(Beyond Pesticides, May 1, 2026) A study in Psychiatry Research, entitled “Toxic Exposure and Rates of Suicidal Thoughts and Behaviors Among U.S. Military Veterans,” adds to the body of science linking poorer mental health among military members with exposure to environmental contaminants. While previous research focuses on mental health broadly, the current observational cohort study focuses on exposure to toxic substances and suicidal thoughts and behaviors (STBs) through the analysis of data from 248,926 U.S. veterans enrolled in the Million Veteran Program (MVP). In comparing self-reported exposures to nine toxicants, including Agent Orange, chemical/biological weapons, anthrax vaccine, solvents/fuels, petroleum combustion products, lead, other metals, pesticides, and open-air burn pits, and mental health records, the researchers find that military veterans with higher toxic exposures are more likely to have STBs. The authors also report that these associations occur across all major service cohorts (pre-Vietnam, Vietnam, post-Vietnam, Gulf War, and post-9/11 eras). “Our work contributes to growing evidence that veterans who report more toxic exposures are more likely to have STBs, consistent with greater risk for other mental health outcomes (e.g., depression, PTSD [post-traumatic stress disorder]),” the researchers conclude. Importance and Background Military members experience increased health risks with exposure to environmental […]

(Beyond Pesticides, March 12, 2026) The science connecting pesticide exposure to neurotoxicity continues to mount. A study in Discover Toxicology highlights neurotoxic pollutants as significant environmental threats, showcasing the adverse impacts on vertebrates’ neurological health from pesticides, including organophosphates, carbamates, and organochlorines. “These substances disrupt normal neurophysiological functions by impairing neurotransmission, generating oxidative stress, provoking neuroinflammation, and initiating neuronal cell death,” the authors say. They continue, “Such disturbances are linked to cognitive deficits, motor impairments, and abnormal neural development.” Neurological conditions can manifest as headaches, muscle weakness, tremors, paralysis, coordination challenges, vision loss, hallucinations, vertigo, seizures, memory loss, slurred speech, trouble breathing with minimal exertion, and more. The range of adverse effects from low-dose, long-term exposure and low-dose (or subchronic) exposure during developmental phases of life raises serious questions about the adequacy of the regulatory review of pesticides, which focuses on acute high and lethal dose exposure. One study on the neurotoxicity of pesticides, published in Chemosphere, concludes, “New regulatory and preventive measures to mitigate the neurotoxic effects of pesticides are needed.” (See also Daily News.) Even at low concentration, chronic exposure to pesticides and other environmental contaminants “poses serious ecological and health concerns” that occur as these chemicals “bioaccumulate […]

(Beyond Pesticides, February 11, 2026) The first U.S. jury trial on the weed killer paraquat against global chemical companies Syngenta Crop Protection, Chevron U.S.A., FMC Corporation, and their predecessors was scuttled last month due to a settlement on the eve of the case being heard in court. Settlements are commonly used by pesticide manufacturers seeking to avoid public disclosure of internal documents on chemical hazards and wrongdoing that could result from a public trial. In Mertens et al. v. Syngenta, Chevron, and FMC, the six plaintiffs suing three corporations allege that exposure to paraquat-based herbicide products contributed to their Parkinson’s Disease diagnosis. While the terms of the settlement have not yet been disclosed, Lawsuit Information Center states that the paraquat class action multidistrict litigation (MDL) includes 8,257 cases as of January 16, 2026. In 2021, multiple cases were settled for more than $187 million. Background on Mertens Complaint In their complaint, the plaintiffs point to five causes of action, including “strict products liability design defect” (Count 1), “strict products liability failure to warn” (Count 2), negligence (Count 3), breach of implied warranty of merchantability (Count 4), and punitive damages (Count 5). Count 1—Strict Products Liability Design Defect: In the first […]

(Beyond Pesticides, January 29, 2026) A study of ecotoxicity risk from neonicotinoid insecticides, published in Environmental Chemistry and Ecotoxicology, finds that chemicals in this class of pesticides, particularly dinotefuron, increase the body temperature of Apis mellifera (European honey bee) and subsequently accelerate the translocation (movement) of contaminants into hives by the honey bees. The research indicates that neonicotinoids affect acetylcholine receptors in the nervous system, leading to an “elevation in octopamine titer [neurotransmitter/hormone] and subsequent increase in the body temperature of honeybees,” the authors report. They continue: “Furthermore, we observed a considerable upregulation [of] the expression of a flight gene flightin in honeybees. This gene accelerates the homing behavior of honeybees and facilitates the rapid and frequent transport of neonicotinoid pesticide-contaminated nectar to the hive.” In describing their results, the researchers state: “For the first time, we propose that neonicotinoid pesticides accelerate the homing ability of honeybees by affecting their body temperature, which leads to more neonicotinoid pesticides entering the hive and explains the prevalence of neonicotinoids and at higher concentrations in terms of their effects on the honeybee body temperature that enhances homing.” This accelerated movement of neonicotinoid pesticides into honey bee hives heightens the toxicity risks to honey […]

(Beyond Pesticides, January 27, 2026) A three-part study published in Molecular Neurodegeneration draws a connection between Parkinson’s disease (PD) and the organophosphate chlorpyrifos. “Since chlorpyrifos (CPF) exposure has been implicated as a risk factor for PD, we investigated its association to incident PD and if this association is biologically plausible using human, rodent, and zebrafish (ZF) studies,” the researchers state. Together, the three experiments “strongly implicate exposure to CPF as a risk factor for developing PD,” as the authors find that exposure, even at very low concentrations, causes selective toxicity to dopaminergic neurons that are critical for functions of movement, cognition, emotion, and more. The results reveal that in humans, long-term residential exposure is associated with more than a 2.5-fold increased risk of developing PD, while exposure in mice causes “motor impairment, dopaminergic neuron loss, microglial activation, and an increase in pathological α-synuclein (α-syn) [proteins primarily found in the brain].” The researchers continue, “Using ZF, we found that CPF-induced dopaminergic neuron loss was at least partially due to autophagy dysfunction and synuclein accumulation, as knocking down LC3 [a protein chain] recapitulated the dopaminergic neuron loss.” These three studies highlight the association of CPF with increased risks for developing PD, as […]

(Beyond Pesticides, December 23, 2025) A literature review of military personnel reveals broad evidence linking their toxic exposure to poorer mental health outcomes. The review, written by medical professionals and researchers throughout the U.S. and published in Medical Care, analyzes the existing literature on associations between military environmental exposures (MEEs) to contaminants, including pesticides, and mental health (MH) outcomes. “We used evidence mapping methodology to systematically search MEDLINE, Embase, PsycINFO, and PTSDpubs for studies of toxic exposure during military service and psychiatric outcomes, which included psychiatric diagnoses, psychiatric symptoms, and neurocognitive functioning,” the authors explain. The 49 studies in the review, covering chemical exposures for military members, involve chemical munitions from the Gulf War era and Agent Orange from the Vietnam War era that are associated with symptoms of depression, PTSD, and anxiety, among others. “Overall, available evidence suggests that veterans reporting environmental toxic exposures may report relatively high levels of mental health needs,” the researchers report. They continue: “To date, no studies have synthesized the existing literature linking MEEs to MH outcomes. In this review, we systematically organize and describe peer-reviewed literature studying associations between MEEs and MH and neurocognitive outcomes (ie, diagnoses and symptoms). Our review focused on […]

(Beyond Pesticides, December 18, 2025) A study in the International Journal of Hygiene and Environmental Health finds peak concentrations of organophosphate pesticide (OP) metabolites in the urine of pregnant mothers 6-12 hours after consuming contaminated fruits and vegetables. “High detection rates were observed for dimethylthiophosphate (DMTP, 96%), dimethylphosphate (DMP, 94%), diethylphosphate (DEP, 89%), and diethylthiophosphate (DETP, 77%) among 431 urine samples taken from 25 pregnant women, over two 24-hr periods, early in pregnancy,” the researchers report. The levels of metabolites within the urine correlate to the consumption of foods treated with organophosphate pesticides, highlighting the importance of adopting an organic diet—particularly for pregnant individuals and their children. “In 2009–2010, 80 pregnant women were recruited from Ottawa, Canada for the Plastics and Personal-care Product use in Pregnancy (P4) Study,” the authors say. “A subset (n = 25) collected multiple spot urines (up to 10 each; total n = 431) over two 24-h periods in early pregnancy—one weekday and weekend day—while logging their food consumption beginning 24 h prior to the first urine void and continuing through the following 24-h urine collection period.” This is the first study looking at the variability of organophosphate metabolites within 24 hours in maternal urine, giving […]

(Beyond Pesticides, November 6, 2025) The report, Designed to Kill: Who Profits from Paraquat, and accompanying interactive storymap, unpacks the supply chain of the infamous herbicide paraquat and underscores the true costs of pesticide products, from manufacturing to use in the fields. This report is part of a larger initiative, the Pesticide Mapping Project—“a collaborative research series that illustrates the health and climate harms of pesticides across their toxic lifecycle: including fossil fuel extraction, manufacturing, international trade, and application on vast areas of U.S. land.” Top Highlights This report highlights, among other notable points, “that every stage of the paraquat supply chain—which spans the globe—emits greenhouse gases and toxic air pollutants.” With SinoChem as the lead producer and player in the paraquat market, the Chinese government-owned pesticide company’s supply chain “includes fossil fuel extraction in Equatorial Guinea and Saudi Arabia, chemical manufacturing in India, Germany, and the United Kingdom, international chemical shipping, and final formulation and distribution in the United States.” Paraquat is not currently manufactured in the U.S., accounting for imports of “between 40 and 156 million pounds of paraquat each year, according to the last eight years of pesticide import records available from the private database.” Despite the […]

(Beyond Pesticides, October 31, 2025) A review in Lancet Neurology provides a clear snapshot of the state of scientific understanding of Parkinson’s disease and how medicine and policy could be improved by shifting focus to the primary causes of the disease, namely environmental toxicants, and to emphasize prevention rather than devoting resources only to treatments and a cure. The study, led by Ray Dorsey, M.D. of the Atria Research and Global Health Institute and the University of Rochester Medical Center, focuses on three classes of environmental toxicants: pesticides, dry cleaning and degreasing chemicals, and air pollution. Because these are pollutants introduced by humans, the authors say, they should be controllable, and “Parkinson’s disease could be thus largely preventable.” According to the review, in the last five years, new evidence has accumulated about three types of pesticides of particular concern. They are not all insecticides, which is the pesticide category most associated with neurological damage. Paraquat is a herbicide used on corn, soybeans, and cotton. Rotenone is used to kill rats and insects. Organochlorine insecticides comprise the third class. The review notes that there are many other pesticides that are neurotoxic and may have common mechanisms of action leading to Parkinson’s and […]

(Beyond Pesticides, September 10, 2025) Published earlier this year, a review of over 1,700 studies in Nature Communications finds pesticides affect a diverse range of nontarget organisms and contribute to global biodiversity loss. The authors* reveal “negative responses of the growth, reproduction, behaviour and other physiological biomarkers within terrestrial and aquatic systems” for nontarget plants, animals, and microorganisms. “To our knowledge, there has been no systematic and overarching synthesis of how different types of pesticides affect the diversity of multiple non-target eukaryotic and prokaryotic organisms across all trophic levels,” the researchers write. They continue, “Furthermore, current syntheses have not considered how the impacts of pesticides differ globally across climatic zones or for major mechanisms of exposure, such as those acting in aquatic or terrestrial environments.” In particular, pesticide regulatory risk assessments analyze a limited range of model species, including rats, zebrafish, clawed frogs, honeybees, and earthworms, among others. As such, they are unlikely to capture the variety of responses to pesticide exposure seen across the diversity of species and communities found in both managed and natural systems,” the authors state. *Authors include Beyond Pesticides 2023 National Forum speaker Dave Goulson—see the Daily News on his keynote address here. Research Results […]

(Beyond Pesticides, July 29, 2025) Are neurological diseases increasing around the world? Yes and no, according to a report published by The Lancet in 2024 on the global burden of nervous system diseases between 1990 and 2021. About 3 billion—a third of the world’s people—suffer from some nervous system condition. These diseases cause 11 million deaths and 443 million disability-adjusted life years (DALYs), which are a measure of the years lost to illness, disability, or early death. Neurological disorders are now the world’s largest source of disability. The Lancet report does not include an analysis of the role of pesticides in the burden of neurological disease worldwide, although environmental health research continues to expand the evidence that pesticide exposure is a major contributor to that burden. The Lancet report indicates that DALYs from Parkinson’s disease have increased by 10 percent, and autism spectrum disorder and dementia by 2 percent each. Multiple sclerosis has declined by 11 percent, according to the report. Importantly, most of the improvement has come from medical interventions, not prevention—in other words, people are living longer with the diseases rather than avoiding them altogether. But this is not true globally: The burden of disease, and particularly premature death, […]

(Beyond Pesticides, July 21, 2025) Beyond Pesticides is asking every member of the U.S. Representatives to voice their opposition in advance of a vote as early as Tuesday, July 22 on a provision before the House Appropriations Committee—in the Interior-Environment Appropriations Bill—that shields pesticide companies from lawsuits by those harmed from pesticide product use and limits states’ authority to regulate pesticides. This is a fight to protect farmers’ and consumers’ right to sue pesticide manufacturers for misbranding products and their failure to warn product users. The language before the Committee is in Section 453 of the bill passed last week by the subcommittee on a straight party-line vote, with Republicans supporting the bill language. Beyond Pesticides is also asking Congress members to remove section 507, which prohibits EPA action on PFAS (per- and polyfluoroalkyl substances), including fluorinated pesticides.  Update from July 21, 2025, at 4 PM: ⏰ Representative Chellie Pingree (D-ME-1) moved forward with amendments to strike sections 453 and 507 of the FY26 Interior-Environment Appropriations Bill, which is a provision that provides immunity for pesticide manufacturers from farmer and consumer lawsuits seeking compensation from product harm. Update from July 23, 2025, at 10 AM: The FY26 Interior-Environment Appropriations Bill passed out of […]

(Beyond Pesticides, June 27, 2025) An article in The New York Times (NYT), entitled “A Killer Within Easy Reach,” highlights the use of the weed killer paraquat, a widely used herbicide in the U.S. and many other parts of the world despite being banned in over 70 countries, as the cause of numerous suicides. The article references the tiny nation of Suriname, located on the northeastern coast of South America, as they have “one of the highest suicide rates in the world,” with the majority of those deaths involving paraquat. Globally, paraquat is prevalently used in self-harm incidents. The chemical, when absorbed into the body, among other deadly effects, causes pulmonary fibrosis, making lung tissue brittle and causing respiratory failure. While this pesticide is intended and generally used for weed control, it is also highly lethal to humans in small amounts and is often easily accessible in many households. As the NYT article states, “Pesticides are among the leading means of suicide in agricultural areas of developing nations, implicated in more than 100,000 deaths annually.” Citing examples from around the world, the article states, “Sri Lanka’s crop yields had surged after the introduction of modern fertilizers and pesticides in the […]

(Beyond Pesticides, May 22, 2025) A medical study published in the Journal of the American Medical Association (JAMA) finds that “living within 1 mile of a golf course was associated with 126% increased odds of developing PD [Parkinson’s Disease] compared with individuals living more than 6 miles away from a golf course.” While organic land management offers a simple solution, current pesticide restrictions do not address chronic neurological diseases such as Parkinson’s Disease, which are linked to pesticide exposure. It has become increasingly clear that viable and cost-effective land management practices, including for golf course management, are critical to the protection of community health. Yet, the federal regulatory agencies, including the U.S. Environmental Protection Agency (EPA) and U.S. Food and Drug Administration (FDA), do not conduct an alternative practices assessment as part of their review process to determine whether the risks are “reasonable” (statutory language) or the risk assessments accept an unnecessary hazard. The complexity of pesticide exposure, which includes mixtures of multiple chemicals and undisclosed hazardous “inert” ingredients, raises broad questions about the threats to public health as well as biodiversity. See a recent Action of the Week, FDA Must Establish Tolerances for Pesticides Used in Mixtures, to see […]

(Beyond Pesticides, April 23, 2025) Recent reviews of scientific literature, in both Chemosphere and Reports in Public Health, associate Parkinson’s disease (PD), the second most prevalent neurodegenerative disease globally, with pesticide exposure. “Given the pervasive nature of pesticide residues in everyday food consumption and inadequate monitoring of their long-term toxicological impacts, the role of pesticide exposure as a modifiable risk factor for neurological disorders, including PD, warrants urgent attention,” the researchers state in the article in Chemosphere. In describing the history of Parkinson’s and previous research, the authors in Reports in Public Health note that while PD etiology is not fully understood, it is a multifactorial disease. “Hereditary factors are present in approximately 10% of diagnosed cases of Parkinson’s disease, presenting early onset; while the other 90% of cases are categorized as idiopathic or sporadic Parkinson’s disease, occurring in older individuals and may be associated with exposure to environmental agents,” the researchers say. This disease, first described by English physician James Parkinson, M.D. in 1817, involves neurochemical changes that present as “the appearance of cardinal motor symptoms, such as bradykinesia, rigidity, postural instability, and rest tremor, which are essential for the clinical diagnosis of the disease,” the researchers note. The […]

(Beyond Pesticides, December 16, 2024) The fact that three-quarters of all U.S. fruits and nuts and one-third of all U.S. vegetables are grown in California means that all U.S. food eaters have a stake in how food is grown there. California is proposing the continued use of the fumigant 1,3-dichloropropene (1,3-D, also known as Telone), which can cause deadly effects to farmworkers and endocrine disrupting effects to communities of people exposed through nontarget chemical drift from farmland. So, it is with deep concern that Beyond Pesticides is urging the state of California, where the chemical is undergoing review, to ban the toxicant. Endocrine disruption, an adverse effect for which the U.S. Environmental Protection Agency (EPA) has never completed a pesticide testing protocol, adversely affects the functioning of glands and hormones and is linked to major life-threatening diseases in most organ systems in the body—contributing to attention deficit hyperactivity disorder (ADHD), Parkinson’s, Alzheimer’s, diabetes, cardiovascular disease, obesity, early puberty, infertility and other reproductive disorders, and childhood and adult cancers. In a recently released draft regulation, the California Department of Pesticide Regulation (CDPR) will allow highly elevated exposure to 1,3-D, ignoring the scientific literature and advice of the state’s own toxicologists at […]

(Beyond Pesticides, December 6, 2024) On December 2, the U.S. Environmental Protection Agency (EPA) announced yet another milestone in the convoluted life span of the insecticide chlorpyrifos. Under the deceptive headline “EPA Proposes Rule to Revoke Most Food Uses of the Insecticide Chlorpyrifos,” EPA stated that it is improving environmental protection by revoking all usages of chlorpyrifos except for 11 food and feed crops. The proposal was deemed “unconscionable” by Beyond Pesticides executive director Jay Feldman in an article in The New Lede. EPA claims this plan would reduce annual chlorpyrifos application by 70% compared to “historical usage.” Chlorpyrifos is a known neurological and reproductive toxicant. EPA has been cutting back on approved uses for years but is far behind other environmental authorities—the European Food Safety Authority and Thailand have banned it altogether, and California has banned its agricultural use. The trouble with EPA’s latest attempt is that it does nothing to clarify and rationalize EPA’s process, and it will not protect the public, because those 11 remaining products are among the most extensively grown and used in the world: soybeans, sugar beets, cotton, wheat, apples, citrus fruits, strawberries, alfalfa, cherries, peaches, and asparagus. Chlorpyrifos is an organophosphate chemical. These […]

(Beyond Pesticides, November 22, 2024) With numerous campaigns at the state and federal level to ban the weed killer paraquat and nearly 6,000 individual lawsuits alleging exposure to it causes Parkinson’s disease (PD), U.S. Senator Cory Booker (D-NJ) and six Senators on October 31 called on the U.S. Environmental Protection Agency (EPA) to ban the chemical. Citing that “[f]armworkers and rural residents are disproportionately exposed to paraquat,” the Senators’ letter to EPA stating that, “Paraquat has been linked to Parkinson’s disease, thyroid cancer, and other health harms such as kidney, liver, and respiratory damage, and reproductive harm, including neurodevelopmental impact on developing fetuses [and] [i]n rural areas, exposure to paraquat and other pesticides during pregnancy can increase the risk of leukemia.” Most of the 6,000 cases against paraquat’s manufacturer, Syngenta, have been consolidated into Multi-District Litigation (MDL) in the U.S. District Court for the Southern District of Illinois. In April, the MDL judge ousted the plaintiffs’ expert witness regarding causality, which resulted in the first five cases ready for trial being tossed out. The defendant sells paraquat globally and is doing everything it can, according to investigative news reports, to discredit any link between paraquat and Parkinson’s, including the use […]

(Beyond Pesticides, November 8-11, 2024) On Veterans Day 2024 we honor those who have served the country and allies. In the 117th (2021-2022) U.S. Congress, legislators enacted The Sergeant First Class Heath Robinson Honoring Our Promise to Address Comprehensive Toxics Act of 2022 (PACT Act). Since the law passed just over two years ago, there has been just under 1.3 million total approved claims marking a roughly 75% approval rate for PACT Act related claims, according to Department of Veteran Affairs (VA) accounting of progress between August 10, 2022, and October 12, 2024 through its dedicated bimonthly VA PACT Act Performance Dashboard. The legacy of toxic burn pits (open air areas where the military has burned toxic waste) and other avenues for toxic exposure in military bases oversees, as well as within the United States in Hawai’i (See coverage on asbestos exposure continuously impacting veterans, as reported on by Honolulu Civil Beat) and Puerto Rico (See peer-reviewed literature review here on toxic heavy metals in International Journal of Environmental Research and Public Health), among other areas, comes at a time when the country assesses the ongoing impacts of a history that has been characterized by critics as colonial or imperialist. […]

(Beyond Pesticides, September 20, 2024) As the California State Assembly wrapped up the 2024 legislative session, what was once a proposed ban of the deadly weed killer paraquat (in both agricultural and nonagricultural contexts) was amended and passed as a requirement for California Department of Pesticide Regulation to complete an “expedited review” by January 1, 2029. Paraquat exposure has been linked to Parkinson’s disease. According to reporting by Los Angeles Times, Assemblymember Laura Friedman (D-Burbank) (the original sponsor of the bill) spoke candidly about the prospects for this legislation, “We never thought we’d get a full ban through the Legislature. But we had to push as hard as we could.” Assemblymember Friedman is chair of the bicameral Environmental Caucus and a self-described “steadfast advocate for the environment [and] sustainable communities.” Environmental advocates, public health professionals, and many who have been affected by Parkinson’s disease are calling for the emergency suspension of paraquat, applying the same standard used by the U.S. Environmental Protection Agency (EPA) to ban the herbicide Dacthal/DCPA last month. (See Daily News here.) Context The original legislation responds to significant scientific documentation of the pesticide’s hazards, and an unresponsive regulatory process, as well as previous legislation efforts. In […]

(Beyond Pesticides, September 3, 2024) A piercing investigative article in the August 14 New York Times by journalist Greg Donahue reveals the abandonment of a group of brain disease patients in an area of Canada with forestry management for paper products, agriculture, and large amounts of pesticide use, including glyphosate. It illustrates the tension in the relationship between government authorities, regulated industries, and neurologist (physician) on the front lines. The article details the manner in which health officials appeared to manipulate their own investigation of a disease cluster to make it less disruptive to the economy of the Canadian province of New Brunswick. (This Beyond Pesticides analysis, where not otherwise indicated, draws on Mr. Donahue’s article.) New Brunswick has one major town, Moncton, and a large rural area characterized by agriculture and forestry. The province’s agriculture industry is dominated by blueberry production, which occupies the fourth largest amount of agricultural land in New Brunswick. About half the province is forested, with increasing amounts of land devoted to tree plantations intended for paper production. Glyphosate is hands-down the most heavily used pesticide in New Brunswick forestry, and New Brunswick is second only to Ontario in Canada’s total area of glyphosate-treated forest. […]

(Beyond Pesticides, August 20, 2024) A study published online in the journal Environmental Toxicology and Pharmacology raises continuing concern about residual exposure to organochlorine pesticides (OCPs) and the disruption that they and their metabolites and isomers cause to biological systems. For the most part, OCPs, including dichlorodiphenyltrichloroethane (DDT), are no longer used worldwide, but the legacy of their poisoning and contamination persists. A 2022 article in Environmental Science & Technology cites California condors and marine mammals along California’s coast contaminated with several dozen different halogenated organic compounds (hazardous, often-chlorinated chemicals) related to DDT, chlordane, and other now-banned legacy chemicals. Other research finds DDT in deep ocean sediment and biota. And, more research finds multigeneration effects from DDT exposure with grandmothers’ exposure to DDT increasing granddaughters’ breast cancer and cardiometabolic disorder risk. This study may be the first compilation of research regarding the modes of action for distinct types of organochlorine pesticides (OCPs). The findings raise the significant danger of legacy chemicals that persist for generations and call for a precautionary regulatory standard that is focused on preventing harm and advancing alternative nontoxic practices and products. In tracking the ongoing scientific literature on a broad spectrum of adverse effects daily, Beyond Pesticides […]

(Beyond Pesticides, August 15, 2024) Adding to research that has linked insecticide disruption of the gut microbial community to the progression of Parkinson’s Disease (PD) in the brain is a recently published study that further examines the gut-brain mechanism at work. A review by neuroscientist Nabanita Ghosh, PhD in Chemical Research in Toxicology—coauthored by Krishnendu Sinha, PhD, molecular toxicologist and applied pharmacologist, and molecular toxicologist Parames C. Sil, PhD—focuses on how pesticide-induced microbial community alterations specifically drive the initiation of PD and the precise mechanism. The study also explores microbiota changes at different stages of PD progression, offering recent findings.     The researchers derive their data from the examination of PD patients, evaluating the “interaction between pesticides and gut bacteria in PD patients, summarizing how pesticides cause imbalances in gut bacteria, the resulting changes, and their overall effects on the PD prognosis.”   The review “looks at how pesticides and gut bacteria separately influence PD development and progression, highlighting the harmful effects of pesticides and changes in gut bacteria.” The team concludes that pesticide exposure is connected to PD onset through “disturbances in gut function and alterations in intestinal microbiota.” However, the “exact role of microbial factors in this connection remains […]