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Daily News Blog

Archive for the 'multi-generational effects' Category


02
Sep

Study Finds Recently Banned, Common Insecticide Promotes Obesity Development, and Related Illnesses

(Beyond Pesticides, September 2, 2021) A McMaster University (Canada) study demonstrates exposure to the recently banned, commonly used insecticide chlorpyrifos promotes obesity development, even at low doses. Obesity generally occurs following a caloric imbalance between food intake, absorption, and energy expenditure. Although various factors can promote obesity, researchers suggest environmental toxicants like chlorpyrifos play a role in obesity development through protein/enzyme suppression. According to the Center for Disease Control, 42 percent of the U.S. population is obese and at risk for type two diabetes, cardiovascular (heart) disease, stroke, several cancers, and other critical health issues. Therefore, research like this highlights the significance of investigating how toxic chemical exposure can impact health to prevent adverse disease outcomes. Researchers note, “These studies suggest that the effects of environmental toxicants on the development of obesity may have been underestimated as all studies to date have been conducted in mice housed at RT [room temperature]. Future studies examining the mechanisms driving reductions in β-AR [beta adrenergic receptors] signaling and whether there are associations between BAT [brown adipose tissue] metabolic activity and CPF [chlorpyrifos] in humans will be important.” Several environmental pollutants have links to obesity development via the effects on gut health, endocrine (hormone) and metabolic system, […]

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22
Apr

Grandmother’s Exposure to DDT Increases Granddaughters’ Breast Cancer and Cardiometabolic Disorder Risk

(Beyond Pesticides, April 22, 2021) Past maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three successive generations, according to a new study published in Cancer Epidemiology, Biomarkers & Prevention. Although previous studies highlight early life or in utero exposure to DDT increasing breast cancer risk later in life, this study is the first to note generational effects on grandchildren’s health. DDT continues to adversely affect the health of the U.S. population, nearly 50 years after its ban. However, this ban is not global, as many countries still use or manufacture the chemical compound. Furthermore, residues of DDT metabolite, DDE, continue to readily contaminate food and water worldwide. Therefore, studies like these highlight the need to investigate how first-generation pesticide exposure can impact future generational health in order to prevent adverse health outcomes, especially during sensitive developmental periods (i.e., in utero, infancy/childhood). The study researchers note, “Discovery of actionable biomarkers of response to ancestral environmental exposures in young women may provide opportunities for breast cancer prevention.” To assess the association between multi-generational health risks and chemical exposure, researchers used the Public Health Institute’s Child […]

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02
Jul

Endocrine Disrupting Chemicals, Including Pesticides, Have a Multi-Generational Impact on Commercially Beneficial Inland Silverside Fish

(Beyond Pesticides, July 2, 2020) Exposure to low levels of endocrine-disrupting chemicals commonly in waterways, including pesticides, can impact future generations of major commercial fish, despite no direct exposure to the chemicals, according to research published in the journal Frontiers in Marine Science by Oregon State University (OSU) researchers. Many studies assess the acute or chronic health implications associated with endocrine disruptors on a single generation but lack information on multi-generational impacts that can provide vital information on the fundamental survivability or fitness of many species. This study highlights the significance of understanding the implications of endocrine disruptors, even at low levels of exposure, as parental exposure can have adverse epigenetic consequences for future generations. Kaley Major, a Ph.D. fellow at Oregon State University (OSU) and lead research author, explains, “What t[his] gets at is something your grandparents may have come into contact within their environment can still be affecting the overall structure of your DNA in your life today.” Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem). Past research shows exposures to endocrine-disrupting chemicals can adversely impact human, animal—and thus environmental—health, by altering the natural hormones in the body responsible for […]

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01
May

Weed Killer Glyphosate Linked to Multi-Generational Adverse Health Effects

(Beyond Pesticides, May 1, 2019) Evidence of the dangers of glyphosate continues to mount: researchers at Washington State University have identified, in research that exposed pregnant rats to the compound, significant disease and pathology in subsequent generations. The rats were exposed, from day 8 through day 14 of gestation, to half the observable adverse effect level (NOAEL) of glyphosate. Although this study found negligible impacts on the pregnant rats themselves or on their first-generation offspring, dramatic increases in incidence of pathology showed up in the two subsequent generations, including reproductive (prostate and ovarian) and kidney diseases; obesity; and birth anomalies. The study, published in the journal Scientific Reports (an open access, multidisciplinary journal from Nature Research), and conducted by Michael Skinner, Ph.D. and five colleagues, is the first to assess the potential transgenerational impacts of glyphosate in mammals. Its results point to an emerging frontier in assessing the risks of glyphosate and other toxic chemicals, and add to the urgent and growing demand that the use of this particular toxic — and pervasive — pesticide be halted. The research team was interested in looking at possible transgenerational impacts of glyphosate in part because of its ubiquity: it is one of the […]

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