(Beyond Pesticides, October 12, 2023) A new study published in Environment International finds novel environmental chemicals (i.e., piperidineÂ insecticide, 2,4-dinitrophenol, benzo[a]carbazole, and a benzoate derivative) involved in developing breast cancer through various inflammation pathways. These new potential factors contribute to breast cancer and highlight the importance of employing epidemiological biomonitoring like exposome (total exposure from birth to death) to discover mechanisms involved in disease development that are otherwise overlooked. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. SeveralÂ studies and reports, including U.S. Environmental Protection Agency (EPA) data, identify hundreds of chemicals as influential factors (either promoting or initiating) associated with breast cancer risk.
Breast cancer is the most common cancer among women, accounting for 12 percent of all new annual cancer cases worldwide and causing the second most cancer-related deaths in the United States. Past studies suggest genetic inheritance factors influence breast cancer occurrence. However, genetic factors only play aÂ minor roleÂ in the incidence of breast cancer, while exposure to external environmental factors (e.g., chemical exposure) appears to play a more notable role. One in ten women will receive a breast cancer diagnosis, and geneticsÂ can only account for five to ten percent of cases. There are grave concerns over exposure to endocrine (hormone) disrupting chemicals and pollutants that cause adverse health effects. Therefore, studies like these highlight the need to investigate how first-generation pesticide exposure can impact future generational health to prevent adverse health outcomes, especially duringÂ sensitive developmental periodsÂ (i.e.,Â in utero, infancy/childhood).Â
This study employs omics scale (cell constituents) biomonitoring to determine associations with a disease, also known as â€śexposome epidemiology.â€ť The goal is to investigate potential new environmental factors influencing breast cancer risk. Using nontargeted, high-resolution mass spectrometry, researchers test the association between pregnancy cohorts from the Child Health and Development Studies (CHDS) and breast cancer incidence from the California Cancer Registry. The research evaluates second and third-trimester samples from the CHDS database to analyze environmental chemicals involved in the development of breast cancer among 182 women and 384 randomly selected women who did not develop breast cancer. Researchers distinguish environmental chemicals using the Toxin and Toxin-Target Database to determine chemical signals with the highest association in breast cancer cases. Researchers employ the exposome epidemiology analysis to establish a framework that identifies suspected chemicals. The study results find that exposure to environmental chemicals during the second and third trimesters exacerbates inflammation pathways associated with breast cancer, including linoleate, arachidonic acid, andÂ prostaglandins. These chemicals include an N-substitutedÂ piperidineÂ insecticide, 2,4-dinitrophenol, benzo[a]carbazole, and a benzoate derivative linked to glycan and amino sugar metabolism.
Inheritance of health issues spanning generations relating to hereditary influence is a familiar phenomenon. However, this study demonstrates multigenerational/transgenerational health problems from chemical exposure, a non-genetic factor. Epigenetic changes occur through environmental factors that alter gene expression that can impact multiple future generations. Considering two-thirds of all breast cancer incidences are related to factors outside of heritable gene mutations (e.g., BRCA1Â andÂ BRCA2), chemical exposure can explain the increasing rates of breast cancer. Many studies have long shown thatÂ childhoodÂ andÂ in-uteroÂ exposure to environmental chemicals increases the risk of developing breast cancer later in life. According to multiple studies,Â glyphosateÂ exposure has adverse multigenerational effects, causing negligible observable effects on pregnant rodents but severe effects on the two subsequent generations. Recent research from the Silent Spring Institute linksÂ 28 different EPA-registered pesticidesÂ with the development of mammary gland tumors in animal studies. Many of these chemicals are endocrine disruptors and thus have implications for breast cancer risk.Â Household cleaners, mainly pesticides, contain endocrine-disrupting chemicals that increase breast cancer risk.Â Furthermore, long-term exposure to organophosphate (OP) pesticidesÂ increasesÂ adverse health and cancer risk, specifically among women. Since DDT/DDE residues, current-use pesticides, and other chemical pollutants contaminate the environment, exposure to these chemical mixtures canÂ synergizeÂ to increase toxicity and disease effects.
Pregnancy provides the most appropriate timeframe to study potential disease development, especially for the initiation, progression, and susceptibility to breast cancer. Past studies note later age pregnancy is a significant breast cancer risk factor, which is considerable given birth rates have increased six-fold for women ages 35â€“39. Thus, the study calls for a â€śmore detailed understanding of the respective contributions and interactions must be a priority to learn how to mitigate risk for this population group of higher risk women.â€ť
The exposome epidemiology approach that this study uses is essential as it assumes â€śchemical exposures which increase cancer risk can occur decades before breast cancer occurrence, that these exposures are detectable and at higher abundance in serum decades before breast cancer detection, and that network analyses of HRM [high-resolution metabolomics] data are sufficient to detect these exposures and link them to biologic responses.â€ť Considering research over the past 50 years lacks development of a strategy to prevent breast cancer, using the exposome approach can allow analysis to more readily identify chemical carcinogens and the pathways involved in disease development.
Past research demonstrates the mechanism by which cancer can develop after pesticides enter the bloodstream. In 2013, anÂ experimental studyÂ showed that pesticide exposure produces volatile reactive oxygen species (ROS) that cause potential DNA and cell damage that propagates cancer development. Additionally, pesticides can increase cancer risk throughÂ alternate mechanisms, including genotoxicity (gene damage), epigenetics (gene expression), immunotoxicity, tumors, and endocrine disruption. Accordingly, this study advocates for the integration of omics scale biomonitoring (exposome epidemiology) with these other risk factors to enhance prediction and intervention strategies, subsequently decreasing the disease burden. Therefore, it is essential to understand how external stimuliâ€”like environmental pollution from pesticidesâ€”can drive breast cancer development, as female health risks need urgent concerns.
PreventionÂ of the causes of breast cancer, not just awareness, is critical to solving this disease. In 1985, Imperial Chemical Industries and the American Cancer Society declared October â€śBreast Cancer Awareness Monthâ€ť as part of a campaign to promoteÂ mammogramsÂ for the earlyÂ detectionÂ of breast cancer. Unfortunately, most people are all tooÂ awareÂ of breast cancer. Detection and treatment of cancers do not prevent the problem.
Cancer is a leading cause of death worldwide. Much pesticide use and exposure are associated with cancer effects. Studies concerning pesticides and cancer help future epidemiological research understand the underlying mechanisms that cause cancer. Although the link between agricultural practices and pesticide-related illnesses is stark, overÂ 63 percentÂ of commonly used lawn pesticides andÂ 70 percentÂ of commonly used school pesticides haveÂ linksÂ to cancer. Advocates argue that global leaders must fully understand the cause of pesticide-induced diseases before the chemicals enter the environment. Policy reform and practices that eliminate toxic pesticide use can end the uncertainty surrounding potential harm. For more information on the multiple health effects associated with pesticides, see Beyond Pesticidesâ€™Â Pesticide-Induced Diseases DatabaseÂ pages onÂ breast cancer,Â endocrine disruption, and other diseases. This database supports the need for strategic action to shift away from pesticide dependency.
Moreover, proper prevention practices, likeÂ buying,Â growing, and supporting organics, can eliminate exposure to toxic pesticides. Organic agriculture has manyÂ healthÂ andÂ environmentalÂ benefits that curtail the need for chemical-intensive agricultural practices.Â Regenerative organic agricultureÂ nurtures soil health through organic carbon sequestration, preventing pests and generating a higher return than chemical-intensive agriculture. For more information on how the organic choice is the right choice, see the Beyond Pesticides webpage,Â Health Benefits of Organic Agriculture.Â
All unattributed positions and opinions in this piece are those of Beyond Pesticides.
Source: Environment International