Archive for the 'Pesticide Mixtures' Category
02
Jan
(Beyond Pesticides, January 2, 2026) Texas-based pecan orchard Swift River Pecans is collaborating with local conservation nonprofit Merlin Tuttle’s Bat Conservation “so they could collect more information on the species that visit his 266-acre property, and to show off the bats’ value to his operation,” according to recent coverage by NPR affiliate KCUR. “Bats love to munch on insects like stink bugs and moths. Some farmers are now relying on the mammals for pest control – and ditching chemicals,” says Michael Marks, reporter for NPR (Harvest Public Media) and Texas Standard. The orchard operator and nonprofit have been collaborating since 2004, after Troy Swift (orchard owner) employed a chemical-intensive approach since purchasing the land in 1988. Merlin Tuttle, “an ecologist and conservationist who has spent 65 years studying bats around the globe,” has been setting up bat boxes using cypress trees from a lumber mill on-site—the researcher has opted for this wood type because it is porous and regulates temperature appropriately. “Our job is to work with Mother Nature instead of against her to make the best pecans money can buy. That’s the way we see it,” says Mr. Swift, who also serves as the president of the Texas Pecan […]
Posted in Alternatives/Organics, Bats, Biodiversity, Climate, Ecosystem Services, Fungicides, Herbicides, Insecticides, Pesticide Drift, Pesticide Mixtures, Uncategorized | No Comments »
03
Dec
(Beyond Pesticides, December 3, 2025) Childhood cancers are on the rise globally; in the U.S. cancer is the second most common cause of death in children between one and 14 years old, and the fourth most common in adolescents. A recent study of Nebraska pesticide use and pediatric cancer incidence by researchers from the University of Nebraska Medical Center and the University of Idaho Department of Fish and Wildlife Sciences found positive associations between pesticides and overall cancer, brain and central nervous system cancers, and leukemia among children (defined as under age 20). The study’s lead author, Jabeen Taiba, PhD, of the University of Nebraska Medical Center, will discuss the study results on December 4, 2025, at the second session of Beyond Pesticides’ 42nd National Pesticide Forum, The Pesticide Threat to Environmental Health – Advancing Holistic Solutions Aligned with Nature. The first session recordings and materials are available here. The authors’ emphasis on evaluating mixtures, and their innovative technical methods for doing so, highlight the direction environmental health research and regulation must take. Studying pesticides singly is an inadequate approach, according to the authors, because pesticides are not applied individually anymore, but very often in mixtures of herbicides, insecticides, and […]
Posted in Agriculture, California, Cancer, Children, Dicamba, Farmworkers, Glyphosate, Paraquat, Pesticide Mixtures, quizalofop, tefluthrin, triasulfuron, Uncategorized | No Comments »
30
Oct
(Beyond Pesticides, October 29, 2025) A study published in Environment International evaluates residues of individual and mixtures of endocrine-disrupting chemicals (EDCs), including pesticides, and finds an association between exposure and hyperactive behavior in children. The researchers evaluated urine samples from over 800 preschoolers, identifying and statistically analyzing concentrations of 22 EDCs, and finding that nine of these chemicals are significantly associated with hyperactivity trajectories and EDC mixtures are positively associated with hyperactive behavior, noting the strongest association in girls. “The current study indicates the adverse health effects of exposure to mixtures of EDCs among preschoolers, and suggests gender specificity in these effects,” the researchers state. They continue, “This highlights the importance of focusing on multi-pollutant exposure in early childhood.” Study Importance “Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children, which has become one of the main factors leading to the burden of disease in children and adolescents worldwide.” The authors continue: “Its core symptoms are high levels of inattention and/or hyperactivity/impulsivity during the preschool period. A meta-analysis showed that the overall prevalence of ADHD in children in China over the past 15 years was as high as 6.2%, and has been increasing over recent years.” In comparison, according […]
Posted in ADHD, Biomonitoring, Body Burden, Chemical Mixtures, Children, Children/Schools, Endocrine Disruption, Pesticide Mixtures, PFAS | No Comments »
21
Oct
(Beyond Pesticides, October 21, 2025) A study, published in International Journal of Hygiene and Environmental Health, calculates cumulative dietary pesticide exposure and finds a significant positive association between pesticide residues in food and urine when analyzing over 40 produce types. The research uses data for 1,837 individuals from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) and compares them to biomonitoring samples of the participants. According to the researchers, “Here we show that consumption of fruits and vegetables, weighted by pesticide load, is associated with increasing levels of urinary pesticide biomarkers.” They continue, “When excluding potatoes, consumption of fruits and vegetables weighted by pesticide contamination was associated with higher levels of urinary pesticide biomarkers for organophosphate, pyrethroid, and neonicotinoid insecticides.” The NHANES data is derived from a national biomonitoring survey from the U.S. Centers for Disease Control and Prevention (CDC), which collects information about consumption of fruits and vegetables as well as urine samples. Background As the study authors explain: “Hundreds of millions of pounds of synthetic pesticide active ingredients are used every year in the United States, and pesticide exposure can occur through food, drinking water, residential proximity to agricultural spraying, household pesticide use, and occupational use. Pesticide […]
Posted in Agriculture, Alternatives/Organics, Azoxystrobin, Biomonitoring, Body Burden, boscalid, Centers for Disease Control and Prevention (CDC), fludioxonil, Imidacloprid, neonicotinoids, organophosphate, Pesticide Mixtures, Pesticide Regulation, Pesticide Residues, pyraclostrobin, pyrethroids, synergistic effects, Synthetic Pyrethroid, thiabendazole | No Comments »
15
Oct
(Beyond Pesticides, October 15, 2025) The latest Scientific Investigations Report for 2025 from the U.S. Geological Survey (USGS), entitled “National Water Quality Program: Multidecadal Change in Pesticide Concentrations Relative to Human Health Benchmarks in the Nation’s Groundwater,” finds moderate concentrations of five pesticides, with the highest percentages in agricultural wells, and concentrations of the carcinogenic soil fumigant DBCP (1,2-dibromo-3-chloropropane), which also causes infertility, that are greater than the maximum containment level, despite being banned over 45 years ago. These results highlight the persistence of pesticides used in agriculture and the elevated risks of pesticide contamination in agricultural areas. This report monitors concentrations of pesticides in well networks across the U.S. in decadal intervals, with this last one incorporating data ranging from 1993-2023. Additionally, DBCP in one well network in the San Joaquin-Tulare River Basin in California continues to be assessed due to previous levels exceeding the human health benchmark (HHB) established by the U.S. Environmental Protection Agency (EPA). The limitations of the study are disclosed in the text of the report. As the authors state: “Only pesticides with an HHB were included in the multidecadal pesticide change analysis… The total number of pesticides included in this study is less than […]
Posted in Agriculture, Alachlor, Atrazine, California, contamination, DBCP, deethylatrazine, Drinking Water, Groundwater, Pesticide Mixtures, Prometon, simazine, synergistic effects, U.S. Geological Survey, Water | 1 Comment »
07
Oct
(Beyond Pesticides, October 7, 2025) Published in Environment International, a study utilizing silicone wristbands provides a snapshot of chemical exposure in over 600 participants across 10 European countries. Using the wristbands as passive and noninvasive samplers, the researchers find that organic farmers’ wristbands contain lower pesticide levels than other groups, offering insight into the benefits of organic and disproportionate risks to farmers using chemical-intensive methods. The results further reveal prevalent environmental pesticide mixtures, in addition to highlighting exposure to current-use pesticides (CUPs) and legacy (banned) pesticides that occurs through multiple exposure routes to workers, residents, and consumers. “Our study offers a comprehensive analysis of non-dietary pesticide exposure patterns among various populations across the EU [European Union], underscoring its widespread prevalence and identifying significant occupational and residential predictors,” the authors explain. As pesticide exposure occurs through both dietary and nondietary routes, such as through dermal (skin) contact and inhalation of contaminated air, there “is a growing need for aggregated [total; combined] exposure estimates across occupationally and nonoccupationally exposed populations.” The study includes testing for 193 pesticides, both legacy pesticides and CUPs, captured in silicone wristbands worn by farmers, residents living close to treated fields (neighbors), and the general population (consumers) in […]
Posted in Agriculture, Alternatives/Organics, Biomonitoring, Chlorpyrifos, European Union, Farmworkers, Metabolites, Occupational Health, Permethrin, Pesticide Mixtures | No Comments »
25
Sep
(Beyond Pesticides, September 25, 2025) Reinforcing numerous studies’ findings of widespread environmental contamination with PFAS (per- and polyfluoroalkyl substances), heavy metals, pesticide metabolites, and pharmaceuticals, researchers detected the chemicals in noncommercial backyard eggs laid in Greece, according to a study published in Science of The Total Environment. The researchers found that “[o]nly 9 out of 17 samples were compliant to the limit….set by the [European Union] for the sum of PFHxS [perfluorohexanesulfonic acid], PFOS [perfluorooctanesulfonic acid], PFOA [perfluorooctanoic acid], and PFNA [perfluorononanoic acid].” They continue: “[A]s regards PFOS, PFHxS, and PFNA, seven, six and one out of 17 samples, respectively, were above the ML (maximum limit) as set by the EU.” With current regulatory standards focused on evaluating exposure to individual chemicals and, in some instances, cumulative risk associated with chemicals that have a common mechanism of effect, this study points out the importance of looking at mixtures of chemicals and the potential synergistic effects. There are some fluorinated pesticides defined as PFAS due to their molecular structure and high toxicity, which makes the chemicals highly persistent in the environment. Center for Food Safety, Center for Biological Diversity, and Public Employees for Environmental Responsibility reviewed the full list of active […]
Posted in European Union, Pesticide Drift, Pesticide Mixtures, Pesticide Regulation, PFAS, Uncategorized | No Comments »
17
Sep
(Beyond Pesticides, September 17, 2025) A study in Environmental Science & Technology finds additive effects of a synthetic pyrethroid insecticide (cypermethrin) and two fungicides (azoxystrobin and prochloraz) on biological control, biomass of major invertebrate trophic groups (position in food web), and soil ecosystem processes in arable systems (land suitable for growing crops). The study authors further highlight the failure of pesticide regulations to consider elaborate trophic interactions and pesticide mixtures, as well as additive and synergistic effects within their assessments, calling attention to the complexity of real-world exposures and the lack of research to fully understand the implications of chemical use for agricultural and land management purposes. “Arable systems have a high dependence on diverse natural biota to support pest control, soil bioturbation, and nutrient recycling,” the researchers write. These communities rely on a balance of organisms within various trophic levels in order to function and provide vital ecosystem services. Disruptions caused by environmental contaminants, such as pesticides to nontarget organisms, impact entire ecosystems and overall biodiversity. As the authors state, current risk assessments underestimate the real-world risks of petrochemical pesticides and synthetic fertilizers that, despite a wide body of science connecting exposure to deleterious health and environmental effects, are […]
Posted in Agriculture, Aphids, Azoxystrobin, Beneficials, Biodiversity, Biological Control, cypermethrin, Ecosystem Services, Environmental Protection Agency (EPA), Fungicides, Pesticide Mixtures, synergistic effects, Synthetic Pyrethroid | No Comments »
10
Sep
(Beyond Pesticides, September 10, 2025) After being criticized by the chemical industry and allied agribusiness and service industry groups on the Make America Healthy Again (MAHA) report in May, the strategy document, released yesterday, has tamped down efforts to reform government programs that regulate pesticides. There are no specific recommendations on improving the regulation of pesticides. Rather, the strategy appears to embrace business-as-usual and could even ramp up government efforts to tout the need for pesticides and claims that current regulatory reviews are effective and comprehensive. In a section of the strategy entitled “Increasing Public Awareness and Knowledge,” the document says: “EPA, partnering with food and agricultural stakeholders, will work to ensure that the public has awareness and confidence in EPA’s pesticide robust review procedures and how that relates to the limiting of risk for users and the general public and informs continual improvement.” This is at odds with the earlier MAHA assessment report which identified pesticides as substances of concern that, citing deficiencies in chemical reviews, “may be neglecting potential synergistic effects and cumulative burdens, thereby missing opportunities to translate cumulative risk assessment into the clinical environment in meaningful ways.” While the earlier report, Make Our Children Healthy Again: Assessment, […]
Posted in Agriculture, and Rodenticide Act (FIFRA), Announcements, Atrazine, Chemical Mixtures, Chemicals, Children, Children/Schools, Chlorpyrifos, Clean Water Act, Corporations, Environmental Protection Agency (EPA), Farmworkers, Federal Insecticide, Fungicide, Glyphosate, Groundwater, Label Claims, Pesticide Mixtures, Pesticide Regulation, Reflection, synergistic effects, Uncategorized, US Department of Agriculture (USDA), Water, Water Regulation | No Comments »
10
Sep
(Beyond Pesticides, September 10, 2025) Published earlier this year, a review of over 1,700 studies in Nature Communications finds pesticides affect a diverse range of nontarget organisms and contribute to global biodiversity loss. The authors* reveal “negative responses of the growth, reproduction, behaviour and other physiological biomarkers within terrestrial and aquatic systems” for nontarget plants, animals, and microorganisms. “To our knowledge, there has been no systematic and overarching synthesis of how different types of pesticides affect the diversity of multiple non-target eukaryotic and prokaryotic organisms across all trophic levels,” the researchers write. They continue, “Furthermore, current syntheses have not considered how the impacts of pesticides differ globally across climatic zones or for major mechanisms of exposure, such as those acting in aquatic or terrestrial environments.” In particular, pesticide regulatory risk assessments analyze a limited range of model species, including rats, zebrafish, clawed frogs, honeybees, and earthworms, among others. As such, they are unlikely to capture the variety of responses to pesticide exposure seen across the diversity of species and communities found in both managed and natural systems,” the authors state. *Authors include Beyond Pesticides 2023 National Forum speaker Dave Goulson—see the Daily News on his keynote address here. Research Results […]
Posted in Aquatic Organisms, Beneficials, Biodiversity, DNA Damage, Fungicides, Herbicides, Nervous System Effects, Pesticide Mixtures, synergistic effects, Wildlife/Endangered Sp. | No Comments »
18
Jul
(Beyond Pesticides, July 18, 2025) A study in Royal Society Open Science shows intraspecific differences (between individuals of a species) in wild bumblebees (Bombus vosnesenskii) exposed to an herbicide (glyphosate), a fungicide (tebuconazole), and an insecticide (imidacloprid), with gut microbiome health as a factor. “Wild pollinator declines are increasingly linked to pesticide exposure, yet it is unclear how intraspecific differences contribute to observed variation in sensitivity, and the role gut microbes play in the sensitivity of wild bees is largely unexplored,” the authors explain. “Here, we investigate site-level differences in survival and microbiome structure of a wild bumble bee exposed to multiple pesticides, both individually and in combination.” In collecting 175 individuals of this wild, foraging species from an alpine meadow, a valley lake shoreline, and a suburban park and exposing them to a diet with individual pesticides and mixtures, the researchers assess the varying lethal and sublethal effects that can occur with pesticide exposure. Between the three sites, the survival differences “emphasize the importance of considering population of origin when studying pesticide toxicity of wild bees” and highlight how pesticide sensitivity not only varies between species but within individuals of the same species with site-specific impacts. (See previous Daily […]
Posted in Beneficials, Biodiversity, Ecosystem Services, Glyphosate, Imidacloprid, Microbiome, Nevada, Pesticide Mixtures, Pesticide Regulation, Pollinators, synergistic effects, tebuconazole, Wildlife/Endangered Sp. | No Comments »
24
Jun
(Beyond Pesticides, June 24, 2025) As changes in the executive branch of the federal government upend expectations among environmental stakeholders, the regulation of food safety in the United States is being revealed as a rickety structure built over a century with unpredictable and sometimes contradictory additions, extensions, remodels, and tear-downs. In the short term, clarity is unavailable, but there have been calls for revision and strengthening of regulatory processes—requiring lawmaker and regulator willingness to incorporate the vast body of evidence that pesticides do far more harm than good, and that organic regenerative agriculture is the surest path to human and ecological health. News reports out of Costa Rica in May brought public attention to drafted legislation to ban pesticides in the country that the World Health Organization (WHO) has defined as “extremely or highly hazardous, or those with evidence of causing cancer, genetic mutations, or affecting reproduction, according to the Globally Harmonized System (GHS).” The headline sparked a relook in this Daily News at the current and historical failure of U.S. policy, which allows cancer-causing pesticides in food production and land management, despite the booming success of a cost-effective and productive, certified organic sector for which petrochemical pesticides are not […]
Posted in Agriculture, Alternatives/Organics, and Rodenticide Act (FIFRA), Breast Cancer, Cancer, Endocrine Disruption, Environmental Protection Agency (EPA), Immunotoxicity, multi-generational effects, non-Hodgkin's Lymphoma, Pesticide Mixtures, Pesticide Regulation, synergistic effects, Uncategorized, World Health Organization | No Comments »
06
Jun
(Beyond Pesticides, June 6, 2025) Published in Environmental Pollution, a study of commercial dry pet products finds dietary pesticide residues in dog and cat food, “highlighting the urgent need for improved regulatory frameworks to address the presence of non-approved pesticides in pet food.” Additionally, the researchers point out: “Current regulatory frameworks primarily assess the toxicity of individual pesticide compounds, yet real-world exposure involves complex mixtures that may lead to additive or synergistic effects. The presence of multiple residues in a single sample suggests that companion animals may be subjected to combined toxicological burdens that are not yet fully understood.” (See studies here, here, and here.) The researchers assess pesticide contamination, and their associated toxicological risks, in 83 total food products for dogs (43) and cats (40). Of the foods tested, the researchers found a total of 51 pesticides, many of which are banned in the European Union (EU), including 47% fungicides and 37% insecticides. “Pesticide residues in pet food pose potential risks to animal health, yet their occurrence and dietary exposure in companion animals remain largely unexplored,” the authors state. They continue: “To our knowledge, this is one of the first comprehensive investigations assessing both pesticide prevalence and potential dietary […]
Posted in Atrazine, Carbendazim, Chlorpyrifos, contamination, European Union, Pesticide Mixtures, Pesticide Regulation, Pesticide Residues, Pets, synergistic effects | No Comments »
30
May
(Beyond Pesticides, May 30, 2025) The Making America Healthy Again (MAHA) Commission report, Make Our Children Healthy Again: Assessment, published on May 23, drew criticism from the pesticide industry and agribusiness allies for pointing to independent science that identifies a range of pesticide-induced health hazards.* The Commission, chaired by Robert F. Kennedy, Jr., Secretary of the Department of Health and Human Services (HHS), is composed of the heads of numerous agencies of the federal government and the White House, from the U.S. Environmental Protection Agency (EPA), the U.S. Department of Agriculture (USDA), and the Office of Management and Budget (OMB), to the Assistant to the President and Deputy Chief of Staff for Policy Stephen Miller. The MAHA Commission was established by Executive Order 14212 on February 13, 2025. Despite extensive citations to the science on pesticide hazards, the report includes a section on “Crop Protection Tools,” in which there is a repetition of chemical industry talking points that pesticide residues in food comply with existing tolerances, thus implying that pesticides in food are safe. (See USDA Pesticide Data Program Continues to Mislead the Public on Pesticide Residue Exposure.) However, overall the report’s introduction sets a tone that seeks to catalogue […]
Posted in Atrazine, Chemical Mixtures, Chemicals, Children, Children/Schools, Chlorpyrifos, Corporations, Corteva, Environmental Protection Agency (EPA), Farm Bill, Farmworkers, Federal Agencies, Glyphosate, Label Claims, Pesticide Mixtures, Preemption, Uncategorized, United Nations | No Comments »
26
May
(Beyond Pesticides, May 23-26, 2025) This Memorial Day, while honoring and mourning the U.S. military personnel who have died serving in the United States Armed Forces, Beyond Pesticides recognizes those who are still fighting the long-term impacts of exposure to toxic chemicals as a result of their use in warfare. A recent review in the Open Journal of Soil Science acts as a reminder of the effects that span multiple generations to both the environment and human health following the use of pesticides. The review analyzes the history and impacts of herbicide use during the Vietnam War, as well as emphasizes the importance and relevance for current and future generations. As the authors state, “The United States (U.S.) and other countries, including Russia and Ukraine, need to learn the historical lessons from the U.S. use of herbicides, containing dioxin TCDD and/or arsenic (As), as chemical weapons during the Vietnam War.” As previously reported by Beyond Pesticides, public attention generally focuses on the “rainbow herbicides,” particularly Agent Orange, used during the Vietnam War; meanwhile, it is the dioxin TCDD (2,3,7,8 tetrachlorodibenzodioxin), a byproduct of Agent Orange’s manufacturing process, that has caused the most lasting damage within the country. While the breakdown […]
Posted in 2,4-D, Agent Orange, air pollution, arsenic, Cancer, dioxin, DNA Damage, Drinking Water, Gulf War Syndrome, Holidays, multi-generational effects, Occupational Health, Pesticide Mixtures, Reproductive Health, TCDD | No Comments »
21
May
(Beyond Pesticides, May 21, 2025) An assessment of the fire hazards of four herbicide products in Science of The Total Environment finds high fire and toxic gas emission risk, particularly in 2,4-D-based weed killer products. The authors note that “Inert [nondisclosed] ingredients significantly influence flammability and toxic gas generation in fires,” and the combustion of these products “releases hazardous gases and polycyclic aromatic hydrocarbons.” These results highlight the fire hazards associated with herbicides, as well as the emission of hazardous substances into the atmosphere, which can threaten environmental and public health. The authors summarize: “[T]he aim of this work is to raise awareness of the fire hazards posed by the storage of pesticides and what effect the ‘inert’ substances in them have. In the past, large fires have occurred around the world, e.g., in Basel (1986), Arkansas (1998), and in Eastern Virginia at the Bayer CropScience plant (2008). It is important to note that in addition to large factories and warehouses, fires can affect small crop protection product stores and local wholesalers.” (See related coverage on the 2023 train derailment, fire, and subsequent release of chemicals here.) The U.S. Fire Administration estimates 344,600 residential building fires nationally, based on […]
Posted in 2,4-D, Glyphosate, Groundwater, Occupational Health, Pesticide Mixtures, Volatile Organic Compounds | 1 Comment »
13
May
(Beyond Pesticides, May 13, 2025) A study in Environmental Pollution examines ecological and health risks in farmland soil with pesticide contamination. “Although agricultural soil pesticide residues have long threatened the environment, a relatively complete system for evaluating their health and ecological risks has not yet been developed,” the authors state. In addressing this research gap, the study finds that “more than ten pesticides were detected in 98.62% of the soil samples, which changed the soil environment” and threatens the health of the soil microbiome. The authors continue, “This study investigated the correlation between pesticide residue risks and soil ecological security and human health, revealed the response characteristics of soil microbial communities under pesticide stress, and identified microbes strongly related to pesticide ecological risks.” Pesticides, as the authors emphasize, “inevitably pollute agricultural soil, affect the ecological environment, and pose a threat to human health.” (See studies here, here, and here.) With this in mind, they assess 50 selected pesticides in 145 soil samples from agricultural land in Zhejiang Province, China and calculate the associated risks to ecosystems and public health. In describing the importance of this research, the authors explain: “Pesticides are prone to leakage and drift in environmental media, turning […]
Posted in Agriculture, Bifenthrin, Biodiversity, Cancer, Chlorpyrifos, Ecosystem Services, Imidacloprid, indoxacarb, Microbiome, Pesticide Mixtures, soil health | No Comments »
29
Apr
(Beyond Pesticides, April 29, 2025) A study in Environment International finds pesticide-induced alterations in the gut microbiota of a farmland raptor species. In collecting blood and cloacal samples from Montagu’s harrier (Circus pygargus) nestlings, the authors “shed light on an overlooked collateral effect of pesticides, i.e., a general modification of gut bacterial assemblages,” which can lead to an imbalance of microorganisms (dysbiosis) and the promotion of potential pathogens, as well as negatively impact the health of birds of prey. “Additionally, our findings support the ‘One Health‘ framework, stressing the interconnectedness of wildlife, ecosystem, and human health, particularly in pesticide-affected agricultural areas,” the researchers share. “The gut microbiota is crucial for host health and can be impacted by various environmental disruptions, yet the effects of multiple pesticide exposures on farmland organisms’ microbiomes remain largely unexplored,” the authors state. In the study, they “assessed microbiota changes in a wild apex predator exposed to multiple pesticides in agricultural landscapes,” which “provides evidence of pesticide impacts on wildlife gut microbiota, highlighting links between pesticide exposure and changes in microbiota composition,” the researchers note. The Montagu’s harrier, as an apex predator, serves as a ‘bio-sentinel’ or bioindicator species for assessing ecosystem health. “As top-level predators […]
Posted in Acetochlor, Alternatives/Organics, Biodiversity, Birds, Chlorpyrifos, Gut Dysbiosis, Microbiome, Pesticide Mixtures, Quinoxyfen, Wildlife/Endangered Sp. | No Comments »
25
Apr
(Beyond Pesticides, April 25, 2025) A novel study in Chemosphere finds impacts on male fertility in a bee species (Osmia bicornis) with exposure to sulfoxaflor, a systemic sulfoximine insecticide with similar mechanisms to neonicotinoids. “For the first time, we demonstrate that short-term chronic, field-realistic exposure to a common pesticide reduced pre-copulatory display (36%) and sounds (27%) [courtship behaviors], increased the number of copulations (+110%) and the mating duration (+166%), while finally reducing sperm quantity (25%) and mating success (43%),” the researchers report. They continue, “Our research raises considerable concern on the impact of field-realistic, low sublethal pesticide levels on the fertility and reproductive success of pollinators.” Mating behaviors and the ability to successfully reproduce determines the survival of species. As the authors state: “Mating disorders may therefore contribute to the recent decline in insect and pollinators’ health worldwide. While the impact of pesticides on pollinators is widely considered as a driving factor for reducing pollinators’ health, their effect on mating behaviour and male fertility remains widely overlooked.” The red mason bee (O. bicornis) can “provide essential pollination service for both crops and wild plants sustaining food production and biodiversity while serving as a bioindicator of environmental health.” The abundance and […]
Posted in Beneficials, Biodiversity, Clothianidin, fenbuconazole, men's health, Oxidative Stress, Pesticide Mixtures, Pollinators, Reproductive Health, Sulfoxaflor, Thiamethoxam | No Comments »
23
Apr
(Beyond Pesticides, April 23, 2025) Recent reviews of scientific literature, in both Chemosphere and Reports in Public Health, associate Parkinson’s disease (PD), the second most prevalent neurodegenerative disease globally, with pesticide exposure. “Given the pervasive nature of pesticide residues in everyday food consumption and inadequate monitoring of their long-term toxicological impacts, the role of pesticide exposure as a modifiable risk factor for neurological disorders, including PD, warrants urgent attention,” the researchers state in the article in Chemosphere. In describing the history of Parkinson’s and previous research, the authors in Reports in Public Health note that while PD etiology is not fully understood, it is a multifactorial disease. “Hereditary factors are present in approximately 10% of diagnosed cases of Parkinson’s disease, presenting early onset; while the other 90% of cases are categorized as idiopathic or sporadic Parkinson’s disease, occurring in older individuals and may be associated with exposure to environmental agents,” the researchers say. This disease, first described by English physician James Parkinson, M.D. in 1817, involves neurochemical changes that present as “the appearance of cardinal motor symptoms, such as bradykinesia, rigidity, postural instability, and rest tremor, which are essential for the clinical diagnosis of the disease,” the researchers note. The […]
Posted in 2,4-D, Atrazine, behavioral and cognitive effects, Brain Effects, Chlorpyrifos, cypermethrin, Dichlorvos, Dieldrin, Environmental Protection Agency (EPA), Glyphosate, Malathion, mancozeb, Maneb, Nervous System Effects, Oxidative Stress, Paraquat, Parkinson's, Pesticide Mixtures, Rotenone | No Comments »
13
Mar
(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.” The researchers studied the toxic effects of the insecticides abamectin and spirodiclofen, as well as the fungicide fluazinam, individually and in combination. In exposing mice and Caco-2 cells to these pesticides, the results show the disruption of intestinal functions and highlight the need to assess potential synergistic effects of pesticide mixtures as a part of the regulatory review process. Effects on the intestinal barriers of mice represent a threat to “the first line of defense against the external environment,” the researchers say. The intestinal mucosal epithelial structure plays an important role in preventing harmful substances from entering the intestines and causing damage to cells. [Caco-2 cells represent a human cell line, derived from a colon cancer patient’s tissue, and mimic the small intestine. These cells are vital in research as a model of the intestinal epithelial barrier.] “Currently, most studies investigating the effects of pesticide residues on the barrier function of Caco-2 cells concentrate on the exposure to a single residue, while the potential toxic effects arising from the concurrent presence of multiple pesticide […]
Posted in Abamectin, Chemical Mixtures, Environmental Protection Agency (EPA), fluazinam, Intestinal Damage, Pesticide Mixtures, spirodiclofen, synergistic effects | No Comments »
13
Nov
(Beyond Pesticides, November 13, 2024) A study in Chemosphere, conducted by researchers from the Institute of Biochemistry and Molecular Biology in Germany, reveals the varied lethal and sublethal effects of different glyphosate mixtures through tests on the South African clawed frog, Xenopus laevis (X. laevis). After exposing embryos to four glyphosate formulations, mortality, morphological defects, altered heartbeat rate, and impaired heart-specific gene expression are observed. Glyphosate, an herbicide and popular weed killer in many Roundup® products, is one of the most commonly detected pesticides in waterbodies worldwide, threatening aquatic organisms and overall biodiversity. This study investigates the effects of Glyphosat TF, Durano TF, Helosate 450 TF, and Kyleo, four formulations containing glyphosate, as compared to the effects of pure glyphosate on embryonic development in amphibians. The formulations consist of varying concentrations of the active ingredient glyphosate, as well as other active and inert ingredients. The authors share that, “Glyphosat TF contains 34% glyphosate and 10–20% d-glucopyranose, while Durano contains 39–44% glyphosate and 1–5% N–N-dimethyl-C12-C14-(even numbered)-alkyl-1-amines. In Helosate most of the ingredients are listed – 50–70% glyphosate, 1–10% isopropylamine, 1–3% lauryl dimethyl betaine, 0.25–1% dodecyl dimethylamine. Kyleo only lists the active ingredients glyphosate (27.9%) and 2,4-D (32%).” 2-cell stage embryos (early […]
Posted in 2,4-D, Aquatic Organisms, Biodiversity, Chemical Mixtures, Death, Developmental Disorders, DNA Damage, Endocrine Disruption, Environmental Protection Agency (EPA), Epigenetic, Glyphosate, Herbicides, Pesticide Mixtures, synergistic effects | No Comments »
24
Sep
(Beyond Pesticides, September 24, 2024) Recent commentary in Frontiers in Toxicology by two researchers, Maricel Maffini, PhD and Laura Vandenberg, PhD, highlights the pitfalls in the current regulatory systems in the United States (U.S.) for chemicals that threaten human health. Despite many advancements in science over the past few decades, and the wealth of studies that tie chemical exposure to negative health effects, risk assessments, and subsequent risk management, remain “static” and “outdated,” according to the authors. “There is increasing concern amongst public health professionals, environmental health scientists, and medical organizations about exposures to synthetic chemicals,” the researchers say. “These organizations’ concerns are based on the overwhelming evidence showing associations between chemical exposures and adverse health outcomes in human populations.” Such concerns have sparked a debate on current regulatory methods for chemicals that are present in highly used products, such as pesticides, plastic containers, and food. The authors continue, “There are now thousands of studies showing associations between these chemicals and adverse health effects in humans including neurological disorders and learning disabilities, metabolic outcomes, infertility, thyroid dysfunction, and cancers.” Additional health effects can be seen in the Pesticide-Induced Diseases Database. Of the many harmful chemicals, per- and polyfluoroalkyl substances […]
Posted in Disease/Health Effects, Environmental Protection Agency (EPA), Farmworkers, Metabolites, Pesticide Mixtures, Pesticide Regulation, synergistic effects | No Comments »