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Daily News Blog

Archive for the 'Arthritis/Joint Inflammation' Category


13
May

Pilot Study Links Celiac Disease to Long-Lived Endocrine Disrupting Chemicals, like DDT, in the Environment

(Beyond Pesticides, May 13, 2020) A pilot study at New York University (NYU) provides evidence of a direct relationship between increased risk for celiac disease (adverse immune response to eating gluten) and exposure to endocrine-disrupting chemicals, including DDE – a metabolite of the infamous, bird-killing pesticide DDT. Researchers at NYU set out to elucidate the connection between the autoimmune disease and persistent organic pollutants (POPs), also known as “forever chemicals” or “legacy chemicals” due to their persistence in nature and the human body. The new research, published in Environmental Science, highlights higher odds for celiac disease among participants with elevated POPs exposure and differing results among male and female participants. Considering the complexity of these initial results, researcher Leonardo Trasande, Ph.D. says, “It’s not as if these chemicals were designed with the human body in mind; These chemicals were designed with materials in mind.” [See video overview here] Celiac disease produces an immune-mediated inflammatory response to the consumption of gluten, a protein found in wheat, rye, and barley. Risk for celiac disease has long been associated with genetic factors, but increased prevalence of the disease inspired further research. Considering previous studies on the deleterious impact of POPs on the immune […]

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05
Feb

EPA-Registered Herbicide Found to Trigger Inflammation Linked to Onset of Multiple Sclerosis

(Beyond Pesticides, February 5, 2019) Linuron, an herbicide registered for use by the U.S. Environmental Protection Agency (EPA), yet recently banned in Europe due to health concerns, appears to trigger inflammatory signals that have been linked to the onset of Multiple Sclerosis (MS). This new evidence, published in the journal Cell by researchers at Brigham and Women’s Hospital in Boston, MA, indicates that exposure to chemicals and pesticides in the environment may be a risk factor in the development of neurodegenerative diseases. “We created a platform to systematically investigate the understudied effects of environmental exposures,” said study coauthor Francisco Quintana, PhD. “The goal of our work is to return results that can guide future epidemiological studies and identify actionable targets.” Researchers began their investigation with 976 chemicals identified by EPA’s ToxCast program, an inventory of compounds that have undergone screening for a battery of laboratory tests. Within that inventory, 75 chemicals, including linuron, were found to interfere with the signaling pathways linked to MS. To confirm the adverse impacts, scientists used the embryos of zebrafish, animals often used as models in laboratory research. The zebrafish embryos were altered to contain low levels of myelin, a protein that protects nerve cells, as […]

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30
Oct

Lupus and other Autoimmune Diseases Linked to Insecticide Use

(Beyond Pesticides, October 30, 2009) A recent study shows that women who use insecticides are at elevated risk for autoimmune diseases such as rheumatoid arthritis and lupus. The results of the yet unpublished study were presented on October 17, 2009 at the American College of Rheumatology annual meeting in Philadelphia, PA. The study, which looked at more than 75,000 women, shows that those who spray insecticides at least six times per year have almost two and a half times the risk of developing lupus and rheumatoid arthritis versus those who do not use insecticides. The risk doubles if insecticides were used in the home for 20 years or more. Hiring a gardener or commercial company to apply insecticides also resulted in a doubling of risk, but only if they were used long-term, says Christine G. Parks, PhD, an epidemiologist with the National Institute of Environmental Health Sciences in Research Triangle Park, N.C., one of the lead researchers who analyzed data from the Women’s Health Initiative (WHI) Observational Study. “Our new results provide support for the idea that environmental factors may increase susceptibility or trigger the development of autoimmune diseases in some individuals,” said Dr. Parks. While the study does not […]

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