21
Jan
Genetically Weakened Skin Barrier Allows for Easier Absorption of Toxic Chemicals
(Beyond Pesticides, January 21, 2021) A new Swedish study in Environmental Health Perspectives demonstrates individuals with genetically weakened skin barrier protection experience higher rates of toxic chemicals (i.e., pesticides) absorption through the skin. Studies provide evidence that filaggrin genetic mutations can exacerbate the impacts of chemicals upon dermal (skin) exposure, causing various skin diseases like dermatitis and other chemical-related effects like asthma and cancer. Filaggrin is a protein that is critical to skin cell structure or epidermal homeostasis. Just as excessive exposure to UV light can cause skin discoloration and cancer, excessive dermal contact with these toxic chemicals can cause a range of adverse reactions, including dermatitis, allergic sensitization, and cancer. Dermal exposure is the most common pesticide exposure routes, compromising 95 percent of all pesticide exposure incidents. Furthermore, many pesticides contain chemicals that act as sensitizers (allergens). Therefore, it is essential to mitigate direct skin contact with these toxic chemicals and enforce proper application protocol. Dermal chemical exposure is an increasing concern for occupational (work-related) health. Likewise, people experience dermal exposure to chemicals from everyday products like cleaning supplies, personal care products, agricultural chemicals, fabrics, non-stick cookware, and general airborne pollution. Furthermore, skin disease risks can increase among those with less protection from chemical exposure due to genetics. The study’s […]
