveyed more than 1,000 adults ages 35 and older who lived in central California. Some 357 of the participants were diagnosed with Parkinson’s disease. Participants with the disease were nearly twice as likely as those without the disease to report having had a head injury in […]

Share

29
Jun

Pesticide Exposure Associated with Sleep Disorder

(Beyond Pesticides, June 29, 2012) New research from the McGill University Health Centre (MUHC) in Montreal suggests that pesticide exposure, as well as smoking, head injury, farming, and less education, may be a risk factor for a rare sleep disorder that causes people to kick or punch during sleep, according to a study entitled “Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study” published in the June 27, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology. People with the disorder, called REM sleep behavior disorder, do not have the normal lack of muscle tone that occurs during rapid eye movement (REM) sleep, causing them to act out their dreams. The movements can sometimes be violent, causing injury to the person or their bed partner. The disorder is estimated to occur in 0.5 percent of adults. “Until now, we didn’t know much about the risk factors for this disorder, except that it was more common in men and in older people,” said study author Ronald B. Postuma, MD, MSc, with the Research Institute at MUHC and a member of the American Academy of Neurology. “Because it is a rare disorder, it was […]

Share

28
Jun

Study Offers Insights into Link between Parkinson’s and Pesticides

(Beyond Pesticides, June 28, 2011) Recent studies have linked Parkinson’s disease to pesticide exposure. In a new article published in the journal Molecular Neurodegeneration, researchers at the University of Missouri School of Medicine take some of the first steps toward understanding this link and unraveling the molecular dysfunction that occurs when proteins are exposed to environmental toxins. The study, “Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation,” helps further explain recent NIH findings that demonstrate the link between Parkinson’s disease and two particular pesticides — rotenone and paraquat. “Fewer than 5 percent of Parkinson’s cases are attributed to genetics, but more than 95 percent of cases have unknown causes,” said Zezong Gu, MD, PhD, assistant professor of pathology and anatomical sciences. “This study provides the evidence that oxidative stress, possibly due to sustained exposure to environmental toxins, may serve as a primary cause of Parkinson’s. This helps us begin to unveil why many people, such as farmers exposed to pesticides, have an increased incidence of the disease.” Scientists previously understood that Parkinson’s is associated with oxidative stress, which is when electronically unstable atoms or molecules damage cells. The MU study yields […]

Share

31
May

Pesticide Exposure Near Workplace Linked to Parkinson’s Disease Risk

(Beyond Pesticides, May 31, 2011) A study has found that people whose workplaces were close to fields sprayed with chemicals — not just those who live nearby — are at higher risk of developing Parkinson’s disease (PD). The pesticide chemicals in question include two fungicides -maneb (in the ethylene bisdithiocarbamate (EDBC) family and ziram (in the dimethylthiocarbamate family)- and the herbicide paraquat that appear to raise the risk of developing the movement disorder. In a study published in the European Journal of Epidemiology, entitled, “Parkinson’s disease risk from ambient exposure to pesticides,” a team of researchers led by UCLA neurologist Beate Ritz, PhD found that exposures to the trio of pesticides are actually higher in workplaces located near sprayed fields than they were in residences. And the combination of exposure to all three pesticides, which act in different ways to harm brain cells involved in Parkinson’s disease, appears to be cumulative, the team led by Dr. Ritz concludes. The study found that the combined exposure to pesticides ziram, maneb and paraquat near any workplace increased the risk of Parkinson’s disease threefold, while combined exposure to ziram and paraquat alone was associated with an 80% increase in risk. The researchers estimate […]

Share

17
Feb

Report Shows Government-Industry Conflict in Pesticide Research

(Beyond Pesticides, February 17, 2011) According to a recent investigative report, a company known for conducting scientific research for the pesticide industry has, in an attempt to refute research linking pesticides to Parkinson’s disease, paid a U.S. government agency, the National Institute for Occupational Safety and Health (NIOSH), to prove that certain pesticides are safe. According to the report, the company, Exponent Inc., is a member of CropLife America, a trade group that represents pesticide manufacturers, and also has worked regularly for Syngenta, which makes paraquat, one of the chemicals it is looking prove as safe. Specifically, the company is looking to refute the research which shows that even small amounts of agricultural chemicals, maneb and paraquat, when combined, can raise the risk of Parkinson’s disease. According to the report, managing scientist of Exponent, Laura McIntosh, PhD, said in an interview that the company donated the money and sought participation at NIOSH to enhance the credibility of its study of maneb and paraquat; they wanted to make their research “bulletproof.” NIOSH is a division of the Centers for Disease Control and Prevention (CDC). Generally, government agencies are supposed to be unbiased, and federal ethics rules prohibit employees from accepting money […]

Share

16
Feb

New Studies Reveal Many Pesticides Block Male Hormones, Others Linked To Parkinson’s Disease

(Beyond Pesticides, February 16, 2011) Many agricultural pesticides —including some previously untested and commonly found in food— disrupt male hormones, according to new tests conducted by British scientists. Meanwhile, U.S. researchers at the National Institutes of Health have found that people who used two specific varieties of pesticide were 2.5 times as likely to develop Parkinson’s disease. Pesticides Impact Male Hormones Evidence suggests that there is widespread decline in male reproductive health and anti-androgenic pollutants, also known as endocrine disruptors, may play a significant role. Thirty out of 37 pesticides tested by the researchers at the University of London altered male hormones, including 16 that had no known hormonal activity until now. There was some previous evidence for the other 14. Most are fungicides applied to fruit and vegetable crops, including strawberries and lettuce. The study, “Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Anti-Androgens,” is published in Environmental Health Perspectives. The British researchers screened the chemicals using in vitro assays, which use human cells to check whether the pesticides activate or inhibit hormone receptors in cells that turn genes on and off. Scientists, however, are uncertain what actually happens in the human body at the […]

Share

16
Jun

Pesticides, Genes Combine to Increase Risk of Parkinson’s Disease

(Beyond Pesticides, June 16, 2010) Men with certain genetic variations who were exposed to some toxic pesticides that are now largely banned run an increased risk of developing Parkinson’s disease, French scientists said Monday. In a study published in Archives of Neurology, entitled “Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease,” French researchers found that among men exposed to pesticides such as DDT, carriers of the gene variants are three and a half times more likely to develop Parkinson’s than those with the more common version of the gene. The scientists think the brains of people with the gene variant fail to flush out toxic chemicals as efficiently as those with common versions of the gene, suggesting that environmental as well as genetic factors are important in the risk of Parkinson’s. Alexis Elbaz, MD, PhD and Fabien Dutheil, PhD, of France’s National Institute for Health and Medical Research (INSERM) studied 101 men with Parkinson’s and 234 without the disease to look at links between organochlorine exposure and Parkinson’s disease. The study includes only men, and all of them had high levels of exposure to pesticides through their work as farmers. The scientists found the link was […]

Share

11
Jan

Gene Variants and Pesticide Exposure Increase Risk of Parkinson’s Disease

(Beyond Pesticides, January 11, 2010) Yet another study has been published that further supports the causative link between pesticide exposure and Parkinson’s disease. The study, funded by the National Institute of Environmental Health Sciences (NIEHS), is published in the January issue of Epidemiology. The University of California, Los Angeles researchers looked at the association between Parkinson’s disease, organophosphate pesticides and the common gene variant, paraoxonase-1 gene Leu-Met 55 polymorphism (PON1-55 MM). The findings show that study participants with two copies of gene variant have a significantly increased risk of developing Parkinson’s disease when exposed to certain organophosphate pesticides used in agriculture. The population-based case-control study examined the DNA of 351 incident cases and 363 controls from three rural counties in California. The researchers then used pesticide usage reports and a geographic information system (GIS) approach to determine the study participants’ residential exposure to organophosphates. The PON1 gene codes for an enzyme that metabolizes organophosphate pesticides. Individuals with the variant MM PONI1-55 genotype that are exposed to organophosphates exhibit more than twice the risk of Parkinson’s disease compared to carriers of wildtype or heterozygous genotype and no exposure. In regards to exposure to diazinon, carriers of variant MM PONI-55 genotype show […]

Share

16
Sep

Occupational Use of 2,4-D, Permethrin Triple the Risk of Parkinson’s Disease

(Beyond Pesticides, September 16, 2009) A new study published in the September issue of Archives of Neurology reports that the risk of Parkinsonism doubled with increased occupational exposure to pesticides, including eight agents associated with experimental Parkinsonism. These data add to the growing number of studies that lend credence to a causative role of certain pesticides in neurological disorders. The study, “Occupation and Risk of Parkinsonism: A Multicenter Case-Control Study,” set out to investigate occupations, specific job tasks, or exposures and risk of parkinsonism in collaboration with eight movement disorders centers in North America including, the Parkinson’s Institute, CA, Department of Neurology, Baylor College of Medicine and Department of Neurology, Beth Israel Medical Center, New York. The investigation focused on five occupations previously suggested as posing an increased risk of Parkinsonism: agriculture, education, healthcare, welding, and mining. This examination of toxicant exposures included solvents and pesticides putatively associated with Parkinsonism. 519 people with Parkinson’s disease and 511 similar people who did not have Parkinson’s were studied. Overall, the study finds that those whose jobs involve using pesticides are 80 percent more likely to develop the condition. The data reveals that any exposure to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) almost triples […]

Share

07
Aug

Pesticide-Contaminated Well Water Linked to Increased Risk of Parkinson’s

(Beyond Pesticides, August 7, 2009) A recent study published in the journal Environmental Health Perspectives has added to evidence that certain pesticides significantly increase one’s risk of developing Parkinson’s disease (PD). Researchers found that rural residents who drank private well water within 500 meters of fields sprayed with certain pesticides had an increased – up to 90 percent – risk of developing PD, and those with Parkinson’s “were more likely to have consumed private well water, and had consumed it on average 4.3 years longer.” The study evaluated more than 700 people, including carefully chosen controls, in Fresno, Kent, and Tulare counties. 17 percent reported drinking private well water between 1974 and 1999. Researchers focused on wells’ proximity to agricultural fields sprayed with pesticides, since private wells are not regulated, and many are shallow enough to be contaminated by pesticides seeping into groundwater. Researchers looked at 26 pesticides and six in particular, “selected for their potential to pollute groundwater or because they are of interest for PD, and to which at least 10% of our population were exposed.” Those are: diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl. Propargite exposure was most closely correlated with incidence of PD, with a 90 […]

Share

30
Jul

Agent Orange Tied to Parkinson’s in Vietnam Vets

(Beyond Pesticides, July 30, 2009) A new report from the Institute of Medicine (IOM) and sponsored by the U.S. Department of Veterans Affairs finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinson’s disease in Vietnam veterans. The report is the latest in a congressionally mandated series by IOM that every two years reviews the evidence about the health effects of these herbicides and a type of dioxin – TCDD – that contaminated some of the defoliants. A finding of “limited or suggestive evidence of an association” means that the evidence indicates there could be a link between exposure to a chemical and increased risk for a particular health effect, though conflicting results from studies, problems with how the studies were conducted, or other confounding factors limit the certainty of the evidence. Until now, the cumulative evidence had been inadequate to draw conclusions about whether these two conditions may be associated with veterans’ exposures to herbicides or TCDD. Ischemic heart disease – a condition characterized by reduced blood supply to the heart, which can lead to heart attack and […]

Share

08
Jun

Pesticide Exposure Link to Parkinson’s Disease Strengthened

(Beyond Pesticides, June 8, 2009) A new epidemiological study finds that Parkinson’s disease patients who have been exposed to pesticides through their work show elevated rates of the disease. The researchers find that French farmworkers have nearly double the risk for the disease if exposed to pesticides, with a dose-effect for the number of years of exposure. When they looked at the three major classes of pesticides (insecticides, fungicides and herbicides), they find that the farmworkers who used insecticides had over a two-fold increase in the risk of Parkinson’s disease. A slightly higher risk is found for exposure to organochlorine insecticides. According to the study, these associations are stronger in men with older onset Parkinson’s disease than in those with younger onset Parkinson’s. The study, “Professional Exposure to Pesticides and Parkinson’s Disease,” published in Annals of Neurology, involved individuals affiliated with the French health insurance organization for agricultural workers who were frequently exposed to pesticides in the course of their work. Occupational health physicians constructed a detailed lifetime exposure history to pesticides by interviewing participants, visiting farms, and collecting a large amount of data on pesticide exposure. These included farm size, type of crops, animal breeding, which pesticides were used, […]

Share

16
Mar

Residential Exposure to Agricultural Pesticides Increases Risk to Parkinson’s Disease

(Beyond Pesticides, March 16, 2009) Exposure to a mixture of the fungicide maneb and the herbicide paraquat significantly increases the risk of developing Parkinson’s disease, according to a new University of California, Berkeley study, “Parkinson’s Disease and Residential Exposure to Maneb and Paraquat from Agricultural Applications in the Central Valley of California.” Published in the American Journal of Epidemiology, the study findings show that exposure to both pesticides within 500 meters of an individual’s home increases the risk of developing Parkinson’s by 75 percent. For individuals 60 years of age or younger at the time of diagnosis, there is a more than four-fold increase in risk of the disease when exposed to a combination of maneb and paraquat and a more than doubling of risk when exposed to either maneb or paraquat alone. The Berkeley researchers used geographic information systems that analyzed data from California Pesticide Use Reports and land-use maps to calculate historical residential exposure to agricultural exposure to the two pesticides. From 1998 to 2007, the researchers enrolled 368 incident Parkinson’s disease cases and 341 population controls from California’s Central Valley and developed potential exposure estimates incurred between 1974 and 1999. Also published this month by some of […]

Share

02
Mar

Gene-Pesticide Interactions Linked to Parkinson’s Disease

(Beyond Pesticides, March 2, 2009) Pesticide exposure and genetic variability in the dopamine transporter (DAT), a protein that plays a central role in dopaminergic neurotransmission of the brain, interact to significantly increase the risk factor for Parkinson’s disease, according to a new study by University of California, Los Angeles (UCLA) researchers. The population based case-control study, “Dopamine Transporter Genetic Variants and Pesticides in Parkinson’s Disease,” builds on the existing body of evidence of animal data and epidemiological studies that link exposure to pesticides, including gene-pesticide interactions, to Parkinson’s disease. The UCLA researchers, looking at incident Parkinson’s disease cases in three rural counties in Central California, find DAT increases the risk of Parkinson’s when individuals have occupational or residential exposure to pesticides. This is the first epidemiologic study of Parkinson’s disease that relies on pesticide data that is from a record-based source versus recall-based data relying on individuals’ memory. The second most common neurodegenerative disease affecting more than one million people in the U.S., Parkinson’s disease occurs when nerve cells in the substantia nigra region of the brain are damaged or destroyed and can no longer produce dopamine, a nerve-signaling molecule that helps control muscle movement. The new UCLA study is […]

Share