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Daily News Blog

Archive for the 'Metabolites' Category


06
May

Breakdown Products (Metabolites) from Pesticides May Be More Toxic than Parent Compound, Study Finds

(Beyond Pesticides, May 6, 2021) Nearly half of all breakdown products (transformation products) from four common-use environmental pesticides produce stronger endocrine (hormone) disrupting (ED) effects than the parent compound, according to new research published in Environment International. Over 300 environmental contaminants and their byproducts—from chemicals in plastics to cosmetic/personal care products—are commonly present in water bodies, food commodities, and human blood/urine samples. These toxicants can alter hormone metabolism, producing endocrine-disrupting effects that put the health of animals, humans, and the environment at risk. Many ecological and health risk assessments for pesticides focus on the effects of parent chemical compound products, overlooking the potential impacts of transformation products (TPs). Therefore, studies like these highlight the need to assess the implications of TPs to safeguard human, animal, and environmental health. The researchers note, “Since an increasing number of pesticide TPs have been detected in various environmental media, a more comprehensive understanding of the ecological risk of pesticide TPs is imperative for risk assessments more extensively and regulatory policy-making on pesticide restriction in the future.” Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem), including pesticides, bisphenols, phthalates, persistent organic pollutants (POPs), and heavy metals. Past research demonstrates exposure […]

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31
Mar

Hazardous Pesticide Breakdown Chemicals Found in Streams Nationwide, Raising Health Concerns

(Beyond Pesticides, March 31, 2021) Pesticide breakdown products are just as ubiquitous as their parent compounds in urban streams throughout the United States, according to research conducted by the U.S. Geological Survey (USGS) and published in Environmental Science and Technology. The first of its kind findings place an important spotlight on the long-term impacts of pesticide use on health and the environment. As new analytical methods provide evidence of dangers that were until now unable to be recorded, the data point to the need for a wholescale rethinking of the way pesticide products are approved by the U.S. Environmental Protection Agency, and community-based measures to protect local waterways.   USGS researchers subdivided the U.S. into five regions (Pacific NW, Coastal California, Midwest, Northeast, and Southeast) and took 76 to 100 water samples in small streams for each region over the course of five years. Samples were tested for 108 pesticide active ingredients, and 116 transformation products (also known as breakdown products or metabolites) that arise as active ingredients degrade after a pesticide application.   Of the active ingredients sampled, at least one pesticide was detected in 418 of 442 total stream samples conducted, representing a 95% detection rate. Breakdown products […]

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