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Daily News Blog

Archive for the 'Oxidative Stress' Category


29
Jul

EPA’s Office of Inspector General Must Investigate EPA’s Failure to Fully Assess Pesticide Hazards

(Beyond Pesticides, July 29, 2019) A research study, published in March in Scientific Reports, uncovers a pesticide effect on a sugar-metabolizing enzyme common to all cells that has broad health ramifications ignored by the U.S. Environmental Protection Agency’s (EPA) safety testing protocol. This finding raises a larger question regarding the need for EPA to test for the synergistic effects of pesticides, whereby pesticides and chemicals in combination have an even greater effect than they do by themselves. The research, by T. Tristan Brandhorst, PhD, Iain Kean, PhD, and others in the lab of Bruce Klein, PhD, of the University of Wisconsin–Madison and UW School ofMedicine and Public Health, specifically sheds light on the mode of action of the fungicide fludioxonil. Fludioxonil, a phenylpyrrole fungicide, was developed to treat seeds during storage, and has come to be used commonly on grains, vegetables, fruits, and ornamental plants during cultivation, and produce after harvest to extend “shelf life.” As reported by the American Association for the Advancement of Science publication, EurekAlert, “The ability of [the fungicide] fludioxonil to act on a sugar-metabolizing enzyme common to all cells, and to produce the damaging compound methylglyoxal, may mean that the pesticide has more potential to harm non-fungal cells than previously […]

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09
Nov

Liver and Kidney Damage Tied to Exposure to the Organophosate Insecticide Malathion

(Beyond Pesticides, November 9, 2018) A Tunisian study (published in January 2018) on the effects in pre-pubertal mice of exposure to malathion — an organophosphate pesticide first registered for use in the U.S. in 1956 — demonstrates significant distortion of liver and kidney biochemistry and function in the animals. Deleterious effects include compromise of feeding ability, metabolism performance, neurologic deficits, reduction of overall body weight, and simultaneous increases in the weights of livers and kidneys, with structural anomalies and lesions in those organs. Organophosphates (OPs) have raised alarm bells for years. Some, such as chlorpyrifos and diazinon, have had their registrations cancelled for household uses because of the extreme health risks to children, but agricultural, golf course, and “public health” (mosquito control) uses remain commercially available and in use. Recently, Beyond Pesticides reported on research whose investigators support — and called publicly for — a worldwide ban on the compounds because of the serious health and environmental risks they pose, particularly for children. Beyond Pesticides has written extensively on OP pesticides, including malathion and chlorpyrifos. Both are used widely in agriculture. Chlorpyrifos has been the subject of quite a ping-pong match in recent years: a scheduled ban by the Environmental Protection […]

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