20
Sep
(Beyond Pesticides, September 20, 2023) Higher concentrations of a pyrethroid metabolite (3-PBA) in the body have an association with increased osteoarthritis (OA) risk among US adults, according to a study published in BMC Public Health. Regardless of analysis sensitivity and population subgroup (e.g., sex, socioeconomic status, etc.), the association between pyrethroid exposure and OA remains. Osteoarthritis is a degenerative joint disease resulting from the degradation (breakdown) of joint cartilage and underlying bone. This disease affects 1 in 7 U.S. adults and is the fourth leading cause of disability in the U.S. Unfortunately, OA is one of the most recently attributed pesticide-induced diseases associated with this dangerous class of chemical insecticides—harm to individual Americans that the U.S. Environmental Protection Agency (EPA) is not considering when it registers pesticides. To remedy the significant deficiencies in EPA’s reviews and protect residents from chronic disease, more and more communities are transitioning to safer, organic pest management practices that do not require pyrethroids and other toxic synthetic pesticides. Thus, this study and others like it highlight the need for increased monitorization of pyrethroid exposure among the general population. Using data from the 1999–2002 and 2007–2014 National Health and Nutrition Examination Survey (NHANES), this study explores the relationship between pyrethroid exposure and osteoarthritis. NHANES is […]
Posted in Arthritis/Joint Inflammation, pyrethroids, Synthetic Pyrethroid | 3 Comments »
22
Aug
A recently completed study (available in preprint before peer review) identifies the development of what the authors term Toxicant-Induced Loss of Tolerance (TILT), the constellation of symptoms associated with chemical exposures.
Posted in chemical sensitivity, Environmental Protection Agency (EPA), Gulf War Syndrome, Hypersensitivity, Pesticide Regulation, Poisoning, Uncategorized | No Comments »
03
Nov
(Beyond Pesticides, November 3, 2021) With a significant and increasing share of the U.S. population reporting sensitivities to certain chemicals, a team of researchers at University of California (Irvine), University of Texas (San Antonio), and the Massachusetts Institute of Technology is working to better understand how these symptoms develop. Although referred to by several names over the years, including Multiple Chemical Sensitivity (MCS) and Idiopathic Environmental Illness, medical professionals are now referring to the disease as Chemical Intolerance, or Toxicant Induced Loss of Tolerance (TILT), to better represent the disease process and range of nervous system symptoms that individuals develop to low level chemical exposures. “We established evidence of this previously understudied disease process,” said Shahir Masri, Sc.D, at University of California, Irvine. “Our insights will help public health scientists, physicians and policymakers better understand how to minimize harmful exposures and prevent future disease.” TILT is characterized by a two-step process. First, there is an “initiation exposure event,” whereby an individual is either repeatedly exposed to low levels of certain chemicals, or experiences a major exposure incident. In the second stage, affected individuals are “triggered” even by minute exposures, not only to the chemical that affected them in the first […]
Posted in Hypersensitivity, Immunotoxicity, Nervous System Effects, Uncategorized | 1 Comment »
13
May
(Beyond Pesticides, May 13, 2020) A pilot study at New York University (NYU) provides evidence of a direct relationship between increased risk for celiac disease (adverse immune response to eating gluten) and exposure to endocrine-disrupting chemicals, including DDE – a metabolite of the infamous, bird-killing pesticide DDT. Researchers at NYU set out to elucidate the connection between the autoimmune disease and persistent organic pollutants (POPs), also known as “forever chemicals” or “legacy chemicals” due to their persistence in nature and the human body. The new research, published in Environmental Science, highlights higher odds for celiac disease among participants with elevated POPs exposure and differing results among male and female participants. Considering the complexity of these initial results, researcher Leonardo Trasande, Ph.D. says, “It’s not as if these chemicals were designed with the human body in mind; These chemicals were designed with materials in mind.” [See video overview here] Celiac disease produces an immune-mediated inflammatory response to the consumption of gluten, a protein found in wheat, rye, and barley. Risk for celiac disease has long been associated with genetic factors, but increased prevalence of the disease inspired further research. Considering previous studies on the deleterious impact of POPs on the immune […]
Posted in Celiac Disease, DDT, Endocrine Disruption, Environmental Protection Agency (EPA), Uncategorized | No Comments »
05
Feb
(Beyond Pesticides, February 5, 2019) Linuron, an herbicide registered for use by the U.S. Environmental Protection Agency (EPA), yet recently banned in Europe due to health concerns, appears to trigger inflammatory signals that have been linked to the onset of Multiple Sclerosis (MS). This new evidence, published in the journal Cell by researchers at Brigham and Women’s Hospital in Boston, MA, indicates that exposure to chemicals and pesticides in the environment may be a risk factor in the development of neurodegenerative diseases. “We created a platform to systematically investigate the understudied effects of environmental exposures,” said study coauthor Francisco Quintana, PhD. “The goal of our work is to return results that can guide future epidemiological studies and identify actionable targets.” Researchers began their investigation with 976 chemicals identified by EPA’s ToxCast program, an inventory of compounds that have undergone screening for a battery of laboratory tests. Within that inventory, 75 chemicals, including linuron, were found to interfere with the signaling pathways linked to MS. To confirm the adverse impacts, scientists used the embryos of zebrafish, animals often used as models in laboratory research. The zebrafish embryos were altered to contain low levels of myelin, a protein that protects nerve cells, as […]
Posted in Environmental Protection Agency (EPA), Lawns/Landscapes, Linuron, Multiple Sclerosis (MS), Pesticide Regulation, Uncategorized | 2 Comments »
30
Oct
(Beyond Pesticides, October 30, 2009) A recent study shows that women who use insecticides are at elevated risk for autoimmune diseases such as rheumatoid arthritis and lupus. The results of the yet unpublished study were presented on October 17, 2009 at the American College of Rheumatology annual meeting in Philadelphia, PA. The study, which looked at more than 75,000 women, shows that those who spray insecticides at least six times per year have almost two and a half times the risk of developing lupus and rheumatoid arthritis versus those who do not use insecticides. The risk doubles if insecticides were used in the home for 20 years or more. Hiring a gardener or commercial company to apply insecticides also resulted in a doubling of risk, but only if they were used long-term, says Christine G. Parks, PhD, an epidemiologist with the National Institute of Environmental Health Sciences in Research Triangle Park, N.C., one of the lead researchers who analyzed data from the Women’s Health Initiative (WHI) Observational Study. “Our new results provide support for the idea that environmental factors may increase susceptibility or trigger the development of autoimmune diseases in some individuals,” said Dr. Parks. While the study does not […]
Posted in Disease/Health Effects, Lupus | No Comments »
