(Beyond Pesticides, July 18, 2025) A study in Royal Society Open Science shows intraspecific differences (between individuals of a species) in wild bumblebees (Bombus vosnesenskii) exposed to an herbicide (glyphosate), a fungicide (tebuconazole), and an insecticide (imidacloprid), with gut microbiome health as a factor. “Wild pollinator declines are increasingly linked to pesticide exposure, yet it is unclear how intraspecific differences contribute to observed variation in sensitivity, and the role gut microbes play in the sensitivity of wild bees is largely unexplored,” the authors explain. “Here, we investigate site-level differences in survival and microbiome structure of a wild bumble bee exposed to multiple pesticides, both individually and in combination.” In collecting 175 individuals of this wild, foraging species from an alpine meadow, a valley lake shoreline, and a suburban park and exposing them to a diet with individual pesticides and mixtures, the researchers assess the varying lethal and sublethal effects that can occur with pesticide exposure. Between the three sites, the survival differences “emphasize the importance of considering population of origin when studying pesticide toxicity of wild bees” and highlight how pesticide sensitivity not only varies between species but within individuals of the same species with site-specific impacts. (See previous Daily […]

(Beyond Pesticides, July 16, 2025) A study following a mass mortality event of approximately 200 monarch butterflies (Danaus plexippus plexippus) in Pacific Grove, California, highlights the role of pesticides, synthetic pyrethroids in particular, in causing lethal and sublethal effects to nontarget organisms. The research, published in Environmental Toxicology and Chemistry, detects residues of 15 pesticides and associated metabolites in the bodies of 10 deceased butterflies collected from the January 2024 event that occurred near an overwintering site frequented by monarchs. “On average, each monarch butterfly contained 7 pesticides,” the authors report. They continue, “Notably, three pyrethroid insecticides—bifenthrin, cypermethrin, and permethrin—were consistently detected at or near each chemical’s lethal dose (LD50).” LC50, or Lethal Concentration 50, values represent the concentrations of chemicals lethal to 50% of a test population. To assess pesticide residues within ten of the deceased butterflies, the researchers use liquid and gas chromatography with tandem mass spectrometry (LC-MS/MS and GC-MS/MS) and find “a total of 15 pesticides and associated metabolites in the butterflies, including 8 insecticides (plus 1 associated metabolite), 2 herbicides (plus 2 associated metabolites), and 2 fungicides.” The study “present[s] evidence that the mortality incident at the Pacific Grove Monarch overwintering site was likely caused by […]

(Beyond Pesticides, July 8, 2025) A commentary published in Science of The Total Environment showcases the occupational and environmental exposure pathways of fossil-fuel-based pesticide and fertilizer products that children across the globe face, particularly in rural areas of low- and middle-income countries. The authors underscore “the urgent need for multi-level systemic change, resilient health systems, and active stakeholder engagement,” which includes “support for safer and more sustainable agricultural practices.” This includes specific asks for governments “to offer technical assistance to producers and encourage organic and agroecological practices to ensure both environmental justice and food security.” Organic food systems, and criteria for land management systems more broadly, are critical to addressing the triple crises of biodiversity loss, public health collapse, and climate emergency. Organic law, as defined in the Organic Foods Production Act (OFPA) of 1991, is designed as a participatory process with accountability and transparency integral to the statutory language. The law creates the National Organic Standards Board (NOSB), comprised of farmers, consumers, and conservation organizations, a scientific expert, an organic certifier, and a retailer with the statutory authority to adopt binding recommendations to the Secretary of Agriculture on the National List of Allowed and Prohibited Substances. Simultaneously, the public […]

(Beyond Pesticides, July 2, 2025) An article in The New Lede, entitled Seeking answers to a cancer crisis in Iowa, researchers question if agriculture is to blame, documents case studies of cancer diagnoses linked to chemical-intensive agriculture. Current national cancer rates, according to the American Cancer Society, show that two million new cancer cases are projected to occur during 2025 in the U.S. Additional research predicts 618,120 cancer deaths this year as well, highlighting a crisis of great concern. A wide body of science links increased cancer risks with exposure to agricultural chemicals, including petrochemical pesticides and synthetic fertilizers. Previous coverage from Beyond Pesticides showcases the disproportionate health risks to farmworkers and their families, as well as those living near agricultural fields, associated with exposure to harmful toxicants. Recent research ties pesticide use to cancer diagnoses among farmer populations through a literature review of clinical trials, as well as epidemiologic, case-control, and experimental studies, from not only the U.S. but Brazil, India, France, Egypt, Columbia, Ecuador, Mexico, Italy, and Spain. (See Daily News here.) Additional risks for children, as reported in a study in GeoHealth, are noted in Nebraska as exposure to agricultural mixtures show statistically significant positive associations with […]

(Beyond Pesticides, June 27, 2025) An article in The New York Times (NYT), entitled “A Killer Within Easy Reach,” highlights the use of the weed killer paraquat, a widely used herbicide in the U.S. and many other parts of the world despite being banned in over 70 countries, as the cause of numerous suicides. The article references the tiny nation of Suriname, located on the northeastern coast of South America, as they have “one of the highest suicide rates in the world,” with the majority of those deaths involving paraquat. Globally, paraquat is prevalently used in self-harm incidents. The chemical, when absorbed into the body, among other deadly effects, causes pulmonary fibrosis, making lung tissue brittle and causing respiratory failure. While this pesticide is intended and generally used for weed control, it is also highly lethal to humans in small amounts and is often easily accessible in many households. As the NYT article states, “Pesticides are among the leading means of suicide in agricultural areas of developing nations, implicated in more than 100,000 deaths annually.” Citing examples from around the world, the article states, “Sri Lanka’s crop yields had surged after the introduction of modern fertilizers and pesticides in the […]

(Beyond Pesticides, June 26, 2025) A review article in Nature Reviews Earth & Environment highlights how the pesticides used in global crop production pose risks to ecosystems and human health through multiple pathways. As the authors note, “Once applied to crops, pesticides are transported through surface and groundwater flows, atmospheric dispersion and wildlife migration.” Residues in food products, such as fruits and vegetables, as well as bioaccumulation within animals that are consumed as food, also threaten consumers around the world, particularly those relying on international trade. The researchers note: “In this Review, we summarize the pathways through which synthetic pesticides transcend boundaries, focusing on the impacts of their use in food production… First, we explain how environmental flows contribute to transporting pesticides to regions far from their original source. Next, we examine the role of international food trade in causing transboundary exposure and impact of pesticide use.” As a result, the study calls for prioritizing biodiversity and human health through sustainable methods while maintaining yield to support the growing population. The use of pesticides in chemical-intensive agriculture has exponentially increased since their first synthesis in the late 1930s. “Globally, pesticides were applied on agricultural land at an average rate of […]

(Beyond Pesticides, June 23, 2025) At the close of National Pollinator week, Beyond Pesticides says in an action that all species—and their ecosystem—are threatened by the failure of the U.S. Environmental Protection Agency (EPA) to perform its statutory duties under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Endangered Species Act (ESA).  Under FIFRA, EPA is required to register pesticides only when they pose no “unreasonable risk to man [sic] or the environment, taking into account the economic, social, and environmental costs and benefits.” Under ESA, EPA must, like all federal agencies, “seek to conserve endangered species and threatened species and shall utilize their authorities in furtherance of the purposes” of the ESA—which are “to provide a means whereby the ecosystems upon which endangered species and threatened species depend may be conserved, to provide a program for the conservation of such endangered species and threatened species, and to take such steps as may be appropriate to achieve the purposes of the treaties and conventions” through which “the United States has pledged itself as a sovereign state in the international community to conserve to the extent practicable the various species of fish or wildlife and plants facing extinction.”  In this context, Beyond Pesticides […]

Image: Art Page submission from Sara Grantham, “Pollen Song.” (Beyond Pesticides, June 20, 2025) A study in Conservation Genetics, entitled “Organic farming fosters arthropod diversity of specific insect guilds – evidence from metabarcoding,” showcases the negative effect of chemical-intensive, conventional farm management on insect populations when compared to organically managed meadows. The researchers find that the diversity and biomass of flying insects are higher with organic land management by 11% and 75%, respectively. “We report a higher diversity on organic meadows in comparison with conventional ones, all over the diversity of flying insects and not only based solely on a few species-poor groups as in previous studies,” the authors state. They continue: “We found significant richness differences between management types and increased functionality on organic meadows. Our results imply the superiority of organic farming in comparison to conventional farming in the conservation of insect diversity.” The topic of insect biodiversity and the decline of insect populations over the last few decades, also referred to as the insect apocalypse, has been extensively covered by Beyond Pesticides. As previously reported in the Daily News, “Continued Decline in Insect Species Biodiversity with Agricultural Pesticide Use Documented,” insects provide many important services, such as […]

(Beyond Pesticides, June 19, 2025) Juneteenth, officially recognized as a federal holiday since 2021, commemorates the arrival of Union soldiers in Galveston, Texas, to free enslaved people per the Emancipation Proclamation that was issued two and a half years prior. While June 19, 1865, does not mark the legal end of slavery nationwide, it was a crucial moment in the fight for freedom and continues to highlight the ongoing fight for human rights, equality, and environmental justice.   As Beyond Pesticides has previously shared in the Daily News, this commemorative day is a time for individuals and organizations to acknowledge and reflect on their past and current actions or inactions that perpetuate systemic racism. The father of environmental justice, Robert Bullard, Ph.D., defines environmental racism as any policy or practice that unequally affects or disadvantages individuals, groups, or communities based on their race. Dr. Bullard states that, until the 1980s, environmental conservation and pollution were separate. Many environmental organizations prioritized the preservation of “wilderness” rather than urban areas, predominantly comprised of POC, who continuously experience the disproportionate impacts of pollution and the effects of environmental racism.   Sharing the Science  A recent study regarding the intersections of urban planning, wildlife management, […]

(Beyond Pesticides, June 17, 2025) Funding cuts in the current budget bill include drastic cuts in research essential to protect farmers, farmworkers, and their families. There are many federal agencies funding research, but among the most important of those funding research affecting farmers, farmworkers, and their families are the U.S. Environmental Protection Agency (EPA) and the National Institute for Occupational Safety and Health (NIOSH).   >> Tell Congress to restore funding that protects the health of farmers, farmworkers, and their families. EPA funding for the Bioecological Center for Research on Children’s Health (BeRCH) project was cut after almost two years. This project had the potential to address farmworker children’s health. Farmworker children can face many challenges–including poverty, language barriers, inadequate housing, discrimination, fear of family separation, exposure to agricultural chemicals, food insecurity, and migration. BeRCH was designed to identify, understand, and address the cumulative impacts on the health, development, and growth of farmworker children. The project goals were to examine farmworker children’s exposures to environmental toxins (pesticides, heavy metals, particulate matter) and non-chemical psychosocial stressors (poverty, food insecurity, trauma, discrimination, etc). Working in collaboration with the Florida State University (FSU) health clinic in Immokalee, the project would have examined threats, implemented strategies to improve health outcomes for farmworker children, and collaboratively established […]

***Featured Art Page submissions for National Pollinator Week, highlighted with the gratitude of Beyond Pesticides: Jesse from Livermore, CA: “Honeybee Pollinating Citrus Blossom”; Yumi from New York, NY: “Birds and the Bees”; Gretchen from Helena, MT: “Butterflies”; Janet from Concord, MA: “Beneath the Big Dipper”; and Trix from Petersburg, NY: “Downy Woodpecker.” (Beyond Pesticides, June 16, 2025) Every year, Beyond Pesticides announces National Pollinator Week to remind eaters of food, gardeners, farmers, communities (including park districts to school districts), civic organizations, responsible corporations, policy makers, and legislators that there are actions that can be taken that are transformative. All the opportunities for action to protect pollinators, and the ecosystems that are critical to their survival, can collectively be transformational in eliminating toxic pesticides that are major contributors to the collapse of biodiversity. This is why Beyond Pesticides starts most discussions and strategic actions for meaningful pollinator and biodiversity protection with the transition to practicing and supporting organic.  In launching National Pollinator Week, Beyond Pesticides makes suggestions for individual actions to increase efforts to think and act holistically to protect the environment that supports pollinators. The impact that people have starts with grocery store purchases and the management of gardens, parks, […]

(Beyond Pesticides, June 12, 2025) Thailand-based researchers, in a study published in BMC Veterinary Research, found significant documentation of the occurrence of anticoagulant rodenticide (AR)-induced toxicosis for nontarget organisms in the country. This includes the finding that “all submitted samples of suspected AR exposure in wild animals and exotic pets tested positive for ARs.” These findings signal the pervasive nature in which agrichemical products, including anticoagulant and nonanticoagulant rodenticides, encroach on broader ecosystem health. In an era of federal deregulation and increasing public scrutiny of the role of government in addressing public health, biodiversity, and the climate crisis, advocates continue to call for a wholesale transition to organically managed food and land management systems. Background and Methodology  “In this retrospective study, we investigated the occurrence of AR poisoning in animal specimens analy[z]ed at the Department of Veterinary Pharmacology, Faculty of Veterinary Science, Chulalongkorn University (DVPCU), between 2018 and 2023,” say the authors on the primary focus of this study. “This study aims to provide a reference dataset for future research on the epidemiology of AR toxicosis in nontarget species.” The authors declared that there were “no competing interests” in engaging in this research.  The anticoagulant rodenticides were detected through two […]

(Beyond Pesticides, June 5, 2025) A study conducted in Pennsylvania and published in Environmental Entomology highlights threats to nontarget organisms from neonicotinoid insecticide exposure. Using species of ground beetles as an example, the study documents sublethal behavioral effects as well as decreased week-long survival. This research fills a notable gap in current research, with the authors explaining, “Predatory soil arthropods are under-represented in insecticide toxicity studies, severely limiting our understanding of how insecticides affect soil-invertebrate communities in agroecosystems.”   The researchers continue, “As a step toward addressing this issue, we conducted novel acute oral, topical, and soil-based toxicity assays on 9 ground beetle species (Coleoptera: Carabidae) in response to the neonicotinoid insecticides clothianidin, thiamethoxam, and imidacloprid.” The nine carabid beetle species, all common to agroecosystems in central Pennsylvania, were exposed to clothianidin, while additional assays with thiamethoxam and imidacloprid were conducted on the two most abundant species. A wide body of science exists that connects neonicotinoid exposure to health effects in a variety of nontarget organisms. Neonicotinoids, a class of neurotoxic insecticides, act as agonists of nicotinic acetylcholine receptors, “persist under field conditions, and are water soluble, enabling them to translocate into plants and provide systemic protection of seedlings,” the […]

(Beyond Pesticides, June 3, 2025) Chemical contaminants in wastewater have long been of concern, especially given the significant costs of upgrading wastewater treatment facilities to remove existing and emerging chemicals. In advancing chemical safety, one of the many regulatory determinations that Beyond Pesticides advocates for, prior to the allowance of any toxic chemical use, is the establishment of a realistic cleanup or disposal strategy. Yet, a plethora of petrochemical pesticides flood the market and contaminate the air, soil, water, and crops before poisoning humans and wildlife. A study in the Journal of Environmental Chemical Engineering uses the detectable levels of metabolites (breakdown products) of pesticides in wastewater to gauge exposure to populations living near flower bulb fields throughout the Netherlands. Wastewater samples were collected from five wastewater treatment plants (WWTPs) located in different parts of the Netherlands, with two of the locations (Tollebeek and Lisse) located near flower bulb fields and the other three representing control areas. The study finds that higher levels of chemicals correlate with proximity to agricultural fields and present a heightened health risk. The authors describe wastewater-based surveillance (WBS) as a complementary approach to human biomonitoring that they use “to assess the spatial differences in human […]

(Beyond Pesticides, May 30, 2025) The Making America Healthy Again (MAHA) Commission report, Make Our Children Healthy Again: Assessment, published on May 23, drew criticism from the pesticide industry and agribusiness allies for pointing to independent science that identifies a range of pesticide-induced health hazards.* The Commission, chaired by Robert F. Kennedy, Jr., Secretary of the Department of Health and Human Services (HHS), is composed of the heads of numerous agencies of the federal government and the White House, from the U.S. Environmental Protection Agency (EPA), the U.S. Department of Agriculture (USDA), and the Office of Management and Budget (OMB), to the Assistant to the President and Deputy Chief of Staff for Policy Stephen Miller. The MAHA Commission was established by Executive Order 14212 on February 13, 2025. Despite extensive citations to the science on pesticide hazards, the report includes a section on “Crop Protection Tools,” in which there is a repetition of chemical industry talking points that pesticide residues in food comply with existing tolerances, thus implying that pesticides in food are safe. (See USDA Pesticide Data Program Continues to Mislead the Public on Pesticide Residue Exposure.) However, overall the report’s introduction sets a tone that seeks to catalogue […]

(Beyond Pesticides, May 29, 2025) A study, published in Environmental Toxicology and Pharmacology, “investigates genotoxic effects on farmers in Paraíba, Brazil, analyzing buccal mucosa cells [cells from inside the cheek] for DNA and cellular damage,” the authors write. In comparing data from 33 pesticide-exposed agricultural workers to 29 unexposed people in a control group, the researchers report that the “findings revealed significantly higher frequencies of cellular alterations and DNA damage among exposed farmers relative to the control group, with no significant impact from factors such as smoking, alcohol consumption, or family cancer history.” They continue, “These results underscore the genotoxic risks linked to prolonged pesticide exposure and highlight the necessity for stricter regulatory measures.” As Beyond Pesticides documents in Disproportionate Pesticide Hazards to Farmworkers and People of Color Documented… Again, farmworkers have been excluded from labor and occupational safety protection laws since their inception. The Occupational Safety and Health Administration (OSHA) defers all policy on pesticide protections to the U.S. Environmental Protection Agency (EPA), which has been widely criticized for providing inadequate worker protection standards. This study focuses on workers in Brazil, but represents issues that impact communities worldwide. “The agricultural sector plays a pivotal role in Brazil’s economy, encompassing […]

(Beyond Pesticides, May 28, 2025) A study in Birth Defects Research bolsters existing evidence that agricultural workers, and specifically Hispanic workers in California, are disproportionately bearing the burden of pesticide exposure. Caroline Cox, formerly of the Center for Environmental Health in Oakland, and Jonathan K. London, PhD of the University of California, Davis, examine how currently-used agricultural pesticides unequally affect communities along racial and ethnic gradients. Ms. Cox is a member of Beyond Pesticides’ board. Using 2022 data from the California Department of Pesticide Regulation (CDPR) and the U.S. Census Bureau, the researchers analyzed county, census tract, and school district data for the percentage of non-Hispanic White population in each population unit and determined the total agricultural use of commercial formulations of pesticides in the same units. CDPR reporting system’s granular data, including application locations at a resolution of one square mile, and the specific products, dates, and amounts of pesticides used, allows comparison of the data with demographic records. The results show that Hispanics’ exposure status is robust, independent of current or past data or “individual pesticides of public health concern.” Pesticides that harm reproductive health were strikingly concentrated among Hispanic populations. There is abundant evidence of racial and ethnic […]

(Beyond Pesticides, May 19, 2025) The Trump administration has removed crucial protections established under the Migratory Bird Treaty Act (MBTA), including those that protect birds from pesticide poisoning. The Migratory Bird Protection Act (MBPA), introduced in May by Rep. Jared Huffman (D-CA) and Rep. Brian Fitzpatrick (R-PA), will restore protections against an “incidental take.” Beyond Pesticides is calling for the protection of migratory birds and the restitution of funds to implement the law. This is not the first time that President Trump has reduced protection for migratory birds. In his first term (2017), the Department of the Interior issued a policy that relieved industries of the requirement to protect birds, and they will no longer be held accountable for bird deaths. In addition, the agency is expected to propose rules to make this policy change permanent. >> Tell your U.S. Representative to cosponsor the Migratory Bird Protection Act (H.R. 3188).  MBTA was passed in 1918 to protect migratory birds soon after the last Passenger Pigeon died in captivity, followed by the last Carolina Parakeet. MBTA originally resulted from the loss of birds due to a number of threats—notably at the time, the collection of bird feathers. It prohibits the take (including killing, […]

(Beyond Pesticides, May 8, 2025) A study, published in Environmental Pollutants and Bioavailability, assesses the impacts on Nile tilapia (Oreochromis niloticus) with subacute and chronic exposure to thiamethoxam, a neonicotinoid insecticide, and finds genotoxicity, oxidative stress, and changes in tissue structure, among other threats to organ function and overall fish health. “The study focused on biochemical markers, genetic damage, pesticide residue levels in fish flesh, and histopathological changes in fish exposed to different concentrations of thiamethoxam,” the authors state. The threats do not end there; human health is also at risk from the consumption of these contaminated fish. “Unfortunately, neonicotinoids, rapidly washed into surface water from agricultural areas, pose a significant threat to environmental water quality and can harm non-target species, particularly aquatic organisms,” the researchers state. The accumulation of these chemicals leads to “ultimately harming both aquatic ecosystems and human health,” they say. In particular, the study highlights that prolonged exposure to high doses of thiamethoxam can cause “significant negative effects on fish health,” the authors note. They continue: “This exposure led to increased levels of urea and ALT [alanine aminotransferase] in the blood, indicating potential damage to the kidneys and liver. Additionally, thiamethoxam caused oxidative stress, as evidenced […]

(Beyond Pesticides, April 29, 2025) A study in Environment International finds pesticide-induced alterations in the gut microbiota of a farmland raptor species. In collecting blood and cloacal samples from Montagu’s harrier (Circus pygargus) nestlings, the authors “shed light on an overlooked collateral effect of pesticides, i.e., a general modification of gut bacterial assemblages,” which can lead to an imbalance of microorganisms (dysbiosis) and the promotion of potential pathogens, as well as negatively impact the health of birds of prey. “Additionally, our findings support the ‘One Health‘ framework, stressing the interconnectedness of wildlife, ecosystem, and human health, particularly in pesticide-affected agricultural areas,” the researchers share. “The gut microbiota is crucial for host health and can be impacted by various environmental disruptions, yet the effects of multiple pesticide exposures on farmland organisms’ microbiomes remain largely unexplored,” the authors state. In the study, they “assessed microbiota changes in a wild apex predator exposed to multiple pesticides in agricultural landscapes,” which “provides evidence of pesticide impacts on wildlife gut microbiota, highlighting links between pesticide exposure and changes in microbiota composition,” the researchers note. The Montagu’s harrier, as an apex predator, serves as a ‘bio-sentinel’ or bioindicator species for assessing ecosystem health. “As top-level predators […]

(Beyond Pesticides, April 25, 2025) A novel study in Chemosphere finds impacts on male fertility in a bee species (Osmia bicornis) with exposure to sulfoxaflor, a systemic sulfoximine insecticide with similar mechanisms to neonicotinoids. “For the first time, we demonstrate that short-term chronic, field-realistic exposure to a common pesticide reduced pre-copulatory display (36%) and sounds (27%) [courtship behaviors], increased the number of copulations (+110%) and the mating duration (+166%), while finally reducing sperm quantity (25%) and mating success (43%),” the researchers report. They continue, “Our research raises considerable concern on the impact of field-realistic, low sublethal pesticide levels on the fertility and reproductive success of pollinators.” Mating behaviors and the ability to successfully reproduce determines the survival of species. As the authors state: “Mating disorders may therefore contribute to the recent decline in insect and pollinators’ health worldwide. While the impact of pesticides on pollinators is widely considered as a driving factor for reducing pollinators’ health, their effect on mating behaviour and male fertility remains widely overlooked.” The red mason bee (O. bicornis) can “provide essential pollination service for both crops and wild plants sustaining food production and biodiversity while serving as a bioindicator of environmental health.” The abundance and […]

(Beyond Pesticides, April 23, 2025) Recent reviews of scientific literature, in both Chemosphere and Reports in Public Health, associate Parkinson’s disease (PD), the second most prevalent neurodegenerative disease globally, with pesticide exposure. “Given the pervasive nature of pesticide residues in everyday food consumption and inadequate monitoring of their long-term toxicological impacts, the role of pesticide exposure as a modifiable risk factor for neurological disorders, including PD, warrants urgent attention,” the researchers state in the article in Chemosphere. In describing the history of Parkinson’s and previous research, the authors in Reports in Public Health note that while PD etiology is not fully understood, it is a multifactorial disease. “Hereditary factors are present in approximately 10% of diagnosed cases of Parkinson’s disease, presenting early onset; while the other 90% of cases are categorized as idiopathic or sporadic Parkinson’s disease, occurring in older individuals and may be associated with exposure to environmental agents,” the researchers say. This disease, first described by English physician James Parkinson, M.D. in 1817, involves neurochemical changes that present as “the appearance of cardinal motor symptoms, such as bradykinesia, rigidity, postural instability, and rest tremor, which are essential for the clinical diagnosis of the disease,” the researchers note. The […]

(Beyond Pesticides, April 18, 2025) A recent study published in Foods assesses the ability of the fungicide azoxystrobin (AZX) and naturally occurring toxins produced by certain fungi, known as mycotoxins, to display effects of cytotoxicity (cell damage). These effects were evaluated using three common mycotoxins found in food, including ochratoxin A (OTA), deoxynivalenol (DON), and T-2 toxin as mixtures with AZX within human hepatocarcinoma (HepG2) cell cultures. In analyzing combinations of these compounds at sublethal concentrations, the authors find modified toxicological behavior and synergistic effects that highlight the complexities of chemical mixtures, and potential threats to liver health through dietary exposure to both toxicants and toxins, that are not adequately regulated for their interactions. While fungicides, like azoxystrobin, are intended to prevent or control fungal diseases, resistance to these pesticides can increase the presence of fungi, and subsequent mycotoxins, on crops. This scenario allows for co-exposure of fungicides and mycotoxins within food products that present a risk to consumers. These chemicals can threaten human health individually, as the researchers confirm in their study, but present a greater threat in combination. The mixture of AZX with all three mycotoxins exhibits the highest toxicity, with synergistic effects at all tested concentration levels. […]