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Daily News Blog

Archive for the 'Motor neuron disease' Category


04
Aug

Glyphosate Weed Killer Crosses Blood-Brain Barrier, Linked to Alzheimer’s and Other Neurodegenerative Diseases

(Beyond Pesticides, August 4, 2022) An Arizona State University (ASU) study shows that the popular herbicide glyphosate can infiltrate the brain through the blood (blood-brain barrier), increasing neurological disease risk. The blood-brain barrier filters various molecules entering the brain from the circulatory system. However, the permeation of glyphosate molecules elevates the expression of TNFα and the accumulation of soluble beta-amyloid (Aβ) proteins in the brain and has associations with immune, inflammatory, and neurodegenerative diseases like Alzheimer’s disease (AD). More than 6 million people in the U.S. are living with Alzheimer’s, and cases are expected to double by 2050. Although Alzheimer’s research has focused heavily on finding genetic causes of the disease, fewer than half of cases are genetic. Thus, researchers are now evaluating how environmental contaminants may increase disease risk. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood and urine samples and can increase neurotoxicity risk when crossing the brain barrier. Therefore, studies like this highlight the importance of understanding how chemical accumulation in the body can impact long-term health and disease prognosis. The study notes, “Brain glyphosate correlates with increased TNFα levels, suggesting that exposure to this herbicide may trigger neuroinflammation in the brain, which may […]

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08
Apr

Motor Neuron Disease Linked to Gene-Environment Interactions

(Beyond Pesticides, April 8, 2008) A team of University of Michigan scientists discover interactions between genes and organophosphate exposure cause some forms of motor neuron disease (MND). The study, which appears in the March issue of the American Journal of Human Genetics, shows the mutations in one key gene (neuropathy target esterase, or NTE) that causes a previously unknown type of inherited MND. The scientists also find the mutations caused changes in a protein already known to be involved when people develop neurologic disorders as a result of exposure to toxic organophosphate chemicals commonly used in solvents and insecticides and also as “nerve gas” agents. Motor neuron disease is a rare, devastating illness in which nerve cells that carry brain signals to muscles gradually deteriorate. One form of it is Lou Gehrig’s disease or ALS (amyotrophic lateral sclerosis). For most MND patients, the cause is unknown. Figuring out why these people develop the disease, which causes muscles to weaken, atrophy and cease to function, is an important step in developing therapies to treat or prevent motor neuron disease. Motor neuron disease affects five per 100,000 people. “Our findings support the possibility that toxic organophosphates contribute to motor neuron disease in […]

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