(Beyond Pesticides, April 5, 2024) Exposure to chemical toxicants, molds, and algae contributes to autism and attention disorders in children, according to research that bolsters earlier findings. The exposures may be most relevant, not in the children, but one generation back—in the parents. The study, “Assessing Chemical Intolerance in Parents Predicts the Risk of Autism and ADHD in Their Children,” was published in the March issue of the Journal of Xenobiotics. Led by Claudia S. Miller, MD, an immunologist at the University of Texas at San Antonio noted for her work on chemical intolerance (CI), the authors build on previous work published in 2015 establishing parental CI as a risk factor for autism and ADHD. Dr. Miller participated in Beyond Pesticides’ 2022 Forum Series. Recordings of her presentation are available on YouTube here and here. In 1996, Dr. Miller concluded that CI is induced by Toxicant-Induced Loss of Tolerance (TILT). For further details, see Beyond Pesticides’ Daily News Blog. Three years later Dr. Miller developed the Quick Environmental Exposure and Sensitivity Inventory (QEESI), a questionnaire for individuals tracing their toxicant exposures and symptom histories. QEESI was first developed with groups exposed to organophosphate pesticides, volatile organic compounds in reconstruction and […]

(Beyond Pesticide, December 20, 2022) A meta-analysis published in Chemosphere finds prenatal pesticide exposure, or pesticide exposure during pregnancy has a positive association with autism spectrum disorder (ASD) and attention deficit/hyperactive disorder (ADHD). Particularly, exposure to chemical classes organophosphate (OP) and pyrethroid (PYR) insecticides, in addition to the mother’s age during pregnancy (≥30 years old), increased the risk factor of ASD. ADHD risk increases among offspring whose mothers encounter organochlorine pesticides (OCPs) during gestation. The etiology or cause of ASD and ADHD involves the interaction of multiple components, including lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, solvents, dietary residues, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects.  ADHD is estimated to affect 8-12% of school-age children worldwide. While it is a complex disease, and genetics may play a role, no specific genes have been identified, and there is increasing evidence that environmental factors like pesticide exposure facilitate the development of the condition. Additionally, U.S. Centers for Disease Control and Prevention (CDC) estimates that 1 in 54 children have been diagnosed with an autism spectrum […]

(Beyond Pesticides, September 1, 2022) Low level exposure to synthetic pyrethroid insecticides at 6-8 months of age is associated with language development delays in two-year old toddlers, according to research published in Neurotoxicology this month. This is the latest study to link this class of chemicals to developmental delays in young children. Despite a steady drum of concerning research, the U.S. Environmental Protection Agency (EPA) in 2019 removed a crucial “safety factor” intended to protect children’s health from synthetic pyrethroids, allowing higher levels of the insecticides to be sprayed on food, in homes, and playing fields around the country.   To investigate the impact of synthetic pyrethroids on language development, scientists enrolled 327 expectant mothers in their third trimester. The mothers, all from rural areas of China, were selected if they had no history of significant pesticide exposure or family history of serious disease. Urine samples were taken from the women during pregnancy, and from infants 6-8 months after birth. Scientists analyzed samples for concentrations of three different synthetic pyrethroid breakdown products (metabolites), including 3-phenoxybenzoic acid (3PBA), 4-fluoro-3-phenoxybenzoic acid (4F3PBA), and cis-2,2dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA). While 3PBA is a metabolite of many synthetic pyrethroids, 4F3PBA a more specific metabolite of cypermethrin, […]

(Beyond Pesticides, September 9, 2021) A new study published in Toxicology Reports finds the same chemicals that disrupt the endocrine (hormone) system also disrupt the nervous system. Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem) present in nearly all organisms and ecosystems. The World Health Organization (WHO), European Union (EU), and endocrine disruptor expert (deceased) Theo Colborn, Ph.D., classify over 55 to 177 chemical compounds as endocrine disruptors, including various household products like detergents, disinfectants, plastics, and pesticides. Past research shows exposure to endocrine-disrupting pesticides adversely affects human health, from reproductive function to cancer development, and effects can span generations. However, this study is one of the few to evaluate associations between endocrine-disrupting chemicals and neurological function. Although the etiology (cause) of many sporadic (non-heritable) neurological diseases are unknown, scientists suggest exposure to environmental toxicants plays a role in disease development. Therefore, government and health officials have been urged to consider how exposure to endocrine-disrupting chemicals can impact bodily function and development apart from hormone disruption.   In the body, cells communicate through electrical or chemical signals transmitted within the nervous or endocrine system. Studies find exposure to endocrine-disrupting chemicals has a direct and indirect impact on hormone function and development. However, researchers investigated whether […]

(Beyond Pesticides, July 20, 2021) Chlorpyrifos exposure results in the expression of genetic mutations associated with autism spectrum disorder in a laboratory model, finds research published in Environmental Health Perspectives by scientists at Johns Hopkins Bloomberg School of Public Health. “This is a step forward in showing an interplay between genetics and environment and its potential role for autism spectrum disorder,” says study lead Lena Smirnova, PhD, a research associate in the Department of Environmental Health and Engineering at the Bloomberg School. The findings support reams of research already conducted that show strong associations between autism and exposure to hazardous environmental stressors like toxic pesticides. Scientists conducted their study using a ‘brain organoid’ model, which is essentially a cluster of cells artificially grown in the lab from stem cells in order to mimic a developing human brain. These tests provide certain benefits over animal testing, as they are more relevant to human disease, and can be performed faster with less cost. The organoid model also represents an improvement on typical 2d cell-based models, increasing cell survival, shelf-life, and thus providing opportunity to model for later stages of brain development. Brain organoids in this study carried a gene called CHD8, which […]

(Beyond Pesticides, March 27, 2019) Exposure to commonly used pesticides in the womb and during the first year of life is linked to a higher risk of developing autism, according to the study, “Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study,” published in the journal BMJ last week. Although the study does not reveal a causal link, it adds to previous literature highlighting autism risks from pesticide exposure, and reinforces calls to limit pesticide exposure during early life critical windows of vulnerability. The authors note their findings “support the need to avoid prenatal and infant exposure to pesticides to protect the developing child’s brain.” Researchers used data from California’s records of autism disorder diagnosis and birth rates from 1998 to 2010. Roughly thirty-five thousand healthy patients acted as a control, while scientists identified nearly three thousand patients with an autism diagnosis, of which 445 also displayed a co-occurring intellectual disability. Data was then drawn from California’s pesticide use recording database, and eleven pesticides (glyphosate, chlorpyrifos, diazinon, acephate, malathion, permethrin, bifenthrin, methyl bromide, imidacloprid, avermectin, and myclobutanil) were analyzed for their use within 2000 meters (1.25 miles) of the homes of those […]

(Beyond Pesticides, August 22, 2018) Mothers with high levels of DDT’s major metabolite, DDE, are more likely to have their children diagnosed with autism, according to a study published in The American Journal of Psychiatry this month. Though this study links autism to long-banned DDT, it raises significant concerns about legacy contamination from this chemical, which remains ubiquitous in the environment and in human bodies. With an increasing number of studies linking autism and other developmental disabilities to pesticides, the need to transition to safer, organic methods of farming is now more important than ever before. The study, Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort, measured maternal serum levels of Finish women during early pregnancy whose children were born between 1987 and 2005. Specimens were analyzed for DDE as well as PCB contamination. Mothers with DDE at the highest 75% threshold reportedly had a 132% (1.32x odds ratio) increased risk of having a children diagnosed with autism after adjusting for confounders such as age and history of psychiatric disorders. Moms above the 75th percentile had their chances of a child’s autism diagnosis increase by 221% (2.21x odds ratio). The study found no connection […]

(Beyond Pesticides, May 3, 2018) Hawaii’s bill to ban the dangerous, neurotoxic pesticide, chlorpyrifos, passed its final hurdle this week in the state legislature. Governor David Ige is expected to readily sign SB3095 into law, in light of the unanimous support it received from lawmakers on both sides of the aisle. The statewide prohibition of chlorpyrifos will take effect beginning in January 2019. This legislative action marks the first time that any state in the country has passed an outright ban on the highly toxic organophosphate pesticide. While multiple scientific studies have determined that chlorpyrifos damages fetal brains and produces cognitive and behavioral dysfunctions, particularly in utero and in children, states have been slow to institute a complete prohibition, due to its widespread use in agriculture. Lawmakers in New Jersey and Maryland have recently tried unsuccessfully to pass similar bans. Hawaii’s bill contains a caveat that allows the state’s Department of Agriculture (DOA) to grant special permits for companies that argue that they need more time to phase-out chlorpyrifos, but that exemption will end at the close of 2022. The new law also requires restricted use pesticide (RUP) users to report to the Hawaii’s DOA which ones they are applying on […]

(Beyond Pesticides, September 14, 2017) Children whose mothers took folic acid while pregnant had a significantly lower risk of developing autism spectrum disorder (ASD) even when their mothers were exposed to household or agricultural pesticides. Researchers at the University of California, Davis found that taking folic acid during the window around conception, reduced the risk of pesticide-induced autism. In the study, “Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder,” children whose mothers took 800 or more micrograms of folic acid (the amount in most prenatal vitamins) had a significantly lower risk of developing autism spectrum disorder, even when their mothers were exposed to household or agricultural pesticides that are associated with increased risk. The study used data from the Childhood Autism Risks from Genetics and the Environment (CHARGE) study, where researchers looked at 296 children between 2 and 5 who had been diagnosed with ASD and 220 who had developed typically. Mothers were interviewed about their household pesticide exposure during pregnancy, as well as their folic acid and B vitamin intake. The team also linked data from California Pesticide Use reports, which provided important details about agricultural spraying, with the mothers’ addresses. The results […]

(Beyond Pesticides, June 15, 2017) Communities exposed to frequent aerial spraying for mosquito control experience elevated rates of autism diagnoses, according to new research. The study identifies the frequent use of synthetic pyrethroid insecticides, which are linked to neurocognitive and behavioral impacts, among other health effects. Pediatric researchers at Penn State University and the University of California examined communities in eight zip codes in Onondaga County, New York with frequent aerial spray programs for mosquito control, and contrasted these findings with communities in 16 zip codes that do not employ similar pesticide use programs. According to the study, between 2007 and 2009, the average yearly pesticide burden across the eight aerial exposed zip codes was approximately 11,000 kilograms, compared to approximately 4,000 kilograms of pesticide exposure across the 16 control zip codes. The study finds that the zip codes with frequent aerial pyrethroid exposure are 37% more likely to have higher rates of childhood developmental delays and autism spectrum disorder. The researchers acknowledge that the study establishes a correlational, not a causal, link between pyrethroid exposure and autism/developmental disorders, it adds to a growing body of research demonstrating an exposure-effect relationship between the two. Other studies have similarly linked developmental disorders and autism […]

(Beyond Pesticides, September 14, 2016) According to a recent study by the U.S. Geological Survey (USGS), high concentrations of dioxins and furans have been detected in tree swallow eggs collected near several sites around the Great Lakes. Other chemicals detected include polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), which were at background levels. The study is part of efforts to clean up a toxic chemical legacy around the Great Lakes, and the researchers believe their results are critical to regulators to assess “bird or animal deformity or reproductive problems” The study, “Concentrations and spatial patterns of organic contaminants in tree swallow (Tachycineta bicolor) eggs at United States and binational Great Lakes Areas of Concern, 2010—2015,” used tree swallows to quantify current exposure to organic contaminants across all five Great Lakes including 59 sites within 27  Areas of Concern (AOCs)  and 10 nearby  locations. The Great Lakes Areas of Concern refers to a U.S.-Canada  Great Lakes Water Quality Agreement  (Annex 1 of the 2012 Protocol) that  defines AOCs as “geographic areas designated by the Parties where significant  impairment of beneficial uses  has occurred as a result of human activities at the local level.” An AOC is a location that has […]

(Beyond Pesticides, August 24, 2016) Researchers at Drexel University report that higher levels of some organochlorine compounds during pregnancy are associated with autism spectrum disorder (ASD) and intellectual disability (ID). The organochlorine compounds under study have long been banned in the U.S., and include pesticides like DDT, underscoring how pervasive and persistent these chemicals are, and their continued impact on human health. The research is reported in the study  Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Sam ples: Association with Autism Spectrum Disorder and Intellectual Disability,  which examines whether prenatal exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) influences offspring risk of ASD and intellectual disability without autism (ID). According to the research, children born after being exposed to the highest levels of organochlorines during their mother’s pregnancy are roughly 80 percent more likely to be diagnosed with autism when compared to individuals with the very lowest levels of these chemicals. The team looked at a population sample of 1,144 children born in Southern California between 2000 and 2003. Data was accrued from mothers who had enrolled in California’s Expanded Alphafetoprotein Prenatal Screening Program, which is dedicated to detecting birth defects during pregnancy. Participants’ children were […]

(Beyond Pesticides, May 16, 2016) Pesticide exposure may increase the risk of amyotrophic lateral sclerosis (ALS), according to a study entitled Association of Environmental Toxins With Amyotrophic Lateral Sclerosis, which was  published in JAMA Neurology. ALS, also known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. The study, which investigated a total of 122 persistent environmental pollutants, including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and brominated flame retardants (BFRs), found that pesticide exposure increased ALS risk five-fold. Researchers conducting the study  looked at 156 patients with ALS and 128 without the disease. Participants were asked about occupational and residential exposure to environmental toxicants  and blood samples were taken to measure their concentrations. Researchers found that the organochlorine pesticides pentachlorobenzene and cis-chlordane increased ALS risk two-fold and nearly six-fold, respectively. This study does not prove that pesticides cause ALS, but it does build on an association suggested in previous research, study co-author Stephen Goutman, MD, told  HealthDay. Dr. Goutman recommends avoiding pesticides. This is especially wise for anyone with a family history of ALS, he added. The link between pesticide exposure and neurological damage has been studied extensively. In 2008, […]

(Beyond Pesticides, April 1, 2016) A study published yesterday finds  that a certain class of fungicides, the strobilurins, causes genetic changes in the neurons of mice that are similar to genetic changes seen in humans with autism and Alzheimer’s disease. Since their introduction to the market over the past 20  years, these fungicides have been used increasingly on conventionally grown crops like cabbage, spinach, lettuce, kale, tomatoes, apples, pears and grapes. After exposing brain cells from mice to over 300 pesticides and fungicides, researchers found that the strobilurin class of fungicides produces patterns of genetic changes often seen in human neurodegenerative diseases. While the fungicides created autism-like signatures in the way the genes were expressed in mouse neurons, the results do not conclusively show that this class of fungicides causes autism or Alzheimer’s disease. Mark Zylka, Ph.D., lead scientist of the study and associate professor of cell biology and physiology at University of North Carolina, states,  “What this work provides is evidence that these chemicals are bad for neurons. They turn the same genes on or off that you see not only in autism brains, but also in neurodegeneration.” Strobilurins work by disrupting mitochondria, commonly known as the “powerhouse of […]

(Beyond Pesticides June 4, 2015) Another study has found links between a commonly used household pesticide and attention deficit hyperactivity disorder (ADHD) in children and young teens. Researchers at Cincinnati Children’s Hospital Medical Center found an association between pyrethroid pesticide exposure and ADHD, particularly in terms of hyperactivity and impulsivity. These results reinforce the findings of a study led by a research team at Rutgers University earlier this year that found links between the pesticide deltamethrin and ADHD. In 2001, over concerns about adverse health consequences, the U.S.  Environmental Protection Agency banned several commonly used organophosphate (organic compounds containing phosphorus) pesticides from residential use due to the chemicals neurotoxic properties. The ban led to the increased use of pyrethroid pesticides, which are now the most commonly used pesticides for residential pest control and public health purposes. Pyrethroids, like deltamethrin, are commonly used in the home,  office buildings,  and on vegetable crops, gardens, lawns and golf courses. This shift to predominantly using pyrethroids is troubling, as they have oft been promoted as a safer choice than banned organophosphates, despite the fact that they pose many real threats to human health. Many recent studies show significant concern with this class of chemicals, […]

(Beyond Pesticides, March 13, 2015) Exposure to endocrine (hormone) disrupting chemicals (EDC) results in approximately € 150 billion ($162 billion) in health care costs in the European Union each year, according to panels of scientists tasked by the EU Commission to study their impact. “The shocking thing is that the major component of that cost is related to the loss of brain function in the next generation,” Philippe Grandjean, M.D. of Harvard University, one of the report’s authors, told the Guardian. EDCs, contained in common household products such as detergents, disinfectants, furniture, plastics, and pesticides, interfere with the body’s hormone system either by mimicking naturally produced hormones, blocking hormone receptors in cells, or effecting the transport, synthesis, metabolism or excretion of hormones. These impacts can result in devastating effects on one’s health, including behavioral and learning disorders, such as Attention Deficit Hyperactivity Disorder (ADHD), birth defects, obesity, early puberty, infertility, cardiovascular disease, and childhood and adult cancers. Nearly 100 percent of people have detectable amounts of EDCs in their bodies, according to the introductory guide to EDCs published by the Endocrine Society and IPEN. “Our brains need particular hormones to develop normally —the thyroid hormone and sex hormones like testosterone […]

(Beyond Pesticides, August 7, 2014) Residents of St. Louis, Michigan aren’t used to seeing large excavators and dump trucks haul piles of dirt from their front yards or entire blocks of big, neighborhood trees felled. What they are used to seeing are dead birds ””sometimes even spontaneous, mid-flight deaths of the birds”” and because of a toxic series of events, disasters, and delays spanning decades, the two sights are inextricably connected. As one St. Louis resident described to the Detroit Free Press, dozens of dead robins and blackbirds had been collected from her backyard in the 18 years she has lived there, with the most recent just a couple weeks ago. This experience and other similar stories from the area prompted researchers at Michigan State University (MSU) to start figuratively and literally digging. Matt Zwiernik, Ph.D., an environmental toxicologist at MSU, and volunteers collected 29 dead birds, including 22 robins, last year from a nine-block residential area in St. Louis. The scientific sampling was only a small portion of the dead birds they could have collected, Dr. Zwiernik explained to reporters at the Detroit Free Press, as time, distance, logistics, and access to property sometimes limited collection efforts. Nevertheless, it […]

(Beyond Pesticides, July 16, 2014) The Canadian Environmental Law Association (CELA) and Clean Production Action (CPA) released a comprehensive assessment of the hazards posed by triclosan and its chemical cousin triclocarbon Thursday, calling on the Canadian Government to create a comprehensive phase-out plan for these harmful antibacterial chemicals. The report, which finds that the chemicals are accumulating in the waters of the Great Lakes, also suggests that the U.S. and all provinces and states bordering the Great Lakes should prohibit use of the chemicals. The two antibacterial chemicals are commonly used in consumer products ranging from liquid soaps and toothpaste to kitchen cutting boards, and have come under increased scrutiny amidst human health concerns and lack of efficacy. The Canadian Medical Association (CMA) has been calling for a ban on the household use of triclosan since 2009, and in 2012, the Canadian government declared triclosan as toxic to the environment. In the U.S., Beyond Pesticides has petitioned the Food and Drug Administration (FDA) and its counterpart, the U.S. Environmental Protection Agency (EPA) (which regulates non-cosmetic products with triclosan) for years to immediately ban triclosan from consumer products, citing endocrine disruption, and other human health concerns. Last December,  FDA announced  it […]

(Beyond Pesticides, July 15, 2014) More nutritional antioxidants, far fewer toxic pesticides; those are the results of a comprehensive meta-analysis on organic foods published yesterday in the British Journal of Nutrition.  Led by Carlo Leifort, Ph.D, at England’s Newcastle University, the analysis is a scientific rebuttal to a previous Stanford University review published in 2012, which found that there was little difference between the nutritional content of organic food over conventionally grown produce. Both studies found there to be fewer pesticides in organic products. While Stanford University’s review only looked at 200 studies, Dr. Leifert and his team of researchers expanded the scope of their meta-analysis to 343 studies, and also employed more robust analytic tools by analyzing the standardized mean differences of the data from the various studies. It shows very clearly how you grow your food has an impact,” said Dr. Leifert to The New York Times. “If you buy organic fruits and vegetables, you can be sure you have, on average, a higher amount of antioxidants at the same calorie level.” Antioxidants, compounds such as phenolic acids, flavanones, stilbenes, flavones, flavonols and anthocyanin, have been linked to lower risks of cancer and other diseases. For many, news […]

(Beyond Pesticides, July 2, 2014) According to a new study, few obstetricians offer their pregnant  patients advice on how to avoid environmental toxins that might harm their babies, even though doctors recognize that exposure to chemicals like pesticides, bisphenol-A (BPA), and metals can affect  a pregnancy. The study recommends that the medical community improve medical education and training, develop recommendations for prevention and less toxic alternatives, as well as lend support to policy change. The first of its kind study of prenatal counselling, published in the journal  PLOS ONE, Counseling Patients on Preventing Prenatal Environmental Exposures – A Mixed-Methods Study of Obstetricians, found that U.S. obstetricians and gynaecologists feel they lack the medical education and training, and evidence-based guidelines and tools for communicating potential environmental risks to patients. Exposure to environmental toxins, the researchers from the University of California, San Francisco (UCSF) found, is rarely discussed with pregnant patients, even though a national survey shows that 80 percent of physicians agree they should play a part in reducing patients’ exposure to toxins. But, of the 2,500 respondents, only one in five routinely asked  their  patients about these exposures, and just one in 15 said they received training on the harmful […]

(Beyond Pesticides, June 24, 2014) Research from the University of California, Davis CHARGE (Childhood Autism Risks from Genetics and the Environment) study finds that pregnant women who lived within a mile of agricultural fields treated with insecticides are more likely to have their child develop autism. The results of the CHARGE study, published in Environmental Health Perspectives, strengthens calls from public health and environmental groups urging regulators take a precautionary approach to agricultural chemicals and institute increased protections for those who live, work, or go to school near pesticide-treated fields. The CHARGE study looked at pregnant women’s addresses to determine their location relative to fields treated with pesticides. For women who lived less than one mile from crops sprayed with organophosphate insecticides during their pregnancy, researchers found the likelihood of their child being diagnosed with autism increased 60%. Women in the second trimester living near fields treated with chlorpyrifos, a widely used organophosphate insecticide banned for household use in 2001, are 3.3 times more likely to have their children diagnosed with autism. In response to a legal petition, the U.S. Environmental Protection Agency (EPA) in 2012 instituted risk mitigation measures for chlorpyrifos, including reduced application rates and no-spray buffer zones […]

(Beyond Pesticides, March 21, 2014) Banned pesticides and flame retardants may be the cause of higher autistic behaviors for children who were exposed in utero, according to new research published last week in the journal Environmental Health Perspectives. Previous research has demonstrated that organochlorine chemicals are linked to learning problems, such as attention-deficit hyperactivity disorder (ADHD), especially in boys. This research is one of the first studies to evaluate their contribution to autistic behaviors. According to the study, Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year Old Children, children who were exposed to higher levels of brominated flame retardant PBDE-28 and trans-nonachlor, a component of the banned pesticide chlordane, scored higher in terms of autistic behavioral patterns as ranked by their mothers. In the study, researchers conducted a case-cohort study recruiting 175 pregnant women from seven prenatal clinics within the greater Cincinnati, Ohio region who provided urine and blood samples during pregnancy to measure the concentration of endocrine disrupting chemicals. On average, pregnant women had 44 suspected hormone disrupting chemicals. Five years later, when children had turned four or five, mothers were asked to rank their children’s behavior based on a series […]

(Beyond Pesticides, May 9, 2013) A review of the scientific literature of the toxic effects of glyphosate, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, links the herbicide  to a wide range of diseases and suggests  that more research is needed. The review, conducted by a scientist at Massachusetts Institute of Technology (MIT), looks at the mechanisms through which the adverse effects may be happening and points to  the chemical’s inhibition of cytochrome P450 (CYP) enzymes, which plays the crucial role of detoxifying xenobiotics. Thus, glyphosate can enhance the negative effects of other environmental toxicants on the body. Authors argue that this has been a critically overlooked component in research on glyphosates’ toxicity to mammals. We “have hit upon something very important that needs to be taken seriously and further investigated,” Stephanie Seneff, PhD, lead author and research scientist at MIT, told Reuters. Not surprisingly, Monsanto, the developer of Roundup, the leading product containing glyphosate, has attempted to discredit the study, claiming that its product has a long track record of being safe – read Another Bogus “Study.” However, Beyond Pesticides has assembled  extensive documentation on the human health and environmental risks […]