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Daily News Blog

Archive for the 'olfactory effects' Category


18
Feb

Implications for Human Health: Chronic Inhalation of Paraquat in Low-Doses Disrupts Sense of Smell

(Beyond Pesticides, February 18, 2021) New research published in the journal Toxicological Sciences finds extended inhalation of the common herbicide paraquat causes male mice to lose some sense of smell, even at low doses. This study highlights the significance of understanding how specific chemical exposure routes can influence disease development. Olfactory (relating to the sense of smell) impairment is a precursory feature of Parkinson’s disease (PD), and studies connect paraquat poisoning to PD risk. Hence, future pesticide management policies should assess specific disease risks with bodily chemical concentration from low-dose, chronic neurotoxic chemical exposure. The study’s researchers note, “These data support the importance of route of exposure in the determination of safety estimates for neurotoxic pesticides, such as [paraquat]. Accurate estimation of the relationship between exposure and internal dose is critical for risk assessment and public health protection.” Despite evidence demonstrating that olfactory  nerve cells transport toxic airborne particles and solutes to the brain upon inhalation, the possibility of olfactory impairment (damage) from paraquat inhalation lacks adequate assessment. To assess the impact paraquat has on olfactory function, researchers exposed a cohort of adult female and male mice to paraquat aerosols in an inhalation chamber for four hours a day, five days a week, for four weeks. Researchers investigated paraquat concentrations […]

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23
Jan

Acute Pesticide Incidents May Lead to Loss of Smell

(Beyond Pesticides, January, 23, 2019) Individuals that have been acutely poisoned by pesticides at some time in their life may be more likely to lose their sense of smell, according to a recent study published in Environmental Health Perspectives.  Researchers focused on the effect of high pesticide exposure events (HPEE), such as a pesticide spill or other incident, on a farmers’ ability to smell later in life. This is the first study to indicate pesticide exposure may result in olfactory impairment. Farmers from Iowa and North Carolina enrolled in an ongoing U.S. Agricultural Health Study have been asked about their pesticide use roughly every 5 to 6 years since 1993. In the most recent survey, taken from 2013-2015, farmers were asked additional questions about HPEE in their lifetime and whether they had a significantly decreased or impaired sense of smell. “Studying farmers gives us more reliable data on pesticide exposures than if we had studied the general population,” says Honglei Chen, MD, PhD, lead author and professor of epidemiology at Michigan State University in a press release. “Because they use pesticides more and it’s part of their job, they’re more likely to remember what pesticides they used and in cases […]

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