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Daily News Blog

Archive for the 'Oxidative Stress' Category


30
Jul

Long-Term Pesticide Exposure Linked to Hearing Loss in Farmworkers

(Beyond Pesticides, July 30, 2020) Simultaneous exposure to pesticides and noise from agricultural machinery increases farmworkers, risk of hearing loss, according to the study, “Hearing Loss in Agricultural Workers Exposed to Pesticides and Noise,” published in the journal Annals of Work Exposures and Health. Hearing loss is the 3rd most common health issue in the U.S., affecting eight million Americans. Although specific conditions like age, illness, and genetics, can mediate hearing loss, research suggests other factors can induce auricle (ear) damage, including medications, exposure to toxic chemicals (including pesticides), and loud, ongoing noise. Past studies find an association between hearing loss and pesticide exposure or noise exposure, alone. However, this study is one of the first to associate hearing loss with the additive effect to concurrent, persistent pesticide exposure, and noise. This research is significant as human senses are integral to everyday human activities, and it is vital to understand how chronic pesticide exposure can limit the body’s ability to function normally, for farmers and everyone alike. Researchers in the study note, “[I]t is necessary to understand what work-related factors are contributing to this high prevalence of hearing loss in [Thai] agricultural workers in order to develop effective interventions and […]

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30
Jun

Implications for Human Health: Pesticides and Other Environmental Contaminants Alter Gut Microbiome

(Beyond Pesticides, June 30, 2020) A review of scientific literature on the toxic effect of environmental contaminants—including pesticides—published in the journal Toxicological Science, “The Impact of Environmental Chemicals on the Gut Microbiome,” associates these chemicals to changes in the gut microbiome and other adverse health implications. The review, by researchers at the University of Illinois, looks at how environmental contaminants adversely effects and reinforce chemical disruption of the gut microbiome. It highlights the importance of evaluating how environmental contaminants, like pesticides, impact body regulation by gut microbiota. The study has significant implications for considerations that should be, but are not currently, a part of pesticide review and registration by the U.S. Environmental Protection Agency (EPA). Gut microbiota plays a crucial role in lifelong digestion, immune, and central nervous system regulation, as wells as other bodily functions. Through the gut biome, pesticide exposure can enhance or exacerbate, the adverse effects of additional environmental toxicants on the body. Since the gut microbiome shapes metabolism, it can mediate some toxic effects of environmental chemicals. However, with prolonged exposure to various environmental contaminants, critical chemical-induced changes may occur in the gut microbes, influencing adverse health outcomes. Karen Chiu, Ph.D., a graduate research fellow at the […]

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09
Oct

Glyphosate, When Combined with Other Stressors, Results in Breast Cancer Development

(Beyond Pesticides, October 9, 2019) Pesticide industry propaganda promoting the safety of glyphosate-based herbicides took another hit last month, as a study published by an international team of researchers found the chemical had the potential to induce breast cancer when combined with other risk factors. The study, Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner, led by scientists from Indiana’s Purdue University and the Institut National de la SantĂ© et de la Recherche MĂ©dicale (INSERM)/Institut de CancĂ©rologie de L’Ouest (ICO) in Nantes, France, provides an important new lens through which to view pesticide-induced cancer development. “This is a major result and nobody has ever shown this before,” says Sophie Lelièvre, PhD, a professor of cancer pharmacology in Purdue’s College of Veterinary Medicine and co-leader of IBCN. “Showing that glyphosate can trigger tumor growth, when combined with another frequently observed risk, is an important missing link when it comes to determining what causes cancer.” To make their determination, scientists exposed human breast cells low levels of glyphosate every three to four days over the course of 21 days. A control group was also dosed with a known cancer-promoting peptide. Glyphosate caused the same changes to exposed cells as […]

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29
Jul

EPA’s Office of Inspector General Must Investigate EPA’s Failure to Fully Assess Pesticide Hazards

(Beyond Pesticides, July 29, 2019) A research study, published in March in Scientific Reports, uncovers a pesticide effect on a sugar-metabolizing enzyme common to all cells that has broad health ramifications ignored by the U.S. Environmental Protection Agency’s (EPA) safety testing protocol. This finding raises a larger question regarding the need for EPA to test for the synergistic effects of pesticides, whereby pesticides and chemicals in combination have an even greater effect than they do by themselves. The research, by T. Tristan Brandhorst, PhD, Iain Kean, PhD, and others in the lab of Bruce Klein, PhD, of the University of Wisconsin–Madison and UW School ofMedicine and Public Health, specifically sheds light on the mode of action of the fungicide fludioxonil. Fludioxonil, a phenylpyrrole fungicide, was developed to treat seeds during storage, and has come to be used commonly on grains, vegetables, fruits, and ornamental plants during cultivation, and produce after harvest to extend “shelf life.” As reported by the American Association for the Advancement of Science publication, EurekAlert, “The ability of [the fungicide] fludioxonil to act on a sugar-metabolizing enzyme common to all cells, and to produce the damaging compound methylglyoxal, may mean that the pesticide has more potential to harm non-fungal cells than previously […]

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09
Nov

Liver and Kidney Damage Tied to Exposure to the Organophosate Insecticide Malathion

(Beyond Pesticides, November 9, 2018) A Tunisian study (published in January 2018) on the effects in pre-pubertal mice of exposure to malathion — an organophosphate pesticide first registered for use in the U.S. in 1956 — demonstrates significant distortion of liver and kidney biochemistry and function in the animals. Deleterious effects include compromise of feeding ability, metabolism performance, neurologic deficits, reduction of overall body weight, and simultaneous increases in the weights of livers and kidneys, with structural anomalies and lesions in those organs. Organophosphates (OPs) have raised alarm bells for years. Some, such as chlorpyrifos and diazinon, have had their registrations cancelled for household uses because of the extreme health risks to children, but agricultural, golf course, and “public health” (mosquito control) uses remain commercially available and in use. Recently, Beyond Pesticides reported on research whose investigators support — and called publicly for — a worldwide ban on the compounds because of the serious health and environmental risks they pose, particularly for children. Beyond Pesticides has written extensively on OP pesticides, including malathion and chlorpyrifos. Both are used widely in agriculture. Chlorpyrifos has been the subject of quite a ping-pong match in recent years: a scheduled ban by the Environmental Protection […]

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