26
May
(Beyond Pesticides, May 26, 2022) A study published in The International Journal of Biochemistry & Cell Biology finds environmental exposure to neurotoxic pesticides increases Parkinsonâs Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinsonâs disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only […]
Posted in Brain Effects, Microbiata, Microbiome, Nervous System Effects, Parkinson's, Rotenone | No Comments »
05
Nov
(Beyond Pesticides, November 5, 2020) Research at the University of California San Francisco (UCSF) finds that pesticide exposure increases the risk of developing Parkinsonâs disease (PD), regardless of whether disease onset is idiopathic (spontaneous) or genetic (GBA genetic risk variant). Although the exact etiology of PD remains unknown, epidemiological and toxicological research repeatedly identifies exposure to pesticides, as well as specific gene-pesticide interactions, as significant adverse risk factors that contribute to PD. Furthermore, this study, âGene Variants May Affect PD Risk After Pesticide Exposure,â suggests that environmental triggers like occupational exposure to pesticides can prompt PD in individuals with or without the genetic precursor. This research demonstrates the importance of assessing disease etiology concerning occupational pesticide exposure, especially if disease triggers are overwhelmingly non-hereditary. Since not all individuals genetically predisposed to the disease develop PD, with only 10 to 15 percent of PD cases being genetic, government officials need to consider alternate etiological pathways that include environmental risk factors. Study researchers note, ââEnvironmental exposures may have differential effects in different genotypesâ and may predispose people with PD to different symptom burden.â Parkinsonâs disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about […]
Posted in Occupational Health, Paraquat, Parkinson's, Rotenone | 1 Comment »
14
Nov
(Beyond Pesticides, November 14, 2012) For years, scientists have shown that pesticide exposures are linked to the onset of Parkinsonâs disease. Now a new study by researchers at University of California, Los Angeles, (UCLA) finds that exposure to pesticides and suffering a head injury are associated with a three-fold increase in oneâs chances of developing Parkinsonâs disease. Parkinson’s disease is the second most common neurodegenerative disease, and occurs when nerve cells in the substantia nigra region of the brain are damaged or destroyed and can no longer produce dopamine, a nerve-signaling molecule that helps control muscle movement. People with Parkinsonâs disease have a variety of symptoms, including loss of muscle control, trembling and lack of coordination. Over time, symptoms intensify. At least one million Americans have Parkinsonâs and about 50,000 new cases are diagnosed each year. The study, âTraumatic brain injury, paraquat exposure, and their relationship to Parkinson disease,â published in the journal Neurology surveyed more than 1,000 adults ages 35 and older who lived in central California. Some 357 of the participants were diagnosed with Parkinson’s disease. Participants with the disease were nearly twice as likely as those without the disease to report having had a head injury in […]
Posted in Paraquat, Parkinson's, Rotenone | No Comments »
28
Jun
(Beyond Pesticides, June 28, 2011) Recent studies have linked Parkinsonâs disease to pesticide exposure. In a new article published in the journal Molecular Neurodegeneration, researchers at the University of Missouri School of Medicine take some of the first steps toward understanding this link and unraveling the molecular dysfunction that occurs when proteins are exposed to environmental toxins. The study, “Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation,” helps further explain recent NIH findings that demonstrate the link between Parkinson’s disease and two particular pesticides â rotenone and paraquat. “Fewer than 5 percent of Parkinson’s cases are attributed to genetics, but more than 95 percent of cases have unknown causes,” said Zezong Gu, MD, PhD, assistant professor of pathology and anatomical sciences. “This study provides the evidence that oxidative stress, possibly due to sustained exposure to environmental toxins, may serve as a primary cause of Parkinson’s. This helps us begin to unveil why many people, such as farmers exposed to pesticides, have an increased incidence of the disease.” Scientists previously understood that Parkinson’s is associated with oxidative stress, which is when electronically unstable atoms or molecules damage cells. The MU study yields […]
Posted in Chemicals, Disease/Health Effects, Paraquat, Parkinson's, Rotenone | No Comments »
16
Feb
(Beyond Pesticides, February 16, 2011) Many agricultural pesticides âincluding some previously untested and commonly found in foodâ disrupt male hormones, according to new tests conducted by British scientists. Meanwhile, U.S. researchers at the National Institutes of Health have found that people who used two specific varieties of pesticide were 2.5 times as likely to develop Parkinson’s disease. Pesticides Impact Male Hormones Evidence suggests that there is widespread decline in male reproductive health and anti-androgenic pollutants, also known as endocrine disruptors, may play a significant role. Thirty out of 37 pesticides tested by the researchers at the University of London altered male hormones, including 16 that had no known hormonal activity until now. There was some previous evidence for the other 14. Most are fungicides applied to fruit and vegetable crops, including strawberries and lettuce. The study, âWidely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Anti-Androgens,â is published in Environmental Health Perspectives. The British researchers screened the chemicals using in vitro assays, which use human cells to check whether the pesticides activate or inhibit hormone receptors in cells that turn genes on and off. Scientists, however, are uncertain what actually happens in the human body at the […]
Posted in Endocrine Disruption, Paraquat, Parkinson's, Rotenone | 1 Comment »
19
Sep
(Beyond Pesticides, September 19, 2008) Adding to the body of epidemiologic evidence linking pesticides to Parkinson’s Disease (PD), a recent study shows a correlation between 100 PD patients and the use of the pesticide rotenone. The study was conducted by physicians and researchers at The University of Texas Health Science Center at Tyler (UTHSCT) and an East Texas Medical Center physician.The studyâs lead author is Aman Dhillon, MD, MS, assistant professor of occupational and environmental medicine at UTHSCT. Rotenone is highly toxic to fish and insects, but mildly toxic to warm-blooded animals and humans. It is made from the roots of tropical plants and is used in home gardens and in fisheries management to remove unwanted fish species, said Jeffrey Levin, MD, MSPH, chair of UTHSCTâs Department of Occupational Health Sciences. Dr. Levin is a co-author of the study, published recently in the peer-reviewed Journal of Agromedicine. A total of 184 people participated in the study: 100 had Parkinsonâs disease and 84 did not, though they had other neurological disorders. All were patients of George M. Plotkin, MD, Ph.D., a neurologist with a special interest in Parkinsonâs disease. Dr. Plotkin, medical director of the ETMC Movement Disorder Center, treats about […]
Posted in Parkinson's, Rotenone, Texas | 1 Comment »
01
Oct
(Beyond Pesticides, October 1, 2007) For the second time in ten years, state officials have poured aquatic insecticide and piscicide rotenone into California’s Lake Davis in an effort to control an invasive species of fish, northern pike. Despite the first failure of rotenone to eradicate the pike in 1997, Fish and Game officials felt they had no alternative but to resort to the toxic chemical once more. The invasive pike were first introduced, illegally, into Lake Davis in 1994. Since then, the population has reached uncontrollable proportions, out-competing local trout. The small town of Portola, which uses Lake Davis as its drinking water supply, is largely supported by fishing and tourism, which are boosted by its reputation for producing extremely large trout. Local businesses fear the consequences of the pikes’ destruction of the attraction. Despite its economic concerns, the town did not universally support the first application of rotenone in 1997. Four residents, including the mayor pro tem, were arrested in a mass protest of the application as Fish and Game put thousands of gallons of the chemical in the lake. Within a year, pike reappeared. Ten years and many failed attempted alternatives later, the pike population thrives. Fish and […]
Posted in Rotenone, Water | No Comments »
08
Feb
(Beyond Pesticides, February 8, 2007) Investigators at St. Jude Children’s Research Hospital have shed new light on the suspected role of pesticides in the development of Parkinsonâs disease (PD). The study, âGST expression mediates dopaminergic neuron sensitivity in experimental parkinsonism” appearing in the Proceedings of the National Academy of Sciences (January 31, 2007), illustrates the mechanism of nerve cell damage by pesticide exposure. The enzyme that prevents damage to the substantia nigra, the part of the brain where nerve cell damage associated with PD occurs, is called GST pi (âpie”). This enzyme stands like a sentry at the crossroads of several biochemical pathways, any one of which can lead to PD. GST pi protects the nerve cell from death caused by either environmental toxics, such as pesticides, or a self-destruction process called apoptosis (cell suicide), triggered by certain stressful conditions in the cell. If GST pi levels are reduced or this enzyme is overwhelmed by toxics, these nerves are at increased risk of death, according to studies in mouse models. GST pi is one of a family of similar enzymes that eliminate free radicals generated by pesticides and other chemicals. Two members of this family are present in the brain, […]
Posted in Chemicals, Dieldrin, Disease/Health Effects, Maneb, Paraquat, Permethrin, Rotenone | 2 Comments »
