(Beyond Pesticides, March 27, 2025) In Ecotoxicology, results of a study on Nile tilapia (Oreochromis niloticus) exposed to florpyrauxifen-benzyl (FPX) suggest the new herbicide causes oxidative stress (imbalances affecting the body’s detoxification abilities that lead to cell and tissue damage), with specific genotoxic (damage to genetic material) and hepatotoxic (damage to the liver) effects on nontarget species. The authors state: “According to the available literature, no data exist on the toxicity of FPX in fish. Therefore, this study aims to investigate, for the first time, the potential toxicity and associated mechanistic effects of the pyridine-carboxylic acid herbicide (FPX) on the non-target species, Nile tilapia.” According to the Wisconsin Department of Natural Resources, “Florpyrauxifen-benzyl is a systemic herbicide (i.e., it moves throughout the plant tissue). It is a WSSA Group 4 herbicide, meaning that the mechanism of action is by mimicking the plant growth hormone auxin and causing excessive elongation of plant cells, ultimately killing the plant.” The researchers, from Menoufia University, the Agricultural Research Center, and Cairo University in Egypt, focus on FPX as it is the active ingredient in Divixton 2.5% EC, a newly released herbicide used in rice fields and applied directly to freshwater aquatic bodies for emergent […]

(Beyond Pesticides, March 25, 2025) An editorial in Expert Review of Cardiovascular Therapy finds that triazole fungicides pose a significant risk of cardiotoxicity with “growing concerns regarding their safety for human health, especially in long-term exposure,” the authors share. After analyzing the known mechanisms of cardiotoxicity of triazole pesticides in mammals, they conclude that “the most effective approach to mitigating triazole-induced cardiotoxicity lies in prevention.”  Triazoles, a class of fungicides, target fungi by inhibiting the biosynthesis of ergosterol, an essential component of their cell membranes. As the researchers share, “Compounds such as tebuconazole, propiconazole, and difenoconazole are among the most used triazoles in agriculture.” Triazoles are utilized as antifungal medications, despite the rise of resistant infections, in addition to their use as systemic pesticides on many fruit and vegetable crops, including grapes, wheat, corn, and soybeans.   As Beyond Pesticides’ previous coverage indicates, many triazole fungicides in the U.S. are registered for use despite evidence of endocrine disruption established over a decade ago in a U.S. Geological Survey report. These pesticides exhibit common mechanisms of toxicity often disregarded in U.S. Environmental Protection Agency (EPA) risk assessments, with a multitude of studies showcasing the myriads of health threats that the agency does […]

(Beyond Pesticides, March 24, 2025) In establishing the Make America Healthy Again Commission in February, the President tapped Secretary of the U.S. Department of Health and Human Services Robert F. Kennedy, Jr. to chair the interagency panel. The stated goal, as described in the founding proclamation, is “drastically lowering chronic disease rates and ending childhood chronic disease.” The commission document states, “Overall, the global comparison data demonstrates that the health of Americans is on an alarming trajectory that requires immediate action.” In this context, on March 10, Secretary Kennedy directed Food and Drug Administration (FDA) Acting Commissioner Sara Brenner, MD to take steps to explore potential rulemaking to revise its Substances Generally Recognized as Safe (GRAS) Final Rule and related guidance to eliminate the self-affirmed GRAS pathway—allowing the food and chemical industry to assign GRAS status to food ingredients without oversight. This “pathway” to allowing food additives has long been recognized as a loophole that allows unidentified and potentially harmful additives in food, including by the 2010 U.S. General Accountability Office (GAO) report, Food Safety: FDA Should Strengthen Its Oversight of Food Ingredients Determined to Be Generally Recognized as Safety.  Beyond Pesticides launched an effort this week to tell FDA to eliminate the self-affirmed […]

(Beyond Pesticides, March 17, 2025) When Secretary of Health and Human Services Robert F. Kennedy, Jr. announced last week that he is directing the U.S. Food and Drug Administration (FDA) to explore rulemaking to review substances in food affirmed by the food companies to be Generally Recognized as Safe (GRAS), he said he is “committed to promoting radical transparency to make sure all Americans know what is in their food.” The issue of independent review of the food industry’s GRAS declarations has long been the subject of critiques raising public health concerns. As this issue emerged, on another food safety issue, Beyond Pesticides is asking  FDA to use its broad authority under the Federal Food, Drug, and Cosmetic Act to “ensur(e) that human foods and animal feeds are safe” from residues of pesticide mixtures, in light of new troubling scientific data. Under various memoranda of understanding between FDA, the U.S. Environmental Protection Agency (EPA), and the U.S. Department of Agriculture (USDA) going back decades, FDA could consult with EPA on food safety issues ignored by the agency, including  recent data published in Pesticide Biochemistry and Physiology, which “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal […]

(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.” The researchers studied the toxic effects of the insecticides abamectin and spirodiclofen, as well as the fungicide fluazinam, individually and in combination. In exposing mice and Caco-2 cells to these pesticides, the results show the disruption of intestinal functions and highlight the need to assess potential synergistic effects of pesticide mixtures as a part of the regulatory review process.  Effects on the intestinal barriers of mice represent a threat to “the first line of defense against the external environment,” the researchers say. The intestinal mucosal epithelial structure plays an important role in preventing harmful substances from entering the intestines and causing damage to cells.  [Caco-2 cells represent a human cell line, derived from a colon cancer patient’s tissue, and mimic the small intestine. These cells are vital in research as a model of the intestinal epithelial barrier.]  “Currently, most studies investigating the effects of pesticide residues on the barrier function of Caco-2 cells concentrate on the exposure to a single residue, while the potential toxic effects arising from the concurrent presence of multiple pesticide […]

(Beyond Pesticides, March 11, 2025) A study in Toxics analyzes ipconazole, a triazole fungicide often used as a coating on treated seeds and as a foliar treatment on the leaves of plants. “Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms,” the researchers state. In the current study, unintended reproductive effects are noted in male sheep (ram) and pigs (also known as porcine or swine). This research focuses on the impact of ipconazole exposure on spermatozoa (sperm) in two mammal species and finds spermiotoxicity through significantly reduced sperm viability, as well as alterations in enzyme and gene expression related to fertility.  “To our knowledge, this is the first study to evaluate the cytotoxic effect of the triazole ipconazole on mammalian spermatozoa,” the authors share. This analysis utilizes semen samples from the Reproductive Biotechnology Laboratory of the Major National University of San Marcos in Lima, Peru, the university where six of the nine researchers are Faculty of Veterinary Medicine.   “The sperm were exposed to ipconazole concentrations of 1, 5, 10, 50 and 100 µM, and to a control without ipconazole,” they say. Similar concentrations have been used in previous cytotoxicity studies with ipconazole. […]

(Beyond Pesticides, March 10, 2025) Following International Women’s Day, celebrated on March 8, 2025, the poignant findings on women, gender, and hazardous substances in a United Nations report raise critical issues of concern and cause for urgent action to phase out petrochemicals. The Report of the Special Rapporteur on the implications for human rights of the environmentally sound management and disposal of hazardous substances and wastes, by Marcos Orellana, was delivered to the 79th Session of the United Nations General Assembly in July 2024. Excerpts from the report follow: “Women make up roughly 60 to 70 per cent of the agricultural labour force in developing countries where pesticides and pesticide handling are especially poorly regulated. In Zambia, for example, two thirds of the labour force is engaged in agriculture, and 78 per cent are women farmers and peasants. Women there play a significant role in pesticide application, often without any or adequate personal protective equipment, especially during activities such as weeding, harvesting, and washing pesticide-laden clothes.” “In higher-income countries, women who do agricultural work are often poor and/or migrants; pesticides are one of many dimensions of marginalization and damage to their well-being. The European agriculture sector uses many seasonal and […]

(Beyond Pesticides, March 7, 2025) In honor of International Women’s Day on Saturday, March 8, 2025, Beyond Pesticides sheds light on the disproportionate risks to women from toxic chemicals that are often unaccounted for and even dismissed throughout pesticide regulatory review and the underlying statutes. In a roundup of Daily News coverage in 2024, as well as the most recent scientific studies in 2025, on the scientific links between pesticide exposure and adverse effects in women, this article highlights the growing inequities in pesticide threats to women’s health.  Women farmers and farmworkers are particularly excluded when assessing pesticide risks. As previously reported by Beyond Pesticides, a study published in Occupational and Environmental Medicine finds that pesticide exposure, especially during puberty, can play a role in ovarian cancer development among female farmers. Although there are many studies that evaluate the risk for cancers among farmers, very few scientific articles cover the risk of ovarian cancer from pesticide exposure.  Additionally, this study suggests the role of hormones in ovarian cancer prognosis and development, highlighting an association with endocrine disruption. Endocrine disruption can lead to numerous health problems in multiple organ systems, including hormone-related cancer development (e.g., thyroid, breast, ovarian, prostate, testicular), reproductive […]

(Beyond Pesticides, March 4, 2025) A study in GeoHealth of pediatric cancers in Nebraska links exposure to agricultural mixtures with the occurrence of these diseases. The authors find statistically significant positive associations between pesticide usage rates and children with cancer, specifically brain and central nervous system (CNS) cancers and leukemia. “Our study is the first to estimate the effect of an agrichemical mixture on the pediatric cancer rate in Nebraska,” the study authors share. “One significant advantage of our study is that we identified the pesticide consistently applied over 22 years in Nebraska counties and then estimated the overall mixture effect of these pesticides on pediatric cancer.” The elevated effect of pesticide mixtures, a reality that is not evaluated in the U.S. Environmental Protection Agency’s (EPA) pesticide registration program, was reported in Oecologia (2008), documenting harm to amphibian populations even if the concentration of the individual chemicals is within limits considered acceptable. (See additional coverage here.) There is a wide body of science highlighting the disproportionate risk of adverse health effects in children with pesticide exposure. Their small size and developing organ systems, propensity to crawl and play near the ground, tendency for frequent hand-to-mouth motion, and greater intake of […]

(Beyond Pesticides, February 27, 2025) In analyzing current scientific literature and data on glyphosate-based herbicides (GBHs), a research article in Environmental Sciences Europe finds that glyphosate (GLY) persists in bones before reentering the bloodstream. The mechanisms in which GLY interacts with important cells for development, called hematopoietic stem cells (HSCs), and breaks and rearranges DNA offer a possible explanation for the heightened risk of cancer, specifically blood cancers like non-Hodgkin lymphoma (NHL), myeloma, and leukemia. “Existing data on GLY/GBH metabolism and genotoxicity provide critical insights into how exposures may be contributing to blood cancers,” according to the study’s author, Charles Benbrook, PhD. Dr. Benbrook continues: “A significant portion of GLY reaching blood moves quickly into bone marrow and then bone, where it can bioaccumulate and persist… Data reviewed herein suggest that a portion of the GLY excreted by most people on a daily basis can be traced to the shedding of calcium-GLY complexes in bone back into the blood supply.” This allows for near-constant contact between glyphosate molecules and hematopoietic stem cells, which are immature cells that can develop into any type of blood cell. Mutations in hematopoietic stem cells can cause blood cancers to emerge. Those at disproportionate risk […]

(Beyond Pesticides, February 25, 2025) A literature review of over 90 scientific articles in Agriculture documents microplastics’ (MPs) increase in the bioavailability, persistence, and toxicity of pesticides used in agriculture. The interactions between MPs and pesticides enhance the threat of pesticide exposure to nontarget organisms, perpetuates the cycle of toxic chemical use, and decreases soil health that is vital for productivity. “The increasing presence of MPs in agricultural ecosystems has raised concerns about their impact on pesticide bioavailability, efficacy, and environmental behavior,” says study author Kuok Ho Daniel Tang, PhD, a global professor in the Department of Environmental Science at the University of Arizona. He continues, “These synthetic particles interact with pesticides through adsorption and desorption processes, altering their distribution, persistence, toxicity, and uptake by plants and other organisms.” Microplastics in the Environment As Beyond Pesticides has previously reported, microplastics are ubiquitous and threaten not only human health but all wildlife in both aquatic and terrestrial ecosystems. The universal distribution of plastics means that they cannot be avoided. Humans and other organisms take up plastics in the form of microparticles and nanoparticles by inhalation, ingestion, and skin contact every day. Microplastics are about the width of a human hair; nanoplastics […]

(Beyond Pesticides, February 20, 2025) Researchers at the University of Oregon found that the rollout of genetically engineered corn in the early 2000s, followed by exponential increases in glyphosate-based herbicides, “caused previously undocumented and unequal health costs for rural U.S. communities over the last 20 years.” Their results “suggest the introduction of GM [genetically modified] seeds and glyphosate significantly reduced average birthweight and gestational length.” The conclusions of this study emerge as fossil fuel advocates, including President Donald Trump, are mobilizing to pioneer “energy dominance” despite the market movement toward renewable energy. Just as chemical-intensive farmers and land managers continue to spray synthetic fertilizers and pesticides, a successful rollout of alternatives must rely on feeding the soil rather than the plant. Advocates continue to demand that elected officials and regulators embody the precautionary principle and scientific integrity in decision-making. Given the hostile federal climate on anything relating to holistic solutions, communities are coming together to move beyond input-dependent land management systems and adopt organic criteria of allowed and prohibited substances, mandatory public comment process, independent third-party certification, and a federal advisory board (National Organic Standards Board) consisting of farmers, environmentalists, consumers, scientists, economists, researchers, and other stakeholders, with binding recommendations […]

(Beyond Pesticides, February 14, 2025) A study in the European Journal of Preventive Cardiology finds that organic food consumption lowers the risk of developing atherosclerotic cardiovascular disease (ASCVD). Heart health is important not just on Valentine’s Day, but every day. While celebrating with friends and family, consider spreading love in ways that promote long-term health and wellness with an organic meal paired with organic flowers and chocolates. Eliminating exposure to petrochemical pesticides and synthetic fertilizers, such as with an organic diet, mitigates disease risks including brain and nervous system disorders, cancer, endocrine disruption, and cardiovascular disease (CVD). In this latest study, the scientists and doctors analyze registered diagnoses of ASCVD from the Danish National Patient Register in comparison with the diets of a cohort of middle-aged women and men from the Danish Diet, Cancer and Health study. The eligible study participants, including 41,407 men and women of which 5,365 developed ASCVD, filled in a detailed 192-item food frequency questionnaire and a lifestyle questionnaire on their consumption of organic vegetables, fruit, dairy products, eggs, meat, and bread and cereal products. The authors report that the results show overall organic food consumption is associated with a 6% lower incidence rate of ASCVD. […]

(Beyond Pesticides, February 11, 2025) In a Science of The Total Environment study, scientists test over 100 blue tit (Cyanistes caeruleus) and great tit (Parus major) birds’ nests for pesticide residues in comparison with the number of dead offspring and unhatched eggs within the nest. Fur-lined nests, from animals treated with ectoparasitic chemicals, expose birds to compounds that can impact reproductive success. The authors found fipronil, a phenyl pyrazole insecticide, in all nests, with the majority also containing the neonicotinoid insecticide imidacloprid and synthetic pyrethroid insecticide permethrin. The data shows higher insecticide levels are linked to increased offspring mortality and threaten biodiversity. This study highlights an important exposure route that is overlooked. “Although not all bird species use fur for nest building, a substantial number do, especially cavity-nesting species,” the researchers share. “Previous research found that 74% of studied woodland bird species in central Europe incorporated fur into their nests.” Many bird species in the U.S. also line their nests with fur, such as black-capped chickadees, tufted titmice, and chipping sparrows. While there is a wide body of science showing reproductive effects from pesticides, the researchers highlight the study’s novel design, saying, “To the best of our knowledge, no previous […]

(Beyond Pesticides, February 7, 2025) With the strong associations established in epidemiologic studies and a dearth of evidence on the actual mechanisms by which pesticides inflict their damage on the brain, a new meta-analysis identifies studies that pesticides can overwhelm cells’ defenses against them, interfere with cell communication in the brain, and disrupt the epigenetic (gene function) regulation of gene expression. In the journal Nucleus, Bilal Ahmad Mir, PhD and colleagues at the University of Kashmir in Srinagar, India, review what is known at the molecular level about pesticides’ role in brain cancer. Brain cancer is a heavy burden for its victims and their families, and attributing a cause is, as with many diseases, fraught with difficulty. But there are strong clues: For example, farming is a known risk factor. In a 2021 meta-analysis of epidemiologic studies between 1998 and 2019, analyzed here by Beyond Pesticides, farming was associated with a 13% increase in the risk of brain cancer. For farmers whose specific exposure to pesticides was documented in the studies, the increase jumped to 20 percent. So there is some reason to point a finger at synthetic chemicals. But agricultural workers are not the only ones at risk. According […]

(Beyond Pesticides, February 5, 2025) A study in PLOS One finds acute and chronic impacts of nontarget toxicity on the American burying beetle, Nicrophorus americanus, with neonicotinoid insecticide exposure. In assessing environmentally relevant concentrations of the neonicotinoid insecticide imidacloprid with N. americanus, the researchers note both mortality and behavioral effects that leave the species at high risk of predation. These effects mean the American burying beetle “may be at greater risk to insecticide exposure than previously thought and vulnerable to episodic, low-dose neonicotinoid exposure,” the authors say. This data sheds important light on a species that has been listed by the U.S. Fish and Wildlife Service (USFWS) as threatened. Burying beetles provide important ecosystem services within the environment such as “burying carrion, increasing available nutrients in soil, and expediting carrion decomposition, while acting as a food source for secondary consumers,” the researchers state. (See more on ecosystem services and beneficial insects here, here, and here.) The N. americanus species are habitat generalists and can be found in grasslands, wet meadows, and forested areas that neighbor agricultural lands and introduce the beetles to pesticide drift and soil residues. While acute and chronic effects vary in duration and severity, pesticide exposure resulting […]

(Beyond Pesticides, February 4, 2025) Adopting a fully organic diet can reduce pesticide levels in urine within just two weeks “by an average of 98.6%” and facilitate faster DNA damage repair relative to a diet of food grown with chemical-intensive practices, according to findings from a randomized clinical trial published in Nutrire. The authors explain that their finding “is likely due to two main factors: the presence of compounds characteristic of [an organic] diet, which may have high levels of antioxidants that can protect DNA and also induce DNA repair [], and the absence or decrease in the incidence of pesticides in this type of diet, which are recognized for their genotoxic effects and have the ability to affect the genetic repair system of organisms [].” Public health professionals and affected families continue to sound the alarm on the unprecedented rates of chronic illnesses, many linked to pesticide exposure, as well as the urgency in developing solutions that acknowledge the connection to policies governing agriculture, nutrition policies, and public health. Background and Methodology The purpose of this study is to identify any relationships in health effects of chemical-intensive versus organic diets in a two week-period. More specifically, the authors say […]

(Beyond Pesticides, January 31, 2025) A recent cross-sectional study in Heliyon highlights the link between sleep disorders in Thai farmers and pesticide exposure. The authors find pesticide exposure as an important risk factor for sleep disorders after surveying 27,334 farmers over the age of 20 who had work experience for at least five years. The importance of sleep health is reflected both physically and mentally, as studies find “sleep deficiency increase[s] mortality and various health complications, including hypertension, obesity and type 2 diabetes, cardiovascular diseases, mood disorders, and neurodegenerative disorder.” Additional studies find that these issues are compounded when sleep health is affected by environmental factors such as pesticide exposure. (See previous Beyond Pesticides’ coverage here and here.) The researchers report: “The study found a positive association of 19 individual pesticides (twelve insecticides, two herbicides, and five fungicides). Some associations demonstrated a dose-response pattern. Additionally, the study revealed that women are at a higher risk of sleep-related issues with pesticide exposure compared to males. These results not only substantiate existing literature but also unveil several new individual pesticides that may impact sleep health.” Focusing on study participants in Thailand, which is “characterized by heavy pesticide use and minimal protective measures, […]

(Beyond Pesticides, January 30, 2025) A research article in Biology Letters, published by The Royal Society, finds that the neonicotinoid insecticide imidacloprid disrupts survival and reproductive patterns in Bombus impatiens bumblebees. The study adds to the wide body of science highlighting how exposure to pesticides “can result in immediate mortality or cause long-term detrimental effects on pollinators‘ health, lifespan and reproductive success,” the authors state. The researchers performed two experiments to assess the effects of various concentrations of imidacloprid, one of which focuses on bees during diapause, a period of dormancy. “Wild bees, which provide the majority of pollination services worldwide, undergo an annual life cycle that includes a winter diapause, that can span over 75% of their life cycle and during which their metabolism, growth and development are halted,” the authors note. They continue: “The time spent in diapause can have lasting effects on pollinator fitness and their ability to establish nests or colonies in the following spring. This period is especially critical for social bee colonies, which are founded by a single queen after diapause and play a vital role in large-scale pollination.” Exposure to pesticides during diapause can occur while bee species overwinter in contaminated soils. In […]

(Beyond Pesticides, January 22, 2025) A study published in Nature Scientific Reports in December 2024 sheds light on how people value the benefits of reducing or eliminating pesticide exposures. The study, based on economic concepts, is a meta-analysis of studies that have attempted to discern what that value is in monetary terms. This study shows the difficulty in gleaning from the existing literature an assignment of true value of social costs associated with pesticide contamination and poisoning, however, was able to glean several points of interest: People’s “willingness to pay” (WTP) is higher for health benefits than ecological ones. In studies that included pesticide risks associated with cancer, the social cost (WTP) tripled. People’s WTP is higher to prevent or ameliorate chronic diseases than to treat or avoid acute exposures. If the study did not specify a pesticide type—even general categories such as herbicide, insecticide and fungicide, and most studies fell into this category—the WTP is significantly higher. In ecosystem terms, use of the term “biodiversity” results in higher WTPs compared to other aspects such as groundwater or aquatic organism health. Consumers are more risk-averse than farmers. The higher the income, the higher the WTP. Social cost is distinguished from the […]

(Beyond Pesticides, January 21, 2025) When the American Cancer Society (ACS) published its annual report last week, it pointed to a rising incidence of cancer in younger women and highlighted disparities by race and ethnicity that are especially timely with the commemoration of Dr. Martin Luther King, Jr. In its report, “Cancer Mortality Continues to Drop Despite Rising Incidence in Women; Rates of New Diagnoses Under 65 Higher in Women Than Men,” ACS writes: “Disparities in cancer occurrence and outcomes are often the result of socioeconomic deprivation as a consequence of structural racism, which limits opportunities for education and other mechanisms of upward mobility. For example, the historical practice of mortgage lending discrimination known as redlining is associated with later stage cancer diagnosis, lower likelihood of receiving recommended treatment, and higher cancer mortality. Inequalities in wealth lead to differences in the prevalence of risk factor exposures as well as access to high-quality cancer prevention, early detection, and treatment. Even beyond higher prevalence of common risk factors like smoking and obesity, exposure to carcinogenic air emissions is up to 50% higher among people experiencing poverty, regardless of race or ethnicity. In 2022, 25% of AIAN [American Indian and Alaska Native] people lived below the federal […]

(Beyond Pesticides, January 17-20, 2025) Martin Luther King Day recognizes the achievements of a remarkable civil rights leader while asking the nation to assess what more the country must do to ensure equality and environmental justice, as well as protection for those who suffer disproportionately from toxic chemical exposure. Advocates and disproportionately affected communities acknowledge the historic nature of the Biden Administration’s commitment to elevating environmental justice in the decision-making of the U.S. Environmental Protection Agency (EPA). However, according to Willy Blackmore, writer for Minnesota Spokesman-Recorder (“the oldest Black-owned newspaper in the state of Minnesota and one of the longest-standing, family-owned newspapers in the country”), “[T]he more systemic change that [Administrator] Regan’s EPA tried to bring about was stonewalled by legal challenges that threatened to undermine the agency’s strongest tool for righting environmental injustices.” Black communities across the nation face disproportionate impacts to petrochemical infrastructure and toxic chemicals, including pesticides and fertilizers. A 2021 study published in BMC Public Health found that biomarkers for 12 dangerous pesticides tracked over the past 20 years were found in the blood and urine of Black participants at average levels up to five times those in White participants. A University of Michigan study found […]

(Beyond Pesticides, January 16, 2025) In Ecotoxicology and Environmental Safety, researchers highlight a multitude of studies on endocrine disrupting chemicals (EDCs) and endocrine disrupting pesticides (EDPs) showing epigenetic effects from exposure. These EDCs imitate the action of endocrine hormones and lead to gene damage and multigenerational adverse effects to health. “These chemicals can interfere with the normal functioning of target tissues by altering their response to hormonal signals, thereby affecting various physiological processes including reproduction, development, the nervous system, the immune system, and even the process of carcinogenesis [causing cancer],” according to the authors from Hebei Agricultural University and Chinese Academy of Agricultural Sciences.   In causing epigenetic modifications, the authors describe that EDCs can create changes “at the nuclear and mitochondrial DNA (nDNA and mtDNA) or RNA levels, without changing the underlying DNA sequence. These alterations modify the structure or conformation of DNA, influencing gene expression and, consequently, cellular function.” They continue, “The mechanisms of epigenetics include changes in DNA methylation, chromatin modifications and the involvement of certain noncoding RNAs.” In reviewing over 80 studies on EDCs, predominantly fluorinated compounds such as per- and polyfluoroalkyl substances (PFAS), the researchers provide a summary of linkages between pesticide exposure and the […]