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Daily News Blog

Archive for the 'fludioxonil' Category


08
Oct

Common Fungicide Causes a Decrease in Antioxidant Responsible for Defense Against Diseases like COVID-19

(Beyond Pesticides, October 8, 2020) Research from the University of Wisconsin—Madison (UWM), suggests that fludioxonil—a commonly used agricultural fungicide—decreases the human body’s ability to defend itself against illnesses, like COVID-19, and promotes disease permanency. Tristan Brandhorst, a Ph.D. scientist at UWM, notes that a pesticide-induced reduction in the antioxidant glutathione could be responsible for this lack of bodily defense against disease. Although many studies examine how pesticides adversely affect the human body (i.e., cancer, respiratory issues, etc.), very few studies assess how pesticides reinforce chemical disruption patterns that reduce levels of vital chemicals needed for normal bodily function. The steady rise in U.S. pesticide use, including disinfectants, threatens animals and humans, as exposure to indiscriminate dispersal of pesticides cause a whirlwind of health risks. As the total U.S. COVID-19 cases rise above 7.5 million, global leaders need to understand extensive pesticide spraying is not a viable solution to prevent illness and causes more chronic harm from exposure in the long run. Dr. Brandhorst stresses the need for proper reevaluation of pesticide risks stating, “The issue needs more study, [and] might also warrant a reworking of how [the U.S. Environmental Protection Agency] evaluates pesticides.” Amidst the outbreak of SARS-CoV-2 (COVID-19), the global demand […]

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29
Jul

EPA’s Office of Inspector General Must Investigate EPA’s Failure to Fully Assess Pesticide Hazards

(Beyond Pesticides, July 29, 2019) A research study, published in March in Scientific Reports, uncovers a pesticide effect on a sugar-metabolizing enzyme common to all cells that has broad health ramifications ignored by the U.S. Environmental Protection Agency’s (EPA) safety testing protocol. This finding raises a larger question regarding the need for EPA to test for the synergistic effects of pesticides, whereby pesticides and chemicals in combination have an even greater effect than they do by themselves. The research, by T. Tristan Brandhorst, PhD, Iain Kean, PhD, and others in the lab of Bruce Klein, PhD, of the University of Wisconsin–Madison and UW School ofMedicine and Public Health, specifically sheds light on the mode of action of the fungicide fludioxonil. Fludioxonil, a phenylpyrrole fungicide, was developed to treat seeds during storage, and has come to be used commonly on grains, vegetables, fruits, and ornamental plants during cultivation, and produce after harvest to extend “shelf life.” As reported by the American Association for the Advancement of Science publication, EurekAlert, “The ability of [the fungicide] fludioxonil to act on a sugar-metabolizing enzyme common to all cells, and to produce the damaging compound methylglyoxal, may mean that the pesticide has more potential to harm non-fungal cells than previously […]

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05
Jul

Widely Used Fungicide Found to Adversely Affect Enzyme Common to All Cells

(Beyond Pesticides, July 5, 2019) This is a story about a chemical pesticide, a fungicide, in wide use for which the mode of action, i.e., the ability to cause harm, has not been fully understood. It is not a story unique to this pesticide. Rather, it is an important story to consider when deciding to use a pesticide or allowing a pesticide to be used. The question is whether the chemical could be broadly problematic beyond the target organisms, in this case fungi? In its coverage of a study published in March, the American Association for the Advancement of Science publication, EurekAlert, reported that, “The ability of [the fungicide] fludioxonil to act on a sugar-metabolizing enzyme common to all cells, and to produce the damaging compound methylglyoxal, may mean that the pesticide has more potential to harm non-fungal cells than previously thought. Although fludioxonil has been deemed safe for use, the authors . . . suggest that the effects of this widely used pesticide has upon animals be re-examined.” The research study, published in March in Scientific Reports and led by T. Tristan Brandhorst, PhD (in the lab of Dr. Bruce Klein at the University of Wisconsin–Madison and UW School of […]

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