(Beyond Pesticides, October 2, 2023) On the 50th anniversary of the Endangered Species Act (ESA), statements out of the U.S. Environmental Protection Agency (EPA) raise concerns about the agency’s ability to meet the challenge of evaluating pesticides for their adverse impact on threatened and endangered species. While EPA has initiated efforts to address a significant backlog of pesticide evaluations, the agency faces a task so extensive that it may require several additional decades to fully catch up. EPA officials stated, “Even if EPA completed this work for all of the pesticides that are currently subject to court decisions and/or ongoing litigation, that work would take until the 2040s, and even then, would represent only 5 percent of EPA’s ESA obligations.”   As part of a “whole of government” approach, EPA must redirect its pesticide program to protecting all species and their habitats.   The speed and depth of biodiversity loss has reached crisis proportions. A 1,500-page report in 2019 by Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES )—Global Assessment Summary for Policymakers, the most comprehensive look to date at the biodiversity crisis and its implications for human civilization, makes the following finding: “Since 1970, trends in agricultural production, fish harvest, […]

(Beyond Pesticides, September 29, 2023) In unsurprising news, the Environmental Protection Agency (EPA) has reversed itself and decided not to ban a dangerous pesticide: tetrachlorovenphos (TCVP) used in pet flea collars and other flea products. This is despite its own earlier decision to ban TCVP in pet collars and scathing criticism of its methods and conclusions by the courts. First registered in 1966, TCVP belongs to the notoriously toxic organophosphate chemical family and is classified by the World Health Organization as “possibly carcinogenic to humans.” It was originally registered to Shell Chemical, then to E.I. duPont de Nemours, then to Hartz Mountain Corporation and Fermenta Animal Health Company.  Early on, it was registered for use on food crops and livestock, but the crop uses were voluntarily de-registered in 1987. It is still widely used on pets and farm animals. In 1995, EPA issued the opinion that “all uses of tetrachlorvinphos, with the exception of oral feed-through larvicide treatment to livestock intended for food use, will not cause unreasonable risk to humans or the environment.” Since then, the agency has contorted itself repeatedly to allow TCVP to remain on the market. There is little research available on TCVP’s human health effects; the […]

(Beyond Pesticides, September 28, 2023) As the United States commemorates the 50th anniversary of the Endangered Species Act (ESA), there is a growing recognition that the planet faces an existential biodiversity crisis, with a rising number of species on the brink of extinction. In a collective effort to address threats to global biodiversity (i.e. diversity of all life), a coalition of environmental organizations including Beyond Pesticides, are sending an urgent letter to President Joe Biden. This letter, titled “Meeting the Challenges of the Biodiversity and Extinction Crisis Over the Next 50 Years,” calls for bold and comprehensive action to preserve our planet’s natural heritage for future generations. The ESA is celebrated as one of the most effective conservation laws globally, credited with preventing the extinction of 99 percent of listed species. Over the past five decades, the ESA has played a pivotal role in preventing these extinctions by safeguarding the most critically endangered species within biological communities. However, this concentration on highly threatened species often results in temporary solutions that may not comprehensively address the broader issue of biodiversity loss. The ESA establishes a framework to categorize species as “endangered” or “threatened,” granting them specific protections. While it is crucial […]

(Beyond Pesticides, September 19, 2023) Farmworkers in Paarl, South Africa took to the streets on Friday, September 8, demanding an end to the indiscriminate importation and use of pesticides, herbicides, and fungicides containing substances prohibited by the European Union (EU). This protest is part of a broader global trend of outcry against systemic issues of environmental racism that disproportionately burden communities with environmental and health risks.   Organized by the Women on Farms Project, the protesters marched to the headquarters of Bayer. The German pharmaceutical, biotechnology, and pesticide company, responsible for producing and exporting agrochemicals known to be toxic to ecosystem and human health, has previously faced multiple lawsuits, including a multimillion-dollar one linking their glyphosate weed killer products (Roundup®) to non-Hodgkin Lymphoma. At the Bayer office, the protesters presented a memorandum demanding an end to the importation and use of EU-prohibited substances.    Protesters sought to expose the hypocritical tactics European agrochemical companies use to sell products in developing nations, even when those products are deemed unsafe in their home countries. Numerous farmworkers, like victim-turned-activist Antie Dina, spoke out about their health issues from petrochemical exposure. In her talk, Dina emphasizes that, “… enough is enough, we do not want any […]

(Beyond Pesticides, September 14, 2023) As we celebrate National Organic Month this September, it is the perfect time to reflect on why you should consider going organic. Do you try to buy organic food when you can? Are you looking for a way to reduce your and your family’s exposure to toxic pesticides? The benefits of choosing an organic lifestyle extend far beyond your diet or your own health. Beyond Pesticides is helping communities transition parks and public lands to organic land management. Here are some reasons why Beyond Pesticides believes in building organic communities: Why Go Organic? Health and Safety: Organic foods and parks are free from harmful pesticides, fossil-fuel-based substances, and toxic chemicals, making them safer and healthier for all ages. Visit Beyond Pesticide’s 40 Common Lawn and Landscape Chemicals page to learn more about the health impacts of pesticides in communities. Environmental Stewardship: Opting for organic parks and products supports practices that protect pollinators, improve soil health, increase biodiversity, and reduce toxic runoff into water bodies. Learn more about how to protect pollinators in your community by reading BEE Protective. Trust and Transparency: The USDA Certified Organic label ensures strict standards and regulations for organic products, providing […]

(Beyond Pesticides, September 13, 2023) A study published in Global Change Biology finds climate change increases bees’ sensitivity to pesticide exposure, impairing the pollinators’ ability to respond to light (Ultra-Violet [UV] stimuli), reducing floral syrup consumption, and lessening longevity (length of life) up to 70 percent. Notably, the reduction in floral syrup consumption indicates nutritional stress that further impacts bee species’ fecundity (productiveness), driving bee declines. Unless more is done to combat the climate crisis, the current global warming scenario increasing bees’ sensitivity to pesticide exposure will continue to threaten all pollinator health. The pervasiveness of pesticide exposure, combined with climate change, threatens global species biodiversity. As has been widely reported, pollinators (such as bees, monarch butterflies, and bats) are a bellwether for environmental stress as individuals and as colonies. Pesticides intensify pollinators’ vulnerability to health risks (such as pathogens and parasites), with pesticide-contaminated conditions limiting colony productivity, growth, and survival. The globe is currently going through the Holocene Extinction, Earth’s 6th mass extinction, with one million species of plants and animals at risk, including pollinators. Pollinator declines directly affect the environment, society, and the economy. Without pollinators, many agricultural and nonagricultural plant species will decline or cease to exist as U.S. pollinator declines, particularly […]

(Beyond Pesticides, September 8, 2023) In a united effort, climate and environmental justice movements from around the world have come together to announce a global “end to fossil fuels,” including the end of pesticides. The “March to End Fossil Fuels” is scheduled for September 17 and the Secretary General’s Summit in New York City on September 20. See the full map for other marches around the world. At the Beyond Pesticides, 2022 National Forum session on climate (November, 2022), we discussed the science and the urgent need for a strategic response to the climate crisis as part of a constellation of crises that intersect. Whether we are talking about a health crisis borne out of chemical-induced diseases, the collapse of life-sustaining biodiversity, or the dramatic catastrophes caused by greenhouse gases and rising temperatures—the interconnectedness of the crises requires strategic solutions that are holistic and nurturing of our relationship with nature —a relationship we have minimized as a matter of policy and practice. The data on climate calls on us to be audacious in our demand for urgent change in our households and communities, and from decision makers at all levels of government. At Beyond Pesticides, our audacious goal is to […]

(Beyond Pesticides, August 30, 2023) Invasive yellow-legged hornets have been spotted near Savannah, Georgia, causing concern among agriculture officials. These hornets are known for their ability to prey on honeybees and other pollinators, and their presence in the United States is a cause for alarm. This is the first time a live specimen of this species has been detected in the open United States, according to the Georgia Department of Agriculture. The hornets, which are native to Southeast Asia, have been spotted in other parts of the world, including Europe, where they have caused significant damage to bee populations. They are considered “invasive,” which means the hornet is not native and officials expect their introduction to result in economic, environmental, or health-related damage to humans, animals, plants, or the environment. In response to the sighting in Georgia, officials are taking action to eradicate the hornets before they can cause any harm to US agriculture. One of the methods being used to eradicate the hornets is the localized use of the highly toxic insecticide cypermethrin on nests. The pesticide has been registered for use in agriculture and residential pest control since the 1970s. It kills insects such as mosquitoes, flies, ticks, […]

(Beyond Pesticides, August 29, 2023) A study published in Insect Biochemistry and Molecular Biology finds the widely used azole fungicide, tebuconazole, has damaging impacts on the redox homeostasis (the process of maintaining balance between oxidizing and reducing reactions) and fatty acid composition in honey bees’ brain via oxidative stress. Acute, field-realistic sublethal exposure to tebuconazole decreased the brain’s antioxidant capacity, key antioxidant defense systems, and oxidative degradation and alteration of lipids (fats) in the brain. Thus, this study adds to the scientific literature on the adverse effects of chemical exposure on pollinator health, especially in sublethal concentrations. Degenerating cognitive skills can threaten honey bee survivability, decreasing colony fitness and individual foraging success. Much research attributes the decline of insect pollinators (e.g., commercial and wild bees and monarch butterflies) over the last several decades to the interaction of multiple environmental stressors, from climate change to pesticide use, disease, habitat destruction, and other factors. Pollinator declines directly affect the environment, society, and the economy. Without pollinators, many plant species, both agricultural and nonagricultural, will decline or cease to exist, as U.S. pollinator declines, particularly among native wild bees, depress crop yields. In turn, the economy will take a hit, since much of the economy (65%) depends upon the […]

(Beyond Pesticides, August 23, 2023) Researchers are investigating a cutting-edge method to identify the impact of pesticides on reproductive health—shrinking the wait time from months to weeks. Scientists at the University of California, Davis, are developing a method for identifying harmful chemicals in pesticides with the help of glowing fish. This scientific breakthrough could revolutionize pesticide research and help prevent long-term health problems caused by exposure to these chemicals.  Pesticide exposure can cause acute and long-term health problems for the human endocrine system, the hormone system that regulates many biological processes from reproduction to blood sugar, growth, and more. Beyond Pesticides has written about the connections between EPA-registered pesticides and involuntary abortions, reproductive cancers, pregnancy loss, early-onset puberty, and more.   The American Academy of Pediatrics (AAP) has expressed concern over the limited or missing data regarding the health effects of pesticides and food additives on infants and children, who are more vulnerable to chemical exposures. AAP has identified several compounds as being of particular concern, including bisphenols, which are commonly used in the lining of metal cans; phthalates, which are used in adhesives and plasticizers; nonpersistent pesticides, which have been addressed in a previous AAP policy statement; perfluoroalkyl chemicals (PFCs), […]

(Beyond Pesticides, August 14, 2023) Marijuana regulators in the state of Washington issued administrative holds on 18 licenses due to pesticide-contaminated marijuana, forcing producers and processors to cease operations until now. This shutdown of legal marijuana businesses serves as a window into a broader historical backdrop of pesticide issues within the marijuana industry. Within Washington, pesticide concerns have been growing since a study in 2018 of legal marijuana farms in the state had 84.6% (of 26 samples) with significant quantities of pesticides including insecticides, fungicides, miticides, and herbicides. Last year, a national study identified a list of contaminants in 36 states and the District of Columbia and found 551 pesticides within cannabis products. For over a decade, Beyond Pesticides has sounded the alarm about the highly-concentrated levels of pesticides in marijuana products, calling on state officials to require organic marijuana, especially in the context of medical marijuana. The absence of federal regulations for pesticides in cannabis production has raised significant concerns about exposure risks for recreational and medicinal use, exposure risks to workers, and potential environmental contamination impacting wildlife. Since marijuana is classified as a Schedule 1 narcotic under the Controlled Substances Act, the EPA does not regulate pesticides in […]

(Beyond Pesticides, August 1, 2023) The U.S. Environmental Protection Agency has announced that it is publishing a decade’s worth of pesticide incident data in a searchable database that will be updated on a monthly basis. The Incident Data System (IDS), with poisoning reports generated mostly from chemical manufacturers, states, a national hotline, and poison control centers, offers information on reported pesticide exposures from accidental poisoning of pets, wildlife, and humans, to pesticide drift, noncompliance, and other pesticide incidents that may be associated with product uses in compliance with label instructions. Tracking this incident data is essential to understanding the risks and damages associated with pesticide use.   The bulk of the data on incidents is from consumer reports to chemical manufacturers. Chemical companies are required under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), Section 6(a)(2) to report incidents: “If at any time after the registration of a pesticide the registrant has additional factual information regarding unreasonable adverse effects on the environment of the pesticide, the registrant shall submit such information to the Administrator.” The determine of threshold number of incidents required to be reported as a pattern of “unreasonable adverse effects” is left to the manufacturers to determine. Through […]

(Beyond Pesticides, July 28, 2023) A study published in Science of the Total Environment finds glyphosate can adversely impact sensory and cognitive processes in bumblebees (Bombus terrestris). Glyphosate exposure impairs bees’ learning of aversive stimuli like electric shocks paired with specific color discrimination. Additionally, the pesticide reduces attraction to UV (ultraviolet) light, specifically the color blue, and temporarily impacts locomotion and phototaxis (movement in response to light). These impairments to sensory and cognitive processes render foraging difficult for these glyphosate-exposed pollinators and vulnerable to unavoidable predators. The study highlights that symptoms of widespread chemical exposure may reduce foraging efficiency and adversely affect ecosystems, especially those dependent on insect pollinators.  Pollinator decline directly affects the environment, society, and the economy. Without pollinators, many plant species, both agricultural and nonagricultural, will decline or cease to exist as U.S. pollinator declines, particularly among native wild bees, limit crop yields. In turn, the economy will take a hit, since much of the economy (65%) depends upon the strength of the agricultural sector. As the science shows, pesticides are one of the most significant stressors for pollinators. In a world where habitat loss and fragmentation show no sign of abating, scientists have concluded that the globe cannot afford to continue […]

(Beyond Pesticides, July 27, 2023) A study published in the Journal of Economic Entomology calls into question the scientific literature on protecting bees from pesticides. The study analyzes actions taken by pesticide users to reduce the risk of pesticides on nontarget organisms, known as “mitigation measures.” Ultimately, the study finds that there is insufficient evidence to support the effectiveness of bee-protecting mitigation measures.    “Almost all research was centered around protecting honey bees. However, honey bees are a managed species that is not endangered,” Edward Straw, Ph.D., a postdoctoral researcher in the School of Agriculture and Food Science at University College Dublin in Ireland and lead author on the study, says, “When we try to protect bees, we really want to be protecting wild, unmanaged bee species, as these are the species which are in decline.”  The study includes a chart of mitigation methods that have been tested in the scientific literature. The mitigation measures under evaluation include: restricting pesticide application to certain times of day, restricting the application of pesticides during weather events, removing flowering weeds that attract pollinators, applying repellents to deter pollinators, and more. The researchers find that there are few empirical tests on the most widely used […]

(Beyond Pesticides, July 21, 2023) A comprehensive and scathing report, “Neonicotinoid insecticides: Failing to come to grips with a predictable environmental disaster,” issued by American Bird Conservancy (ABC)in June, lays out the dire consequences of neonicotinoid (neonic) pesticides’ continued use. The report is an update of an earlier review from 2013, which warned of the risks to birds, stating starkly: “A single corn kernel coated with a neonicotinoid can kill a songbird. Even a tiny grain of wheat or canola treated with the oldest neonicotinoid, imidacloprid, can poison a bird. As little as 1/10th of a corn seed per day during egg-laying season is all that is needed to affect reproduction with any of the neonicotinoids registered to date.” The story of neonic harm is one that has been repeated for generations with different pesticides. Pesticide manufacturers claim every new generation of their products is safer and more environmentally benign than the previous one. This is seldom true. There is ample evidence that pesticides pose threats to nearly every class of organism on Earth, from earthworms to elephants. The neonicotinoids, introduced in the early 1990s, have been marketed as safe for vertebrates, non-bioaccumulative, and, because of their flexible application methods […]

(Beyond Pesticides, July 20, 2023) Despite evidence of toxicity to pets from Seresto pet collars (manufactured with the neurotoxic insecticide flumethrin, as well as the notorious neonicotinoid imidacloprid), the U.S. Environmental Protection Agency’s (EPA) has announced that the popular flea and tick collars will remain on the market, but with new mitigation measures. However, advocates say that these measures will do little to protect people and pets from chemical exposure using these collars. The agency will require Elanco — the manufacturer of Seresto — to conduct enhanced reporting for various factors, including adverse symptoms, veterinary community outreach, and warnings on the product’s label. Seresto, developed by Bayer and sold by Elanco, has been linked to nearly 1,700 pet deaths, injuries to tens of thousands of animals, and harm to hundreds of people. There are nontoxic ways to protect pets from fleas and other pests while protecting human family members. Children Ignored by the Agency EPA has a history of ignoring the exposure patterns to children who come into close contact with pets and their flea collars and the potential adverse health threats, opting for warnings instead of regulatory action. In 2017, EPA issued a warning for tetrachlorvinphos (TCVP) flea collars that advised: “not […]

(Beyond Pesticides, June 29, 2023) In the first major settlement amid an influx of PFAS litigation, industrial chemical giants DuPont, Chemours, and Corteva will pay $1.185 billion dollars to cities and towns across the U.S. to cover the cost of PFAS remediation and monitoring in public drinking water systems. The significance of this nationwide class-action settlement cannot be overstated, as citizens have battled powerful chemical corporations for decades with limited success. Dangerous toxicants have been indiscriminately discharged into the environment by chemical companies since the mid-1900s, and the PFAS litigation is important in the company’s acceptance of responsibility for contamination. Of course, the damage to health and the environment is incalculable, given the pervasive environmental contamination and poisoning that it has caused, and additional lawsuits are pending, with more expected. Advocates maintain that this case exemplifies the inadequacies of regulatory controls that do a poor job of capturing the long-term effects of chemicals before being introduced into the market and a worse job of questioning the essentiality of toxic substances for which there are alternative practices and products. PFAS bring into sharp focus the legacy of chemical contamination and the impact on  future generations—a problem well-documented with pesticides like DDT […]

(Beyond Pesticides, June 23, 2023) Pollinators are especially important to the ecosystem. They pollinate plants by going from flower to flower and transferring pollen. Without pollinators, availability would be severely limited or cut off to many delicious foods, such as apples, almonds, cherries, blueberries, pumpkins, and many others. Many types of pollinators, like honey bees, bumble bees, and butterflies, are declining due to loss of habitat, widespread use of toxic pesticides, parasites, and disease. Help these important beneficial creatures by Not using toxic pesticides Planting pollinator habitats, like colorful flowers, gardens, and trees Telling your friends and family all about the importance of pollinators. Wild and Managed Bees Wild and managed bees play a crucial role in the global food system. About two-thirds of the world’s most important crops benefit from bee pollination, including coffee, cacao, and many fruits and vegetables. Wild pollination is becoming increasingly important with the growing instability of managed honey bee colonies. According to one study, wild bees’ agricultural value is now similar to that of honey bees, which are no longer considered wild in many regions due to their intense management. While many may prefer butterflies and birds to pay a visit to their gardens […]

(Beyond Pesticides, June 22, 2023) Since the early twentieth century, ‘migratory’ beekeepers have provided a critical service to U.S. agriculture by moving their hives seasonally to pollinate a variety of crops. Annually, commercial beekeeping adds between $15 and $20 billion in economic value to agriculture, which is a major industry in the United States, with 21.1 million full- and part-time jobs related to the agricultural and food sectors—10.5 percent of total U.S. employment. Before insects and pollinators like bees evolved to pollinate, pollination occurred through the wind, scattering the pollen from the plants and landing on other flowers that could reproduce. However, commercial pollination services contribute to increased yields. Without commercial pollination, food prices would rise, the farm sector would suffer globally, and the security and variety of the food supply would diminish. With the wild insect pollinator populations already in serious decline, commercial, migratory beekeeping is more than ever a vital piece of the agricultural economy. With pollinator decline, as an integral part of worldwide biodiversity collapse and the “insect apocalypse,” commercial beekeepers face collapse as well. The United Nations states that 80 percent of the 115 top global food crops depend on insect pollination, with one-third of all U.S. crops depending on pollinators, according to the U.S. […]

(Beyond Pesticides, June 21, 2023) Pollinators––bees, butterflies, birds, bats, and other organisms––make a critical contribution to plant health, crop productivity, and the preservation of natural resources. However, pesticides consistently act as a key contributor to dramatic pollinator declines. Much research attributes the decline of insect pollinators over the last several decades to the interaction of multiple environmental stressors, from climate change to pesticide use, disease, habitat destruction, and other factors. Roughly a quarter of the global insect population has disappeared since 1990, according to research published in the journal Science. Monarchs are near extinction, and beekeepers continue to experience declines that are putting them out of business. We continue to lose mayflies, the foundation of many food chains, and fireflies, the foundation of many childhood summer memories. The declines in many bird species likely have close links to insect declines. Recent research finds that three billion birds, or 29% of bird abundance, have been lost since the 1970s. In a world where habitat loss and fragmentation show no sign of abating, scientists have concluded that the globe cannot afford to continue to subject its critically important wild insects to these combined threats.  Clean air, water, and healthy soils are integral to ecosystem function, interacting between Earth’s four main spheres (i.e., hydrosphere, […]

(Beyond Pesticides, June 5, 2023) Butterflies—the most attractive of our insect fauna—are disappearing at an appalling rate, largely due to pesticide use. Recent studies have documented declines of almost 50% from 1990 to 2011 in Europe (with trends continuing), of 58 percent between 2000 and 2009 in the U.K., and of 33% from 1996–2016 in the state of Ohio in the U.S. Even steeper declines have been documented for Monarch butterflies, with an 80 percent decline of Eastern monarchs and 99 percent decline of Western monarchs. Tell EPA to eliminate pesticides that threaten butterflies. Tell the U.S. Fish and Wildlife Service and Department of Interior to help bring back butterflies by eliminating the use of pesticides that threaten them. Tell Congress that EPA and other agencies need to do their job and protect our most charismatic insects. Last year, EPA admitted that three neonicotinoid pesticides are “likely to adversely affect from two-thirds to over three-fourths of America’s endangered species—1,225 to 1,445 species in all,” including many butterfly species. On May 5 of this year, EPA released new analyses of these neonics’ effects on endangered species. EPA’s analyses focus on the species most at risk of extinction, and the results represent […]

(Beyond Pesticides, May 26, 2023)The use of pesticides in agriculture, transportation, and domestic settings has created a disastrous conflict for the human species. Two irreconcilable facts confront humans as they try to adapt to the consequences of earlier choices: One, industrial civilization came to believe that because some insects, fungi, and other organisms like to eat the same plants humans eat, humans can kill them with impunity; two, because some insects and other organisms are necessary to the health and reproduction of plants, humans need to protect them. At no point in history have people acknowledged that it is very difficult to kill the “bad” actors while protecting the “good” ones. There are not really two sides to the biological fact; rather, pesticides and biodiversity meet each other on a single plane, like a Möbius strip. Among the most dire effects of pesticides are their ruination of pollinators. Bees spring to mind as our primary pollinators, but they are by no means the only ones. Butterflies, often regarded as mere ornamental additions to a landscape, are actually significant pollinators themselves. Monarchs pollinate many flowers, including calendula and yarrow. Other butterflies pollinate dill, celery, fennel, cilantro, lettuce, peas, and basil, among […]

(Beyond Pesticides, May 18, 2023) A study published in Food and Chemical Toxicology finds pesticide residues in beehive products pose a safety risk from dietary consumption. Beehive products (i.e., bee bread, propolis, beeswax, and royal jelly) from beekeeping or apiculture are said to have nutraceutical (health and medicinal benefits) properties. However, a wide range of pesticide residues (i.e., tau-fluvalinate, coumaphos, chlorfenvinphos, chlorpyrifos, and amitraz), especially acaricides for killing ticks and mites in hives, may accumulate in beehive products up to concentrations that pose a potential health risk. Environmental contaminants like pesticides are ubiquitous in the environment, with 90 percent of Americans having at least one pesticide compound in their body. Many of these chemical compounds remain in soils, water (solid and liquid), and the surrounding air at levels exceeding U.S. Environmental Protection Agency (EPA) standards. Therefore, individuals still encounter pesticide compounds at varying concentrations, adding to the toxic body burden of those harmful chemicals currently in use. The research methodology includes a review of the scientific literature on pesticide contamination in hive products and a dietary risk assessment. The risk assessment calculation uses scientific studies to determine the recommended daily intake values and concentration data. Researchers compare exposure values in products to health-based guidance, determining the potential acute and […]